rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(5) 125186 5 5 5 1 1 0 1 1 2 0 0.548 0.00891 1.000 2 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(2), FMOD(9), KERA(1), LUM(2) 629673 16 14 16 2 8 3 0 5 0 0 0.0825 0.0325 1.000 3 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(3), ERBB4(16), NRG2(4), NRG3(9), PSEN1(1) 1555655 33 24 33 5 7 13 4 5 4 0 0.0234 0.0558 1.000 4 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(2) 196753 4 4 3 1 0 1 1 0 2 0 0.822 0.105 1.000 5 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(2), NR3C1(4), PPARG(1), RXRA(2), TNF(1) 999771 10 10 10 1 2 1 1 5 1 0 0.207 0.210 1.000 6 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCL5(1), CCR3(4), HLA-DRA(3), HLA-DRB1(1), IL3(1) 526404 11 10 11 3 4 4 0 2 1 0 0.352 0.227 1.000 7 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(3), AKT1(2), ANXA1(3), CALM1(1), CALM2(2), CALM3(1), GNAS(11), GNGT1(3), NFKB1(5), NOS3(3), NPPA(1), NR3C1(4), PIK3R1(5), RELA(1) 2722623 45 28 45 7 13 12 0 11 9 0 0.0412 0.265 1.000 8 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(2), CD3G(2), IFNG(2), IL2RA(1), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6), TGFBR3(2), TOB1(1), TOB2(4) 1836086 34 24 33 6 6 11 3 10 4 0 0.107 0.300 1.000 9 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(4), GABRA6(5), PRKCE(5) 1366369 33 21 33 9 11 7 5 9 1 0 0.197 0.308 1.000 10 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(3), IL8(1), SLPI(1) 296007 5 4 5 1 2 2 0 1 0 0 0.387 0.379 1.000 11 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), UGDH(4) 1471353 23 19 23 4 6 6 0 8 3 0 0.0892 0.393 1.000 12 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(2), FOSB(2), GRIA2(13) 648611 17 13 17 4 5 9 0 2 1 0 0.196 0.427 1.000 13 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(2), CAT(4), GH1(1), GHR(3), IGF1(2), IGF1R(10), PIK3R1(5), SHC1(3) 1918453 30 20 30 5 5 11 2 6 6 0 0.0713 0.534 1.000 14 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(1), FLT3(6), IGF1(2), IL11(2), IL3(1), KITLG(3), TGFB1(3), TGFB2(6), TGFB3(3) 1437254 27 19 27 6 6 10 0 7 4 0 0.193 0.543 1.000 15 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(5), AOC2(4), AOC3(3), CES1(6), ESD(1) 1047338 19 14 19 3 4 7 1 7 0 0 0.101 0.560 1.000 16 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6) 976965 16 14 15 4 2 6 0 4 4 0 0.349 0.575 1.000 17 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(4), CD4(2), HLA-DRA(3), HLA-DRB1(1), IL1B(1), IL5RA(1) 926361 13 12 13 4 3 4 0 4 2 0 0.487 0.590 1.000 18 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IFNG(2), IL12B(1) 517423 4 4 4 1 0 1 1 2 0 0 0.614 0.594 1.000 19 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(1), TGDS(2), UGDH(4), UXS1(3) 678604 11 10 11 3 4 3 1 2 1 0 0.437 0.599 1.000 20 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(1), CASP8(5), CFL1(1) 667026 8 7 8 2 1 2 1 3 1 0 0.530 0.631 1.000 21 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3) 2297442 36 24 35 7 7 11 0 11 7 0 0.0647 0.636 1.000 22 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1), SUCLA2(3) 363781 4 4 4 0 1 0 0 1 2 0 0.380 0.639 1.000 23 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(3), HGD(2) 386905 6 5 6 2 3 0 0 3 0 0 0.606 0.662 1.000 24 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(2), PIK3R1(5), PLCB1(10), PLCG1(10), VAV1(6) 1841841 33 23 32 7 12 10 0 4 7 0 0.143 0.672 1.000 25 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CCL2(1), LDLR(4), LPL(2) 920322 9 9 9 3 3 2 0 2 2 0 0.453 0.727 1.000 26 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(2) 280776 3 3 3 0 2 1 0 0 0 0 0.319 0.733 1.000 27 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2), PDXK(3), PDXP(1), PNPO(1), PSAT1(2) 834435 9 8 9 3 1 3 0 3 1 1 0.604 0.766 1.000 28 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), CAMP(1), DAG1(5), GNAQ(1), ITPKA(1), ITPKB(5) 1043326 15 13 15 4 5 4 0 3 2 1 0.393 0.771 1.000 29 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(1), MST1(2), MST1R(7), TNF(1) 1128041 12 11 12 1 5 3 0 3 1 0 0.0685 0.795 1.000 30 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(1), GNGT1(3), HTR2C(3), PLCB1(10), TUB(5) 1237819 24 16 24 7 8 7 0 4 5 0 0.376 0.812 1.000 31 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(1), CASP7(2), DFFA(2), DFFB(2), ENDOG(1), HMGB2(1), TOP2A(6), TOP2B(8) 1651071 23 14 21 4 2 9 1 4 7 0 0.248 0.816 1.000 32 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(7), SP1(3), SP3(3) 1152948 13 11 12 3 1 8 0 2 2 0 0.284 0.820 1.000 33 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(19), CREBBP(10), EP300(13), MAP2K1(2), MAP3K7(6), MAPK3(1), SKIL(2), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6) 4144930 73 37 72 17 15 24 3 13 17 1 0.114 0.825 1.000 34 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(2), CD3E(2), CD3G(2), CD4(2), CD58(1), CD8A(2), CSF3(1), IL3(1), IL8(1), KITLG(3) 1072958 19 17 18 6 3 6 1 5 4 0 0.530 0.827 1.000 35 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(3), GAD1(3), GAD2(3), GGT1(3) 992300 13 11 13 3 6 2 0 5 0 0 0.283 0.849 1.000 36 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(2), ALDOC(2), TPI1(2) 672915 7 7 7 2 2 2 0 3 0 0 0.533 0.869 1.000 37 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(2), HLA-DRA(3), HLA-DRB1(1) 413147 6 6 6 3 1 2 0 3 0 0 0.823 0.872 1.000 38 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(8), HSD17B1(3), HSD17B3(1), HSD17B4(1), HSD17B7(1), HSD3B1(1), HSD3B2(1) 1406263 18 17 18 5 4 6 1 4 3 0 0.259 0.880 1.000 39 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(2), COQ6(2), COQ7(1), NDUFA13(1) 696871 7 6 7 2 3 3 0 1 0 0 0.554 0.881 1.000 40 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CDC34(1), CDK2(2), CUL1(8), FBXW7(8), RB1(7), TFDP1(2) 1439623 31 18 28 9 9 9 1 7 5 0 0.273 0.887 1.000 41 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(2), CD80(1), HLA-DRA(3), HLA-DRB1(1), IL10(1) 691290 8 8 8 3 2 2 0 4 0 0 0.716 0.887 1.000 42 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), CD36(2), FYN(5), JUN(2), MAPK14(1), THBS1(7) 1275013 18 13 18 4 5 6 0 5 2 0 0.207 0.891 1.000 43 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(14), C5(8), C6(6), C7(2), C8A(6), C9(3) 2199552 39 25 39 10 14 10 1 12 2 0 0.170 0.896 1.000 44 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(4), GLUD1(4), GLUD2(6) 