Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.449 0.295 -9999.0 0.0 -0.714 159.0 159.0 IHH -0.492 0.393 -9999.0 0.0 -0.831 198.0 198.0 SHH Np/Cholesterol/GAS1 -0.078 0.176 -9999.0 0.0 -0.469 55.0 55.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.078 0.174 0.465 55.0 -9999.0 0.0 55.0 SMO/beta Arrestin2 -0.378 0.254 -9999.0 0.0 -0.613 168.0 168.0 SMO -0.399 0.275 -9999.0 0.0 -0.651 168.0 168.0 AKT1 -0.157 0.109 -9999.0 0.0 -0.313 2.0 2.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.392 0.27 -9999.0 0.0 -0.63 176.0 176.0 STIL -0.348 0.254 -9999.0 0.0 -0.552 183.0 183.0 DHH N/PTCH2 -0.052 0.169 -9999.0 0.0 -0.587 31.0 31.0 DHH N/PTCH1 -0.384 0.247 -9999.0 0.0 -0.594 176.0 176.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.059 0.204 -9999.0 0.0 -0.76 27.0 27.0 PTHLH -0.609 0.361 -9999.0 0.0 -0.955 159.0 159.0 determination of left/right symmetry -0.392 0.27 -9999.0 0.0 -0.63 176.0 176.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.601 0.354 -9999.0 0.0 -0.941 159.0 159.0 IHH N/Hhip -0.677 0.384 -9999.0 0.0 -0.84 279.0 279.0 DHH N/Hhip -0.421 0.306 -9999.0 0.0 -0.616 237.0 237.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.392 0.27 -9999.0 0.0 -0.63 176.0 176.0 pancreas development -0.503 0.359 -9999.0 0.0 -0.758 230.0 230.0 HHAT 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.013 0.099 -9999.0 0.0 -0.76 6.0 6.0 somite specification -0.392 0.27 -9999.0 0.0 -0.63 176.0 176.0 SHH Np/Cholesterol/PTCH1 -0.372 0.26 -9999.0 0.0 -0.583 181.0 181.0 SHH Np/Cholesterol/PTCH2 -0.077 0.171 -9999.0 0.0 -0.45 59.0 59.0 SHH Np/Cholesterol/Megalin -0.314 0.284 -9999.0 0.0 -0.524 208.0 208.0 SHH -0.073 0.214 -9999.0 0.0 -0.565 55.0 55.0 catabolic process -0.389 0.256 -9999.0 0.0 -0.59 201.0 201.0 SMO/Vitamin D3 -0.392 0.273 -9999.0 0.0 -0.616 181.0 181.0 SHH Np/Cholesterol/Hhip -0.371 0.271 -9999.0 0.0 -0.524 244.0 244.0 LRP2 -0.409 0.379 -9999.0 0.0 -0.76 187.0 187.0 receptor-mediated endocytosis -0.529 0.322 -9999.0 0.0 -0.75 206.0 206.0 SHH Np/Cholesterol/BOC -0.07 0.163 -9999.0 0.0 -0.455 50.0 50.0 SHH Np/Cholesterol/CDO -0.077 0.169 -9999.0 0.0 -0.446 60.0 60.0 mesenchymal cell differentiation 0.367 0.268 0.52 244.0 -9999.0 0.0 244.0 mol:Vitamin D3 -0.371 0.268 -9999.0 0.0 -0.589 181.0 181.0 IHH N/PTCH2 -0.323 0.278 -9999.0 0.0 -0.559 198.0 198.0 CDON -0.011 0.091 -9999.0 0.0 -0.76 5.0 5.0 IHH N/PTCH1 -0.395 0.26 -9999.0 0.0 -0.599 201.0 201.0 Megalin/LRPAP1 -0.31 0.287 -9999.0 0.0 -0.576 187.0 187.0 PTCH2 -0.011 0.087 -9999.0 0.0 -0.729 5.0 5.0 SHH Np/Cholesterol -0.072 0.166 -9999.0 0.0 -0.452 55.0 55.0 PTCH1 -0.391 0.257 -9999.0 0.0 -0.593 201.0 201.0 HHIP -0.504 0.359 -9999.0 0.0 -0.76 230.0 230.0