Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	185.0	9439.0	51.0	-0.04	0.813	1000.0	-1000.0	-0.097	-1000.0
Glypican 2 network	132.0	530.0	4.0	0.085	0.137	1000.0	-1000.0	0.018	-1000.0
Angiopoietin receptor Tie2-mediated signaling	107.0	9471.0	88.0	-0.534	0.106	1000.0	-1000.0	-0.056	-1000.0
Aurora B signaling	101.0	6781.0	67.0	-0.155	0.288	1000.0	-1000.0	-0.029	-1000.0
HIF-1-alpha transcription factor network	95.0	7246.0	76.0	-0.053	0.437	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by the Hedgehog family	83.0	4326.0	52.0	-0.222	0.105	1000.0	-1000.0	-0.026	-1000.0
PLK1 signaling events	63.0	5357.0	85.0	-0.053	0.204	1000.0	-1000.0	-0.025	-1000.0
Endothelins	63.0	6068.0	96.0	-0.296	0.199	1000.0	-1000.0	-0.031	-1000.0
Aurora C signaling	54.0	384.0	7.0	-0.0	0.172	1000.0	-1000.0	-0.01	-1000.0
Visual signal transduction: Cones	48.0	1839.0	38.0	-0.087	0.12	1000.0	-1000.0	-0.017	-1000.0
Signaling mediated by p38-alpha and p38-beta	48.0	2113.0	44.0	-0.098	0.021	1000.0	-1000.0	-0.016	-1000.0
Osteopontin-mediated events	44.0	1675.0	38.0	-0.004	0.251	1000.0	-1000.0	-0.018	-1000.0
Fc-epsilon receptor I signaling in mast cells	44.0	4272.0	97.0	-0.105	0.022	1000.0	-1000.0	-0.055	-1000.0
FOXA2 and FOXA3 transcription factor networks	43.0	1997.0	46.0	-0.205	0.154	1000.0	-1000.0	-0.08	-1000.0
Signaling events regulated by Ret tyrosine kinase	43.0	3549.0	82.0	-0.081	0.063	1000.0	-1000.0	-0.042	-1000.0
IL4-mediated signaling events	42.0	3865.0	91.0	-0.648	0.356	1000.0	-1000.0	-0.1	-1000.0
BMP receptor signaling	40.0	3308.0	81.0	-0.177	0.232	1000.0	-1000.0	-0.022	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	40.0	2088.0	52.0	-0.139	0.045	1000.0	-1000.0	-0.031	-1000.0
amb2 Integrin signaling	39.0	3228.0	82.0	-0.296	0.077	1000.0	-1000.0	-0.03	-1000.0
Visual signal transduction: Rods	37.0	1942.0	52.0	-0.087	0.102	1000.0	-1000.0	-0.033	-1000.0
Ephrin B reverse signaling	36.0	1751.0	48.0	-0.079	0.08	1000.0	-1000.0	-0.03	-1000.0
IL23-mediated signaling events	33.0	2011.0	60.0	-0.191	0.028	1000.0	-1000.0	-0.083	-1000.0
p75(NTR)-mediated signaling	31.0	3959.0	125.0	-0.139	0.14	1000.0	-1000.0	-0.043	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	31.0	2167.0	68.0	-0.149	0.064	1000.0	-1000.0	-0.049	-1000.0
Syndecan-1-mediated signaling events	29.0	993.0	34.0	-0.0	0.218	1000.0	-1000.0	-0.023	-1000.0
Integrins in angiogenesis	28.0	2422.0	84.0	-0.084	0.247	1000.0	-1000.0	-0.033	-1000.0
TCGA08_retinoblastoma	28.0	226.0	8.0	-0.022	0.1	1000.0	-1000.0	-0.002	-1000.0
LPA4-mediated signaling events	27.0	325.0	12.0	-0.073	0.0	1000.0	-1000.0	-0.015	-1000.0
HIF-2-alpha transcription factor network	27.0	1169.0	43.0	-0.135	0.148	1000.0	-1000.0	-0.031	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	27.0	3274.0	120.0	-0.164	0.143	1000.0	-1000.0	-0.04	-1000.0
Arf6 signaling events	26.0	1631.0	62.0	-0.106	0.075	1000.0	-1000.0	-0.017	-1000.0
TCGA08_p53	26.0	185.0	7.0	-0.021	0.02	1000.0	-1000.0	-0.01	-1000.0
