Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.054 0.246 0.643 3.0 -0.657 4.0 7.0 IHH 0.021 0.187 0.382 3.0 -0.902 2.0 5.0 SHH Np/Cholesterol/GAS1 -0.127 0.253 -9999.0 0.0 -0.591 15.0 15.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.126 0.25 0.586 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 0.009 0.197 -9999.0 0.0 -0.675 4.0 4.0 SMO 0.011 0.211 -9999.0 0.0 -0.717 4.0 4.0 AKT1 0.019 0.097 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.012 0.208 0.345 2.0 -0.701 4.0 6.0 STIL 0.024 0.221 0.432 2.0 -0.57 5.0 7.0 DHH N/PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.016 0.199 0.331 3.0 -0.67 4.0 7.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.062 0.267 0.626 3.0 -0.715 4.0 7.0 determination of left/right symmetry 0.012 0.208 0.345 2.0 -0.701 4.0 6.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.062 0.265 0.625 3.0 -0.707 4.0 7.0 IHH N/Hhip -0.404 0.407 -9999.0 0.0 -0.762 38.0 38.0 DHH N/Hhip -0.381 0.344 -9999.0 0.0 -0.691 38.0 38.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.012 0.208 0.345 2.0 -0.701 4.0 6.0 pancreas development -0.486 0.439 -9999.0 0.0 -0.882 38.0 38.0 HHAT 0.011 0.061 0.367 2.0 -9999.0 0.0 2.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.154 0.335 -9999.0 0.0 -0.884 12.0 12.0 somite specification 0.012 0.208 0.345 2.0 -0.701 4.0 6.0 SHH Np/Cholesterol/PTCH1 -0.009 0.213 -9999.0 0.0 -0.561 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.029 0.133 -9999.0 0.0 -0.559 4.0 4.0 SHH Np/Cholesterol/Megalin -0.144 0.26 -9999.0 0.0 -0.56 19.0 19.0 SHH -0.035 0.166 -9999.0 0.0 -0.692 4.0 4.0 catabolic process 0.025 0.227 0.429 3.0 -0.734 4.0 7.0 SMO/Vitamin D3 0.0 0.227 0.368 2.0 -0.575 7.0 9.0 SHH Np/Cholesterol/Hhip -0.337 0.304 -9999.0 0.0 -0.585 40.0 40.0 LRP2 -0.182 0.375 0.367 2.0 -0.884 15.0 17.0 receptor-mediated endocytosis -0.081 0.258 -9999.0 0.0 -0.696 6.0 6.0 SHH Np/Cholesterol/BOC -0.029 0.133 -9999.0 0.0 -0.559 4.0 4.0 SHH Np/Cholesterol/CDO -0.029 0.133 -9999.0 0.0 -0.559 4.0 4.0 mesenchymal cell differentiation 0.334 0.3 0.58 40.0 -9999.0 0.0 40.0 mol:Vitamin D3 0.0 0.223 0.369 2.0 -0.563 7.0 9.0 IHH N/PTCH2 0.008 0.122 -9999.0 0.0 -0.61 2.0 2.0 CDON 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.037 0.24 0.471 3.0 -0.741 4.0 7.0 Megalin/LRPAP1 -0.143 0.291 -9999.0 0.0 -0.69 15.0 15.0 PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.027 0.139 -9999.0 0.0 -0.566 4.0 4.0 PTCH1 0.025 0.228 0.43 3.0 -0.738 4.0 7.0 HHIP -0.487 0.44 -9999.0 0.0 -0.884 38.0 38.0