Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Angiopoietin receptor Tie2-mediated signaling	103.0	9140.0	88.0	-0.626	0.061	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by the Hedgehog family	98.0	5143.0	52.0	-0.469	0.25	1000.0	-1000.0	-0.038	-1000.0
Endothelins	66.0	6343.0	96.0	-0.364	0.097	1000.0	-1000.0	-0.053	-1000.0
Fc-epsilon receptor I signaling in mast cells	45.0	4440.0	97.0	-0.14	0.024	1000.0	-1000.0	-0.064	-1000.0
amb2 Integrin signaling	45.0	3761.0	82.0	-0.543	0.043	1000.0	-1000.0	-0.038	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	44.0	2297.0	52.0	-0.305	0.048	1000.0	-1000.0	-0.043	-1000.0
Thromboxane A2 receptor signaling	42.0	4477.0	105.0	-0.191	0.054	1000.0	-1000.0	-0.044	-1000.0
TCGA08_retinoblastoma	40.0	323.0	8.0	-0.013	0.09	1000.0	-1000.0	-0.003	-1000.0
IL4-mediated signaling events	39.0	3616.0	91.0	-0.776	0.465	1000.0	-1000.0	-0.111	-1000.0
Aurora B signaling	37.0	2488.0	67.0	-0.306	0.269	1000.0	-1000.0	-0.039	-1000.0
Aurora C signaling	35.0	250.0	7.0	-0.003	0.148	1000.0	-1000.0	-0.017	-1000.0
Signaling mediated by p38-alpha and p38-beta	35.0	1583.0	44.0	-0.099	0.023	1000.0	-1000.0	-0.027	-1000.0
Signaling events regulated by Ret tyrosine kinase	31.0	2546.0	82.0	-0.114	0.065	1000.0	-1000.0	-0.06	-1000.0
Nongenotropic Androgen signaling	28.0	1485.0	52.0	-0.149	0.095	1000.0	-1000.0	-0.038	-1000.0
BMP receptor signaling	27.0	2210.0	81.0	-0.276	0.163	1000.0	-1000.0	-0.046	-1000.0
Integrins in angiogenesis	24.0	2027.0	84.0	-0.35	0.139	1000.0	-1000.0	-0.057	-1000.0
Calcium signaling in the CD4+ TCR pathway	24.0	756.0	31.0	-0.174	0.024	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	24.0	1898.0	78.0	-0.132	0.044	1000.0	-1000.0	-0.05	-1000.0
Arf6 signaling events	23.0	1475.0	62.0	-0.137	0.044	1000.0	-1000.0	-0.039	-1000.0
IL6-mediated signaling events	23.0	1764.0	75.0	-0.465	0.054	1000.0	-1000.0	-0.05	-1000.0
Canonical Wnt signaling pathway	22.0	1160.0	51.0	-0.374	0.148	1000.0	-1000.0	-0.045	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	22.0	1513.0	68.0	-0.189	0.029	1000.0	-1000.0	-0.076	-1000.0
FOXA2 and FOXA3 transcription factor networks	21.0	1007.0	46.0	-0.706	0.101	1000.0	-1000.0	-0.1	-1000.0
PLK1 signaling events	20.0	1703.0	85.0	-0.032	0.148	1000.0	-1000.0	-0.033	-1000.0
LPA4-mediated signaling events	19.0	229.0	12.0	-0.111	0.003	1000.0	-1000.0	-0.023	-1000.0
Presenilin action in Notch and Wnt signaling	19.0	1202.0	61.0	-0.374	0.147	1000.0	-1000.0	-0.049	-1000.0
IL23-mediated signaling events	19.0	1178.0	60.0	-0.241	0.024	1000.0	-1000.0	-0.098	-1000.0
Syndecan-3-mediated signaling events	18.0	662.0	35.0	-0.254	0.058	1000.0	-1000.0	-0.027	-1000.0
Coregulation of Androgen receptor activity	17.0	1361.0	76.0	-0.348	0.09	1000.0	-1000.0	-0.027	-1000.0
Visual signal transduction: Cones	17.0	677.0	38.0	-0.028	0.112	1000.0	-1000.0	-0.011	-1000.0
Glucocorticoid receptor regulatory network	17.0	2040.0	114.0	-0.356	0.057	1000.0	-1000.0	-0.059	-1000.0
