Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.021 0.085 -9999.0 0.0 -0.365 4.0 4.0 epithelial cell differentiation -0.03 0.122 -9999.0 0.0 -0.521 4.0 4.0 CYFIP2 -0.064 0.229 -9999.0 0.0 -0.884 5.0 5.0 ENAH -0.037 0.115 -9999.0 0.0 -0.522 2.0 2.0 EGFR -0.013 0.106 -9999.0 0.0 -0.884 1.0 1.0 EPHA2 -0.064 0.229 -9999.0 0.0 -0.884 5.0 5.0 MYO6 -0.029 0.116 -9999.0 0.0 -0.498 4.0 4.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.044 0.157 -9999.0 0.0 -0.604 5.0 5.0 AQP5 -0.024 0.096 -9999.0 0.0 -0.44 3.0 3.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.028 0.114 -9999.0 0.0 -0.488 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.122 -9999.0 0.0 -0.488 4.0 4.0 EGF 0.112 0.169 0.367 21.0 -9999.0 0.0 21.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.062 0.175 -9999.0 0.0 -0.638 4.0 4.0 cortical microtubule organization -0.03 0.122 -9999.0 0.0 -0.521 4.0 4.0 GO:0000145 -0.027 0.109 -9999.0 0.0 -0.466 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.031 0.123 -9999.0 0.0 -0.528 4.0 4.0 MLLT4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.054 0.17 -9999.0 0.0 -0.81 2.0 2.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.04 0.144 -9999.0 0.0 -0.555 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.027 0.108 -9999.0 0.0 -0.462 4.0 4.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.029 0.116 -9999.0 0.0 -0.498 4.0 4.0 ARF6/GTP -0.037 0.133 -9999.0 0.0 -0.514 5.0 5.0 CDH1 -0.051 0.207 -9999.0 0.0 -0.884 4.0 4.0 EGFR/EGFR/EGF/EGF 0.001 0.161 -9999.0 0.0 -0.577 4.0 4.0 RhoA/GDP -0.028 0.115 -9999.0 0.0 -0.491 4.0 4.0 actin cytoskeleton organization -0.027 0.11 -9999.0 0.0 -0.469 4.0 4.0 IGF-1R heterotetramer 0.005 0.044 0.366 1.0 -9999.0 0.0 1.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.005 0.044 0.367 1.0 -9999.0 0.0 1.0 IGF1 -0.397 0.44 -9999.0 0.0 -0.884 31.0 31.0 DIAPH1 -0.058 0.19 -9999.0 0.0 -0.733 5.0 5.0 Wnt receptor signaling pathway 0.03 0.122 0.521 4.0 -9999.0 0.0 4.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.054 0.17 -9999.0 0.0 -0.811 2.0 2.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.028 0.113 -9999.0 0.0 -0.483 4.0 4.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.027 0.11 -9999.0 0.0 -0.469 4.0 4.0 Ephrin A1/EPHA2 -0.063 0.198 -9999.0 0.0 -0.617 7.0 7.0 SEC6/SEC8 -0.026 0.103 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.022 0.124 -9999.0 0.0 -0.498 4.0 4.0 HGF/MET -0.238 0.291 -9999.0 0.0 -0.548 30.0 30.0 HGF -0.384 0.438 -9999.0 0.0 -0.884 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.021 0.086 -9999.0 0.0 -0.368 4.0 4.0 actin cable formation 0.01 0.116 -9999.0 0.0 -0.475 2.0 2.0 KIAA1543 -0.027 0.11 -9999.0 0.0 -0.469 4.0 4.0 KIFC3 -0.029 0.116 -9999.0 0.0 -0.498 4.0 4.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.029 0.116 -9999.0 0.0 -0.498 4.0 4.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.03 0.122 -9999.0 0.0 -0.521 4.0 4.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.029 0.116 -9999.0 0.0 -0.498 4.0 4.0 PIP5K1C -0.029 0.116 -9999.0 0.0 -0.498 4.0 4.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.046 0.142 -9999.0 0.0 -0.659 2.0 2.0 adherens junction assembly 0.009 0.113 -9999.0 0.0 -0.47 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.245 0.279 -9999.0 0.0 -0.528 32.0 32.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.029 0.116 -9999.0 0.0 -0.498 4.0 4.0 mol:GTP -0.04 0.143 -9999.0 0.0 -0.55 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.025 0.099 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.021 0.085 -9999.0 0.0 -0.365 4.0 4.0 regulation of cell-cell adhesion -0.027 0.11 -9999.0 0.0 -0.469 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.021 0.086 -9999.0 0.0 -0.368 4.0 4.0