783586 18 12 18 5 5 5 0 7 1 0 0.391 0.900 1.000 45 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(8), APOBEC1(3), APOBEC3A(1), APOBEC3B(2), APOBEC3G(2), APOBEC4(1) 1268440 17 13 17 4 8 3 2 3 1 0 0.280 0.902 1.000 46 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(3) 265065 4 4 4 2 0 2 0 1 1 0 0.754 0.906 1.000 47 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(2), IFNGR2(1), JAK1(2), JAK2(8), STAT1(4) 1423019 19 12 19 5 4 6 1 4 3 1 0.366 0.907 1.000 48 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(2), APC(19), AXIN1(7), CCND1(1), CD14(1), CTNNB1(10), DVL1(2), FZD1(5), GJA1(8), GNAI1(1), GSK3B(2), IRAK1(4), LEF1(4), MYD88(1), NFKB1(5), PDPK1(1), PIK3R1(5), PPP2CA(3), RELA(1), TIRAP(2), TLR4(11), TOLLIP(1), WNT1(3) 4927943 99 47 96 24 22 24 5 27 19 2 0.0606 0.907 1.000 49 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(1), HLCS(1), SPCS3(1) 535499 3 3 3 0 2 0 0 1 0 0 0.294 0.915 1.000 50 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD3E(2), CD3G(2), CD4(2) 557038 7 7 6 3 0 2 1 2 2 0 0.907 0.919 1.000 51 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(1), TGDS(2), UGDH(4), UGP2(1), UXS1(3) 860376 12 11 12 4 5 3 1 2 1 0 0.511 0.923 1.000 52 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(2), BCAR1(4), GRB2(1), ILK(1), ITGB1(4), MAPK1(2), MAPK3(1), PDPK1(1), PIK3R1(5), PTEN(8), PTK2(7), SHC1(3), SOS1(3) 2946236 42 27 41 9 4 15 4 7 12 0 0.127 0.926 1.000 53 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(1), BMPR1B(2), BMPR2(10) 1080536 18 14 17 6 7 4 0 3 2 2 0.658 0.927 1.000 54 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(11), GNGT1(3), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6) 1656186 30 22 30 8 11 7 1 7 4 0 0.321 0.928 1.000 55 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(3), F13A1(7), F2(3), F2R(1), FGA(4), FGB(2), PLAT(2), PLAU(2), PLG(8), SERPINB2(2), SERPINE1(2) 2319038 36 24 36 9 12 9 2 8 5 0 0.122 0.933 1.000 56 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(8), FH(2), MDH1(3), SDHB(3), SUCLA2(3) 1539444 19 13 18 3 9 5 0 3 2 0 0.0907 0.934 1.000 57 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(2), BAK1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP3(1), CASP6(1), CASP7(2), CASP8(5), CASP9(1), DFFA(2), DFFB(2), DIABLO(1), ENDOG(1) 2348900 27 18 27 4 7 11 1 5 3 0 0.0592 0.939 1.000 58 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), HS3ST1(1), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(2), XYLT1(7), XYLT2(4) 1117084 23 16 23 6 11 8 0 1 3 0 0.198 0.944 1.000 59 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), HS3ST1(1), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(2), XYLT1(7), XYLT2(4) 1117084 23 16 23 6 11 8 0 1 3 0 0.198 0.944 1.000 60 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(2), JAK1(2), JAK2(8), PTPRU(11), REG1A(3), STAT1(4) 1985131 33 18 33 6 11 8 1 8 4 1 0.0850 0.945 1.000 61 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(4), ESR2(5), ITPKA(1), PDE1A(3), PDE1B(2), PLCB1(10), PLCB2(3), PRL(1), TRH(3), VIP(1) 1918359 33 23 32 9 11 9 2 7 4 0 0.245 0.950 1.000 62 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDK2(2), CUL1(8), NEDD8(1), RB1(7), SKP2(3), TFDP1(2) 1493358 26 16 25 8 4 10 1 7 4 0 0.379 0.954 1.000 63 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(3), SQLE(4) 564069 7 5 7 2 3 2 0 1 1 0 0.500 0.955 1.000 64 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(1), GGT1(3), SHMT1(1), SHMT2(3) 718711 8 8 8 5 2 0 0 3 3 0 0.836 0.958 1.000 65 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), CHPT1(1), LCMT1(1), LCMT2(6), METTL6(1), PCYT1A(7), PCYT1B(3), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), WBSCR22(2) 2440306 36 22 36 8 11 11 1 8 5 0 0.0912 0.963 1.000 66 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(3), GGPS1(1), SQLE(4) 751305 8 6 8 2 3 2 0 1 2 0 0.500 0.966 1.000 67 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(4), GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(4), GABRA6(5), GPHN(7), NSF(2), UBQLN1(3) 2076100 44 24 44 12 10 10 7 12 5 0 0.218 0.968 1.000 68 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(2), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF4E(1), EIF4EBP1(1), GSK3B(2), IGF1(2), IGF1R(10), INPPL1(12), PDPK1(1), PIK3R1(5), PPP2CA(3), PTEN(8), RPS6(1), RPS6KB1(2) 3030833 56 33 55 12 18 16 2 8 12 0 0.0716 0.970 1.000 69 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(3), MTMR2(3), MTMR6(3), PHPT1(2), THTPA(1), TPK1(2) 1114563 16 10 16 4 5 7 1 2 1 0 0.339 0.972 1.000 70 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(2), GOSR1(2), GOSR2(2), SNAP25(1), SNAP29(1), STX10(3), STX11(2), STX16(3), STX17(1), STX19(3), STX2(1), STX3(1), STX4(1), STX5(1), STX6(3), STX7(1), TSNARE1(5), USE1(2), VAMP4(1), VAMP5(1), VAMP7(2), VTI1B(1), YKT6(1) 2879545 41 23 41 8 15 15 1 8 2 0 0.0518 0.972 1.000 71 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(10), GNAS(11), GNGT1(3), PRKACA(1), PRKAR1A(1) 1139688 26 15 26 8 12 7 0 3 4 0 0.455 0.973 1.000 72 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(3), CYP2E1(3), NR1I3(3), PTGS1(5), PTGS2(2) 922911 16 12 16 4 7 5 1 2 1 0 0.280 0.973 1.000 73 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(4), GSS(1), IL8(1), NFKB1(5), NOX1(4), RELA(1), TNF(1), XDH(8) 1733277 25 15 25 7 5 10 1 6 3 0 0.292 0.976 1.000 74 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(2), C1S(3), C2(2), C3(14), C5(8), C6(6), C7(2), C8A(6), C8B(7), C9(3), MASP1(1) 3637229 55 31 54 12 18 11 2 18 5 1 0.0864 0.977 1.000 75 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(2), IFNAR1(4), IFNAR2(4), IFNB1(2), MAPK8(3), NFKB1(5), RELA(1), TNFRSF11A(2), TRAF6(4) 1925055 27 16 27 5 7 8 1 8 3 0 0.110 0.977 1.000 76 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(10), EP300(13), ESR1(4), MAPK1(2), MAPK3(1), PELP1(5) 2530202 35 22 34 7 11 10 1 2 11 0 0.0940 0.980 1.000 77 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), GPR109B(1), GPR161(2), GPR39(5), GPR45(4), GPR68(3), GPR75(3), GPR81(2) 1708922 22 16 22 6 12 3 2 4 1 0 0.165 0.980 1.000 78 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS3(1), DHRS7(1), DHRSX(2), ESCO2(1), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), SH3GLB1(1) 2868455 27 21 27 6 7 9 2 6 3 0 0.128 0.981 1.000 79 