Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	34 (15%)	191	0.16762	1	0.026897	1	0.35597	1	0.15873	1	0.18093	1	0.51201	1	0.28273	1	0.058384	1
BRAF	115 (51%)	110	9.5946e-08	9.84e-05	0.05716	1	0.017402	1	0.0073078	1	0.0074679	1	1.9368e-05	0.0199	0.19507	1	0.086399	1
C15ORF23	14 (6%)	211	0.10437	1	0.21493	1	0.83814	1	0.81515	1	0.78693	1	1	1	0.73082	1	0.71906	1
CDKN2A	31 (14%)	194	0.15341	1	0.27522	1	0.4169	1	0.77049	1	0.65159	1	0.3645	1	0.75334	1	0.81433	1
NRAS	65 (29%)	160	0.00052961	0.542	0.038322	1	0.089874	1	0.32086	1	0.89816	1	0.83933	1	0.86312	1	0.68209	1
OXA1L	6 (3%)	219	0.28761	1	0.58248	1	0.61661	1	0.47481	1	0.67924	1	0.22176	1	0.24049	1	0.24741	1
STK19	10 (4%)	215	0.92075	1	0.13301	1	0.23766	1	0.99927	1	0.78032	1	0.49105	1	0.60077	1	0.71839	1
PTEN	18 (8%)	207	0.67418	1	0.24327	1	0.14881	1	0.1352	1	0.95242	1	0.068821	1	0.81647	1	0.34559	1
RAC1	16 (7%)	209	0.76275	1	0.9456	1	0.94048	1	0.4504	1	0.46278	1	0.94217	1	0.40525	1	0.22393	1
ACSM2B	36 (16%)	189	0.45378	1	0.43622	1	0.81548	1	0.4015	1	0.44097	1	0.5699	1	0.15312	1	0.62138	1
CADM2	22 (10%)	203	0.66046	1	0.17467	1	0.15346	1	0.35266	1	0.81589	1	0.58279	1	0.34513	1	0.016989	1
OR51S1	26 (12%)	199	0.36561	1	0.64876	1	0.89774	1	0.11298	1	0.30636	1	0.79471	1	0.53586	1	0.79046	1
LCE1B	13 (6%)	212	0.15827	1	0.62646	1	0.22113	1	0.89236	1	0.51994	1	0.70652	1	1	1	1	1
IDH1	11 (5%)	214	0.36724	1	0.17994	1	0.10374	1	0.28059	1	0.43259	1	0.71473	1	0.21194	1	0.1066	1
TAF1A	14 (6%)	211	0.44865	1	0.69178	1	0.44606	1	0.054988	1	0.64722	1	0.24327	1	0.3817	1	0.71906	1
NAP1L2	21 (9%)	204	0.60081	1	0.73965	1	0.78954	1	0.80931	1	0.80903	1	1	1	0.67262	1	1	1
MUC7	19 (8%)	206	1	1	0.46799	1	0.14324	1	0.70607	1	0.50275	1	0.039319	1	0.092929	1	0.051133	1
PPP6C	17 (8%)	208	0.50806	1	0.37064	1	0.095201	1	0.77953	1	0.41344	1	0.54214	1	0.28707	1	0.1508	1
FRG2B	17 (8%)	208	1	1	0.77279	1	0.97516	1	0.99688	1	0.48745	1	0.94485	1	0.80998	1	0.32568	1
USP29	35 (16%)	190	0.91974	1	0.9455	1	0.88257	1	0.7195	1	0.91833	1	1	1	0.30617	1	0.74303	1
PRB4	18 (8%)	207	0.38497	1	0.64303	1	0.13661	1	0.19099	1	0.011914	1	0.19117	1	0.43942	1	0.39413	1
HIST1H2AA	10 (4%)	215	0.3627	1	0.71234	1	0.65519	1	0.72061	1	0.33485	1	0.91912	1	0.34324	1	0.2311	1
RPTN	38 (17%)	187	0.33216	1	0.16719	1	0.37959	1	0.36663	1	0.018224	1	0.40185	1	0.47063	1	0.47909	1
ZNF479	22 (10%)	203	0.72115	1	1	1	0.74139	1	0.11208	1	0.68056	1	0.5462	1	0.068501	1	0.48778	1
C8A	26 (12%)	199	0.70142	1	0.083537	1	0.30192	1	0.39362	1	0.09711	1	0.79471	1	0.28372	1	0.11524	1