Glucocorticoid receptor regulatory network	25.0	2857.0	114.0	-0.271	0.175	1000.0	-1000.0	-0.038	-1000.0
Thromboxane A2 receptor signaling	24.0	2559.0	105.0	-0.102	0.075	1000.0	-1000.0	-0.038	-1000.0
Aurora A signaling	24.0	1468.0	60.0	-0.029	0.191	1000.0	-1000.0	-0.02	-1000.0
Reelin signaling pathway	24.0	1380.0	56.0	-0.039	0.048	1000.0	-1000.0	-0.023	-1000.0
Canonical Wnt signaling pathway	24.0	1265.0	51.0	-0.206	0.095	1000.0	-1000.0	-0.036	-1000.0
EGFR-dependent Endothelin signaling events	24.0	513.0	21.0	-0.024	0.075	1000.0	-1000.0	-0.03	-1000.0
Presenilin action in Notch and Wnt signaling	23.0	1454.0	61.0	-0.206	0.095	1000.0	-1000.0	-0.034	-1000.0
IL6-mediated signaling events	23.0	1726.0	75.0	-0.149	0.053	1000.0	-1000.0	-0.047	-1000.0
FoxO family signaling	22.0	1469.0	64.0	0.0	0.209	1000.0	-1000.0	-0.041	-1000.0
Glypican 1 network	21.0	1030.0	48.0	-0.052	0.038	1000.0	-1000.0	-0.021	-1000.0
Effects of Botulinum toxin	21.0	560.0	26.0	-0.0	0.043	1000.0	-1000.0	-0.01	-1000.0
Nongenotropic Androgen signaling	20.0	1076.0	52.0	-0.069	0.049	1000.0	-1000.0	-0.019	-1000.0
S1P4 pathway	20.0	501.0	25.0	-0.028	0.028	1000.0	-1000.0	-0.014	-1000.0
ErbB4 signaling events	19.0	1315.0	69.0	-0.112	0.14	1000.0	-1000.0	-0.028	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	19.0	649.0	33.0	-0.077	0.098	1000.0	-1000.0	-0.017	-1000.0
Syndecan-4-mediated signaling events	18.0	1207.0	67.0	-0.045	0.135	1000.0	-1000.0	-0.026	-1000.0
ErbB2/ErbB3 signaling events	17.0	1139.0	65.0	-0.051	0.03	1000.0	-1000.0	-0.065	-1000.0
PDGFR-alpha signaling pathway	17.0	781.0	44.0	-0.184	0.038	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	17.0	1091.0	62.0	-0.076	0.043	1000.0	-1000.0	-0.038	-1000.0
Wnt signaling	17.0	125.0	7.0	-0.026	0.039	1000.0	-1000.0	-0.012	-1000.0
LPA receptor mediated events	17.0	1812.0	102.0	-0.055	0.072	1000.0	-1000.0	-0.048	-1000.0
Noncanonical Wnt signaling pathway	16.0	424.0	26.0	-0.048	0.039	1000.0	-1000.0	-0.025	-1000.0
Syndecan-2-mediated signaling events	16.0	1146.0	69.0	-0.045	0.057	1000.0	-1000.0	-0.027	-1000.0
Calcium signaling in the CD4+ TCR pathway	16.0	496.0	31.0	-0.037	0.034	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	16.0	2060.0	125.0	-0.184	0.042	1000.0	-1000.0	-0.039	-1000.0
Regulation of Androgen receptor activity	16.0	1183.0	70.0	-0.137	0.123	1000.0	-1000.0	-0.031	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	15.0	518.0	34.0	-0.036	0.06	1000.0	-1000.0	-0.027	-1000.0
Ceramide signaling pathway	15.0	1184.0	76.0	-0.02	0.075	1000.0	-1000.0	-0.021	-1000.0
S1P5 pathway	15.0	270.0	17.0	-0.019	0.021	1000.0	-1000.0	-0.003	-1000.0
FAS signaling pathway (CD95)	15.0	731.0	47.0	-0.23	0.035	1000.0	-1000.0	-0.047	-1000.0
EPHB forward signaling	15.0	1302.0	85.0	-0.033	0.089	1000.0	-1000.0	-0.044	-1000.0
Class IB PI3K non-lipid kinase events	15.0	45.0	3.0	-0.008	0.008	1000.0	-1000.0	-0.025	-1000.0