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(3), ALPP(4), ALPPL2(4), FPGS(1), GGH(1), SPR(2) 1121941 18 13 18 7 10 3 0 2 3 0 0.451 0.981 1.000 80 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15(2), ALOX15B(1), ALOX5(4), ALOX5AP(2), DPEP1(1), GGT1(3), LTA4H(4), PLA2G6(3), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(1) 2595660 36 24 36 7 15 8 3 8 2 0 0.0508 0.982 1.000 81 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3), ST3GAL5(1), ST6GALNAC4(1), ST8SIA1(3) 977599 16 15 16 5 7 3 0 6 0 0 0.374 0.984 1.000 82 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(3), SNAP25(1) 565083 6 6 6 3 2 1 0 3 0 0 0.813 0.984 1.000 83 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(2), CD3G(2), ETV5(4), IFNG(2), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(2), JAK2(8), JUN(2), MAP2K6(1), MAPK14(1), MAPK8(3), STAT4(3), TYK2(4) 3220385 44 23 43 9 9 13 3 11 8 0 0.0905 0.985 1.000 84 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADM(1), ACADS(1), ACAT1(2), HADHA(2) 937112 7 5 6 2 2 3 0 0 2 0 0.381 0.986 1.000 85 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(19), ASAH1(2), CAMP(1), CASP3(1), CERK(3), CREB1(4), CREB3(2), CREB5(1), CXCL2(1), DAG1(5), EPHB2(6), GNAQ(1), ITPKA(1), ITPKB(5), JUN(2), MAP2K4(5), MAP2K7(12), MAPK1(2), MAPK10(1), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3) 4906978 89 35 88 19 29 24 1 18 15 2 0.00947 0.986 1.000 86 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(4), JUN(2), KEAP1(5), MAPK1(2), MAPK14(1), MAPK8(3), NFE2L2(1) 1522301 18 13 18 5 5 8 0 4 1 0 0.279 0.987 1.000 87 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADM(1), ACADS(1), ACSL1(2), ACSL3(5), ACSL4(2), CPT1A(4), CPT2(4), EHHADH(2), HADHA(2), SCP2(3), SLC25A20(1) 2911333 28 16 27 5 5 7 3 6 7 0 0.0782 0.987 1.000 88 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(4), GRB2(1), JAK2(8), JUN(2), MAP2K1(2), MAPK3(1), PIK3R1(5), PLCG1(10), RAF1(5), RASA1(9), SHC1(3), SOS1(3), STAT1(4), STAT3(6), STAT5A(1), STAT5B(2), THPO(2) 4808288 68 31 66 13 16 24 2 12 13 1 0.0185 0.988 1.000 89 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(2), CDC25B(2), CDC25C(2), CSK(2), GRB2(1), PTPRA(4) 1593950 14 11 14 3 5 5 0 1 3 0 0.200 0.989 1.000 90 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(2), NAT1(1), NAT2(4), XDH(8) 1381142 23 17 22 6 7 12 1 3 0 0 0.141 0.989 1.000 91 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(2), CTH(2), GOT1(1), GOT2(2), LDHB(1), LDHC(1), MPST(1) 1164826 10 9 10 3 4 3 1 1 1 0 0.403 0.991 1.000 92 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(4), NDUFS2(2), NDUFV1(1) 1195543 12 11 12 3 1 5 1 3 2 0 0.468 0.991 1.000 93 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 9 GPR37(2), SNCAIP(7), UBE2F(3), UBE2G2(1), UBE2L3(1), UBE2L6(1) 945765 15 11 15 5 5 6 0 2 2 0 0.370 0.991 1.000 94 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(4), GBA3(1), GGT1(3), SHMT1(1), SHMT2(3) 960448 13 11 13 6 5 2 0 3 3 0 0.642 0.992 1.000 95 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(2), CALM1(1), CALM2(2), CALM3(1), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(2), MAP2K4(5), MAP2K7(12), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8(3), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), PAK2(5), PIK3R1(5), PLA2G4A(3), PLCG1(10), PPP3CA(3), PPP3CB(1), RAF1(5), SHC1(3), SOS1(3), SYK(3), VAV1(6) 7050126 117 41 116 24 39 40 1 18 19 0 0.00143 0.993 1.000 96 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CASP9(1), GH1(1), GHR(3), NFKB1(5), PDPK1(1), PIK3R1(5), PPP2CA(3), RELA(1), YWHAH(1) 2069222 24 14 24 6 5 8 2 4 5 0 0.330 0.993 1.000 97 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(3), CBS(3), CTH(2), MUT(1) 842448 9 8 9 7 3 2 1 0 3 0 0.961 0.993 1.000 98 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(3), FUT1(1), FUT9(2), HEXA(1), HEXB(2), NAGA(3), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3), ST8SIA1(3) 1751383 24 21 24 7 9 4 0 10 1 0 0.403 0.993 1.000 99 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(2), CD3G(2), HLA-A(6), ICAM1(2), ITGAL(5), ITGB2(5), PRF1(1) 1508849 25 18 24 8 8 5 2 4 6 0 0.523 0.993 1.000 100 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CD8A(2), CSF3(1), IL11(2), IL3(1), IL8(1) 1057424 9 9 9 4 3 2 0 3 1 0 0.767 0.993 1.000 101 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(1), BRAF(5), CAMP(1), CREB1(4), CREB3(2), CREB5(1), MAPK1(2), RAF1(5), SNX13(5), TERF2IP(3) 1964062 31 22 31 8 12 8 0 6 5 0 0.266 0.993 1.000 102 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(1), EPOR(2), GRIN1(2), HIF1A(2), JAK2(8), NFKB1(5), RELA(1) 2191142 21 13 21 5 3 7 1 4 6 0 0.369 0.994 1.000 103 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(3), IL1R1(3), IRAK1(4), MAP3K1(6), MAP3K14(2), MAP3K7(6), MYD88(1), NFKB1(5), RELA(1), TLR4(11), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRAF6(4) 4206804 55 32 54 13 15 12 5 16 7 0 0.107 0.995 1.000 104 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(5), PLCB1(10), RELA(1) 1430110 17 12 17 5 5 4 0 4 4 0 0.548 0.995 1.000 105 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(2), C1S(3), C2(2), C3(14), C5(8), C6(6), C7(2), C8A(6), C9(3) 3066302 47 28 47 12 16 10 2 14 4 1 0.197 0.995 1.000 106 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(4), ELK1(2), GRB2(1), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(3), NGFR(4), PIK3R1(5), PLCG1(10), RAF1(5), SHC1(3), SOS1(3) 2926224 45 24 44 11 14 15 0 10 6 0 0.153 0.995 1.000 107 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(1), CDC25A(2), CDC25B(2), CDC25C(2), MNAT1(2), XPO1(3) 1496899 13 8 13 2 4 3 1 3 2 0 0.195 0.995 1.000 108 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(8), ACSS1(6), ACSS2(3), FH(2), MDH1(3), SUCLA2(3) 2301548 27 17 26 8 8 6 3 5 5 0 0.316 0.995 1.000 109 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(2), JAK2(8), JAK3(3), PIAS1(3), PIAS3(1), PTPRU(11), REG1A(3), SOAT1(3) 2387331 35 19 35 8 11 9 0 8 6 1 0.219 0.995 1.000 110 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(12), GNA12(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAR2A(1), PRKAR2B(6) 1740622 27 19 27 7 5 13 1 6 2 0 0.164 0.995 1.000 111 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(2), GRB2(1), NTRK1(3), PIK3R1(5), PLCG1(10), SHC1(3), SOS1(3) 2312184 27 18 26 6 7 11 0 4 5 0 0.193 0.996 1.000 112 