E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.1 0.187 0.229 1.0 -0.364 78.0 79.0 KLHL20 -0.03 0.094 0.192 5.0 -0.212 23.0 28.0 CYFIP2 0.016 0.067 0.124 3.0 -0.316 9.0 12.0 Rac1/GDP -0.047 0.119 0.209 3.0 -0.229 56.0 59.0 ENAH -0.096 0.183 0.224 1.0 -0.364 73.0 74.0 AP1M1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.019 0.083 -9999.0 0.0 -0.155 52.0 52.0 ABI1/Sra1/Nap1 -0.04 0.055 -9999.0 0.0 -0.142 30.0 30.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.007 0.115 -9999.0 0.0 -0.174 74.0 74.0 RAPGEF1 -0.082 0.169 0.22 3.0 -0.329 71.0 74.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.096 0.196 -9999.0 0.0 -0.375 78.0 78.0 CRK -0.088 0.178 0.216 1.0 -0.345 74.0 75.0 E-cadherin/gamma catenin/alpha catenin -0.012 0.113 -9999.0 0.0 -0.19 66.0 66.0 alphaE/beta7 Integrin 0.027 0.057 -9999.0 0.0 -0.215 12.0 12.0 IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.044 0.029 -9999.0 0.0 -0.155 2.0 2.0 DLG1 -0.099 0.186 -9999.0 0.0 -0.367 77.0 77.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.041 0.048 -9999.0 0.0 -0.122 53.0 53.0 MLLT4 0.022 0.033 -9999.0 0.0 -0.316 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.041 0.05 -9999.0 0.0 -0.165 12.0 12.0 PI3K -0.051 0.06 -9999.0 0.0 -0.153 53.0 53.0 ARF6 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.029 0.123 -9999.0 0.0 -0.225 66.0 66.0 TIAM1 0.011 0.075 0.124 1.0 -0.316 12.0 13.0 E-cadherin(dimer)/Ca2+ 0.003 0.102 -9999.0 0.0 -0.159 66.0 66.0 AKT1 -0.024 0.051 0.128 3.0 -0.124 3.0 6.0 PIK3R1 0.025 0.032 -9999.0 0.0 -0.316 2.0 2.0 CDH1 -0.062 0.157 0.124 12.0 -0.316 66.0 78.0 RhoA/GDP -0.044 0.129 0.254 4.0 -0.228 61.0 65.0 actin cytoskeleton organization -0.02 0.073 0.157 7.0 -0.155 23.0 30.0 CDC42/GDP -0.044 0.129 0.254 4.0 -0.228 61.0 65.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.038 0.096 -9999.0 0.0 -0.19 66.0 66.0 ITGB7 0.012 0.075 -9999.0 0.0 -0.316 12.0 12.0 RAC1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.003 0.11 -9999.0 0.0 -0.17 66.0 66.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.007 0.093 -9999.0 0.0 -0.155 66.0 66.0 mol:GDP -0.062 0.137 0.258 4.0 -0.258 61.0 65.0 CDC42/GTP/IQGAP1 0.037 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.034 0.124 4.0 -0.316 2.0 6.0 p120 catenin/RhoA/GDP -0.039 0.133 0.23 4.0 -0.232 61.0 65.0 RAC1/GTP/IQGAP1 0.033 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.01 0.057 0.135 9.0 -0.106 23.0 32.0 NME1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.102 0.187 -9999.0 0.0 -0.369 77.0 77.0 regulation of cell-cell adhesion -0.026 0.066 -9999.0 0.0 -0.139 52.0 52.0 WASF2 -0.014 0.04 0.093 3.0 -0.084 21.0 24.0 Rap1/GTP -0.019 0.096 0.254 3.0 -0.168 53.0 56.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.001 0.119 -9999.0 0.0 -0.17 73.0 73.0 CCND1 -0.013 0.067 0.154 9.0 -0.129 23.0 32.0 VAV2 -0.121 0.25 0.355 1.0 -0.44 78.0 79.0 RAP1/GDP -0.025 0.109 0.301 2.0 -0.186 57.0 59.0 adherens junction assembly -0.1 0.183 -9999.0 0.0 -0.358 78.0 78.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.01 0.109 0.209 3.0 -0.167 72.0 75.0 E-cadherin/beta catenin -0.065 0.129 -9999.0 0.0 -0.276 65.0 65.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.098 0.183 0.224 1.0 -0.359 77.0 78.0 PIK3CA 0.026 0.032 -9999.0 0.0 -0.316 2.0 2.0 Rac1/GTP -0.076 0.125 -9999.0 0.0 -0.335 26.0 26.0 E-cadherin/beta catenin/alpha catenin -0.011 0.11 -9999.0 0.0 -0.185 66.0 66.0 ITGAE 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.099 0.199 -9999.0 0.0 -0.383 78.0 78.0