Network No.ofgenes p-value RepeatTimes GSTM1(30),GSTM2(32),GSTM3(31) 3 0 4 APLP2(49),APBB2(5),APBB3(71) 3 0 3 CD14(71),MUC7(15),LTF(51) 3 0 3 CLU(5),C9(101),C7(104) 3 0 3 FBN2(89),MFAP5(63),MEGF6(3) 3 0 3 FLT4(48),VEGFC(94),KDR(49) 3 0 3 HSPA9(72),MVD(101),HSP90B1(2) 3 0 3 KLC1(100),PLEKHM2(2),CLSTN1(1) 3 0 3 MRE11A(2),LIG1(88),RAD50(73) 3 0 3 NPC2(99),LOX(71),DHDDS(1) 3 0 3 NPFFR2(10),NPY(102),MC4R(62) 3 0 3 RNF216(103),TLR1(3),TLR9(52) 3 0 3 ST8SIA3(64),GDNF(101),NCAM1(6) 3 0 3 TMPO(1),LMNB1(72),SGTB(72) 3 0 3 APOBEC1(63),BAG4(47),TNFRSF25(1),DNAJB11(51) 4 0 3 KLRC1(63),KLRC3(65),KLRC2(63),KLRD1(62) 4 0 3 PIWIL4(2),DICER1(103),PIWIL2(5),PIWIL1(7) 4 0 3 SFMBT1(50),LYPLA2(1),PHC1(63),SCMH1(49) 4 0 3 TULP2(88),PAX1(73),PAX3(4),MEOX2(102) 4 0 3 VDAC3(58),PTPN23(48),BCS1L(1),DDX24(99) 4 0 3 SART3(3),FAM175A(2),MEGF10(78),UIMC1(42),CEP57(2) 5 0 3 C7orf26(102),WIPI2(104),STRN4(88),DFFA(2),AK5(8),MTG1(42),C11orf61(2) 7 0 3 ANK1(66),NBPF3(1),SLC4A3(6) 3 0 2 CXCL9(3),CCL28(102),CCR3(48) 3 0 2 DKK2(4),LRP6(66),ANTXR2(2) 3 0 2 HES1(51),SMARCC1(51),FANCA(102) 3 0 2 HIPK1(35),TBX5(11),NKX2-5(42) 3 0 2 JAG2(101),LFNG(102),NOTCH2(8) 3 0 2 MTNR1B(3),HNRNPA0(71),MTNR1A(92) 3 0 2 NDUFAF3(48),LSM1(47),NARS(63) 3 0 2 NFYC(49),NFYB(1),CSDA(64) 3 0 2 PHLDA1(2),OLR1(63),HSPA4(71) 3 0 2 POU1F1(3),PITX1(75),EGR1(72) 3 0 2 STT3A(5),PCSK7(3),CSDE1(34) 3 0 2 SYT8(55),SYNCRIP(4),KLHL3(72) 3 0 2 TNFRSF1B(1),TRAIP(49),HIVEP3(56) 3 0 2 UBE3A(112),PHF17(5),UBE2D3(3) 3 0 2 YTHDC1(2),LUM(4),TRA2B(51) 3 0 2 CDC25C(71),CDC25B(1),BRSK2(59),LZTS1(3) 4 0 2 FCGR1A(1),HRG(53),C1QB(2),C1QA(1) 4 0 2 NAP1L1(1),ARIH2(47),ENSA(123),DLST(100) 4 0 2 HOMER1(72),GRIK1(6),AGAP2(62),STX12(2),FAT1(101) 5 0 2 TRIP12(9),DST(22),CELSR3(58),ERBB2IP(71),LRRC1(3) 5 0 2 IRF2(91),IRF1(72),ZBTB17(1),HK3(48),IRF8(103),HPGDS(1) 6 0 2 NCBP2(51),EIF4G1(52),EIF5(99),HNRNPH1(41),EIF3B(104),EIF4A2(52) 6 0 2 PPFIA2(6),CAST(72),PTPRF(50),PTPRE(39),PTPRD(120),PTPRA(4) 6 0 2 RASGEF1C(40),TP63(52),TNK2(51),TP73(3),PPP1R13B(99),WWOX(97) 6 0 2 ADAP1(103),PURA(71),YBX1(50) 3 0 1 ANKRA2(72),HDAC4(10),ANKRD11(101) 3 0 1 CAMKV(49),TCEA2(92),WDR47(32) 3 0 1 CARD8(88),CARD16(2),CASP1(2) 3 0 1 CD53(31),IL4(71),IL2(4) 3 0 1 CGA(1),TSHR(102),TSHB(30) 3 0 1 DST(22),CELSR3(58),TRIP12(9) 3 0 1 FGF19(64),FGF4(63),FGFR4(41) 3 0 1 FXYD2(1),ADD1(4),ATP1A1(31) 3 0 1 GABRR1(6),GABRR2(4),MAP1B(76) 3 0 1 GRK6(41),GRK4(4),BDKRB2(99) 3 0 1 