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(2), MAPK14(1), MAPK8(3), NFKB1(5), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF2(2), TRAF3(2), TRAF6(4) 2519767 22 16 22 4 5 4 1 9 3 0 0.242 0.996 1.000 113 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS1(3), PAPSS2(2), SULT1A2(3), SULT1E1(3) 1057272 12 10 12 4 6 5 0 0 1 0 0.559 0.996 1.000 114 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 5 ARG1(2), ASL(3), GLS(4), GLUD1(4), GOT1(1) 807340 14 11 14 5 5 4 0 4 1 0 0.531 0.996 1.000 115 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(4), CREM(1), JUN(2), MAPK3(1), OPRK1(3), POLR2A(8), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6) 2223518 32 21 32 9 10 11 0 8 3 0 0.197 0.996 1.000 116 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACAT2(2), ACYP2(1), EHHADH(2), GCDH(3), HADHA(2), SDHB(3), SDS(1) 1352417 16 10 15 4 4 9 1 0 2 0 0.169 0.996 1.000 117 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(10), EP300(13), LPL(2), NCOA1(10), NCOA2(12), PPARG(1), RXRA(2) 3202156 50 26 50 11 9 23 3 6 9 0 0.0390 0.996 1.000 118 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD3E(2), CD3G(2), CD80(1), CD86(1), CTLA4(3), GRB2(1), HLA-DRA(3), HLA-DRB1(1), ICOS(1), ITK(4), PIK3R1(5), PTPN11(4) 1836044 28 23 27 9 6 8 2 7 5 0 0.569 0.996 1.000 119 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP19(1), SRP54(2), SRP72(4), SRPR(3) 1301838 11 9 11 3 4 4 0 2 1 0 0.521 0.997 1.000 120 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(4), IFNB1(2), JAK1(2), PTPRU(11), REG1A(3), STAT1(4), STAT2(3), TYK2(4) 2158365 33 20 33 7 14 7 0 8 3 1 0.133 0.997 1.000 121 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(1), DPYD(10), DPYS(1), ENPP1(1), ENPP3(2), PANK1(2), PANK2(2), PANK4(2), UPB1(1) 2413587 23 18 23 5 6 7 0 6 4 0 0.144 0.997 1.000 122 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), JAK1(2), JAK2(8), JAK3(3), PIAS3(1), PTPRU(11), REG1A(3), STAT3(6) 2636821 35 20 35 9 11 11 0 9 3 1 0.191 0.997 1.000 123 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(4), FADS2(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3) 1760099 27 19 27 7 11 5 1 9 1 0 0.284 0.997 1.000 124 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(2), B4GALT2(5), B4GALT5(3), FUT8(2), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3) 1360747 22 19 21 6 9 7 0 5 1 0 0.306 0.997 1.000 125 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(14), CPT1A(4), LEPR(6), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2) 2506064 33 17 33 8 14 7 2 5 5 0 0.174 0.998 1.000 126 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(4), AASS(2), KARS(2) 819834 8 5 8 3 2 4 1 1 0 0 0.626 0.998 1.000 127 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(8), EIF2AK4(3), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF5(3), GSK3B(2), PPP1CA(1) 2000110 23 18 23 6 4 9 1 8 1 0 0.297 0.998 1.000 128 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMA7(3), PSMB2(1), PSMB3(1), PSMB4(1), PSMC3(5), RPN1(1), RPN2(3), UBE2A(2), UBE3A(4) 2243499 29 16 29 7 6 12 4 4 3 0 0.153 0.998 1.000 129 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(2), CREB1(4), GRB2(1), MAPK1(2), MAPK3(1), MAPK7(6), MEF2B(3), MEF2C(2), MEF2D(5), NTRK1(3), PIK3R1(5), PLCG1(10), RPS6KA1(6), SHC1(3) 2891371 53 26 52 11 19 19 1 7 7 0 0.0277 0.998 1.000 130 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(3), HSD3B7(3), RDH11(1), RDH12(1) 830690 8 8 8 4 2 4 0 2 0 0 0.689 0.999 1.000 131 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(2), MAX(1), SP1(3), SP3(3), WT1(1) 1072760 10 9 10 6 3 4 0 1 2 0 0.780 0.999 1.000 132 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMA7(3), PSMB2(1), PSMB3(1), PSMB4(1), PSMC2(3), PSMC3(5), PSMD1(3), PSMD11(1), PSMD12(1), PSMD2(9), PSMD6(1) 2756257 37 19 37 7 10 15 2 7 3 0 0.0664 0.999 1.000 133 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(4), NR0B2(1), NR1H3(2), NR1H4(3), RXRA(2) 944252 15 13 15 6 7 2 0 4 2 0 0.520 0.999 1.000 134 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), DHRS3(1), DHRS7(1), DHRSX(2), ESCO2(1), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), SH3GLB1(1) 4332583 47 28 46 10 10 18 2 10 7 0 0.0456 0.999 1.000 135 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(2), GPI(4), HK1(5), PFKL(4), PGK1(1), PKLR(4), TPI1(2) 1596632 24 16 24 8 9 10 1 4 0 0 0.274 0.999 1.000 136 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(2), HADHA(2), SDS(1) 840338 5 3 4 3 0 3 0 0 2 0 0.773 0.999 1.000 137 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(3), ACP6(2), ACPP(2), ACPT(1), ENPP1(1), ENPP3(2), FLAD1(2), LHPP(2), MTMR1(3), MTMR2(3), MTMR6(3), PHPT1(2), RFK(1), TYR(3) 2584727 30 20 30 9 7 12 2 6 3 0 0.299 0.999 1.000 138 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(4), ELK1(2), GRB2(1), IGF1(2), IGF1R(10), IRS1(6), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(3), PIK3R1(5), PTPN11(4), RAF1(5), RASA1(9), SHC1(3), SOS1(3) 3911521 62 29 61 16 15 21 1 13 11 1 0.108 0.999 1.000 139 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(1), COASY(1), DPYD(10), DPYS(1), ENPP1(1), ENPP3(2), ILVBL(1), PANK1(2), PANK2(2), PANK4(2), PPCDC(1), UPB1(1), VNN1(1) 2998314 27 18 27 5 9 8 0 6 4 0 0.0609 0.999 1.000 140 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), ARG1(2), GLS(4), GLUD1(4) 955793 12 9 12 5 4 4 0 3 1 0 0.587 0.999 1.000 141 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(3), NDUFA1(1), SDHA(5), SDHB(3), SDHC(1), UQCRC1(2) 1144498 16 12 16 5 6 5 1 2 2 0 0.372 0.999 1.000 142 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDC25B(2), CDKN1A(1), CHEK1(1), NEK1(3) 1222747 9 8 9 3 1 4 0 1 3 0 0.746 0.999 1.000 143 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(4), ELOVL2(1), ELOVL5(2), FADS1(2), FADS2(3), FASN(9), HADHA(2), HSD17B12(2), SCD(1) 2462512 28 15 26 8 10 6 1 6 5 0 0.298 0.999 1.000 144 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 ARF1(2), CCND1(1), CDK2(2), CDKN1A(1), CDKN2A(3), CFL1(1), E2F2(2), MDM2(3), NXT1(1), PRB1(2) 1265626 18 16 18 7 6 7 1 1 3 0 0.531 0.999 1.000 145 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(4), CYP11A1(2), CYP11B2(2), CYP17A1(2), HSD11B2(2), HSD3B1(1), HSD3B2(1) 1198061 14 10 14 5 4 3 1 5 1 0 0.485 0.999 1.000 146 