Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.178 0.241 -9999.0 0.0 -0.811 19.0 19.0 IHH -0.326 0.327 -9999.0 0.0 -0.617 191.0 191.0 SHH Np/Cholesterol/GAS1 -0.035 0.133 0.191 1.0 -0.351 50.0 51.0 LRPAP1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.035 0.132 0.349 50.0 -0.189 1.0 51.0 SMO/beta Arrestin2 -0.22 0.231 -9999.0 0.0 -0.417 182.0 182.0 SMO -0.236 0.235 -9999.0 0.0 -0.436 184.0 184.0 AKT1 -0.12 0.164 -9999.0 0.0 -0.582 25.0 25.0 ARRB2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.233 0.232 -9999.0 0.0 -0.43 184.0 184.0 STIL -0.192 0.198 0.244 1.0 -0.511 54.0 55.0 DHH N/PTCH2 -0.005 0.131 -9999.0 0.0 -0.417 30.0 30.0 DHH N/PTCH1 -0.199 0.214 -9999.0 0.0 -0.357 209.0 209.0 PIK3CA 0.013 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.023 0.161 -9999.0 0.0 -0.588 26.0 26.0 PTHLH -0.22 0.274 -9999.0 0.0 -0.855 18.0 18.0 determination of left/right symmetry -0.233 0.232 -9999.0 0.0 -0.43 184.0 184.0 PIK3R1 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.219 0.272 -9999.0 0.0 -0.844 18.0 18.0 IHH N/Hhip -0.469 0.298 -9999.0 0.0 -0.599 274.0 274.0 DHH N/Hhip -0.294 0.243 -9999.0 0.0 -0.447 235.0 235.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.233 0.232 -9999.0 0.0 -0.43 184.0 184.0 pancreas development -0.352 0.296 -9999.0 0.0 -0.587 211.0 211.0 HHAT 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.017 0.018 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.012 0.08 -9999.0 0.0 -0.588 6.0 6.0 somite specification -0.233 0.232 -9999.0 0.0 -0.43 184.0 184.0 SHH Np/Cholesterol/PTCH1 -0.198 0.209 -9999.0 0.0 -0.436 90.0 90.0 SHH Np/Cholesterol/PTCH2 -0.034 0.129 0.191 1.0 -0.345 49.0 50.0 SHH Np/Cholesterol/Megalin -0.217 0.217 -9999.0 0.0 -0.392 195.0 195.0 SHH -0.053 0.153 0.286 1.0 -0.438 46.0 47.0 catabolic process -0.198 0.217 -9999.0 0.0 -0.378 195.0 195.0 SMO/Vitamin D3 -0.224 0.232 -9999.0 0.0 -0.503 80.0 80.0 SHH Np/Cholesterol/Hhip -0.252 0.208 -9999.0 0.0 -0.393 219.0 219.0 LRP2 -0.301 0.305 -9999.0 0.0 -0.588 183.0 183.0 receptor-mediated endocytosis -0.348 0.273 -9999.0 0.0 -0.606 154.0 154.0 SHH Np/Cholesterol/BOC -0.028 0.117 -9999.0 0.0 -0.345 39.0 39.0 SHH Np/Cholesterol/CDO -0.035 0.131 -9999.0 0.0 -0.344 51.0 51.0 mesenchymal cell differentiation 0.25 0.206 0.39 219.0 -9999.0 0.0 219.0 mol:Vitamin D3 -0.196 0.213 -9999.0 0.0 -0.486 68.0 68.0 IHH N/PTCH2 -0.204 0.218 -9999.0 0.0 -0.391 193.0 193.0 CDON 0.014 0.073 -9999.0 0.0 -0.588 5.0 5.0 IHH N/PTCH1 -0.192 0.229 -9999.0 0.0 -0.382 195.0 195.0 Megalin/LRPAP1 -0.215 0.233 -9999.0 0.0 -0.433 183.0 183.0 PTCH2 0.018 0.058 0.227 1.0 -0.588 3.0 4.0 SHH Np/Cholesterol -0.039 0.12 -9999.0 0.0 -0.342 46.0 46.0 PTCH1 -0.199 0.218 -9999.0 0.0 -0.38 195.0 195.0 HHIP -0.352 0.296 -9999.0 0.0 -0.588 211.0 211.0