Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.003 0.071 -9999.0 0.0 -0.283 4.0 4.0 epithelial cell differentiation 0.023 0.096 -9999.0 0.0 -0.359 4.0 4.0 CYFIP2 -0.024 0.172 -9999.0 0.0 -0.639 5.0 5.0 ENAH -0.014 0.084 -9999.0 0.0 -0.418 1.0 1.0 EGFR 0.014 0.079 -9999.0 0.0 -0.639 1.0 1.0 EPHA2 -0.025 0.172 -9999.0 0.0 -0.639 5.0 5.0 MYO6 -0.028 0.079 -9999.0 0.0 -0.344 4.0 4.0 CTNNB1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.018 0.113 -9999.0 0.0 -0.416 4.0 4.0 AQP5 -0.009 0.073 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.028 0.078 -9999.0 0.0 -0.341 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.087 -9999.0 0.0 -0.341 4.0 4.0 EGF 0.123 0.16 0.374 20.0 -9999.0 0.0 20.0 NCKAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.037 0.142 -9999.0 0.0 -0.524 4.0 4.0 cortical microtubule organization 0.023 0.096 -9999.0 0.0 -0.359 4.0 4.0 GO:0000145 -0.027 0.074 -9999.0 0.0 -0.326 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.027 0.098 -9999.0 0.0 -0.362 4.0 4.0 MLLT4 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.043 0.102 -9999.0 0.0 -0.417 4.0 4.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.023 0.09 -9999.0 0.0 -0.383 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.015 0.075 -9999.0 0.0 -0.319 4.0 4.0 PVRL2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.028 0.079 -9999.0 0.0 -0.347 4.0 4.0 ARF6/GTP 0.028 0.088 -9999.0 0.0 -0.359 2.0 2.0 CDH1 -0.017 0.155 -9999.0 0.0 -0.639 4.0 4.0 EGFR/EGFR/EGF/EGF 0.046 0.114 -9999.0 0.0 -0.447 2.0 2.0 RhoA/GDP 0.025 0.093 -9999.0 0.0 -0.343 4.0 4.0 actin cytoskeleton organization -0.028 0.076 -9999.0 0.0 -0.334 4.0 4.0 IGF-1R heterotetramer 0.029 0.042 0.373 1.0 -9999.0 0.0 1.0 GIT1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.029 0.042 0.374 1.0 -9999.0 0.0 1.0 IGF1 -0.274 0.33 -9999.0 0.0 -0.639 31.0 31.0 DIAPH1 -0.017 0.187 -9999.0 0.0 -0.64 5.0 5.0 Wnt receptor signaling pathway -0.023 0.096 0.359 4.0 -9999.0 0.0 4.0 RHOA 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.043 0.102 -9999.0 0.0 -0.418 4.0 4.0 CTNNA1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.029 0.078 -9999.0 0.0 -0.342 4.0 4.0 EFNA1 0.018 0.011 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.029 0.076 -9999.0 0.0 -0.333 4.0 4.0 Ephrin A1/EPHA2 -0.005 0.126 -9999.0 0.0 -0.457 4.0 4.0 SEC6/SEC8 -0.031 0.073 -9999.0 0.0 -0.322 4.0 4.0 MGAT3 -0.022 0.089 -9999.0 0.0 -0.347 4.0 4.0 HGF/MET -0.143 0.219 -9999.0 0.0 -0.384 29.0 29.0 HGF -0.261 0.325 -9999.0 0.0 -0.629 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.003 0.072 -9999.0 0.0 -0.285 4.0 4.0 actin cable formation 0.009 0.101 -9999.0 0.0 -0.327 2.0 2.0 KIAA1543 -0.028 0.075 -9999.0 0.0 -0.331 4.0 4.0 KIFC3 -0.029 0.079 -9999.0 0.0 -0.347 4.0 4.0 NCK1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.029 0.079 -9999.0 0.0 -0.347 4.0 4.0 NCK1/GIT1 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.023 0.096 -9999.0 0.0 -0.359 4.0 4.0 EXOC4 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.029 0.079 -9999.0 0.0 -0.347 4.0 4.0 PIP5K1C -0.028 0.079 -9999.0 0.0 -0.347 4.0 4.0 LIMA1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.01 0.117 -9999.0 0.0 -0.452 2.0 2.0 adherens junction assembly -0.028 0.086 -9999.0 0.0 -0.323 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.144 0.213 -9999.0 0.0 -0.367 31.0 31.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.028 0.079 -9999.0 0.0 -0.347 4.0 4.0 mol:GTP 0.022 0.089 -9999.0 0.0 -0.381 2.0 2.0 establishment of epithelial cell apical/basal polarity -0.02 0.088 0.319 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization 0.003 0.071 -9999.0 0.0 -0.283 4.0 4.0 regulation of cell-cell adhesion -0.028 0.076 -9999.0 0.0 -0.334 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.003 0.072 -9999.0 0.0 -0.285 4.0 4.0