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(5), CALCR(4), CALCRL(5), CD97(1), CRHR1(2), CRHR2(3), ELTD1(7), EMR1(10), EMR2(1), GLP1R(1), GLP2R(3), GPR64(6), LPHN1(6), LPHN2(9), LPHN3(10), SCTR(2), VIPR1(3), VIPR2(3) 4621431 81 37 81 20 19 25 6 25 6 0 0.0348 1.000 1.000 147 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(2), MDH1(3), OGDH(6), SDHA(5), SUCLA2(3) 1619443 19 15 18 6 6 4 1 4 4 0 0.516 1.000 1.000 148 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(1), JUN(2), MAP2K1(2), MAPK1(2), MAPK3(1), NFKB1(5), PLCB1(10), RAF1(5), RELA(1), TNF(1) 2689071 30 19 30 9 9 7 0 9 5 0 0.432 1.000 1.000 149 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(2), C1S(3), C2(2), C3(14), C5(8), C6(6), C7(2), C8A(6), C9(3), MASP1(1), MASP2(2), MBL2(1) 3727605 51 28 51 13 17 12 2 15 4 1 0.151 1.000 1.000 150 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT1(1), GOT2(2), TAT(1), TYR(3) 813195 10 10 10 6 3 3 0 3 1 0 0.888 1.000 1.000 151 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(4), BAIAP2(3), CASP1(1), CASP3(1), CASP7(2), CASP8(5), GAPDH(1), INSR(9), ITCH(3), MAGI1(14), MAGI2(9), RERE(15), WWP1(7), WWP2(8) 4138190 82 38 81 21 23 17 5 17 20 0 0.0971 1.000 1.000 152 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(5), LCT(7), PGM1(2), PYGL(3), PYGM(5), TPI1(2), TREH(2) 2312184 26 18 26 8 12 8 1 2 3 0 0.310 1.000 1.000 153 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(8), JAK3(3), MAPK1(2), MAPK3(1), STAT3(6), TYK2(4) 2020547 26 19 26 8 5 10 0 6 4 1 0.477 1.000 1.000 154 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(10), DFFA(2), DFFB(2), HMGB2(1), PRF1(1), SET(2) 1831851 20 17 20 8 3 6 2 3 6 0 0.687 1.000 1.000 155 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), AMT(4), ATIC(4), GART(6), MTHFD1(2), MTHFD1L(2), MTHFD2(1), MTHFR(5), MTR(9), SHMT1(1), SHMT2(3), TYMS(1) 3096509 43 26 43 11 11 13 2 8 9 0 0.121 1.000 1.000 156 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(5), ALDH1A3(5), ALDH3A1(3), ALDH3B2(4), AOC2(4), AOC3(3), DDC(3), EPX(4), ESCO2(1), GOT1(1), GOT2(2), HPD(1), LPO(2), MAOA(1), MAOB(3), MPO(5), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(1), TPO(13) 5922836 84 41 84 22 25 22 3 27 7 0 0.0803 1.000 1.000 157 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(13), ATR(5), CDC25C(2), CHEK1(1), CHEK2(5), YWHAH(1) 2637446 27 20 26 8 8 9 2 3 4 1 0.513 1.000 1.000 158 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(3), CASP8(5), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2) 1441241 15 14 15 6 5 3 1 5 1 0 0.583 1.000 1.000 159 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(2), CALM3(1), CCL2(1), CCR5(1), GNAQ(1), JUN(2), MAPK14(1), MAPK8(3), PLCG1(10), PTK2B(5) 2383778 28 18 27 8 12 8 0 8 0 0 0.247 1.000 1.000 160 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(4), ALAS1(1), ALAS2(4), FECH(4), PPOX(2), UROD(1), UROS(3) 1317535 19 17 19 7 5 4 1 7 2 0 0.686 1.000 1.000 161 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3) 1379699 26 19 26 10 7 6 0 9 4 0 0.589 1.000 1.000 162 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3) 1379699 26 19 26 10 7 6 0 9 4 0 0.589 1.000 1.000 163 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(6), LARS(2), LARS2(5), PDHA1(1), PDHA2(4), PDHB(2) 1737723 21 16 21 7 2 7 1 8 3 0 0.580 1.000 1.000 164 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(1), IKBKAP(2), IKBKB(3), MAP3K1(6), MAP3K14(2), NFKB1(5), RELA(1), TNFAIP3(5), TRAF3(2), TRAF6(4) 3148918 31 18 31 6 12 6 2 6 5 0 0.118 1.000 1.000 165 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(4), ALAS1(1), ALAS2(4), CPO(2), FECH(4), GATA1(1), HBB(1), UROD(1), UROS(3) 1368528 21 18 21 8 6 3 2 8 2 0 0.702 1.000 1.000 166 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMA7(3), PSMB10(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB8(2) 1509924 17 8 17 5 5 6 2 2 2 0 0.408 1.000 1.000 167 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACAT2(2), ACOT11(3), ACYP2(1), DHRS3(1), DHRS7(1), DHRSX(2), EHHADH(2), ESCO2(1), FN3K(2), GCDH(3), HADHA(2), ITGB1BP3(2), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), SH3GLB1(1), YOD1(1) 4500446 47 27 46 10 11 21 3 7 5 0 0.0249 1.000 1.000 168 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(2), BAD(1), BAK1(2), BCL2(1), BCL2L11(1), BID(1), CASP8AP2(6), CASP9(1), CES1(6) 1947885 21 12 21 7 7 8 0 5 1 0 0.522 1.000 1.000 169 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 DNAJC3(1), EIF2S1(1), EIF2S2(2), MAP3K14(2), NFKB1(5), RELA(1) 1563960 12 8 12 3 3 2 0 5 2 0 0.631 1.000 1.000 170 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(1), MMP2(4), MMP9(6), RECK(5), TIMP2(1), TIMP3(2) 1298465 19 15 19 9 7 5 0 3 4 0 0.743 1.000 1.000 171 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(4), ELK1(2), GRB2(1), INSR(9), IRS1(6), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(3), PIK3R1(5), PTPN11(4), RAF1(5), RASA1(9), SHC1(3), SLC2A4(1), SOS1(3) 4031518 60 30 59 16 15 20 1 10 13 1 0.0981 1.000 1.000 172 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(16), CR2(4), FCGR2B(1), HLA-DRA(3), HLA-DRB1(1), ICAM1(2), ITGAL(5), ITGB2(5), PTPRC(14) 2645466 52 31 49 15 16 16 0 14 6 0 0.207 1.000 1.000 173 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(4), ELK1(2), EPOR(2), GRB2(1), JAK2(8), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(3), PLCG1(10), PTPN6(3), RAF1(5), SHC1(3), SOS1(3), STAT5A(1), STAT5B(2) 3720687 52 24 51 12 14 20 0 12 6 0 0.0828 1.000 1.000 174 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(1), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD11B2(2), HSD3B1(1), HSD3B2(1) 1525719 19 14 19 7 9 5 0 4 1 0 0.444 1.000 1.000 175 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(1), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD11B2(2), HSD3B1(1), HSD3B2(1) 1525719 19 14 19 7 9 5 0 4 1 0 0.444 1.000 1.000 176 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(1), DRD1(2), DRD2(5), GRM1(17), PLCB1(10), PPP1CA(1), PPP2CA(3), PPP3CA(3), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6) 2766518 57 32 57 18 17 20 0 14 6 0 0.262 1.000 1.000 177 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(5), AGT(1), AGTR1(1), AGTR2(1), COL4A1(12), COL4A2(6), COL4A3(3), COL4A4(5), COL4A5(3), COL4A6(6), REN(2) 4413098 45 26 45 13 12 18 1 11 3 0 0.142 1.000 1.000 178 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(3), B3GALNT1(1), B3GALT5(1), FUT1(1), FUT9(2), HEXA(1), HEXB(2), NAGA(3), ST3GAL1(2), ST3GAL2(4), ST8SIA1(3) 