FUT9	22 (10%)	203	0.28817	1	0.038679	1	0.48684	1	0.84998	1	0.51845	1	0.10933	1	0.1572	1	0.6101	1
ZNF679	18 (8%)	207	0.5583	1	0.78041	1	0.63207	1	0.67328	1	0.23451	1	0.40427	1	0.34743	1	0.41944	1
NRK	28 (12%)	197	0.90428	1	0.90374	1	0.63199	1	0.30302	1	0.28869	1	0.83608	1	0.7582	1	0.60823	1
CDH9	32 (14%)	193	0.88784	1	0.14053	1	0.25142	1	0.57663	1	0.8875	1	0.53851	1	0.0012329	1	0.28778	1
PRAMEF11	21 (9%)	204	0.80797	1	0.058473	1	0.93714	1	0.95985	1	0.18345	1	0.49764	1	0.87667	1	0.71064	1
DDX3X	18 (8%)	207	0.58555	1	0.95308	1	0.22927	1	0.17407	1	0.6761	1	0.95012	1	0.86025	1	0.21057	1
GRXCR1	18 (8%)	207	0.90877	1	0.067023	1	0.41596	1	0.94992	1	0.035061	1	1	1	0.67102	1	0.21057	1
PRB2	29 (13%)	196	0.55476	1	0.57207	1	0.77334	1	0.74067	1	0.0073617	1	0.071236	1	0.17136	1	0.11136	1
ELF5	7 (3%)	218	0.71075	1	1	1	0.93308	1	0.52135	1	0.34352	1	1	1	0.065289	1	0.068396	1
IL32	9 (4%)	216	0.39171	1	0.11426	1	0.68976	1	0.14866	1	0.57999	1	1	1	0.6257	1	1	1
LUZP2	19 (8%)	206	1	1	0.46799	1	0.20488	1	0.75752	1	1	1	0.67088	1	0.03773	1	0.46555	1
PDE1A	30 (13%)	195	0.49807	1	0.90905	1	0.52333	1	0.38376	1	0.037367	1	0.31009	1	0.55876	1	0.17748	1
RBM11	12 (5%)	213	0.18569	1	0.059947	1	0.79259	1	0.87229	1	0.57216	1	0.073787	1	0.30781	1	0.57054	1
GLRB	22 (10%)	203	0.25537	1	0.5125	1	0.053194	1	0.032994	1	0.46007	1	0.23196	1	0.41009	1	0.38715	1
PRB1	21 (9%)	204	0.50282	1	0.62274	1	0.12694	1	0.089679	1	0.29867	1	0.60227	1	0.47212	1	0.20845	1
KIAA1257	14 (6%)	211	0.42016	1	1	1	0.6373	1	0.77513	1	0.78693	1	0.76479	1	0.5331	1	0.4801	1
USP17L2	18 (8%)	207	0.261	1	0.11013	1	0.18531	1	0.26038	1	0.12729	1	0.44535	1	0.38302	1	0.67552	1
SPAG16	16 (7%)	209	0.48679	1	1	1	0.13249	1	0.28869	1	0.046956	1	0.043962	1	0.060357	1	0.10839	1
OR4M2	22 (10%)	203	1	1	0.95972	1	0.067813	1	0.4546	1	0.29838	1	0.70347	1	0.13168	1	0.3648	1
GFRAL	28 (12%)	197	0.34034	1	0.30492	1	0.681	1	0.76374	1	0.9048	1	0.83608	1	0.8731	1	0.95606	1
UNC119B	6 (3%)	219	0.44842	1	0.39786	1	0.21512	1	0.91489	1	0.59239	1	0.55105	1	1	1	0.46765	1
PHGDH	8 (4%)	217	0.66823	1	1	1	1	1	0.42468	1	0.90313	1	0.89366	1	0.73056	1	0.4251	1
STXBP5L	42 (19%)	183	0.37026	1	0.92963	1	0.83685	1	0.61675	1	0.095651	1	0.33294	1	0.46177	1	0.55913	1
TRAT1	12 (5%)	213	0.93195	1	0.36494	1	0.73237	1	0.6789	1	0.43259	1	1	1	0.21859	1	0.46647	1
ZNF844	9 (4%)	216	1	1	1	1	0.65519	1	0.91489	1	0.82067	1	0.72351	1	0.56366	1	0.78046	1
TTN	171 (76%)	54	0.40255	1	0.019848	1	0.41453	1	0.091227	1	0.12521	1	0.18085	1	0.1555	1	0.27635	1