Glypican 2 network	17.0	71.0	4.0	0.03	0.055	1000.0	-1000.0	0.015	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	17.0	572.0	33.0	-0.178	0.09	1000.0	-1000.0	-0.037	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	16.0	1391.0	85.0	-0.138	0.031	1000.0	-1000.0	-0.05	-1000.0
Reelin signaling pathway	16.0	897.0	56.0	-0.047	0.06	1000.0	-1000.0	-0.046	-1000.0
Plasma membrane estrogen receptor signaling	16.0	1381.0	86.0	-0.114	0.04	1000.0	-1000.0	-0.05	-1000.0
Regulation of Androgen receptor activity	16.0	1165.0	70.0	-0.382	0.146	1000.0	-1000.0	-0.052	-1000.0
ErbB4 signaling events	15.0	1078.0	69.0	-0.143	0.174	1000.0	-1000.0	-0.052	-1000.0
TCR signaling in naïve CD8+ T cells	15.0	1401.0	93.0	-0.046	0.034	1000.0	-1000.0	-0.056	-1000.0
IL12-mediated signaling events	14.0	1272.0	87.0	-0.22	0.048	1000.0	-1000.0	-0.084	-1000.0
Syndecan-1-mediated signaling events	14.0	505.0	34.0	-0.076	0.149	1000.0	-1000.0	-0.046	-1000.0
HIF-1-alpha transcription factor network	14.0	1092.0	76.0	-0.134	0.14	1000.0	-1000.0	-0.116	-1000.0
Wnt signaling	14.0	102.0	7.0	0.004	0.054	1000.0	-1000.0	-0.016	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	14.0	1689.0	120.0	-0.173	0.064	1000.0	-1000.0	-0.048	-1000.0
FOXM1 transcription factor network	14.0	743.0	51.0	0.023	0.303	1000.0	-1000.0	-0.117	-1000.0
Glypican 1 network	13.0	671.0	48.0	-0.151	0.089	1000.0	-1000.0	-0.032	-1000.0
FAS signaling pathway (CD95)	13.0	627.0	47.0	-0.259	0.061	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	13.0	1742.0	125.0	-0.14	0.052	1000.0	-1000.0	-0.059	-1000.0
Caspase cascade in apoptosis	12.0	924.0	74.0	-0.076	0.086	1000.0	-1000.0	-0.042	-1000.0
PDGFR-alpha signaling pathway	11.0	486.0	44.0	-0.159	0.048	1000.0	-1000.0	-0.045	-1000.0
Nectin adhesion pathway	11.0	747.0	63.0	-0.032	0.118	1000.0	-1000.0	-0.05	-1000.0
TCGA08_p53	11.0	79.0	7.0	-0.032	0.023	1000.0	-1000.0	-0.003	-1000.0
EGFR-dependent Endothelin signaling events	11.0	232.0	21.0	-0.034	0.044	1000.0	-1000.0	-0.049	-1000.0
Osteopontin-mediated events	10.0	381.0	38.0	-0.069	0.142	1000.0	-1000.0	-0.048	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	10.0	583.0	54.0	-0.047	0.067	1000.0	-1000.0	-0.048	-1000.0
p75(NTR)-mediated signaling	10.0	1370.0	125.0	-0.067	0.146	1000.0	-1000.0	-0.074	-1000.0
S1P1 pathway	10.0	376.0	36.0	-0.083	0.023	1000.0	-1000.0	-0.046	-1000.0
Effects of Botulinum toxin	10.0	269.0	26.0	-0.035	0.033	1000.0	-1000.0	-0.006	-1000.0
Visual signal transduction: Rods	10.0	561.0	52.0	-0.028	0.088	1000.0	-1000.0	-0.041	-1000.0
Ras signaling in the CD4+ TCR pathway	10.0	179.0	17.0	-0.029	0.03	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by PTP1B	9.0	724.0	76.0	-0.052	0.061	1000.0	-1000.0	-0.04	-1000.0
Ephrin B reverse signaling	9.0	459.0	48.0	-0.055	0.06	1000.0	-1000.0	-0.029	-1000.0
Regulation of nuclear SMAD2/3 signaling	8.0	1089.0	136.0	-0.204	0.14	1000.0	-1000.0	-0.051	-1000.0
Noncanonical Wnt signaling pathway	8.0	209.0	26.0	-0.037	0.054	1000.0	-1000.0	-0.048	-1000.0