1859330 23 21 23 9 8 4 1 9 1 0 0.688 1.000 1.000 179 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(2), ARHGAP5(5), CASP1(1), CASP10(3), CASP3(1), CASP8(5), CASP9(1), JUN(2), PRF1(1) 2234591 21 15 21 7 5 5 2 6 2 1 0.525 1.000 1.000 180 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(5), GUSB(2), UCHL1(2), UCHL3(3), UGDH(4), UGT1A1(1), UGT1A5(3), UGT2B15(1), UGT2B4(2) 3039052 23 14 23 6 6 10 0 3 4 0 0.224 1.000 1.000 181 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), HMOX1(3), IL10(1), IL10RB(1), JAK1(2), STAT1(4), STAT3(6), STAT5A(1), TNF(1) 2113380 21 15 21 8 4 9 0 6 1 1 0.568 1.000 1.000 182 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(4), GRB2(1), HBXIP(1), PTK2B(5), SHC1(3), SOS1(3) 1529747 17 11 17 5 3 7 0 3 4 0 0.424 1.000 1.000 183 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(4), IFNAR2(4), IFNB1(2), JAK1(2), STAT1(4), STAT2(3), TYK2(4) 1877009 24 13 24 8 8 7 0 5 3 1 0.463 1.000 1.000 184 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(3), ABP1(5), ACADM(1), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), AOC2(4), AOC3(3), DPYD(10), DPYS(1), EHHADH(2), GAD1(3), GAD2(3), HADHA(2), MLYCD(3), SMS(2), SRM(1), UPB1(1) 4674384 63 32 61 17 19 21 1 16 6 0 0.0706 1.000 1.000 185 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(2), CALM3(1), CDKN1A(1), GNAQ(1), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), PLCG1(10), PPP3CA(3), PPP3CB(1), SP1(3), SP3(3) 3602362 52 28 51 14 20 22 0 6 4 0 0.0616 1.000 1.000 186 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT1(1), FUT9(2), ST8SIA1(3) 1058584 7 7 7 4 2 2 0 3 0 0 0.833 1.000 1.000 187 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(8), AKT1(2), ATM(13), CDKN1A(1), CPB2(3), FHL2(2), HIC1(1), HIF1A(2), HSPA1A(1), IGFBP3(4), MAPK8(3), MDM2(3), NFKBIB(4), NQO1(2) 3459531 49 31 48 13 16 14 2 8 8 1 0.112 1.000 1.000 188 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADH(2), HADHA(2), HADHB(2), HSD17B4(1), MECR(3), PPT2(2) 1468900 13 7 12 4 1 4 1 3 4 0 0.388 1.000 1.000 189 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(3), ACPP(2), ACPT(1), ENPP1(1), ENPP3(2), FLAD1(2), RFK(1), TYR(3) 1659467 15 12 15 6 2 6 1 3 3 0 0.639 1.000 1.000 190 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), ABP1(5), AOC2(4), AOC3(3), CES1(6), CES7(5), DDHD1(7), ESCO2(1), LIPA(1), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), PRDX6(1), SH3GLB1(1) 4402118 57 30 56 14 15 21 3 15 3 0 0.0673 1.000 1.000 191 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(2), CD3E(2), CD3G(2), CD4(2), IFNG(2), IL12B(1), IL12RB1(4), IL12RB2(4), JAK2(8), STAT4(3), TYK2(4) 2542681 35 23 34 10 5 11 3 9 7 0 0.418 1.000 1.000 192 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS3(1), DHRS7(1), DHRSX(2), LCMT1(1), LCMT2(6), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), WBSCR22(2) 2598272 29 19 29 9 6 10 1 7 5 0 0.331 1.000 1.000 193 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(3), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), CYP2C19(6), DHRS3(1), DHRS7(1), DHRSX(2), EHHADH(2), ESCO2(1), HADHA(2), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), SH3GLB1(1), YOD1(1) 5352035 60 31 59 15 15 19 2 16 8 0 0.0680 1.000 1.000 194 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(2), CAMK2A(1), CAMK2G(4), CAMK4(4), CAMKK1(3), CREB1(4) 1996562 23 13 23 9 6 11 1 3 2 0 0.473 1.000 1.000 195 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(2), BIRC3(3), CASP3(1), CASP8(5), JUN(2), MAP2K4(5), MAP3K3(2), MAP3K7(6), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), NR2C2(2), RALBP1(4), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2) 4705602 62 27 62 14 22 15 4 13 8 0 0.0371 1.000 1.000 196 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(4), EPX(4), LPO(2), MPO(5), MTHFR(5), PRDX6(1), SHMT1(1), SHMT2(3), TPO(13) 2009478 39 26 39 12 13 7 2 11 6 0 0.356 1.000 1.000 197 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(5), ALDH1A3(5), ALDH3A1(3), ALDH3B2(4), AOC2(4), AOC3(3), DDC(3), EPX(4), GOT1(1), GOT2(2), HPD(1), LPO(2), MAOA(1), MAOB(3), MPO(5), PRDX6(1), TAT(1), TPO(13) 3801791 61 32 61 19 19 15 1 22 4 0 0.280 1.000 1.000 198 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 29 ABP1(5), ADC(1), AGMAT(2), ALDH18A1(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), AMD1(2), AOC2(4), AOC3(3), ARG1(2), ASL(3), ASS1(4), GATM(2), MAOA(1), MAOB(3), NAGS(1), ODC1(2), OTC(2), SAT1(1), SMS(2), SRM(1) 4565621 64 28 64 12 20 21 3 16 4 0 0.00568 1.000 1.000 199 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), AMT(4), ATIC(4), GART(6), MTHFD1(2), MTHFD1L(2), MTHFD2(1), MTHFR(5), MTR(9), SHMT1(1), SHMT2(3), TYMS(1) 3271806 43 26 43 12 11 13 2 8 9 0 0.173 1.000 1.000 200 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX12(3), ALOX15(2), ALOX5(4), CBR3(3), CYP4F2(4), CYP4F3(3), EPX(4), GGT1(3), LPO(2), LTA4H(4), MPO(5), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PRDX6(1), PTGES2(4), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(1), TPO(13) 4814601 85 41 84 25 33 19 4 22 7 0 0.148 1.000 1.000 201 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2A1(2), GTF2B(1), GTF2E1(4), GTF2F1(1), HDAC3(3), NCOA1(10), NCOA2(12), NCOA3(4), NCOR2(13), POLR2A(8), RARA(1), RXRA(2), TBP(1) 4311170 65 33 65 20 16 28 1 13 7 0 0.153 1.000 1.000 202 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT1(2), ACAT2(2), EHHADH(2), HADHA(2), HADHB(2), SDS(1) 1447076 12 6 11 5 1 7 0 1 3 0 0.572 1.000 1.000 203 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(19), AXIN1(7), BTRC(3), CCND1(1), CREBBP(10), CSNK2A1(4), CTBP1(2), CTNNB1(10), DVL1(2), FZD1(5), GSK3B(2), HDAC1(2), MAP3K7(6), NLK(4), PPARD(4), PPP2CA(3), TLE1(3), WIF1(2), WNT1(3) 5076758 92 44 89 27 28 21 5 14 22 2 0.208 1.000 1.000 204 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(3), ABP1(5), ACADL(1), ACADM(1), ACADSB(3), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), AOC2(4), AOC3(3), DPYD(10), DPYS(1), EHHADH(2), GAD1(3), GAD2(3), HADHA(2), MLYCD(3), SDS(1), SMS(2), UPB1(1) 5031893 74 34 72 22 21 27 1 18 7 0 0.107 1.000 1.000 205 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(2), CREB1(4), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K6(1), MAP3K1(6), MAPK1(2), MAPK14(1), MAPK3(1), NFKB1(5), PIK3R1(5), RB1(7), RELA(1), SP1(3) 