PLK2 and PLK4 events	14.0	42.0	3.0	-0.007	0.038	1000.0	-1000.0	-0.017	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	14.0	781.0	54.0	-0.033	0.11	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by PTP1B	14.0	1073.0	76.0	-0.052	0.075	1000.0	-1000.0	-0.039	-1000.0
Coregulation of Androgen receptor activity	13.0	1028.0	76.0	-0.06	0.097	1000.0	-1000.0	-0.022	-1000.0
IL12-mediated signaling events	13.0	1194.0	87.0	-0.133	0.06	1000.0	-1000.0	-0.061	-1000.0
Nectin adhesion pathway	13.0	834.0	63.0	-0.04	0.051	1000.0	-1000.0	-0.052	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1241.0	93.0	-0.031	0.033	1000.0	-1000.0	-0.037	-1000.0
BCR signaling pathway	13.0	1351.0	99.0	-0.045	0.082	1000.0	-1000.0	-0.058	-1000.0
Plasma membrane estrogen receptor signaling	13.0	1199.0	86.0	-0.063	0.06	1000.0	-1000.0	-0.033	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	12.0	1064.0	85.0	-0.065	0.036	1000.0	-1000.0	-0.027	-1000.0
S1P1 pathway	12.0	455.0	36.0	-0.086	0.021	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	12.0	974.0	78.0	-0.042	0.023	1000.0	-1000.0	-0.039	-1000.0
Caspase cascade in apoptosis	11.0	846.0	74.0	-0.03	0.077	1000.0	-1000.0	-0.026	-1000.0
BARD1 signaling events	11.0	682.0	57.0	-0.047	0.117	1000.0	-1000.0	-0.035	-1000.0
Syndecan-3-mediated signaling events	11.0	385.0	35.0	-0.114	0.047	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class III	10.0	433.0	40.0	-0.06	0.066	1000.0	-1000.0	-0.031	-1000.0
Regulation of p38-alpha and p38-beta	10.0	571.0	54.0	-0.039	0.058	1000.0	-1000.0	-0.04	-1000.0
IL2 signaling events mediated by STAT5	10.0	223.0	22.0	-0.028	0.1	1000.0	-1000.0	-0.025	-1000.0
IL27-mediated signaling events	9.0	509.0	51.0	-0.043	0.036	1000.0	-1000.0	-0.04	-1000.0
PDGFR-beta signaling pathway	9.0	887.0	97.0	-0.038	0.053	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by PRL	9.0	308.0	34.0	-0.023	0.088	1000.0	-1000.0	-0.028	-1000.0
Class I PI3K signaling events	8.0	632.0	73.0	-0.04	0.053	1000.0	-1000.0	-0.025	-1000.0
VEGFR1 specific signals	8.0	467.0	56.0	-0.184	0.05	1000.0	-1000.0	-0.024	-1000.0
Sphingosine 1-phosphate (S1P) pathway	7.0	197.0	28.0	-0.018	0.033	1000.0	-1000.0	-0.018	-1000.0
Ephrin A  reverse signaling	7.0	55.0	7.0	-0.014	0.03	1000.0	-1000.0	-0.009	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	7.0	580.0	74.0	-0.094	0.075	1000.0	-1000.0	-0.046	-1000.0
Insulin Pathway	7.0	566.0	74.0	-0.1	0.052	1000.0	-1000.0	-0.037	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	934.0	136.0	-0.17	0.075	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	116.0	17.0	-0.008	0.047	1000.0	-1000.0	-0.018	-1000.0
Cellular roles of Anthrax toxin	6.0	260.0	39.0	-0.031	0.029	1000.0	-1000.0	-0.016	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	453.0	65.0	-0.133	0.048	1000.0	-1000.0	-0.035	-1000.0
EPO signaling pathway	6.0	347.0	55.0	-0.026	0.045	1000.0	-1000.0	-0.026	-1000.0
mTOR signaling pathway	6.0	355.0	53.0	-0.062	0.025	1000.0	-1000.0	-0.029	-1000.0
IFN-gamma pathway	6.0	421.0	68.0	-0.03	0.061	1000.0	-1000.0	-0.039	-1000.0
