Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.001 0.017 -9999.0 0.0 -0.315 1.0 1.0 epithelial cell differentiation -0.001 0.023 -9999.0 0.0 -0.42 1.0 1.0 CYFIP2 -0.02 0.121 -9999.0 0.0 -0.76 9.0 9.0 ENAH 0.058 0.032 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.025 0.129 -9999.0 0.0 -0.677 13.0 13.0 EPHA2 -0.007 0.07 -9999.0 0.0 -0.76 3.0 3.0 MYO6 -0.001 0.021 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.079 -9999.0 0.0 -0.495 9.0 9.0 AQP5 -0.17 0.256 -9999.0 0.0 -0.557 105.0 105.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.001 0.021 -9999.0 0.0 -0.391 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.119 0.184 -9999.0 0.0 -0.401 103.0 103.0 EGF -0.019 0.118 -9999.0 0.0 -0.743 9.0 9.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.084 0.202 -9999.0 0.0 -0.563 52.0 52.0 cortical microtubule organization -0.001 0.023 -9999.0 0.0 -0.42 1.0 1.0 GO:0000145 0.033 0.022 -9999.0 0.0 -0.373 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.001 0.023 -9999.0 0.0 -0.425 1.0 1.0 MLLT4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.004 0.035 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.004 0.041 -9999.0 0.0 -0.448 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.044 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.001 0.021 -9999.0 0.0 -0.398 1.0 1.0 ARF6/GTP -0.004 0.038 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.002 0.041 -9999.0 0.0 -0.76 1.0 1.0 EGFR/EGFR/EGF/EGF -0.023 0.092 -9999.0 0.0 -0.783 1.0 1.0 RhoA/GDP -0.001 0.021 -9999.0 0.0 -0.393 1.0 1.0 actin cytoskeleton organization 0.039 0.022 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.013 0.096 -9999.0 0.0 -0.734 6.0 6.0 DIAPH1 -0.017 0.103 -9999.0 0.0 -0.648 9.0 9.0 Wnt receptor signaling pathway 0.001 0.023 0.42 1.0 -9999.0 0.0 1.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.004 0.035 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.04 0.023 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.04 0.022 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.004 0.041 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.001 0.019 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.121 0.188 -9999.0 0.0 -0.408 103.0 103.0 HGF/MET -0.072 0.152 -9999.0 0.0 -0.779 1.0 1.0 HGF -0.134 0.289 -9999.0 0.0 -0.76 61.0 61.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.001 0.017 -9999.0 0.0 -0.318 1.0 1.0 actin cable formation 0.07 0.033 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.04 0.022 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 -0.001 0.021 -9999.0 0.0 -0.398 1.0 1.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.001 0.021 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.001 0.023 -9999.0 0.0 -0.42 1.0 1.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.001 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.001 0.021 -9999.0 0.0 -0.398 1.0 1.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.003 0.031 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.054 0.022 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.007 0.052 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.006 0.066 -9999.0 0.0 -0.708 3.0 3.0 PLEKHA7 -0.001 0.021 -9999.0 0.0 -0.398 1.0 1.0 mol:GTP -0.004 0.041 -9999.0 0.0 -0.445 3.0 3.0 establishment of epithelial cell apical/basal polarity -0.001 0.018 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.001 0.017 -9999.0 0.0 -0.315 1.0 1.0 regulation of cell-cell adhesion 0.039 0.022 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.001 0.017 -9999.0 0.0 -0.318 1.0 1.0