Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.03 0.209 0.502 81.0 -0.451 15.0 96.0 IHH -0.006 0.078 0.16 88.0 -9999.0 0.0 88.0 SHH Np/Cholesterol/GAS1 -0.045 0.037 0.143 1.0 -0.131 76.0 77.0 LRPAP1 0.028 0.007 -9999.0 0.0 0.0 33.0 33.0 dorsoventral neural tube patterning 0.044 0.037 0.131 76.0 -0.142 1.0 77.0 SMO/beta Arrestin2 0.025 0.133 0.297 84.0 -0.388 9.0 93.0 SMO 0.028 0.134 0.307 84.0 -0.397 9.0 93.0 AKT1 -0.024 0.146 0.329 2.0 -0.449 18.0 20.0 ARRB2 0.028 0.006 -9999.0 0.0 0.0 25.0 25.0 BOC 0.025 0.01 -9999.0 0.0 0.0 80.0 80.0 ADRBK1 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 heart looping 0.028 0.133 0.306 84.0 -0.392 9.0 93.0 STIL 0.002 0.065 0.273 20.0 -9999.0 0.0 20.0 DHH N/PTCH2 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.006 0.134 0.314 79.0 -0.254 23.0 102.0 PIK3CA 0.02 0.014 -9999.0 0.0 0.0 172.0 172.0 DHH 0.029 0.003 -9999.0 0.0 0.0 5.0 5.0 PTHLH 0.031 0.194 0.495 71.0 -0.426 14.0 85.0 determination of left/right symmetry 0.028 0.133 0.306 84.0 -0.392 9.0 93.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 159.0 159.0 skeletal system development 0.032 0.193 0.494 71.0 -0.423 14.0 85.0 IHH N/Hhip 0.048 0.042 0.181 3.0 -0.088 8.0 11.0 DHH N/Hhip 0.041 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.028 0.133 0.306 84.0 -0.392 9.0 93.0 pancreas development 0.028 0.006 -9999.0 0.0 0.0 26.0 26.0 HHAT 0.028 0.005 -9999.0 0.0 0.0 18.0 18.0 PI3K -0.001 0.068 -9999.0 0.0 -0.163 76.0 76.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.024 0.011 -9999.0 0.0 0.0 94.0 94.0 somite specification 0.028 0.133 0.306 84.0 -0.392 9.0 93.0 SHH Np/Cholesterol/PTCH1 -0.003 0.115 0.269 75.0 -0.262 9.0 84.0 SHH Np/Cholesterol/PTCH2 -0.032 0.016 0.143 1.0 -0.13 5.0 6.0 SHH Np/Cholesterol/Megalin -0.025 0.019 -9999.0 0.0 -0.13 4.0 4.0 SHH -0.03 0.014 0.194 1.0 -9999.0 0.0 1.0 catabolic process 0.023 0.159 0.379 84.0 -0.318 8.0 92.0 SMO/Vitamin D3 0.004 0.122 0.26 76.0 -0.363 9.0 85.0 SHH Np/Cholesterol/Hhip -0.032 0.016 0.143 1.0 -0.13 5.0 6.0 LRP2 0.022 0.013 -9999.0 0.0 0.0 141.0 141.0 receptor-mediated endocytosis 0.025 0.125 0.278 75.0 -0.402 8.0 83.0 SHH Np/Cholesterol/BOC -0.041 0.032 0.143 1.0 -0.13 55.0 56.0 SHH Np/Cholesterol/CDO -0.032 0.018 0.143 1.0 -0.13 7.0 8.0 mesenchymal cell differentiation 0.031 0.016 0.129 5.0 -0.142 1.0 6.0 mol:Vitamin D3 0.004 0.119 0.238 102.0 -0.268 8.0 110.0 IHH N/PTCH2 0.049 0.041 0.181 4.0 -9999.0 0.0 4.0 CDON 0.028 0.007 -9999.0 0.0 0.0 32.0 32.0 IHH N/PTCH1 -0.034 0.053 -9999.0 0.0 -0.276 24.0 24.0 Megalin/LRPAP1 0.03 0.023 -9999.0 0.0 -0.163 2.0 2.0 PTCH2 0.028 0.006 -9999.0 0.0 0.0 21.0 21.0 SHH Np/Cholesterol -0.022 0.013 0.156 1.0 -0.119 5.0 6.0 PTCH1 0.023 0.159 0.379 84.0 -0.319 8.0 92.0 HHIP 0.028 0.006 -9999.0 0.0 0.0 26.0 26.0