2983877 42 21 41 10 8 17 0 8 9 0 0.173 1.000 1.000 206 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(3), F2R(1), F5(8), F7(6), FGA(4), FGB(2), PROC(3), PROS1(5), SERPINC1(2), TFPI(3) 2839062 40 26 40 13 12 9 2 14 3 0 0.464 1.000 1.000 207 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(1), SRD5A1(2), SRD5A2(2) 4022748 65 33 64 22 16 21 0 17 11 0 0.342 1.000 1.000 208 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(2), CD3G(2), CD8A(2), ICAM1(2), ITGAL(5), ITGB2(5), PTPRC(14) 1859732 34 21 32 13 10 8 1 10 5 0 0.640 1.000 1.000 209 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(1), ACADM(1), ACADS(1), ACADSB(3), ACAT1(2), ACAT2(2), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(5), ACSL4(2), ACSL5(2), ACSL6(4), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), CPT1A(4), CPT1B(3), CPT1C(2), CPT2(4), CYP4A11(1), CYP4A22(1), EHHADH(2), GCDH(3), HADH(2), HADHA(2), HADHB(2), HSD17B4(1) 8478112 95 37 93 24 19 30 4 24 18 0 0.0315 1.000 1.000 210 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 23 AMT(4), ASNS(3), ASRGL1(1), CA12(1), CA13(2), CA14(1), CA4(2), CA5B(1), CA6(3), CA7(2), CA8(1), CA9(2), CTH(2), GLS(4), GLS2(4), GLUD1(4), GLUD2(6), GLUL(1), HAL(1) 3130228 45 24 45 14 14 12 1 13 5 0 0.318 1.000 1.000 211 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(2), CRY1(1), CRY2(1), CSNK1E(6), PER1(3) 1463670 15 11 15 7 5 2 1 5 2 0 0.850 1.000 1.000 212 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(2), HADH(2), HADHA(2), HSD17B4(1), NTAN1(2), SIRT1(3), SIRT2(1), SIRT5(3), SIRT7(1), VNN2(1) 2052889 18 9 17 8 3 3 3 4 5 0 0.783 1.000 1.000 213 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 DUSP1(1), GORASP1(2), MAP2K4(5), MAP2K7(12), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3), MAPKAPK5(2), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PIK3CD(8), PIK3R1(5), TRAF2(2), TRAF3(2), TRAF6(4) 5405678 82 35 81 18 33 20 3 14 12 0 0.00893 1.000 1.000 214 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(2), FARS2(5), GOT1(1), GOT2(2), PAH(3), TAT(1), YARS(1) 1435911 18 14 18 9 7 5 0 5 1 0 0.820 1.000 1.000 215 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(3), CYB5R3(1), GCK(3), GFPT1(2), GNE(3), GNPDA1(3), HEXA(1), HEXB(2), HK1(5), HK2(5), HK3(3), PGM3(6), RENBP(2) 2926041 39 22 39 10 17 12 3 5 2 0 0.0911 1.000 1.000 216 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(1), HSPA1A(1), IFNG(2), IFNGR1(2), IFNGR2(1), IKBKB(3), JAK2(8), LIN7A(4), NFKB1(5), RB1(7), RELA(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), USH1C(1), WT1(1) 3014217 41 24 39 13 8 12 1 14 6 0 0.418 1.000 1.000 217 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(5), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A3(5), ALDH3A1(3), ALDH3B2(4), AOC2(4), AOC3(3), AOX1(2), COMT(3), DBH(1), DCT(6), DDC(3), FAH(1), GOT1(1), GOT2(2), GSTZ1(3), HGD(2), HPD(1), MAOA(1), MAOB(3), PNMT(3), TAT(1), TH(1), TPO(13), TYR(3) 5490318 90 43 89 28 26 24 1 29 9 1 0.198 1.000 1.000 218 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(7), CHAT(1), CHKA(1), PCYT1A(7), PDHA1(1), PDHA2(4), PEMT(1), SLC18A3(5) 1204326 27 18 27 11 14 6 0 7 0 0 0.458 1.000 1.000 219 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), MDH1(3), ME1(2), PC(5), PDHA1(1), SLC25A1(1) 1599966 14 9 14 7 6 2 2 3 1 0 0.766 1.000 1.000 220 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK1(5), HK2(5), HK3(3), IMPA1(3), PGM1(2), PGM3(6), TGDS(2) 1768900 29 17 29 10 11 13 2 1 2 0 0.235 1.000 1.000 221 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(1), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), HSD3B7(3), LIPA(1), RDH11(1), RDH12(1), SLC27A5(4), SOAT1(3), SOAT2(1), SRD5A1(2), SRD5A2(2) 5487083 75 37 74 21 19 25 1 19 11 0 0.104 1.000 1.000 222 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(4), B3GAT2(1), B3GAT3(1), B4GALT7(1), CHPF(2), CHST11(1), CHST12(4), CHST13(1), CHST7(1), CHSY1(3), DSE(5), UST(5), XYLT1(7), XYLT2(4) 2381911 40 22 40 12 19 14 1 4 2 0 0.164 1.000 1.000 223 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(2), CALM1(1), CALM2(2), CALM3(1), CD79A(5), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(2), MAP3K1(6), MAPK14(1), MAPK3(1), MAPK8(3), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), PLCG1(10), PPP3CA(3), PPP3CB(1), RAF1(5), SHC1(3), SOS1(3), SYK(3), VAV1(6) 6599171 93 37 92 26 35 32 1 15 10 0 0.0604 1.000 1.000 224 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2B(1), GTF2E1(4), GTF2E2(1), GTF2F1(1), GTF2F2(2), GTF2H1(1), GTF2H3(1), GTF2I(4), GTF2IRD1(7), TAF1(5), TAF10(1), TAF13(1), TAF1L(10), TAF2(5), TAF4(3), TAF4B(2), TAF5(2), TAF5L(4), TAF6(4), TAF6L(1), TAF7(4), TAF7L(3), TAF9B(2), TBPL2(3) 6251691 74 35 72 19 21 27 3 14 9 0 0.0675 1.000 1.000 225 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(12), COL4A2(6), COL4A3(3), COL4A4(5), COL4A5(3), COL4A6(6), F10(3), F11(3), F12(2), F2(3), F2R(1), F5(8), F8(11), F9(4), FGA(4), FGB(2), KLKB1(4), PROC(3), PROS1(5), SERPINC1(2), SERPING1(2) 7730670 92 42 92 27 21 30 4 28 9 0 0.132 1.000 1.000 226 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(10), DUSP1(1), EP300(13), IKBKB(3), IL1B(1), IL8(1), MAP2K3(1), MAP2K6(1), MAP3K14(2), MAP3K7(6), MAPK14(1), MYD88(1), NFKB1(5), NR3C1(4), RELA(1), TGFBR1(2), TGFBR2(6), TLR2(1), TNF(1) 5123280 61 32 61 18 13 17 4 14 13 0 0.316 1.000 1.000 227 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(14), C5(8), C6(6), C7(2), ICAM1(2), IL8(1), ITGA4(5), ITGAL(5), ITGB1(4), ITGB2(5), SELP(2), SELPLG(5), TNF(1), VCAM1(5) 4310301 65 32 64 22 24 16 0 20 5 0 0.274 1.000 1.000 228 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), EIF4E(1), FBL(2), LDHB(1), LDHC(1), MAPK14(1), NCL(6) 1532132 14 10 14 7 3 4 0 6 1 0 0.858 1.000 1.000 229 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(8), PGAP1(4), PIGA(1), PIGB(4), PIGC(2), PIGG(5), PIGK(1), PIGL(1), PIGM(4), PIGN(2), PIGO(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGX(2), PIGZ(2) 4149837 46 24 46 14 16 19 2 4 4 1 0.129 1.000 1.000 230 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(2), BAD(1), GRB2(1), IGF1R(10), IRS1(6), MAP2K1(2), MAPK1(2), MAPK3(1), PIK3R1(5), RAF1(5), SHC1(3), SOS1(3), YWHAH(1) 2901136 42 20 42 13 10 19 0 6 7 0 0.315 1.000 1.000 231 