Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	6.0	341.0	51.0	-0.588	0.038	1000.0	-1000.0	-0.104	-1000.0
HIF-1-alpha transcription factor network	5.0	404.0	76.0	-0.393	0.052	1000.0	-1000.0	-0.047	-1000.0
Osteopontin-mediated events	4.0	170.0	38.0	-0.272	0.044	1000.0	-1000.0	-0.035	-1000.0
IL23-mediated signaling events	4.0	271.0	60.0	-0.529	0.038	1000.0	-1000.0	-0.07	-1000.0
Signaling events mediated by the Hedgehog family	3.0	174.0	52.0	-0.26	0.099	1000.0	-1000.0	-0.039	-1000.0
IL4-mediated signaling events	3.0	340.0	91.0	-0.669	0.532	1000.0	-1000.0	-0.114	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	351.0	97.0	-0.139	0.043	1000.0	-1000.0	-0.063	-1000.0
Endothelins	3.0	377.0	96.0	-0.232	0.053	1000.0	-1000.0	-0.049	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	139.0	44.0	-0.119	0.039	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	386.0	125.0	-0.11	0.052	1000.0	-1000.0	-0.041	-1000.0
IL27-mediated signaling events	3.0	166.0	51.0	-0.19	0.144	1000.0	-1000.0	-0.056	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	239.0	68.0	-0.426	0.161	1000.0	-1000.0	-0.068	-1000.0
TCGA08_retinoblastoma	3.0	28.0	8.0	-0.044	0.045	1000.0	-1000.0	-0.006	-1000.0
EGFR-dependent Endothelin signaling events	3.0	67.0	21.0	-0.086	0.052	1000.0	-1000.0	-0.043	-1000.0
Caspase cascade in apoptosis	2.0	149.0	74.0	-0.056	0.052	1000.0	-1000.0	-0.042	-1000.0
IL12-mediated signaling events	2.0	205.0	87.0	-0.273	0.039	1000.0	-1000.0	-0.063	-1000.0
Syndecan-1-mediated signaling events	2.0	75.0	34.0	-0.119	0.039	1000.0	-1000.0	-0.03	-1000.0
Visual signal transduction: Cones	2.0	87.0	38.0	-0.136	0.044	1000.0	-1000.0	-0.001	-1000.0
Arf6 signaling events	2.0	129.0	62.0	-0.086	0.039	1000.0	-1000.0	-0.012	-1000.0
amb2 Integrin signaling	2.0	190.0	82.0	-0.13	0.049	1000.0	-1000.0	-0.039	-1000.0
Glucocorticoid receptor regulatory network	2.0	240.0	114.0	-0.369	0.087	1000.0	-1000.0	-0.056	-1000.0
IL1-mediated signaling events	2.0	129.0	62.0	-0.126	0.064	1000.0	-1000.0	-0.032	-1000.0
Ephrin B reverse signaling	2.0	112.0	48.0	-0.112	0.039	1000.0	-1000.0	-0.031	-1000.0
S1P1 pathway	2.0	72.0	36.0	-0.118	0.038	1000.0	-1000.0	-0.037	-1000.0
TCGA08_p53	2.0	16.0	7.0	-0.052	0.034	1000.0	-1000.0	-0.003	-1000.0
Integrins in angiogenesis	2.0	169.0	84.0	-0.137	0.048	1000.0	-1000.0	-0.044	-1000.0
Glypican 2 network	2.0	9.0	4.0	-0.02	0.0	1000.0	-1000.0	0.0	-1000.0
Wnt signaling	2.0	15.0	7.0	-0.072	0.038	1000.0	-1000.0	-0.01	-1000.0
IL6-mediated signaling events	2.0	161.0	75.0	-0.418	0.046	1000.0	-1000.0	-0.042	-1000.0
BCR signaling pathway	2.0	280.0	99.0	-0.19	0.06	1000.0	-1000.0	-0.052	-1000.0
Plasma membrane estrogen receptor signaling	2.0	230.0	86.0	-0.188	0.178	1000.0	-1000.0	-0.057	-1000.0
Visual signal transduction: Rods	2.0	120.0	52.0	-0.176	0.053	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	191.0	78.0	-0.1	0.041	1000.0	-1000.0	-0.062	-1000.0
