Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.001 0.112 0.355 22.0 -9999.0 0.0 22.0 KIRREL 0.023 0.027 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.001 0.112 -9999.0 0.0 -0.355 22.0 22.0 PLCG1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.027 0.093 -9999.0 0.0 -0.275 20.0 20.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.003 0.077 -9999.0 0.0 -0.26 20.0 20.0 FYN -0.006 0.092 0.272 2.0 -0.256 22.0 24.0 mol:Ca2+ 0.025 0.093 -9999.0 0.0 -0.273 21.0 21.0 mol:DAG 0.026 0.094 -9999.0 0.0 -0.274 21.0 21.0 NPHS2 0.012 0.029 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.026 0.094 -9999.0 0.0 -0.274 21.0 21.0 regulation of endocytosis 0.023 0.084 -9999.0 0.0 -0.246 21.0 21.0 Nephrin/NEPH1/podocin/Cholesterol 0.014 0.088 -9999.0 0.0 -0.272 21.0 21.0 establishment of cell polarity 0.001 0.112 -9999.0 0.0 -0.355 22.0 22.0 Nephrin/NEPH1/podocin/NCK1-2 0.04 0.092 -9999.0 0.0 -0.254 20.0 20.0 Nephrin/NEPH1/beta Arrestin2 0.025 0.086 -9999.0 0.0 -0.249 21.0 21.0 NPHS1 -0.03 0.147 -9999.0 0.0 -0.495 23.0 23.0 Nephrin/NEPH1/podocin 0.016 0.086 -9999.0 0.0 -0.257 22.0 22.0 TJP1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.027 0.095 -9999.0 0.0 -0.275 21.0 21.0 CD2AP 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.029 0.093 -9999.0 0.0 -0.275 20.0 20.0 GRB2 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.015 0.092 0.157 27.0 -0.253 22.0 49.0 cytoskeleton organization -0.022 0.092 0.2 2.0 -0.329 19.0 21.0 Nephrin/NEPH1 0.006 0.079 -9999.0 0.0 -0.255 21.0 21.0 Nephrin/NEPH1/ZO-1 0.017 0.096 -9999.0 0.0 -0.293 21.0 21.0