Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	117.0	6135.0	52.0	-0.677	0.367	1000.0	-1000.0	-0.101	-1000.0
Angiopoietin receptor Tie2-mediated signaling	101.0	8961.0	88.0	-0.684	0.048	1000.0	-1000.0	-0.133	-1000.0
FOXM1 transcription factor network	97.0	4957.0	51.0	-0.797	0.002	1000.0	-1000.0	-0.214	-1000.0
Aurora B signaling	93.0	6235.0	67.0	-0.637	0.005	1000.0	-1000.0	-0.089	-1000.0
Endothelins	54.0	5204.0	96.0	-0.437	0.055	1000.0	-1000.0	-0.1	-1000.0
amb2 Integrin signaling	43.0	3593.0	82.0	-0.713	0.0	1000.0	-1000.0	-0.097	-1000.0
Glucocorticoid receptor regulatory network	42.0	4793.0	114.0	-0.629	0.416	1000.0	-1000.0	-0.094	-1000.0
TCGA08_retinoblastoma	42.0	337.0	8.0	-0.293	0.089	1000.0	-1000.0	-0.029	-1000.0
Signaling events regulated by Ret tyrosine kinase	38.0	3128.0	82.0	-0.219	0.0	1000.0	-1000.0	-0.102	-1000.0
Glypican 2 network	37.0	149.0	4.0	-0.072	-0.064	1000.0	-1000.0	-0.044	-1000.0
Thromboxane A2 receptor signaling	36.0	3816.0	105.0	-0.175	0.034	1000.0	-1000.0	-0.082	-1000.0
Aurora C signaling	35.0	251.0	7.0	-0.431	0.0	1000.0	-1000.0	-0.054	-1000.0
Visual signal transduction: Cones	34.0	1319.0	38.0	-0.263	0.009	1000.0	-1000.0	-0.085	-1000.0
Fc-epsilon receptor I signaling in mast cells	33.0	3247.0	97.0	-0.244	0.033	1000.0	-1000.0	-0.105	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	32.0	1694.0	52.0	-0.426	0.063	1000.0	-1000.0	-0.086	-1000.0
IL4-mediated signaling events	31.0	2901.0	91.0	-0.77	0.42	1000.0	-1000.0	-0.195	-1000.0
BMP receptor signaling	27.0	2261.0	81.0	-0.422	0.04	1000.0	-1000.0	-0.111	-1000.0
Canonical Wnt signaling pathway	27.0	1391.0	51.0	-0.501	0.173	1000.0	-1000.0	-0.086	-1000.0
PLK1 signaling events	26.0	2240.0	85.0	-0.38	0.072	1000.0	-1000.0	-0.069	-1000.0
Presenilin action in Notch and Wnt signaling	25.0	1526.0	61.0	-0.501	0.016	1000.0	-1000.0	-0.087	-1000.0
FOXA2 and FOXA3 transcription factor networks	25.0	1190.0	46.0	-0.794	0.068	1000.0	-1000.0	-0.122	-1000.0
Nongenotropic Androgen signaling	25.0	1307.0	52.0	-0.147	0.061	1000.0	-1000.0	-0.073	-1000.0
Glypican 1 network	24.0	1157.0	48.0	-0.24	0.028	1000.0	-1000.0	-0.067	-1000.0
Arf6 signaling events	23.0	1477.0	62.0	-0.294	0.017	1000.0	-1000.0	-0.081	-1000.0
TCGA08_p53	23.0	164.0	7.0	-0.205	0.104	1000.0	-1000.0	-0.036	-1000.0
Integrins in angiogenesis	23.0	1989.0	84.0	-0.484	0.036	1000.0	-1000.0	-0.109	-1000.0
Nectin adhesion pathway	22.0	1440.0	63.0	-0.288	0.0	1000.0	-1000.0	-0.093	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	22.0	1768.0	78.0	-0.102	0.03	1000.0	-1000.0	-0.1	-1000.0
LPA4-mediated signaling events	21.0	253.0	12.0	-0.158	0.015	1000.0	-1000.0	-0.04	-1000.0
IL23-mediated signaling events	21.0	1264.0	60.0	-0.297	0.017	1000.0	-1000.0	-0.183	-1000.0
Calcium signaling in the CD4+ TCR pathway	20.0	648.0	31.0	-0.22	0.013	1000.0	-1000.0	-0.142	-1000.0
HIF-1-alpha transcription factor network	19.0	1479.0	76.0	-0.471	0.017	1000.0	-1000.0	-0.206	-1000.0