COPG2	9 (4%)	216	0.31924	1	0.91442	1	0.28667	1	0.25113	1	0.69303	1	0.61777	1	0.90828	1	0.78046	1
DSG3	41 (18%)	184	0.53997	1	0.97578	1	0.78194	1	0.30194	1	0.59719	1	0.29861	1	0.34494	1	0.65384	1
GML	9 (4%)	216	0.17649	1	0.38693	1	0.94036	1	0.41776	1	0.83501	1	0.9034	1	0.18095	1	0.78046	1
HHLA2	14 (6%)	211	0.10437	1	0.4699	1	0.43389	1	0.0037974	1	1	1	0.10781	1	0.11138	1	0.65985	1
LILRB4	27 (12%)	198	0.21397	1	1	1	0.22443	1	0.66839	1	0.55576	1	0.18815	1	0.52829	1	0.54342	1
SLC38A4	25 (11%)	200	0.008452	1	0.77174	1	0.98339	1	0.9622	1	0.040251	1	0.72492	1	0.71263	1	0.70878	1
OR2L3	14 (6%)	211	0.60895	1	0.014789	1	0.7448	1	0.46765	1	0.73931	1	0.32019	1	0.77526	1	0.51676	1
HBD	9 (4%)	216	0.58016	1	1	1	0.83208	1	0.24089	1	0.053968	1	0.25287	1	0.50696	1	0.88851	1
TBC1D3B	5 (2%)	220	0.22606	1	0.74505	1	0.060642	1	0.25787	1	0.86023	1	1	1	0.85579	1	0.6451	1
TCEB3C	26 (12%)	199	0.52371	1	0.3127	1	0.34342	1	0.54305	1	0.24562	1	0.057231	1	0.69426	1	0.24164	1
CYLC2	19 (8%)	206	0.35359	1	0.56877	1	0.093435	1	0.12103	1	0.20709	1	0.12164	1	0.29667	1	0.33924	1
HBG2	7 (3%)	218	0.33997	1	0.55836	1	0.23446	1	0.33919	1	0.29841	1	1	1	0.22869	1	0.30165	1
LOC649330	22 (10%)	203	0.24474	1	0.47167	1	0.7912	1	0.75565	1	0.075586	1	0.76725	1	0.71435	1	0.4343	1
FIGLA	3 (1%)	222	0.63189	1	0.62791	1	NA	NA	NA	NA	0.51236	1	0.43158	1	0.61247	1	0.69132	1
PARM1	17 (8%)	208	0.85564	1	1	1	0.72566	1	0.13108	1	0.77504	1	0.67355	1	0.19469	1	0.46039	1
CCK	6 (3%)	219	0.58397	1	0.66194	1	0.32162	1	0.072431	1	0.44688	1	0.87903	1	0.57707	1	0.71369	1
ZFP106	10 (4%)	215	0.84963	1	0.77653	1	0.26377	1	0.26395	1	0.51225	1	0.91912	1	0.55172	1	0.44895	1
UGT2B15	19 (8%)	206	0.33632	1	0.38239	1	0.76688	1	0.73423	1	0.43137	1	1	1	0.35736	1	0.46555	1
FGF16	7 (3%)	218	1	1	0.89714	1	0.0047925	1	0.014242	1	1	1	0.15438	1	0.092874	1	0.52788	1
NUDT4	5 (2%)	220	1	1	0.37488	1	0.36102	1	0.14505	1	1	1	0.83945	1	0.61201	1	0.50314	1
DSG1	37 (16%)	188	0.60359	1	0.52441	1	0.084114	1	0.057477	1	0.3334	1	0.77134	1	0.3148	1	0.54614	1
ARL16	7 (3%)	218	0.18005	1	0.34357	1	0.13983	1	0.6493	1	0.39542	1	1	1	1	1	1	1
VEGFC	16 (7%)	209	0.64913	1	0.1435	1	0.34852	1	0.025517	1	0.16538	1	0.3185	1	0.008206	1	0.040574	1
PSG4	23 (10%)	202	0.48903	1	0.96096	1	0.42552	1	0.38712	1	0.64869	1	0.71289	1	0.26751	1	0.11947	1
DEFB119	6 (3%)	219	1	1	0.77077	1	0.49345	1	0.88457	1	0.87633	1	0.87903	1	0.43719	1	1	1
KLHL4	20 (9%)	205	0.79937	1	0.53211	1	0.76225	1	0.86292	1	0.21321	1	0.20833	1	0.95494	1	0.48156	1