Ephrin A  reverse signaling	1.0	7.0	7.0	-0.0	0.031	1000.0	-1000.0	-0.0	-1000.0
Noncanonical Wnt signaling pathway	1.0	44.0	26.0	-0.072	0.038	1000.0	-1000.0	-0.04	-1000.0
Thromboxane A2 receptor signaling	1.0	203.0	105.0	-0.093	0.051	1000.0	-1000.0	-0.045	-1000.0
Syndecan-2-mediated signaling events	1.0	119.0	69.0	-0.161	0.064	1000.0	-1000.0	-0.038	-1000.0
Cellular roles of Anthrax toxin	1.0	47.0	39.0	-0.052	0.036	1000.0	-1000.0	-0.023	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	127.0	85.0	-0.105	0.048	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by PTP1B	1.0	116.0	76.0	-0.124	0.085	1000.0	-1000.0	-0.034	-1000.0
BMP receptor signaling	1.0	141.0	81.0	-0.169	0.084	1000.0	-1000.0	-0.042	-1000.0
PLK1 signaling events	1.0	91.0	85.0	-0.13	0.058	1000.0	-1000.0	-0.036	-1000.0
mTOR signaling pathway	1.0	98.0	53.0	-0.071	0.039	1000.0	-1000.0	-0.036	-1000.0
IFN-gamma pathway	1.0	126.0	68.0	-0.087	0.039	1000.0	-1000.0	-0.047	-1000.0
Nectin adhesion pathway	1.0	116.0	63.0	-0.096	0.059	1000.0	-1000.0	-0.061	-1000.0
Ceramide signaling pathway	1.0	79.0	76.0	-0.044	0.054	1000.0	-1000.0	-0.041	-1000.0
TRAIL signaling pathway	1.0	76.0	48.0	-0.026	0.039	1000.0	-1000.0	-0.034	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	59.0	52.0	-0.074	0.07	1000.0	-1000.0	-0.029	-1000.0
HIF-2-alpha transcription factor network	1.0	60.0	43.0	-0.145	0.073	1000.0	-1000.0	-0.045	-1000.0
FAS signaling pathway (CD95)	1.0	60.0	47.0	-0.068	0.05	1000.0	-1000.0	-0.042	-1000.0
Syndecan-3-mediated signaling events	1.0	51.0	35.0	-0.161	0.053	1000.0	-1000.0	-0.027	-1000.0
TCR signaling in naïve CD8+ T cells	1.0	179.0	93.0	-0.043	0.052	1000.0	-1000.0	-0.045	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	49.0	45.0	-0.041	0.06	1000.0	-1000.0	-0.058	-1000.0
Canonical Wnt signaling pathway	1.0	65.0	51.0	-0.133	0.098	1000.0	-1000.0	-0.051	-1000.0
EPHB forward signaling	1.0	99.0	85.0	-0.053	0.074	1000.0	-1000.0	-0.057	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	55.0	31.0	-0.204	0.039	1000.0	-1000.0	-0.063	-1000.0
LPA receptor mediated events	1.0	156.0	102.0	-0.209	0.066	1000.0	-1000.0	-0.089	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	115.0	74.0	-0.089	0.058	1000.0	-1000.0	-0.064	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	76.0	76.0	-0.043	0.064	1000.0	-1000.0	-0.063	-1000.0
Syndecan-4-mediated signaling events	1.0	127.0	67.0	-0.1	0.045	1000.0	-1000.0	-0.056	-1000.0
IGF1 pathway	1.0	72.0	57.0	-0.06	0.069	1000.0	-1000.0	-0.036	-1000.0
Insulin Pathway	1.0	140.0	74.0	-0.112	0.063	1000.0	-1000.0	-0.037	-1000.0
VEGFR1 specific signals	1.0	62.0	56.0	-0.03	0.048	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling in keratinocytes	1.0	49.0	43.0	-0.07	0.039	1000.0	-1000.0	-0.031	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	-0.004	0.035	1000.0	-1000.0	0.02	-1000.0
Aurora B signaling	1.0	90.0	67.0	-0.119	0.048	1000.0	-1000.0	-0.052	-1000.0
