Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.057 0.239 -9999.0 0.0 -0.771 21.0 21.0 IHH -0.058 0.154 -9999.0 0.0 -0.401 41.0 41.0 SHH Np/Cholesterol/GAS1 -0.063 0.164 -9999.0 0.0 -0.442 33.0 33.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.062 0.162 0.438 33.0 -9999.0 0.0 33.0 SMO/beta Arrestin2 -0.019 0.121 -9999.0 0.0 -0.538 4.0 4.0 SMO -0.027 0.127 -9999.0 0.0 -0.523 6.0 6.0 AKT1 0.004 0.064 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.007 0.096 -9999.0 0.0 -0.471 10.0 10.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.026 0.125 -9999.0 0.0 -0.515 6.0 6.0 STIL -0.062 0.158 -9999.0 0.0 -0.487 15.0 15.0 DHH N/PTCH2 -0.042 0.147 -9999.0 0.0 -0.379 39.0 39.0 DHH N/PTCH1 -0.035 0.142 -9999.0 0.0 -0.493 12.0 12.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.015 0.119 -9999.0 0.0 -0.544 12.0 12.0 PTHLH -0.052 0.249 -9999.0 0.0 -0.831 18.0 18.0 determination of left/right symmetry -0.026 0.125 -9999.0 0.0 -0.515 6.0 6.0 PIK3R1 0.008 0.035 -9999.0 0.0 -0.394 2.0 2.0 skeletal system development -0.051 0.244 -9999.0 0.0 -0.817 18.0 18.0 IHH N/Hhip -0.099 0.185 -9999.0 0.0 -0.41 56.0 56.0 DHH N/Hhip -0.072 0.178 -9999.0 0.0 -0.388 57.0 57.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.026 0.125 -9999.0 0.0 -0.515 6.0 6.0 pancreas development -0.086 0.209 -9999.0 0.0 -0.511 48.0 48.0 HHAT -0.016 0.133 -9999.0 0.0 -0.652 11.0 11.0 PI3K 0.015 0.025 -9999.0 0.0 -0.267 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.026 0.151 -9999.0 0.0 -0.634 15.0 15.0 somite specification -0.026 0.125 -9999.0 0.0 -0.515 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.067 0.161 -9999.0 0.0 -0.504 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.073 0.156 -9999.0 0.0 -0.393 41.0 41.0 SHH Np/Cholesterol/Megalin -0.193 0.196 -9999.0 0.0 -0.415 97.0 97.0 SHH -0.062 0.162 -9999.0 0.0 -0.503 21.0 21.0 catabolic process -0.029 0.137 -9999.0 0.0 -0.541 7.0 7.0 SMO/Vitamin D3 -0.058 0.159 -9999.0 0.0 -0.575 8.0 8.0 SHH Np/Cholesterol/Hhip -0.097 0.177 -9999.0 0.0 -0.426 46.0 46.0 LRP2 -0.258 0.285 -9999.0 0.0 -0.529 130.0 130.0 receptor-mediated endocytosis -0.152 0.184 -9999.0 0.0 -0.538 24.0 24.0 SHH Np/Cholesterol/BOC -0.052 0.139 -9999.0 0.0 -0.414 23.0 23.0 SHH Np/Cholesterol/CDO -0.046 0.14 -9999.0 0.0 -0.435 21.0 21.0 mesenchymal cell differentiation 0.096 0.176 0.423 46.0 -9999.0 0.0 46.0 mol:Vitamin D3 -0.065 0.162 -9999.0 0.0 -0.504 15.0 15.0 IHH N/PTCH2 -0.065 0.156 -9999.0 0.0 -0.396 38.0 38.0 CDON 0.003 0.068 -9999.0 0.0 -0.523 4.0 4.0 IHH N/PTCH1 -0.029 0.138 -9999.0 0.0 -0.547 7.0 7.0 Megalin/LRPAP1 -0.18 0.212 -9999.0 0.0 -0.379 130.0 130.0 PTCH2 -0.045 0.162 -9999.0 0.0 -0.48 30.0 30.0 SHH Np/Cholesterol -0.049 0.127 -9999.0 0.0 -0.399 21.0 21.0 PTCH1 -0.029 0.137 -9999.0 0.0 -0.543 7.0 7.0 HHIP -0.086 0.21 -9999.0 0.0 -0.512 48.0 48.0