Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.019 0.183 -9999.0 0.0 -0.672 18.0 18.0 IHH 0.022 0.058 -9999.0 0.0 -0.248 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.021 0.108 -9999.0 0.0 -0.305 30.0 30.0 LRPAP1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.021 0.107 0.303 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 0.017 0.101 -9999.0 0.0 -0.377 6.0 6.0 SMO -0.007 0.098 -9999.0 0.0 -0.374 9.0 9.0 AKT1 -0.002 0.08 -9999.0 0.0 -0.313 2.0 2.0 ARRB2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.019 0.057 -9999.0 0.0 -0.492 3.0 3.0 ADRBK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.004 0.098 -9999.0 0.0 -0.369 9.0 9.0 STIL -0.022 0.113 -9999.0 0.0 -0.271 37.0 37.0 DHH N/PTCH2 0.014 0.097 -9999.0 0.0 -0.358 16.0 16.0 DHH N/PTCH1 0.01 0.107 -9999.0 0.0 -0.311 24.0 24.0 PIK3CA 0.022 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.013 0.085 -9999.0 0.0 -0.492 7.0 7.0 PTHLH -0.023 0.19 -9999.0 0.0 -0.691 17.0 17.0 determination of left/right symmetry -0.004 0.098 -9999.0 0.0 -0.369 9.0 9.0 PIK3R1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.022 0.188 -9999.0 0.0 -0.683 17.0 17.0 IHH N/Hhip 0.001 0.12 -9999.0 0.0 -0.387 21.0 21.0 DHH N/Hhip -0.003 0.125 -9999.0 0.0 -0.369 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.004 0.098 -9999.0 0.0 -0.369 9.0 9.0 pancreas development -0.02 0.138 -9999.0 0.0 -0.491 20.0 20.0 HHAT 0.008 0.1 -9999.0 0.0 -0.492 10.0 10.0 PI3K 0.03 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.003 0.11 -9999.0 0.0 -0.492 12.0 12.0 somite specification -0.004 0.098 -9999.0 0.0 -0.369 9.0 9.0 SHH Np/Cholesterol/PTCH1 -0.017 0.111 -9999.0 0.0 -0.281 36.0 36.0 SHH Np/Cholesterol/PTCH2 -0.019 0.099 -9999.0 0.0 -0.287 29.0 29.0 SHH Np/Cholesterol/Megalin -0.08 0.141 -9999.0 0.0 -0.29 77.0 77.0 SHH -0.031 0.102 -9999.0 0.0 -0.373 20.0 20.0 catabolic process 0.003 0.098 -9999.0 0.0 -0.345 18.0 18.0 SMO/Vitamin D3 -0.014 0.12 -9999.0 0.0 -0.383 11.0 11.0 SHH Np/Cholesterol/Hhip -0.033 0.119 -9999.0 0.0 -0.313 36.0 36.0 LRP2 -0.118 0.219 -9999.0 0.0 -0.492 65.0 65.0 receptor-mediated endocytosis -0.071 0.137 -9999.0 0.0 -0.45 10.0 10.0 SHH Np/Cholesterol/BOC -0.009 0.088 -9999.0 0.0 -0.293 21.0 21.0 SHH Np/Cholesterol/CDO -0.008 0.094 -9999.0 0.0 -0.314 20.0 20.0 mesenchymal cell differentiation 0.033 0.118 0.311 36.0 -9999.0 0.0 36.0 mol:Vitamin D3 -0.012 0.118 -9999.0 0.0 -0.281 36.0 36.0 IHH N/PTCH2 0.018 0.093 -9999.0 0.0 -0.394 11.0 11.0 CDON 0.023 0.046 -9999.0 0.0 -0.492 2.0 2.0 IHH N/PTCH1 0.012 0.101 -9999.0 0.0 -0.347 18.0 18.0 Megalin/LRPAP1 -0.061 0.172 -9999.0 0.0 -0.357 65.0 65.0 PTCH2 0.003 0.101 -9999.0 0.0 -0.492 10.0 10.0 SHH Np/Cholesterol -0.014 0.082 -9999.0 0.0 -0.288 20.0 20.0 PTCH1 0.003 0.098 -9999.0 0.0 -0.346 18.0 18.0 HHIP -0.02 0.138 -9999.0 0.0 -0.492 20.0 20.0