Aurora A signaling	8.0	526.0	60.0	-0.038	0.19	1000.0	-1000.0	-0.016	-1000.0
mTOR signaling pathway	8.0	437.0	53.0	-0.012	0.09	1000.0	-1000.0	-0.039	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	8.0	611.0	74.0	-0.135	0.048	1000.0	-1000.0	-0.072	-1000.0
S1P4 pathway	8.0	203.0	25.0	-0.031	0.034	1000.0	-1000.0	-0.029	-1000.0
Sphingosine 1-phosphate (S1P) pathway	7.0	220.0	28.0	-0.114	0.045	1000.0	-1000.0	-0.02	-1000.0
JNK signaling in the CD4+ TCR pathway	7.0	135.0	17.0	-0.022	0.036	1000.0	-1000.0	-0.036	-1000.0
Hedgehog signaling events mediated by Gli proteins	7.0	519.0	65.0	-0.541	0.057	1000.0	-1000.0	-0.052	-1000.0
LPA receptor mediated events	7.0	777.0	102.0	-0.069	0.043	1000.0	-1000.0	-0.066	-1000.0
BCR signaling pathway	7.0	785.0	99.0	-0.064	0.055	1000.0	-1000.0	-0.056	-1000.0
Syndecan-4-mediated signaling events	7.0	473.0	67.0	-0.033	0.089	1000.0	-1000.0	-0.045	-1000.0
ErbB2/ErbB3 signaling events	6.0	419.0	65.0	-0.056	0.034	1000.0	-1000.0	-0.049	-1000.0
Syndecan-2-mediated signaling events	6.0	469.0	69.0	-0.046	0.089	1000.0	-1000.0	-0.043	-1000.0
Retinoic acid receptors-mediated signaling	6.0	355.0	58.0	-0.178	0.047	1000.0	-1000.0	-0.059	-1000.0
IL27-mediated signaling events	6.0	333.0	51.0	-0.102	0.032	1000.0	-1000.0	-0.048	-1000.0
Insulin Pathway	6.0	445.0	74.0	-0.096	0.061	1000.0	-1000.0	-0.06	-1000.0
Cellular roles of Anthrax toxin	5.0	215.0	39.0	-0.061	0.026	1000.0	-1000.0	-0.021	-1000.0
IFN-gamma pathway	5.0	358.0	68.0	-0.028	0.068	1000.0	-1000.0	-0.058	-1000.0
HIF-2-alpha transcription factor network	5.0	252.0	43.0	-0.08	0.082	1000.0	-1000.0	-0.068	-1000.0
TCGA08_rtk_signaling	5.0	141.0	26.0	-0.061	0.082	1000.0	-1000.0	-0.01	-1000.0
IL2 signaling events mediated by STAT5	5.0	127.0	22.0	0.009	0.077	1000.0	-1000.0	-0.04	-1000.0
PDGFR-beta signaling pathway	5.0	494.0	97.0	-0.056	0.064	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling in keratinocytes	5.0	215.0	43.0	-0.051	0.063	1000.0	-1000.0	-0.042	-1000.0
Ephrin A  reverse signaling	4.0	29.0	7.0	-0.0	0.031	1000.0	-1000.0	-0.016	-1000.0
Ceramide signaling pathway	4.0	377.0	76.0	-0.007	0.06	1000.0	-1000.0	-0.037	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	403.0	83.0	-0.094	0.041	1000.0	-1000.0	-0.029	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	182.0	45.0	-0.016	0.053	1000.0	-1000.0	-0.045	-1000.0
EPHB forward signaling	4.0	413.0	85.0	-0.042	0.086	1000.0	-1000.0	-0.07	-1000.0
Regulation of p38-alpha and p38-beta	4.0	258.0	54.0	-0.06	0.055	1000.0	-1000.0	-0.051	-1000.0
Class I PI3K signaling events	4.0	306.0	73.0	-0.025	0.043	1000.0	-1000.0	-0.048	-1000.0
IGF1 pathway	4.0	271.0	57.0	-0.063	0.065	1000.0	-1000.0	-0.042	-1000.0
S1P3 pathway	4.0	193.0	42.0	-0.114	0.044	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by PRL	4.0	137.0	34.0	-0.025	0.065	1000.0	-1000.0	-0.048	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	3.0	106.0	34.0	-0.035	0.056	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class II	3.0	226.0	75.0	-0.043	0.059	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by HDAC Class III	3.0	130.0	40.0	-0.074	0.042	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	3.0	202.0	62.0	-0.008	0.043	1000.0	-1000.0	-0.057	-1000.0
