Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.04 0.021 0.198 1.0 -9999.0 0.0 1.0 KIRREL -0.022 0.03 0.048 80.0 -9999.0 0.0 80.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.04 0.021 -9999.0 0.0 -0.198 1.0 1.0 PLCG1 0.028 0.007 -9999.0 0.0 0.0 31.0 31.0 ARRB2 0.028 0.006 -9999.0 0.0 0.0 25.0 25.0 WASL 0.028 0.006 -9999.0 0.0 0.0 22.0 22.0 Nephrin/NEPH1/podocin/CD2AP 0.064 0.038 0.2 1.0 -9999.0 0.0 1.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.014 0.034 0.164 1.0 -0.191 1.0 2.0 FYN -0.004 0.064 0.145 76.0 -0.215 1.0 77.0 mol:Ca2+ 0.061 0.038 -9999.0 0.0 -0.168 1.0 1.0 mol:DAG 0.062 0.039 -9999.0 0.0 -0.169 1.0 1.0 NPHS2 -0.02 0.033 0.05 96.0 -9999.0 0.0 96.0 mol:IP3 0.062 0.039 -9999.0 0.0 -0.169 1.0 1.0 regulation of endocytosis 0.031 0.052 -9999.0 0.0 -0.211 1.0 1.0 Nephrin/NEPH1/podocin/Cholesterol 0.051 0.03 0.153 2.0 -0.157 1.0 3.0 establishment of cell polarity 0.04 0.021 -9999.0 0.0 -0.198 1.0 1.0 Nephrin/NEPH1/podocin/NCK1-2 0.081 0.047 -9999.0 0.0 -0.164 1.0 1.0 Nephrin/NEPH1/beta Arrestin2 0.033 0.054 -9999.0 0.0 -0.213 1.0 1.0 NPHS1 -0.024 0.027 0.05 52.0 -9999.0 0.0 52.0 Nephrin/NEPH1/podocin 0.03 0.049 0.187 3.0 -0.215 1.0 4.0 TJP1 0.027 0.007 -9999.0 0.0 0.0 38.0 38.0 NCK1 0.026 0.009 -9999.0 0.0 0.0 63.0 63.0 NCK2 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.063 0.04 -9999.0 0.0 -0.169 1.0 1.0 CD2AP 0.028 0.007 -9999.0 0.0 0.0 31.0 31.0 Nephrin/NEPH1/podocin/GRB2 0.064 0.039 0.2 1.0 -0.169 1.0 2.0 GRB2 0.028 0.005 -9999.0 0.0 0.0 20.0 20.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.013 0.072 0.15 82.0 -9999.0 0.0 82.0 cytoskeleton organization -0.017 0.048 0.201 12.0 -0.205 1.0 13.0 Nephrin/NEPH1 0.034 0.018 -9999.0 0.0 -0.13 1.0 1.0 Nephrin/NEPH1/ZO-1 0.049 0.03 -9999.0 0.0 -0.164 1.0 1.0