Coregulation of Androgen receptor activity	18.0	1437.0	76.0	-0.421	0.028	1000.0	-1000.0	-0.061	-1000.0
IL6-mediated signaling events	18.0	1360.0	75.0	-0.475	0.052	1000.0	-1000.0	-0.108	-1000.0
Visual signal transduction: Rods	18.0	945.0	52.0	-0.173	0.0	1000.0	-1000.0	-0.101	-1000.0
ErbB4 signaling events	17.0	1199.0	69.0	-0.404	0.208	1000.0	-1000.0	-0.1	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	17.0	1197.0	68.0	-0.24	0.015	1000.0	-1000.0	-0.162	-1000.0
Regulation of Androgen receptor activity	17.0	1202.0	70.0	-0.445	0.018	1000.0	-1000.0	-0.08	-1000.0
Osteopontin-mediated events	15.0	594.0	38.0	-0.364	0.011	1000.0	-1000.0	-0.135	-1000.0
Wnt signaling	15.0	107.0	7.0	-0.096	0.0	1000.0	-1000.0	-0.065	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	15.0	1890.0	120.0	-0.284	0.147	1000.0	-1000.0	-0.101	-1000.0
Syndecan-1-mediated signaling events	14.0	507.0	34.0	-0.377	0.0	1000.0	-1000.0	-0.092	-1000.0
Aurora A signaling	14.0	866.0	60.0	-0.49	0.034	1000.0	-1000.0	-0.076	-1000.0
Syndecan-3-mediated signaling events	14.0	519.0	35.0	-0.37	0.0	1000.0	-1000.0	-0.096	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	14.0	1812.0	125.0	-0.217	0.006	1000.0	-1000.0	-0.115	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	14.0	483.0	33.0	-0.284	0.0	1000.0	-1000.0	-0.082	-1000.0
IL12-mediated signaling events	13.0	1141.0	87.0	-0.2	0.018	1000.0	-1000.0	-0.167	-1000.0
p75(NTR)-mediated signaling	13.0	1687.0	125.0	-0.37	0.0	1000.0	-1000.0	-0.129	-1000.0
Ephrin A  reverse signaling	12.0	85.0	7.0	-0.026	0.002	1000.0	-1000.0	-0.033	-1000.0
Reelin signaling pathway	12.0	693.0	56.0	-0.119	0.0	1000.0	-1000.0	-0.127	-1000.0
HIF-2-alpha transcription factor network	12.0	517.0	43.0	-0.403	0.238	1000.0	-1000.0	-0.122	-1000.0
PDGFR-alpha signaling pathway	11.0	501.0	44.0	-0.217	0.022	1000.0	-1000.0	-0.077	-1000.0
Signaling mediated by p38-alpha and p38-beta	11.0	512.0	44.0	-0.117	0.0	1000.0	-1000.0	-0.074	-1000.0
Plasma membrane estrogen receptor signaling	11.0	1020.0	86.0	-0.175	0.036	1000.0	-1000.0	-0.096	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	10.0	919.0	85.0	-0.134	0.017	1000.0	-1000.0	-0.083	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	981.0	93.0	-0.054	0.04	1000.0	-1000.0	-0.105	-1000.0
EGFR-dependent Endothelin signaling events	10.0	218.0	21.0	-0.074	0.0	1000.0	-1000.0	-0.085	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1242.0	136.0	-0.347	0.094	1000.0	-1000.0	-0.103	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	8.0	473.0	54.0	-0.143	0.02	1000.0	-1000.0	-0.122	-1000.0
Effects of Botulinum toxin	8.0	217.0	26.0	-0.078	0.005	1000.0	-1000.0	-0.074	-1000.0
Caspase cascade in apoptosis	7.0	520.0	74.0	-0.087	0.035	1000.0	-1000.0	-0.073	-1000.0
Sphingosine 1-phosphate (S1P) pathway	7.0	210.0	28.0	-0.175	0.02	1000.0	-1000.0	-0.069	-1000.0
Syndecan-2-mediated signaling events	7.0	510.0	69.0	-0.188	0.035	1000.0	-1000.0	-0.086	-1000.0
Signaling events mediated by HDAC Class III	7.0	285.0	40.0	-0.142	0.047	1000.0	-1000.0	-0.05	-1000.0