ceramide signaling pathway	3.0	153.0	49.0	-0.0	0.039	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class I	3.0	386.0	104.0	-0.043	0.057	1000.0	-1000.0	-0.043	-1000.0
IL2 signaling events mediated by PI3K	3.0	207.0	58.0	-0.021	0.104	1000.0	-1000.0	-0.039	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	263.0	76.0	-0.019	0.058	1000.0	-1000.0	-0.062	-1000.0
BARD1 signaling events	2.0	167.0	57.0	-0.044	0.089	1000.0	-1000.0	-0.045	-1000.0
EPO signaling pathway	2.0	159.0	55.0	0.004	0.064	1000.0	-1000.0	-0.048	-1000.0
Insulin-mediated glucose transport	2.0	64.0	32.0	-0.0	0.044	1000.0	-1000.0	-0.031	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	137.0	68.0	-0.037	0.049	1000.0	-1000.0	-0.034	-1000.0
TRAIL signaling pathway	2.0	138.0	48.0	-0.018	0.066	1000.0	-1000.0	-0.036	-1000.0
FoxO family signaling	2.0	141.0	64.0	-0.015	0.074	1000.0	-1000.0	-0.052	-1000.0
Regulation of Telomerase	2.0	286.0	102.0	-0.069	0.058	1000.0	-1000.0	-0.067	-1000.0
VEGFR1 specific signals	2.0	163.0	56.0	-0.14	0.062	1000.0	-1000.0	-0.057	-1000.0
p38 MAPK signaling pathway	2.0	106.0	44.0	-0.004	0.056	1000.0	-1000.0	-0.033	-1000.0
Canonical NF-kappaB pathway	1.0	74.0	39.0	-0.0	0.047	1000.0	-1000.0	-0.039	-1000.0
Circadian rhythm pathway	1.0	24.0	22.0	-0.006	0.05	1000.0	-1000.0	-0.04	-1000.0
Arf6 downstream pathway	1.0	45.0	43.0	-0.047	0.048	1000.0	-1000.0	-0.041	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	43.0	37.0	-0.009	0.056	1000.0	-1000.0	-0.035	-1000.0
S1P5 pathway	1.0	20.0	17.0	-0.016	0.03	1000.0	-1000.0	-0.02	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	25.0	15.0	-0.01	0.023	1000.0	-1000.0	-0.04	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	50.0	36.0	-0.045	0.047	1000.0	-1000.0	-0.034	-1000.0
Arf6 trafficking events	1.0	91.0	71.0	-0.058	0.042	1000.0	-1000.0	-0.034	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.021	0.021	1000.0	-1000.0	-0.019	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	8.0	23.0	0.003	0.043	1000.0	-1000.0	-0.029	-1000.0
PLK2 and PLK4 events	0.0	1.0	3.0	0.009	0.023	1000.0	-1000.0	-0.016	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.02	0.033	1000.0	-1000.0	0.012	-1000.0
Atypical NF-kappaB pathway	0.0	11.0	31.0	-0.0	0.026	1000.0	-1000.0	-0.02	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.008	0.054	1000.0	-1000.0	-0.05	-1000.0
Rapid glucocorticoid signaling	0.0	16.0	20.0	-0.008	0.027	1000.0	-1000.0	-0.005	-1000.0
E-cadherin signaling events	0.0	3.0	5.0	0.021	0.041	1000.0	-1000.0	0.013	-1000.0
Arf1 pathway	0.0	46.0	54.0	-0.002	0.032	1000.0	-1000.0	-0.017	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	0.0	0.062	1000.0	-1000.0	-0.0	-1000.0
Total	1685	110403	7203	-14.8827528018	9.54882067284	131000	-131000	-5.55998693313	-131000