Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.007 0.03 -9999.0 0.0 -0.176 7.0 7.0 epithelial cell differentiation 0.042 0.021 -9999.0 0.0 -0.171 2.0 2.0 CYFIP2 0.016 0.043 -9999.0 0.0 -0.328 6.0 6.0 ENAH -0.019 0.06 0.404 2.0 -0.233 1.0 3.0 EGFR 0.015 0.043 0.331 1.0 -0.328 5.0 6.0 EPHA2 0.015 0.047 -9999.0 0.0 -0.328 7.0 7.0 MYO6 -0.018 0.044 0.223 9.0 -9999.0 0.0 9.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.039 0.024 -9999.0 0.0 -0.199 3.0 3.0 AQP5 -0.057 0.165 0.381 4.0 -0.371 72.0 76.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.019 0.044 0.215 10.0 -9999.0 0.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.092 0.076 0.162 3.0 -0.303 1.0 4.0 EGF 0.075 0.127 0.331 72.0 -0.328 4.0 76.0 NCKAP1 0.022 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.023 0.076 0.238 1.0 -0.317 20.0 21.0 cortical microtubule organization 0.042 0.021 -9999.0 0.0 -0.171 2.0 2.0 GO:0000145 -0.018 0.042 0.204 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.046 0.022 -9999.0 0.0 -0.172 2.0 2.0 MLLT4 0.02 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.034 0.026 -9999.0 0.0 -0.169 5.0 5.0 ARF6 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.037 -9999.0 0.0 -0.184 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.011 0.043 0.423 2.0 -9999.0 0.0 2.0 PVRL2 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.019 0.045 0.217 10.0 -9999.0 0.0 10.0 ARF6/GTP 0.042 0.037 -9999.0 0.0 -0.176 5.0 5.0 CDH1 0.019 0.025 -9999.0 0.0 -0.328 2.0 2.0 EGFR/EGFR/EGF/EGF 0.041 0.057 0.246 1.0 -0.186 8.0 9.0 RhoA/GDP 0.042 0.022 -9999.0 0.0 -0.167 2.0 2.0 actin cytoskeleton organization -0.02 0.042 0.207 9.0 -0.173 2.0 11.0 IGF-1R heterotetramer 0.02 0.018 -9999.0 0.0 -0.328 1.0 1.0 GIT1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.02 0.018 -9999.0 0.0 -0.328 1.0 1.0 IGF1 0.018 0.043 0.331 1.0 -0.328 5.0 6.0 DIAPH1 0.013 0.127 -9999.0 0.0 -0.513 20.0 20.0 Wnt receptor signaling pathway -0.042 0.021 0.171 2.0 -9999.0 0.0 2.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.035 0.028 -9999.0 0.0 -0.189 6.0 6.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.042 0.209 9.0 -0.176 2.0 11.0 EFNA1 0.017 0.019 -9999.0 0.0 -0.328 1.0 1.0 LPP -0.022 0.043 0.207 10.0 -9999.0 0.0 10.0 Ephrin A1/EPHA2 0.026 0.037 -9999.0 0.0 -0.184 8.0 8.0 SEC6/SEC8 -0.026 0.02 -9999.0 0.0 -0.169 1.0 1.0 MGAT3 -0.094 0.077 0.163 3.0 -0.307 1.0 4.0 HGF/MET 0.022 0.056 -9999.0 0.0 -0.174 24.0 24.0 HGF 0.009 0.075 0.331 3.0 -0.328 16.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.007 0.03 -9999.0 0.0 -0.177 7.0 7.0 actin cable formation 0.01 0.091 0.313 15.0 -0.25 3.0 18.0 KIAA1543 -0.021 0.032 0.174 8.0 -9999.0 0.0 8.0 KIFC3 -0.024 0.024 0.163 4.0 -9999.0 0.0 4.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.016 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.019 0.044 0.217 10.0 -9999.0 0.0 10.0 NCK1/GIT1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.042 0.021 -9999.0 0.0 -0.171 2.0 2.0 EXOC4 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.022 0.032 0.188 7.0 -9999.0 0.0 7.0 PIP5K1C -0.019 0.045 0.217 10.0 -9999.0 0.0 10.0 LIMA1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.006 0.083 0.336 8.0 -0.264 1.0 9.0 adherens junction assembly -0.026 0.097 0.343 7.0 -0.455 8.0 15.0 IGF-1R heterotetramer/IGF1 0.032 0.034 -9999.0 0.0 -0.165 8.0 8.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.013 0.072 0.331 5.0 -0.328 13.0 18.0 PLEKHA7 -0.022 0.034 0.185 8.0 -9999.0 0.0 8.0 mol:GTP 0.038 0.036 -9999.0 0.0 -0.183 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.021 0.098 0.299 15.0 -9999.0 0.0 15.0 cortical actin cytoskeleton stabilization 0.007 0.03 -9999.0 0.0 -0.176 7.0 7.0 regulation of cell-cell adhesion -0.02 0.042 0.207 9.0 -0.173 2.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.007 0.03 -9999.0 0.0 -0.177 7.0 7.0