LPA4-mediated signaling events	0.0	4.0	12.0	-0.006	0.047	1000.0	-1000.0	-0.023	-1000.0
ErbB2/ErbB3 signaling events	0.0	29.0	65.0	-0.022	0.08	1000.0	-1000.0	-0.077	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	83.0	136.0	-0.148	0.145	1000.0	-1000.0	-0.046	-1000.0
Coregulation of Androgen receptor activity	0.0	70.0	76.0	-0.206	0.053	1000.0	-1000.0	-0.027	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	8.0	23.0	-0.003	0.067	1000.0	-1000.0	-0.023	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	9.0	34.0	-0.044	0.087	1000.0	-1000.0	-0.025	-1000.0
Canonical NF-kappaB pathway	0.0	14.0	39.0	-0.011	0.081	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class II	0.0	31.0	75.0	-0.087	0.074	1000.0	-1000.0	-0.03	-1000.0
ErbB4 signaling events	0.0	42.0	69.0	-0.256	0.066	1000.0	-1000.0	-0.034	-1000.0
BARD1 signaling events	0.0	10.0	57.0	-0.073	0.076	1000.0	-1000.0	-0.04	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	13.0	28.0	-0.032	0.044	1000.0	-1000.0	-0.019	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.002	0.038	1000.0	-1000.0	-0.005	-1000.0
Circadian rhythm pathway	0.0	10.0	22.0	-0.079	0.079	1000.0	-1000.0	-0.031	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	21.0	54.0	-0.036	0.053	1000.0	-1000.0	-0.035	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	11.0	17.0	-0.003	0.081	1000.0	-1000.0	-0.025	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.036	0.056	1000.0	-1000.0	0.016	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	58.0	65.0	-0.232	0.083	1000.0	-1000.0	-0.043	-1000.0
Presenilin action in Notch and Wnt signaling	0.0	50.0	61.0	-0.133	0.053	1000.0	-1000.0	-0.042	-1000.0
Aurora A signaling	0.0	27.0	60.0	-0.029	0.085	1000.0	-1000.0	-0.014	-1000.0
p75(NTR)-mediated signaling	0.0	65.0	125.0	-0.147	0.088	1000.0	-1000.0	-0.053	-1000.0
Arf6 downstream pathway	0.0	34.0	43.0	-0.049	0.053	1000.0	-1000.0	-0.024	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.021	0.041	1000.0	-1000.0	-0.018	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	42.0	46.0	-0.223	0.042	1000.0	-1000.0	-0.109	-1000.0
Glypican 1 network	0.0	47.0	48.0	-0.013	0.055	1000.0	-1000.0	-0.02	-1000.0
EPO signaling pathway	0.0	30.0	55.0	0.0	0.081	1000.0	-1000.0	-0.036	-1000.0
Insulin-mediated glucose transport	0.0	5.0	32.0	-0.021	0.057	1000.0	-1000.0	-0.022	-1000.0
PDGFR-alpha signaling pathway	0.0	32.0	44.0	-0.063	0.06	1000.0	-1000.0	-0.042	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	63.0	68.0	-0.021	0.067	1000.0	-1000.0	-0.034	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	18.0	37.0	-0.007	0.088	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by HDAC Class III	0.0	16.0	40.0	-0.073	0.069	1000.0	-1000.0	-0.028	-1000.0
Reelin signaling pathway	0.0	55.0	56.0	-0.049	0.076	1000.0	-1000.0	-0.034	-1000.0
Signaling events regulated by Ret tyrosine kinase	0.0	63.0	82.0	-0.042	0.054	1000.0	-1000.0	-0.063	-1000.0
S1P5 pathway	0.0	8.0	17.0	-0.027	0.039	1000.0	-1000.0	-0.014	-1000.0