EIF3D	4 (2%)	221	0.83167	1	0.83668	1	0.24582	1	0.43577	1	1	1	0.36709	1	0.46935	1	0.43013	1
OR2W1	16 (7%)	209	0.15672	1	0.71898	1	0.24411	1	0.088793	1	0.63297	1	1	1	0.51458	1	1	1
OR4N2	21 (9%)	204	0.3404	1	0.14391	1	0.6395	1	0.36353	1	0.028167	1	0.2419	1	0.43021	1	0.055876	1
CCDC11	17 (8%)	208	0.90315	1	0.064408	1	0.26486	1	0.2116	1	0.080176	1	0.12627	1	0.02725	1	1	1
LIN7A	10 (4%)	215	0.92075	1	0.26747	1	0.55574	1	0.64788	1	0.17588	1	0.69334	1	0.022543	1	0.39545	1
RAPGEF5	11 (5%)	214	1	1	0.45923	1	0.60379	1	0.49445	1	0.31113	1	0.60664	1	0.2736	1	0.062857	1
CD2	16 (7%)	209	0.39511	1	0.57866	1	0.77572	1	0.51583	1	1	1	0.83935	1	0.67105	1	0.51413	1
C2ORF40	7 (3%)	218	0.23607	1	0.798	1	0.94036	1	0.7248	1	0.89446	1	0.7883	1	0.42868	1	0.62939	1
SGCZ	19 (8%)	206	0.62584	1	0.62524	1	0.86565	1	0.70019	1	0.27843	1	0.041916	1	0.95329	1	0.78358	1
SPANXN2	14 (6%)	211	0.28311	1	0.69178	1	0.58421	1	0.17084	1	0.30185	1	0.67444	1	0.60677	1	0.10633	1
TLL1	42 (19%)	183	0.97605	1	0.018293	1	0.6177	1	0.042055	1	0.083973	1	0.14856	1	0.82111	1	0.40342	1
C9ORF119	7 (3%)	218	1	1	0.1776	1	0.47567	1	0.56303	1	0.34352	1	0.15438	1	0.37851	1	0.52788	1
CCDC54	13 (6%)	212	0.081183	1	0.33374	1	0.29449	1	0.86254	1	0.10989	1	0.087466	1	0.087864	1	0.77161	1
DEFB118	8 (4%)	217	0.19663	1	0.31557	1	0.93308	1	0.26947	1	0.66684	1	0.72351	1	0.3802	1	0.66826	1
HTR3B	16 (7%)	209	0.016933	1	0.13495	1	0.026117	1	0.05977	1	0.00054137	0.554	0.020162	1	0.28344	1	0.22393	1
MARCH11	10 (4%)	215	0.84963	1	1	1	0.37779	1	0.72061	1	0.17588	1	0.16606	1	1	1	0.89111	1
MKX	14 (6%)	211	0.13948	1	0.20003	1	0.58305	1	0.97102	1	0.069111	1	0.38228	1	0.19647	1	0.20786	1
OR5H2	14 (6%)	211	0.78336	1	1	1	0.45805	1	0.51845	1	0.73931	1	0.67444	1	0.31817	1	0.20786	1
SIGLEC14	11 (5%)	214	0.36724	1	0.33836	1	0.035758	1	0.46418	1	0.58131	1	0.71473	1	0.62534	1	0.81049	1
TUBB8	12 (5%)	213	0.7037	1	0.86673	1	0.21413	1	0.13784	1	0.5419	1	0.30189	1	0.2841	1	0.25028	1
ZIM3	23 (10%)	202	0.19414	1	0.14008	1	0.67513	1	0.43126	1	0.20758	1	0.87883	1	0.64007	1	0.68986	1
PRC1	13 (6%)	212	0.9377	1	0.41954	1	0.056371	1	0.71626	1	0.27873	1	0.56006	1	0.29066	1	0.4582	1
MUM1L1	25 (11%)	200	0.55488	1	0.80154	1	0.73829	1	0.091809	1	0.59711	1	0.13291	1	0.58935	1	0.78123	1
TRIM58	15 (7%)	210	0.5613	1	0.89082	1	0.81512	1	0.86076	1	0.56189	1	0.68726	1	0.43213	1	0.86078	1
ANKRD20A4	4 (2%)	221	0.38535	1	0.45433	1	0.32162	1	0.13465	1	0.10642	1	0.80909	1	0.46935	1	1	1
OR5J2	13 (6%)	212	0.63308	1	0.55002	1	0.31161	1	0.4999	1	0.93767	1	1	1	0.10718	1	0.4582	1