HDAC9(104),FLI1(52),ETV6(65) 3 0 1 LIG4(25),NHEJ1(1),XRCC4(72) 3 0 1 LRP1B(82),CKAP4(4),PLAT(60) 3 0 1 MET(81),MUC20(50),SPSB1(1) 3 0 1 PEBP1(1),STC2(42),PPP1R8(1) 3 0 1 PRKCI(68),RAB2A(78),FAM71C(3) 3 0 1 PRLR(102),TEC(5),PTPN21(99) 3 0 1 PTPN13(4),PDLIM4(71),RAPGEF6(76) 3 0 1 RASGEF1C(40),TNK2(51),WWOX(97) 3 0 1 STXBP3(31),SPRY1(1),GEMIN4(73) 3 0 1 TCEB3(1),NINL(73),CLEC1B(65) 3 0 1 TOLLIP(55),SIRPA(4),IL1RAP(52) 3 0 1 TP63(52),PPP1R13B(99),TP73(3) 3 0 1 TRAF3IP1(3),TRAF3(99),ALPL(2) 3 0 1 ALPP(3),PIGK(1),ALPPL2(3) 3 0.036 1 CNTNAP3(63),KIF17(4),FHL5(4) 3 0.036 1 GUCA2B(49),GUCA1A(56),GUCA1B(55) 3 0.036 1 LIMD1(48),POP5(1),POP4(49) 3 0.036 1 RRS1(76),MUL1(1),EID3(2) 3 0.036 1 CHGB(5),CHRD(52),YLPM1(104),BMP1(3) 4 0 1 CUL4A(25),CDT1(101),CCNA2(3),SKP2(102) 4 0 1 ERBB2(86),ERRFI1(1),BTC(1),MUC4(53) 4 0 1 FEZ1(2),HEATR2(102),BRD1(121),RAI14(102) 4 0 1 FYB(102),SORBS2(91),EVL(99),SEMA6A(76) 4 0 1 GABRR1(6),GABRR2(4),MAP1B(76),STRAP(63) 4 0 1 HDAC9(104),BCL6(50),FLI1(52),ETV6(65) 4 0 1 IRF2(91),IRF1(72),IRF8(103),ZBTB17(1) 4 0 1 LAPTM5(2),HEYL(50),RNF168(52),NEDD4L(64) 4 0 1 LIG4(25),NHEJ1(1),XRCC4(72),PRKDC(85) 4 0 1 LIN7A(1),EXOSC9(2),FTL(89),MPP6(103) 4 0 1 MAD1L1(103),MAD2L1(1),TRIM29(8),HINT1(72) 4 0 1 MED8(50),CCNC(1),USP49(55),MED17(3) 4 0 1 MYO16(38),RTN4IP1(3),PPP1CC(1),WBP11(63) 4 0 1 PDGFA(103),PDGFRA(43),HSPG2(10),A2M(68) 4 0 1 PGR(5),UBE3A(112),PHF17(5),UBE2D3(3) 4 0 1 PPP1R15A(88),LMO4(1),KIF3B(74),KIF3A(72) 4 0 1 RGS20(76),NUCB1(88),GNAZ(32),NDN(112) 4 0 1 SRP19(72),TNPO1(73),HARS(72),RPL5(30) 4 0 1 STXBP3(31),DDX20(30),SPRY1(1),GEMIN4(73) 4 0 1 TACC3(3),TTF2(33),MATR3(73),DCP1A(48) 4 0 1 TIAM1(14),NBPF3(1),SLC4A3(6),ANK1(66) 4 0 1 TRIP11(101),SIM1(7),SENP6(4),ARNT(122) 4 0 1 ETV1(104),HSPB2(1),CLK4(43),KCNA2(33),RPS6KA5(101) 5 0 1 FGF18(41),FGF5(2),FGF4(63),FGFR4(41),FGF19(64) 5 0 1 FYB(102),LCP2(43),SORBS2(91),EVL(99),SEMA6A(76) 5 0 1 GRIK2(12),AGL(35),PRKAG3(3),PRKAA1(102),PRKAB1(3) 5 0 1 MAPKAPK5(3),DUSP16(64),MAPK10(4),MAPK11(121),MAPK4(64) 5 0 1 SKI(1),RBPJ(1),SNW1(99),LRP2BP(91),MAML1(43) 5 0 1 TGFBI(73),COL4A4(8),COL4A3(3),COL4A2(32),COL4A1(31) 5 0 1 CD53(31),CD58(31),IL2(4),IL4(71),CD2(31) 5 0.0015 1 CUL4A(25),CDKN1B(65),CCNA2(3),SKP2(102),CDT1(101) 5 0.0015 1 IGF2(55),IGFBP2(1),ADAM12(43),EGF(5),IGFBP5(1) 5 0.0015 1 LIG4(25),TREX1(48),NHEJ1(1),XRCC4(72),PRKDC(85) 5 0.0015 1 PIAS3(6),STXBP3(31),DDX20(30),SPRY1(1),GEMIN4(73) 5 0.0015 