E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.047 0.101 -9999.0 0.0 -0.323 63.0 63.0 KLHL20 -0.058 0.077 0.476 1.0 -0.277 15.0 16.0 CYFIP2 0.028 0.006 -9999.0 0.0 0.0 24.0 24.0 Rac1/GDP -0.046 0.078 0.235 5.0 -0.249 21.0 26.0 ENAH -0.048 0.102 -9999.0 0.0 -0.32 65.0 65.0 AP1M1 0.026 0.01 -9999.0 0.0 0.0 67.0 67.0 RAP1B 0.028 0.006 -9999.0 0.0 0.0 22.0 22.0 RAP1A 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CTNNB1 0.028 0.007 -9999.0 0.0 -0.013 13.0 13.0 CDC42/GTP -0.059 0.05 0.116 21.0 -0.233 2.0 23.0 ABI1/Sra1/Nap1 -0.053 0.045 -9999.0 0.0 -0.169 33.0 33.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.047 -9999.0 0.0 -0.141 9.0 9.0 RAPGEF1 -0.047 0.098 0.237 4.0 -0.307 54.0 58.0 CTNND1 0.029 0.004 -9999.0 0.0 -0.005 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.113 -9999.0 0.0 -0.322 67.0 67.0 CRK -0.047 0.101 -9999.0 0.0 -0.316 60.0 60.0 E-cadherin/gamma catenin/alpha catenin 0.043 0.044 -9999.0 0.0 -0.156 20.0 20.0 alphaE/beta7 Integrin 0.04 0.014 -9999.0 0.0 -0.163 1.0 1.0 IQGAP1 0.028 0.006 -9999.0 0.0 0.0 25.0 25.0 NCKAP1 0.028 0.005 -9999.0 0.0 0.0 17.0 17.0 Rap1/GTP/I-afadin 0.04 0.042 -9999.0 0.0 -0.131 21.0 21.0 DLG1 -0.033 0.102 0.193 1.0 -0.323 53.0 54.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.044 0.042 -9999.0 0.0 -0.16 8.0 8.0 MLLT4 0.026 0.01 -9999.0 0.0 0.0 70.0 70.0 ARF6/GTP/NME1/Tiam1 0.048 0.024 -9999.0 0.0 -0.13 1.0 1.0 PI3K -0.054 0.054 -9999.0 0.0 -0.208 7.0 7.0 ARF6 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.03 0.042 -9999.0 0.0 -0.176 19.0 19.0 TIAM1 0.028 0.006 -9999.0 0.0 -0.001 21.0 21.0 E-cadherin(dimer)/Ca2+ 0.052 0.043 -9999.0 0.0 -0.132 9.0 9.0 AKT1 -0.013 0.07 0.132 60.0 -9999.0 0.0 60.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 159.0 159.0 CDH1 0.025 0.011 -9999.0 0.0 -0.002 77.0 77.0 RhoA/GDP -0.045 0.077 0.237 4.0 -0.25 20.0 24.0 actin cytoskeleton organization -0.043 0.058 0.412 1.0 -0.23 5.0 6.0 CDC42/GDP -0.045 0.078 0.237 5.0 -0.251 19.0 24.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.015 0.058 -9999.0 0.0 -0.188 36.0 36.0 ITGB7 0.029 0.004 -9999.0 0.0 0.0 9.0 9.0 RAC1 0.028 0.007 -9999.0 0.0 -0.001 28.0 28.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.056 0.046 -9999.0 0.0 -0.142 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.033 -9999.0 0.0 -0.121 9.0 9.0 mol:GDP -0.044 0.084 0.239 5.0 -0.274 22.0 27.0 CDC42/GTP/IQGAP1 0.037 0.014 -9999.0 0.0 -0.134 2.0 2.0 JUP 0.027 0.008 -9999.0 0.0 0.0 42.0 42.0 p120 catenin/RhoA/GDP -0.048 0.081 0.23 5.0 -0.257 18.0 23.0 RAC1/GTP/IQGAP1 0.036 0.015 -9999.0 0.0 -0.134 2.0 2.0 PIP5K1C/AP1M1 0.036 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 6.0 6.0 CDC42 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 CTNNA1 0.029 0.005 -9999.0 0.0 -0.002 12.0 12.0 positive regulation of S phase of mitotic cell cycle -0.045 0.056 0.115 1.0 -0.13 141.0 142.0 NME1 0.027 0.008 -9999.0 0.0 0.0 43.0 43.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.048 0.104 -9999.0 0.0 -0.322 67.0 67.0 regulation of cell-cell adhesion -0.055 0.041 0.083 20.0 -0.206 2.0 22.0 WASF2 -0.031 0.035 0.09 4.0 -0.105 30.0 34.0 Rap1/GTP -0.055 0.057 0.251 2.0 -0.252 2.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.063 -9999.0 0.0 -0.151 20.0 20.0 CCND1 -0.055 0.069 0.131 1.0 -0.159 141.0 142.0 VAV2 -0.039 0.163 -9999.0 0.0 -0.661 23.0 23.0 RAP1/GDP -0.047 0.065 0.253 3.0 -0.246 4.0 7.0 adherens junction assembly -0.047 0.101 -9999.0 0.0 -0.313 67.0 67.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 15.0 15.0 PIP5K1C 0.027 0.008 -9999.0 0.0 0.0 43.0 43.0 regulation of heterotypic cell-cell adhesion -0.06 0.03 0.171 4.0 -0.229 2.0 6.0 E-cadherin/beta catenin -0.022 0.046 -9999.0 0.0 -0.18 40.0 40.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.046 0.101 -9999.0 0.0 -0.324 61.0 61.0 PIK3CA 0.02 0.014 -9999.0 0.0 0.0 172.0 172.0 Rac1/GTP -0.089 0.111 0.567 1.0 -0.396 33.0 34.0 E-cadherin/beta catenin/alpha catenin 0.048 0.032 -9999.0 0.0 -0.146 9.0 9.0 ITGAE 0.028 0.007 -9999.0 0.0 0.0 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.024 0.115 -9999.0 0.0 -0.328 67.0 67.0