Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.036 0.056 0.242 4.0 -0.237 19.0 23.0 KIRREL 0.017 0.038 -9999.0 0.0 -0.337 4.0 4.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.036 0.056 0.238 19.0 -0.243 4.0 23.0 PLCG1 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.052 0.054 0.224 19.0 -0.184 4.0 23.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.013 0.038 0.163 2.0 -0.198 4.0 6.0 FYN 0.017 0.085 0.211 53.0 -0.176 4.0 57.0 mol:Ca2+ 0.049 0.052 0.216 19.0 -0.183 4.0 23.0 mol:DAG 0.05 0.053 0.22 19.0 -0.183 4.0 23.0 NPHS2 -0.004 0.024 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.05 0.053 0.22 19.0 -0.183 4.0 23.0 regulation of endocytosis 0.035 0.046 0.201 16.0 -0.171 4.0 20.0 Nephrin/NEPH1/podocin/Cholesterol 0.042 0.05 0.209 19.0 -0.178 4.0 23.0 establishment of cell polarity 0.036 0.056 0.237 19.0 -0.242 4.0 23.0 Nephrin/NEPH1/podocin/NCK1-2 0.06 0.055 0.284 1.0 -0.172 4.0 5.0 Nephrin/NEPH1/beta Arrestin2 0.037 0.047 0.209 16.0 -0.172 4.0 20.0 NPHS1 0.038 0.078 0.339 23.0 -9999.0 0.0 23.0 Nephrin/NEPH1/podocin 0.039 0.048 0.208 19.0 -0.167 5.0 24.0 TJP1 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.022 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.052 0.054 0.224 19.0 -0.184 4.0 23.0 CD2AP 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.051 0.053 0.224 18.0 -0.179 4.0 22.0 GRB2 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.007 0.096 0.222 49.0 -0.178 22.0 71.0 cytoskeleton organization -0.004 0.052 0.215 11.0 -0.207 4.0 15.0 Nephrin/NEPH1 0.03 0.044 0.194 19.0 -0.162 4.0 23.0 Nephrin/NEPH1/ZO-1 0.041 0.049 0.22 17.0 -0.194 4.0 21.0