E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.005 0.067 -9999.0 0.0 -0.311 16.0 16.0 KLHL20 0.0 0.052 0.168 2.0 -0.216 7.0 9.0 CYFIP2 0.016 0.043 -9999.0 0.0 -0.328 6.0 6.0 Rac1/GDP -0.01 0.062 0.319 3.0 -0.257 7.0 10.0 ENAH -0.004 0.067 -9999.0 0.0 -0.316 16.0 16.0 AP1M1 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.026 0.028 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.025 -9999.0 0.0 -0.146 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.029 -9999.0 0.0 -0.185 3.0 3.0 RAPGEF1 -0.009 0.058 0.203 2.0 -0.286 10.0 12.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.006 0.072 -9999.0 0.0 -0.319 17.0 17.0 CRK -0.012 0.057 -9999.0 0.0 -0.311 12.0 12.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.021 -9999.0 0.0 -0.199 2.0 2.0 alphaE/beta7 Integrin 0.028 0.017 -9999.0 0.0 -0.232 1.0 1.0 IQGAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.022 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.003 0.063 -9999.0 0.0 -0.317 14.0 14.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.027 0.016 -9999.0 0.0 -0.133 2.0 2.0 MLLT4 0.02 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.052 0.059 0.216 38.0 -0.174 4.0 42.0 PI3K -0.033 0.02 -9999.0 0.0 -0.167 2.0 2.0 ARF6 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.029 0.02 -9999.0 0.0 -0.232 2.0 2.0 TIAM1 0.016 0.04 -9999.0 0.0 -0.328 5.0 5.0 E-cadherin(dimer)/Ca2+ 0.046 0.022 -9999.0 0.0 -0.172 2.0 2.0 AKT1 -0.018 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.019 0.025 -9999.0 0.0 -0.328 2.0 2.0 RhoA/GDP -0.011 0.066 0.289 4.0 -0.247 7.0 11.0 actin cytoskeleton organization 0.004 0.045 0.154 8.0 -0.158 7.0 15.0 CDC42/GDP -0.011 0.065 0.289 4.0 -0.255 7.0 11.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.008 0.019 -9999.0 0.0 -0.179 4.0 4.0 ITGB7 0.02 0.018 -9999.0 0.0 -0.328 1.0 1.0 RAC1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.024 -9999.0 0.0 -0.184 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.035 0.018 -9999.0 0.0 -0.166 2.0 2.0 mol:GDP -0.011 0.07 0.3 4.0 -0.29 7.0 11.0 CDC42/GTP/IQGAP1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.012 0.059 0.198 2.0 -0.256 4.0 6.0 RAC1/GTP/IQGAP1 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.006 0.043 0.155 12.0 -0.147 5.0 17.0 NME1 0.055 0.097 0.331 43.0 -9999.0 0.0 43.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.001 0.058 -9999.0 0.0 -0.315 11.0 11.0 regulation of cell-cell adhesion -0.027 0.019 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.003 0.024 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.025 0.032 0.145 5.0 -9999.0 0.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.034 -9999.0 0.0 -0.178 3.0 3.0 CCND1 0.005 0.044 0.147 10.0 -0.18 5.0 15.0 VAV2 -0.006 0.119 -9999.0 0.0 -0.596 11.0 11.0 RAP1/GDP -0.02 0.046 0.194 1.0 -0.234 2.0 3.0 adherens junction assembly -0.002 0.061 -9999.0 0.0 -0.308 13.0 13.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.036 0.03 -9999.0 0.0 -0.176 3.0 3.0 E-cadherin/beta catenin 0.004 0.022 -9999.0 0.0 -0.279 2.0 2.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.006 0.07 -9999.0 0.0 -0.315 17.0 17.0 PIK3CA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.005 0.062 -9999.0 0.0 -0.336 9.0 9.0 E-cadherin/beta catenin/alpha catenin 0.039 0.021 -9999.0 0.0 -0.199 2.0 2.0 ITGAE 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.005 0.073 -9999.0 0.0 -0.324 17.0 17.0