E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.037 0.159 -9999.0 0.0 -0.43 30.0 30.0 KLHL20 0.006 0.077 0.158 1.0 -0.199 2.0 3.0 CYFIP2 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.01 0.112 0.251 4.0 -0.275 26.0 30.0 ENAH -0.044 0.166 -9999.0 0.0 -0.446 31.0 31.0 AP1M1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.02 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.011 0.077 -9999.0 0.0 -0.204 3.0 3.0 ABI1/Sra1/Nap1 -0.016 0.037 -9999.0 0.0 -0.14 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.004 0.146 -9999.0 0.0 -0.311 36.0 36.0 RAPGEF1 -0.032 0.155 0.246 4.0 -0.39 31.0 35.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.042 0.174 -9999.0 0.0 -0.45 33.0 33.0 CRK -0.044 0.157 -9999.0 0.0 -0.42 31.0 31.0 E-cadherin/gamma catenin/alpha catenin 0.002 0.128 -9999.0 0.0 -0.301 32.0 32.0 alphaE/beta7 Integrin 0.014 0.085 -9999.0 0.0 -0.345 11.0 11.0 IQGAP1 0.022 0.019 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.036 0.029 -9999.0 0.0 -0.265 1.0 1.0 DLG1 -0.044 0.166 -9999.0 0.0 -0.434 33.0 33.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.019 0.054 -9999.0 0.0 -0.154 14.0 14.0 MLLT4 0.022 0.034 -9999.0 0.0 -0.479 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.046 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.021 0.069 -9999.0 0.0 -0.198 4.0 4.0 ARF6 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.035 0.139 -9999.0 0.0 -0.354 32.0 32.0 TIAM1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.018 0.106 -9999.0 0.0 -0.25 28.0 28.0 AKT1 -0.007 0.049 0.124 1.0 -9999.0 0.0 1.0 PIK3R1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.066 0.176 -9999.0 0.0 -0.479 31.0 31.0 RhoA/GDP -0.007 0.117 0.25 4.0 -0.274 28.0 32.0 actin cytoskeleton organization 0.009 0.063 0.158 5.0 -0.147 2.0 7.0 CDC42/GDP -0.011 0.111 0.233 2.0 -0.27 28.0 30.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.017 0.091 -9999.0 0.0 -0.241 30.0 30.0 ITGB7 -0.005 0.112 -9999.0 0.0 -0.479 11.0 11.0 RAC1 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.02 0.113 -9999.0 0.0 -0.266 28.0 28.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.005 0.104 -9999.0 0.0 -0.249 31.0 31.0 mol:GDP -0.023 0.128 0.257 4.0 -0.313 30.0 34.0 CDC42/GTP/IQGAP1 0.026 0.017 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.02 0.048 -9999.0 0.0 -0.479 2.0 2.0 p120 catenin/RhoA/GDP -0.003 0.117 0.268 2.0 -0.281 27.0 29.0 RAC1/GTP/IQGAP1 0.028 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.021 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.01 0.053 0.14 5.0 -0.199 5.0 10.0 NME1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.043 0.166 -9999.0 0.0 -0.446 31.0 31.0 regulation of cell-cell adhesion -0.014 0.065 -9999.0 0.0 -0.182 3.0 3.0 WASF2 0.01 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.008 0.094 0.229 2.0 -0.224 14.0 16.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.014 0.149 -9999.0 0.0 -0.308 36.0 36.0 CCND1 0.01 0.064 0.16 5.0 -0.247 5.0 10.0 VAV2 -0.026 0.167 -9999.0 0.0 -0.535 2.0 2.0 RAP1/GDP -0.003 0.103 0.242 2.0 -0.247 16.0 18.0 adherens junction assembly -0.041 0.161 -9999.0 0.0 -0.432 31.0 31.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.002 0.139 0.211 1.0 -0.296 36.0 37.0 E-cadherin/beta catenin -0.04 0.122 -9999.0 0.0 -0.344 30.0 30.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.044 0.166 -9999.0 0.0 -0.435 33.0 33.0 PIK3CA 0.022 0.034 -9999.0 0.0 -0.479 1.0 1.0 Rac1/GTP -0.038 0.086 -9999.0 0.0 -0.313 2.0 2.0 E-cadherin/beta catenin/alpha catenin 0.004 0.122 -9999.0 0.0 -0.292 31.0 31.0 ITGAE 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.043 0.177 -9999.0 0.0 -0.46 33.0 33.0