ceramide signaling pathway	0.0	22.0	49.0	-0.044	0.045	1000.0	-1000.0	-0.044	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	14.0	83.0	-0.035	0.072	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class I	0.0	17.0	104.0	-0.054	0.081	1000.0	-1000.0	-0.036	-1000.0
FoxO family signaling	0.0	48.0	64.0	-0.236	0.053	1000.0	-1000.0	-0.052	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	14.0	15.0	-0.04	0.038	1000.0	-1000.0	-0.021	-1000.0
Retinoic acid receptors-mediated signaling	0.0	36.0	58.0	-0.03	0.071	1000.0	-1000.0	-0.042	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	12.0	36.0	-0.07	0.078	1000.0	-1000.0	-0.036	-1000.0
Atypical NF-kappaB pathway	0.0	8.0	31.0	-0.0	0.057	1000.0	-1000.0	-0.015	-1000.0
IL2 signaling events mediated by PI3K	0.0	27.0	58.0	-0.023	0.07	1000.0	-1000.0	-0.041	-1000.0
Regulation of p38-alpha and p38-beta	0.0	27.0	54.0	-0.05	0.069	1000.0	-1000.0	-0.051	-1000.0
Effects of Botulinum toxin	0.0	16.0	26.0	-0.012	0.033	1000.0	-1000.0	-0.007	-1000.0
Nongenotropic Androgen signaling	0.0	44.0	52.0	-0.031	0.051	1000.0	-1000.0	-0.031	-1000.0
TCGA08_rtk_signaling	0.0	15.0	26.0	-0.07	0.057	1000.0	-1000.0	-0.004	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.068	1000.0	-1000.0	-0.04	-1000.0
IL2 signaling events mediated by STAT5	0.0	10.0	22.0	-0.059	0.045	1000.0	-1000.0	-0.053	-1000.0
Class I PI3K signaling events	0.0	52.0	73.0	-0.036	0.039	1000.0	-1000.0	-0.035	-1000.0
Arf6 trafficking events	0.0	5.0	71.0	-0.044	0.068	1000.0	-1000.0	-0.024	-1000.0
Regulation of Telomerase	0.0	71.0	102.0	-0.086	0.078	1000.0	-1000.0	-0.059	-1000.0
S1P3 pathway	0.0	22.0	42.0	-0.026	0.044	1000.0	-1000.0	-0.035	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	39.0	88.0	-0.093	0.084	1000.0	-1000.0	-0.071	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	16.0	33.0	-0.115	0.102	1000.0	-1000.0	-0.04	-1000.0
Rapid glucocorticoid signaling	0.0	6.0	20.0	-0.0	0.034	1000.0	-1000.0	-0.002	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	0.0	68.0	120.0	-0.091	0.081	1000.0	-1000.0	-0.054	-1000.0
PDGFR-beta signaling pathway	0.0	37.0	97.0	-0.041	0.088	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by PRL	0.0	25.0	34.0	-0.094	0.056	1000.0	-1000.0	-0.032	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.032	0.032	1000.0	-1000.0	-0.02	-1000.0
S1P4 pathway	0.0	9.0	25.0	-0.0	0.044	1000.0	-1000.0	-0.028	-1000.0
p38 MAPK signaling pathway	0.0	26.0	44.0	-0.065	0.063	1000.0	-1000.0	-0.027	-1000.0
Arf1 pathway	0.0	7.0	54.0	-0.0	0.048	1000.0	-1000.0	-0.017	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.096	1000.0	-1000.0	-0.0	-1000.0
Regulation of Androgen receptor activity	0.0	48.0	70.0	-0.213	0.05	1000.0	-1000.0	-0.047	-1000.0
Ras signaling in the CD4+ TCR pathway	0.0	9.0	17.0	-0.0	0.046	1000.0	-1000.0	-0.02	-1000.0
Total	120	10719	7203	-13.7351607347	8.36487928809	131000	-131000	-4.93955102085	-131000