Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.011 0.057 -9999.0 0.0 -0.195 27.0 27.0 epithelial cell differentiation 0.047 0.041 -9999.0 0.0 -0.131 9.0 9.0 CYFIP2 0.028 0.006 -9999.0 0.0 0.0 24.0 24.0 ENAH -0.05 0.062 0.207 7.0 -9999.0 0.0 7.0 EGFR 0.027 0.009 -9999.0 0.0 0.0 54.0 54.0 EPHA2 0.029 0.005 -9999.0 0.0 0.0 16.0 16.0 MYO6 -0.047 0.026 0.158 3.0 -0.218 1.0 4.0 CTNNB1 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 ABI1/Sra1/Nap1 0.051 0.03 -9999.0 0.0 -0.146 9.0 9.0 AQP5 -0.012 0.049 -9999.0 0.0 -0.322 4.0 4.0 CTNND1 0.029 0.003 -9999.0 0.0 0.0 5.0 5.0 mol:PI-4-5-P2 -0.045 0.027 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.045 0.027 -9999.0 0.0 -9999.0 0.0 0.0 EGF 0.027 0.008 -9999.0 0.0 0.0 40.0 40.0 NCKAP1 0.028 0.005 -9999.0 0.0 0.0 17.0 17.0 AQP3 -0.127 0.167 -9999.0 0.0 -0.405 138.0 138.0 cortical microtubule organization 0.047 0.041 -9999.0 0.0 -0.131 9.0 9.0 GO:0000145 -0.043 0.025 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.043 -9999.0 0.0 -0.132 9.0 9.0 MLLT4 0.026 0.01 -9999.0 0.0 0.0 70.0 70.0 ARF6/GDP -0.065 0.034 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 Ephrin A1/EPHA2/NCK1/GIT1 0.067 0.04 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.051 0.065 -9999.0 0.0 -0.227 59.0 59.0 PVRL2 0.028 0.007 -9999.0 0.0 0.0 32.0 32.0 ZYX -0.042 0.026 -9999.0 0.0 -0.218 1.0 1.0 ARF6/GTP 0.071 0.044 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.01 -9999.0 0.0 0.0 71.0 71.0 EGFR/EGFR/EGF/EGF -0.062 0.032 0.094 7.0 -0.219 2.0 9.0 RhoA/GDP 0.047 0.044 -9999.0 0.0 -0.134 10.0 10.0 actin cytoskeleton organization -0.051 0.027 -9999.0 0.0 -0.223 1.0 1.0 IGF-1R heterotetramer 0.022 0.013 -9999.0 0.0 0.0 140.0 140.0 GIT1 0.028 0.007 -9999.0 0.0 0.0 31.0 31.0 IGF1R 0.022 0.013 -9999.0 0.0 0.0 140.0 140.0 IGF1 0.028 0.007 -9999.0 0.0 0.0 32.0 32.0 DIAPH1 0.028 0.128 -9999.0 0.0 -0.552 20.0 20.0 Wnt receptor signaling pathway -0.047 0.041 0.131 9.0 -9999.0 0.0 9.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 6.0 6.0 RhoA/GTP -0.065 0.034 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 VCL -0.052 0.028 -9999.0 0.0 -0.228 1.0 1.0 EFNA1 0.027 0.008 -9999.0 0.0 0.0 46.0 46.0 LPP -0.048 0.033 0.139 4.0 -0.298 1.0 5.0 Ephrin A1/EPHA2 -0.05 0.033 0.094 21.0 -9999.0 0.0 21.0 SEC6/SEC8 -0.064 0.034 -9999.0 0.0 -0.227 1.0 1.0 MGAT3 -0.045 0.027 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.044 0.048 0.094 49.0 -9999.0 0.0 49.0 HGF 0.028 0.005 -9999.0 0.0 0.0 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.011 0.058 -9999.0 0.0 -0.197 27.0 27.0 actin cable formation -0.031 0.086 0.276 12.0 -0.285 7.0 19.0 KIAA1543 -0.047 0.022 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 -0.047 0.023 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.026 0.009 -9999.0 0.0 0.0 63.0 63.0 EXOC3 0.026 0.009 -9999.0 0.0 0.0 60.0 60.0 ACTN1 -0.048 0.026 0.157 4.0 -0.218 1.0 5.0 NCK1/GIT1 0.036 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.047 0.041 -9999.0 0.0 -0.131 9.0 9.0 EXOC4 0.028 0.007 -9999.0 0.0 0.0 34.0 34.0 STX4 -0.049 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.046 0.027 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.028 0.005 -9999.0 0.0 0.0 20.0 20.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 15.0 15.0 ROCK1 -0.046 0.076 0.236 12.0 -9999.0 0.0 12.0 adherens junction assembly -0.064 0.099 0.223 1.0 -0.58 13.0 14.0 IGF-1R heterotetramer/IGF1 -0.075 0.042 0.094 3.0 -0.221 3.0 6.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.03 0.042 -9999.0 0.0 -0.163 22.0 22.0 MET 0.025 0.011 -9999.0 0.0 0.0 87.0 87.0 PLEKHA7 -0.049 0.024 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.065 0.039 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.044 0.09 0.283 15.0 -9999.0 0.0 15.0 cortical actin cytoskeleton stabilization -0.011 0.057 -9999.0 0.0 -0.195 27.0 27.0 regulation of cell-cell adhesion -0.051 0.027 -9999.0 0.0 -0.223 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.011 0.058 -9999.0 0.0 -0.197 27.0 27.0