ceramide signaling pathway	6.0	308.0	49.0	-0.01	0.027	1000.0	-1000.0	-0.026	-1000.0
Retinoic acid receptors-mediated signaling	6.0	384.0	58.0	-0.091	0.041	1000.0	-1000.0	-0.041	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	278.0	45.0	-0.024	0.05	1000.0	-1000.0	-0.03	-1000.0
Arf6 trafficking events	6.0	483.0	71.0	-0.038	0.039	1000.0	-1000.0	-0.031	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	103.0	17.0	-0.005	0.031	1000.0	-1000.0	-0.02	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	5.0	470.0	83.0	-0.057	0.041	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class I	5.0	556.0	104.0	-0.035	0.048	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	76.0	15.0	-0.018	0.022	1000.0	-1000.0	-0.02	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	417.0	76.0	-0.033	0.055	1000.0	-1000.0	-0.044	-1000.0
Regulation of Telomerase	5.0	555.0	102.0	-0.021	0.096	1000.0	-1000.0	-0.044	-1000.0
S1P3 pathway	5.0	220.0	42.0	-0.025	0.035	1000.0	-1000.0	-0.018	-1000.0
Arf6 downstream pathway	4.0	196.0	43.0	-0.05	0.054	1000.0	-1000.0	-0.026	-1000.0
IL2 signaling events mediated by PI3K	4.0	267.0	58.0	-0.014	0.07	1000.0	-1000.0	-0.028	-1000.0
TCGA08_rtk_signaling	4.0	129.0	26.0	-0.01	0.048	1000.0	-1000.0	-0.009	-1000.0
IGF1 pathway	4.0	229.0	57.0	-0.032	0.048	1000.0	-1000.0	-0.028	-1000.0
E-cadherin signaling in keratinocytes	4.0	189.0	43.0	-0.015	0.04	1000.0	-1000.0	-0.02	-1000.0
p38 MAPK signaling pathway	4.0	213.0	44.0	-0.009	0.061	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class II	3.0	286.0	75.0	-0.02	0.057	1000.0	-1000.0	-0.023	-1000.0
Circadian rhythm pathway	3.0	74.0	22.0	-0.004	0.048	1000.0	-1000.0	-0.033	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	262.0	68.0	-0.028	0.046	1000.0	-1000.0	-0.025	-1000.0
Canonical NF-kappaB pathway	2.0	99.0	39.0	-0.017	0.043	1000.0	-1000.0	-0.019	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	76.0	37.0	-0.026	0.051	1000.0	-1000.0	-0.021	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.02	0.03	1000.0	-1000.0	0.016	-1000.0
Insulin-mediated glucose transport	1.0	61.0	32.0	-0.016	0.038	1000.0	-1000.0	-0.021	-1000.0
TRAIL signaling pathway	1.0	84.0	48.0	-0.018	0.046	1000.0	-1000.0	-0.021	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	58.0	36.0	-0.036	0.039	1000.0	-1000.0	-0.026	-1000.0
Atypical NF-kappaB pathway	1.0	38.0	31.0	-0.018	0.03	1000.0	-1000.0	-0.018	-1000.0
Rapid glucocorticoid signaling	1.0	35.0	20.0	-0.008	0.027	1000.0	-1000.0	-0.01	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.019	0.039	1000.0	-1000.0	0.018	-1000.0
Arf1 pathway	1.0	100.0	54.0	-0.008	0.034	1000.0	-1000.0	-0.013	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	22.0	23.0	-0.0	0.036	1000.0	-1000.0	-0.013	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	21.0	27.0	-0.019	0.046	1000.0	-1000.0	-0.028	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.056	1000.0	-1000.0	0.0	-1000.0
Total	2743	162692	7203	-9.61660158921	10.9429262502	131000	-131000	-3.81934062402	-131000