FAS signaling pathway (CD95)	7.0	364.0	47.0	-0.253	0.009	1000.0	-1000.0	-0.058	-1000.0
Noncanonical Wnt signaling pathway	6.0	169.0	26.0	-0.096	0.0	1000.0	-1000.0	-0.11	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	406.0	65.0	-0.62	0.045	1000.0	-1000.0	-0.102	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	510.0	74.0	-0.17	0.07	1000.0	-1000.0	-0.121	-1000.0
Syndecan-4-mediated signaling events	6.0	458.0	67.0	-0.188	0.011	1000.0	-1000.0	-0.103	-1000.0
S1P4 pathway	6.0	157.0	25.0	-0.068	0.001	1000.0	-1000.0	-0.066	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	118.0	17.0	-0.067	0.007	1000.0	-1000.0	-0.077	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	89.0	17.0	-0.035	0.027	1000.0	-1000.0	-0.085	-1000.0
Signaling events mediated by PTP1B	5.0	388.0	76.0	-0.117	0.032	1000.0	-1000.0	-0.099	-1000.0
S1P1 pathway	5.0	185.0	36.0	-0.036	0.02	1000.0	-1000.0	-0.085	-1000.0
IL2 signaling events mediated by STAT5	5.0	123.0	22.0	-0.173	0.065	1000.0	-1000.0	-0.066	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	169.0	34.0	-0.029	0.0	1000.0	-1000.0	-0.083	-1000.0
TRAIL signaling pathway	4.0	196.0	48.0	-0.07	0.048	1000.0	-1000.0	-0.082	-1000.0
Retinoic acid receptors-mediated signaling	4.0	276.0	58.0	-0.242	0.036	1000.0	-1000.0	-0.085	-1000.0
IL27-mediated signaling events	4.0	216.0	51.0	-0.159	0.011	1000.0	-1000.0	-0.121	-1000.0
LPA receptor mediated events	4.0	456.0	102.0	-0.12	0.036	1000.0	-1000.0	-0.117	-1000.0
BCR signaling pathway	4.0	486.0	99.0	-0.081	0.043	1000.0	-1000.0	-0.115	-1000.0
Insulin Pathway	4.0	301.0	74.0	-0.116	0.032	1000.0	-1000.0	-0.104	-1000.0
S1P3 pathway	4.0	184.0	42.0	-0.175	0.042	1000.0	-1000.0	-0.069	-1000.0
Signaling events mediated by PRL	4.0	142.0	34.0	-0.134	0.025	1000.0	-1000.0	-0.077	-1000.0
ErbB2/ErbB3 signaling events	3.0	229.0	65.0	-0.09	0.052	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by HDAC Class II	3.0	235.0	75.0	-0.088	0.0	1000.0	-1000.0	-0.071	-1000.0
BARD1 signaling events	3.0	211.0	57.0	-0.134	0.023	1000.0	-1000.0	-0.088	-1000.0
Cellular roles of Anthrax toxin	3.0	145.0	39.0	-0.086	0.018	1000.0	-1000.0	-0.039	-1000.0
IL1-mediated signaling events	3.0	244.0	62.0	-0.071	0.043	1000.0	-1000.0	-0.127	-1000.0
Ephrin B reverse signaling	3.0	167.0	48.0	-0.066	0.035	1000.0	-1000.0	-0.09	-1000.0
Signaling events mediated by HDAC Class I	3.0	348.0	104.0	-0.088	0.042	1000.0	-1000.0	-0.091	-1000.0
IL2 signaling events mediated by PI3K	3.0	183.0	58.0	-0.208	0.078	1000.0	-1000.0	-0.096	-1000.0
Regulation of p38-alpha and p38-beta	3.0	210.0	54.0	-0.116	0.039	1000.0	-1000.0	-0.094	-1000.0
Arf6 trafficking events	3.0	221.0	71.0	-0.093	0.033	1000.0	-1000.0	-0.094	-1000.0
Circadian rhythm pathway	2.0	45.0	22.0	-0.037	0.039	1000.0	-1000.0	-0.069	-1000.0
IFN-gamma pathway	2.0	185.0	68.0	-0.077	0.067	1000.0	-1000.0	-0.116	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	248.0	83.0	-0.087	0.05	1000.0	-1000.0	-0.098	-1000.0