1 ROBO1(10),GPC1(1),ROBO2(17),SLIT3(46),SLIT2(16) 5 0.0015 1 FUBP1(3),AIMP2(103),AIMP1(2),RARS(43),EPS8(63),QARS(48) 6 0 1 NECAP1(64),MYO6(4),MIB1(36),SNAP91(5),AP2A2(57),DAB2(101) 6 0 1 NOS1(6),BDKRB2(99),GRK6(41),GRK4(4),CAMK4(74),CAMKK2(1) 6 0 1 PDLIM4(71),RASIP1(88),PTPN13(4),RAP1A(32),RAPGEF5(103),RAPGEF6(76) 6 0 1 RAD17(71),TAF1D(2),RFC4(50),POLE(11),POLB(59),RAD1(101) 6 0 1 RGS20(76),NGB(100),NDN(112),GNAZ(32),NUCB1(88),GNAI3(31) 6 0 1 WDR1(2),UBE2N(1),CARD11(103),UBE2V2(77),BCL10(1),MALT1(63) 6 0 1 FYB(102),EVL(99),CLNK(5),LCP2(43),SORBS2(91),SEMA6A(76) 6 0.0085 1 MED28(1),USP49(55),MED17(3),CCNC(1),MED8(50),PEX14(1) 6 0.0085 1 AGL(35),PRKAB1(3),GRIK2(12),PRKAA1(102),MTOR(14),RICTOR(103),PRKAG3(3) 7 0 1 SKP1(73),FBXO16(2),FBXL5(2),FBXL4(2),FBXW8(2),FBXO4(101),FBXO8(90) 7 0 1 TRAF3(99),TNFRSF8(1),TNFRSF9(3),TNFRSF4(1),TRAF3IP1(3),TNFRSF18(1),ALPL(2) 7 0 1 WDR1(2),UBE2N(1),CARD11(103),IGSF21(3),UBE2V2(77),BCL10(1),MALT1(63) 7 0 1 DIAPH1(72),PKD2(6),MCM4(79),RHOC(31),CDC7(2),PACS2(101),MCM8(1) 7 5e-04 1 EFNB2(24),GRIK1(6),RHBDL2(49),FAT1(101),AGAP2(62),STX12(2),HOMER1(72) 7 5e-04 1 FNTA(78),MBIP(80),GBP1(3),RASSF2(6),PGGT1B(72),RAP1GDS1(4),KRAS(90) 7 5e-04 1 HEATR2(102),ZBTB16(2),FEZ1(2),RAI14(102),KIAA1377(5),COQ6(101),BRD1(121) 7 5e-04 1 MOAP1(99),GPR183(24),SH3GLB1(1),BAX(87),MTA1(99),CCNH(71),KCNA3(32) 7 5e-04 1 ANXA5(1),NCBP2(51),EIF4G1(52),EIF5(99),HNRNPH1(41),EIF4E(2),EIF3B(104),EIF4A2(52) 8 0 1 FNTA(78),MBIP(80),GBP1(3),RASSF2(6),COPS4(1),PGGT1B(72),RAP1GDS1(4),KRAS(90) 8 0 1 NECAP1(64),MYO6(4),MIB1(36),SNAP91(5),DPYSL2(1),NUMB(99),AP2A2(57),DAB2(101) 8 0 1 TAF7(71),SIM1(7),ARNT(122),SENP6(4),NR2F1(71),BCL11B(102),AHR(104),TRIP11(101) 8 0 1 NECAP1(64),MYO6(4),FGR(1),MIB1(36),SNAP91(5),DPYSL2(1),NUMB(99),AP2A2(57),DAB2(101) 9 0 1 PPP2R1B(2),PPP2CA(71),GNB2L1(42),PDE4DIP(18),ST7(76),NSMAF(77),GABRB3(112),PDE4D(83),PPP2R5C(99) 9 0 1 SNW1(99),MAML1(43),NR0B2(1),RBPJ(1),NOTCH2(8),SKI(1),JAG2(101),LFNG(102),LRP2BP(91) 9 0 1 TAF7(71),SIM1(7),ARNT(122),SENP6(4),NR2F1(71),TAF9(71),BCL11B(102),AHR(104),TRIP11(101) 9 0 1 BRIX1(101),C11orf1(2),ASAH1(1),CKMT2(72),OLFML3(30),PLEKHA4(87),PGAM5(1),MRPL44(1),GIPC2(2),SETDB1(122) 10 0 1 DIAPH1(72),PKD2(6),PPP2R2A(4),MCM4(79),GRIN2D(89),CIT(7),RHOC(31),MCM8(1),PACS2(101),CDC7(2) 10 0.0065 1 PLXNB2(122),ARHGEF12(9),PLXNB1(50),CDH15(103),DRD5(4),F2R(71),CDON(1),GNA12(103),GNAT1(47),CTNNA1(72) 10 0.0065 1