Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.009 0.094 0.27 16.0 -9999.0 0.0 16.0 KIRREL -0.003 0.114 -9999.0 0.0 -0.463 10.0 10.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.009 0.094 -9999.0 0.0 -0.27 16.0 16.0 PLCG1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.037 0.084 -9999.0 0.0 -0.252 10.0 10.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.004 0.061 -9999.0 0.0 -0.241 9.0 9.0 FYN -0.009 0.077 0.3 4.0 -0.238 10.0 14.0 mol:Ca2+ 0.033 0.083 -9999.0 0.0 -0.251 10.0 10.0 mol:DAG 0.034 0.084 -9999.0 0.0 -0.251 10.0 10.0 NPHS2 0.013 0.03 -9999.0 0.0 -0.232 1.0 1.0 mol:IP3 0.034 0.084 -9999.0 0.0 -0.251 10.0 10.0 regulation of endocytosis 0.02 0.069 -9999.0 0.0 -0.223 10.0 10.0 Nephrin/NEPH1/podocin/Cholesterol 0.023 0.078 -9999.0 0.0 -0.25 10.0 10.0 establishment of cell polarity 0.009 0.094 -9999.0 0.0 -0.27 16.0 16.0 Nephrin/NEPH1/podocin/NCK1-2 0.039 0.082 -9999.0 0.0 -0.232 10.0 10.0 Nephrin/NEPH1/beta Arrestin2 0.022 0.07 -9999.0 0.0 -0.226 10.0 10.0 NPHS1 0.011 0.051 -9999.0 0.0 -0.232 6.0 6.0 Nephrin/NEPH1/podocin 0.021 0.071 -9999.0 0.0 -0.239 10.0 10.0 TJP1 0.025 0.02 -9999.0 0.0 -0.232 1.0 1.0 NCK1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.035 0.084 -9999.0 0.0 -0.252 10.0 10.0 CD2AP 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.036 0.084 -9999.0 0.0 -0.252 10.0 10.0 GRB2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.053 0.123 0.28 1.0 -0.286 34.0 35.0 cytoskeleton organization -0.005 0.066 0.205 1.0 -0.267 9.0 10.0 Nephrin/NEPH1 0.011 0.067 -9999.0 0.0 -0.234 10.0 10.0 Nephrin/NEPH1/ZO-1 0.024 0.082 -9999.0 0.0 -0.258 11.0 11.0