Regulation of Telomerase	2.0	298.0	102.0	-0.118	0.028	1000.0	-1000.0	-0.122	-1000.0
VEGFR1 specific signals	2.0	132.0	56.0	-0.217	0.05	1000.0	-1000.0	-0.09	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.004	-1000.0	1000.0	-1000.0	-0.032	-1000.0
p38 MAPK signaling pathway	2.0	116.0	44.0	-0.077	0.035	1000.0	-1000.0	-0.082	-1000.0
Insulin-mediated glucose transport	1.0	33.0	32.0	-0.051	0.037	1000.0	-1000.0	-0.077	-1000.0
Ceramide signaling pathway	1.0	94.0	76.0	-0.024	0.041	1000.0	-1000.0	-0.079	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	39.0	37.0	-0.014	0.033	1000.0	-1000.0	-0.096	-1000.0
S1P5 pathway	1.0	19.0	17.0	-0.011	0.007	1000.0	-1000.0	-0.064	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	15.0	15.0	-0.001	0.027	1000.0	-1000.0	-0.065	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	81.0	45.0	-0.024	0.064	1000.0	-1000.0	-0.112	-1000.0
EPHB forward signaling	1.0	148.0	85.0	-0.066	0.036	1000.0	-1000.0	-0.13	-1000.0
TCGA08_rtk_signaling	1.0	44.0	26.0	-0.042	0.041	1000.0	-1000.0	-0.037	-1000.0
Class I PI3K signaling events	1.0	138.0	73.0	-0.055	0.032	1000.0	-1000.0	-0.101	-1000.0
IGF1 pathway	1.0	109.0	57.0	-0.01	0.046	1000.0	-1000.0	-0.112	-1000.0
PDGFR-beta signaling pathway	1.0	164.0	97.0	-0.044	0.055	1000.0	-1000.0	-0.106	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.037	1000.0	-1000.0	-0.082	-1000.0
Canonical NF-kappaB pathway	0.0	28.0	39.0	-0.024	0.074	1000.0	-1000.0	-0.103	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.002	0.019	1000.0	-1000.0	-0.03	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	-0.004	0.0	1000.0	-1000.0	-0.041	-1000.0
Arf6 downstream pathway	0.0	11.0	43.0	-0.025	0.026	1000.0	-1000.0	-0.051	-1000.0
EPO signaling pathway	0.0	40.0	55.0	-0.011	0.067	1000.0	-1000.0	-0.107	-1000.0
mTOR signaling pathway	0.0	7.0	53.0	-0.004	0.03	1000.0	-1000.0	-0.075	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	34.0	68.0	-0.051	0.045	1000.0	-1000.0	-0.077	-1000.0
ceramide signaling pathway	0.0	27.0	49.0	-0.015	0.043	1000.0	-1000.0	-0.065	-1000.0
FoxO family signaling	0.0	57.0	64.0	-0.099	0.083	1000.0	-1000.0	-0.096	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	12.0	36.0	-0.008	0.02	1000.0	-1000.0	-0.084	-1000.0
Atypical NF-kappaB pathway	0.0	5.0	31.0	-0.002	0.031	1000.0	-1000.0	-0.091	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	63.0	76.0	-0.02	0.053	1000.0	-1000.0	-0.106	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.026	1000.0	-1000.0	-0.067	-1000.0
Rapid glucocorticoid signaling	0.0	18.0	20.0	-0.005	0.008	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in keratinocytes	0.0	41.0	43.0	-0.025	0.044	1000.0	-1000.0	-0.095	-1000.0
E-cadherin signaling events	0.0	3.0	5.0	-0.002	0.0	1000.0	-1000.0	-0.066	-1000.0
Arf1 pathway	0.0	15.0	54.0	-0.009	0.023	1000.0	-1000.0	-0.053	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.002	0.0	1000.0	-1000.0	-0.076	-1000.0
Total	1790	113994	7203	-25.9127558132	-994.429328743	131000	-131000	-11.961009316	-131000