CLEC14A	18 (8%)	207	0.04246	1	0.49542	1	0.1432	1	0.48327	1	0.13489	1	0.58707	1	0.43942	1	1	1
FAM19A1	8 (4%)	217	0.15606	1	0.38625	1	0.45835	1	0.11246	1	0.48544	1	1	1	0.90429	1	0.87651	1
GK2	28 (12%)	197	0.79191	1	0.60282	1	0.32804	1	0.1868	1	0.58678	1	0.58077	1	0.15158	1	0.80301	1
LONRF2	16 (7%)	209	0.89763	1	0.34259	1	0.94532	1	0.98763	1	0.94821	1	0.83935	1	0.48621	1	0.69082	1
HAPLN1	11 (5%)	214	1	1	0.095855	1	0.77155	1	0.88158	1	0.80027	1	1	1	0.85724	1	0.60751	1
NAP1L4	9 (4%)	216	0.020453	1	0.04602	1	0.035758	1	0.59993	1	0.63375	1	0.061095	1	0.6257	1	1	1
CLCC1	13 (6%)	212	0.9377	1	0.36086	1	0.53285	1	0.1437	1	0.14991	1	0.38833	1	0.019331	1	0.5419	1
OR52J3	13 (6%)	212	0.30101	1	0.27768	1	0.36701	1	0.46386	1	0.51994	1	0.60375	1	0.71688	1	0.27694	1
TMCO5A	8 (4%)	217	0.0088529	1	0.46957	1	0.16386	1	0.095561	1	0.023462	1	0.29067	1	0.90429	1	1	1
C4ORF22	11 (5%)	214	0.63313	1	0.92527	1	0.59267	1	0.28125	1	0.92584	1	0.85172	1	0.14999	1	0.27262	1
MAP2K1	11 (5%)	214	0.15694	1	0.065751	1	0.055753	1	0.12432	1	0.031624	1	0.047469	1	0.85724	1	0.43653	1
OR7D2	17 (8%)	208	0.5347	1	0.35045	1	0.77805	1	0.83786	1	0.029393	1	0.84749	1	0.45173	1	0.53279	1
CXCR2	11 (5%)	214	0.85951	1	0.49473	1	0.86642	1	0.95232	1	0.46482	1	0.77827	1	0.79014	1	0.81049	1
RBM22	7 (3%)	218	0.44156	1	0.1776	1	NA	NA	NA	NA	0.34352	1	0.4615	1	1	1	0.52788	1
CX3CL1	4 (2%)	221	0.14298	1	0.13935	1	NA	NA	NA	NA	1	1	0.55454	1	0.12399	1	0.43013	1
IGF2BP3	6 (3%)	219	0.87926	1	1	1	0.86833	1	0.64558	1	0.51613	1	1	1	0.24049	1	0.58923	1
KLRC3	10 (4%)	215	1	1	0.55826	1	0.51662	1	0.011316	1	0.61037	1	0.10082	1	0.29103	1	1	1
LRRIQ4	19 (8%)	206	0.19982	1	0.095723	1	0.11068	1	0.35677	1	0.71116	1	0.72947	1	0.079986	1	0.0024423	1
NR1H4	11 (5%)	214	0.26348	1	0.33836	1	0.37364	1	0.36239	1	0.80027	1	0.77827	1	1	1	0.43653	1
OR4A15	21 (9%)	204	0.43707	1	0.32096	1	1	1	0.20157	1	0.020321	1	0.339	1	0.64326	1	0.41946	1
MAGEA4	10 (4%)	215	0.39768	1	0.55826	1	0.01435	1	0.35295	1	0.14434	1	0.69334	1	0.41994	1	0.51178	1
DGAT2L6	10 (4%)	215	0.50849	1	0.71234	1	0.85315	1	0.11049	1	0.33485	1	0.69334	1	0.65367	1	0.39545	1
RGS18	8 (4%)	217	0.35006	1	0.89934	1	0.12159	1	0.40267	1	0.22618	1	0.72351	1	0.2176	1	0.77117	1
TSGA13	9 (4%)	216	0.52999	1	0.57919	1	0.11789	1	0.33261	1	0.57999	1	0.74538	1	0.76231	1	0.78046	1
OPN5	7 (3%)	218	0.20775	1	0.89714	1	1	1	0.34283	1	0.39542	1	0.59875	1	1	1	1	1
SPINK13	7 (3%)	218	0.29909	1	0.23271	1	0.89235	1	0.45681	1	0.56578	1	0.68342	1	0.32891	1	0.73929	1