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(8), GABBR1(6), GPRC5B(4), GPRC5C(3), GPRC5D(1), GRM1(17), GRM2(10), GRM3(4), GRM4(2), GRM5(12), GRM7(9), GRM8(9) 3614831 85 45 85 29 38 16 5 20 6 0 0.188 1.000 1.000 232 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(2), BCL2(1), BCR(6), GRB2(1), JAK2(8), JUN(2), MAP2K1(2), MAP2K4(5), MAP3K1(6), MAPK3(1), MAPK8(3), PIK3R1(5), RAF1(5), SOS1(3), STAT1(4), STAT5A(1), STAT5B(2) 4482305 57 27 57 16 14 21 0 9 13 0 0.164 1.000 1.000 233 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(4), EGF(4), EGFR(7), ELK1(2), GRB2(1), JAK1(2), JUN(2), MAP2K1(2), MAP2K4(5), MAP3K1(6), MAPK3(1), MAPK8(3), PIK3R1(5), PLCG1(10), RAF1(5), RASA1(9), SHC1(3), SOS1(3), STAT1(4), STAT3(6), STAT5A(1) 6114199 85 37 83 25 22 27 1 17 16 2 0.173 1.000 1.000 234 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS3(1), DHRS7(1), DHRSX(2), HSD3B7(3), PON1(1), PON2(2), RDH11(1), RDH12(1) 1558128 12 12 12 9 4 4 1 2 1 0 0.954 1.000 1.000 235 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(13), CDC25A(2), CDC25B(2), CDC25C(2), CDK2(2), CHEK1(1), MYT1(9), RB1(7), YWHAH(1) 2917735 39 23 37 10 11 15 2 5 5 1 0.204 1.000 1.000 236 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CDK5(2), F2(3), FYN(5), GNA11(4), GNAI1(1), GNGT1(3), GRB2(1), JAK2(8), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(3), MAPT(3), MYLK(7), PLCG1(10), PTK2B(5), RAF1(5), SHC1(3), SOS1(3), STAT1(4), STAT3(6), STAT5A(1) 7204857 95 38 94 27 29 34 3 20 9 0 0.0821 1.000 1.000 237 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(3), F12(2), F13B(8), F2(3), F5(8), F7(6), F8(11), F9(4), FGA(4), FGB(2), LPA(10), PLAT(2), PLAU(2), PLG(8), SERPINB2(2), SERPINE1(2), SERPINF2(4), VWF(9) 6108030 93 40 93 27 26 28 5 24 10 0 0.133 1.000 1.000 238 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(1), CHST12(4), CHST13(1), PAPSS1(3), PAPSS2(2), SULT1A1(2), SULT1A2(3), SULT1E1(3) 1591150 20 14 20 8 9 6 1 2 2 0 0.581 1.000 1.000 239 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(2), DUSP14(1), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(2), IL1R1(3), NR4A3(1), WDR1(1) 1854898 16 11 16 7 4 3 4 4 1 0 0.698 1.000 1.000 240 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(5), ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), FPGT(3), GCK(3), GMDS(1), GMPPA(3), HK1(5), HK2(5), HK3(3), PFKFB3(2), PFKFB4(1), PFKM(2), PFKP(7), PMM1(1), PMM2(1), TPI1(2) 4157001 52 23 52 15 27 16 1 5 3 0 0.0641 1.000 1.000 241 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 IFNG(2), IKBKB(3), JUN(2), MAP3K1(6), MAP3K5(3), MAP4K5(3), MAPK14(1), MAPK8(3), NFKB1(5), RELA(1), TNFRSF9(3), TRAF2(2) 3375838 34 18 33 10 13 4 2 9 6 0 0.416 1.000 1.000 242 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(2), CARS2(1), CTH(2), GOT1(1), GOT2(2), LDHAL6B(2), LDHB(1), LDHC(1), MPST(1), SDS(1), SULT1B1(2), SULT1C4(1), SULT4A1(1) 2149557 18 13 18 8 7 5 1 3 2 0 0.651 1.000 1.000 243 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(3), IRAK1(4), IRAK2(4), IRAK3(2), JUN(2), MAP2K3(1), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP3K7(6), MAPK14(1), MAPK8(3), MYD88(1), NFKB1(5), RELA(1), TGFB1(3), TGFB2(6), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4) 5128676 70 33 69 20 18 18 3 22 9 0 0.263 1.000 1.000 244 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(2), BIRC2(2), BIRC3(3), CASP10(3), CASP3(1), CASP7(2), CASP8(5), CASP9(1), DFFA(2), DFFB(2), PRF1(1), SCAP(6), SREBF1(2), SREBF2(5) 3132494 37 25 37 11 11 13 2 7 4 0 0.327 1.000 1.000 245 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(4), ELK1(2), GRB2(1), JAK1(2), JUN(2), MAP2K1(2), MAP2K4(5), MAP3K1(6), MAPK3(1), MAPK8(3), PDGFA(1), PDGFRA(3), PIK3R1(5), PLCG1(10), RAF1(5), RASA1(9), SHC1(3), SOS1(3), STAT1(4), STAT3(6), STAT5A(1) 5667776 78 36 76 24 21 27 1 12 15 2 0.204 1.000 1.000 246 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(2), BIRC2(2), BIRC3(3), CASP1(1), CASP10(3), CASP2(2), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(5), CASP9(1), DFFA(2), DFFB(2), LMNA(5), LMNB1(1), LMNB2(2), PRF1(1) 3337798 38 24 38 11 12 13 4 6 3 0 0.259 1.000 1.000 247 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(2), BAD(1), CASP9(1), CDC42(1), ELK1(2), MAP2K1(2), MAPK3(1), NFKB1(5), PIK3R1(5), RAF1(5), RALBP1(4), RALGDS(7), RELA(1) 2868087 37 19 37 12 12 13 1 5 6 0 0.417 1.000 1.000 248 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), AGPS(2), CHPT1(1), ENPP2(3), ENPP6(2), PAFAH1B1(3), PAFAH1B2(2), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLD1(7), PLD2(10), PPAP2C(4) 4023692 63 27 63 18 19 23 3 11 7 0 0.123 1.000 1.000 249 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 COPS5(1), CREB1(4), EDN1(3), EP300(13), HIF1A(2), JUN(2), NOS3(3), P4HB(2) 2932702 30 20 30 10 9 9 2 6 4 0 0.398 1.000 1.000 250 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 13 GALNT10(3), GALNT2(2), GALNT4(1), GALNT6(2), GALNT8(3), GALNT9(2), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3) 2285186 22 16 22 9 10 2 1 7 2 0 0.746 1.000 1.000 251 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(14), ACACB(10), FASN(9), MCAT(1), OXSM(3) 2721333 37 19 36 12 13 9 1 6 8 0 0.345 1.000 1.000 252 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), EHHADH(2), HADHA(2), SDS(1) 2103088 31 20 30 13 7 9 0 9 6 0 0.628 1.000 1.000 253 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(9), EXT2(3), EXTL1(3), EXTL2(2), EXTL3(5), GLCE(2), HS3ST1(1), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(4), HS6ST1(1), HS6ST2(1), HS6ST3(4), NDST1(7), NDST2(5), NDST3(4), NDST4(9) 3575992 69 36 68 22 21 26 1 15 6 0 0.248 1.000 1.000 254 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(2), DLG4(3), EPHB2(6), F2(3), F2RL1(1), F2RL2(1), JUN(2), MAPK1(2), MAPK7(6), MAPK8(3), MYEF2(4), PLD1(7), PLD2(10), PLD3(5), PTK2(7), RAF1(5), RASAL1(1), TEC(3), VAV1(6) 4735723 77 32 77 23 24 26 4 15 8 0 0.145 1.000 1.000 255 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(5), GUSB(2), UGDH(4), UGP2(1), UGT1A1(1), UGT1A5(3), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), XYLB(4) 4536383 37 23 37 11 6 16 1 9 5 0 0.276 1.000 1.000 256 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(1), GHR(3), GRB2(1), INSR(9), IRS1(6), JAK2(8), MAP2K1(2), MAPK1(2), MAPK3(1), PIK3R1(5), PLCG1(10), PTPN6(3), RAF1(5), RPS6KA1(6), SHC1(3), SLC2A4(1), SOCS1(1), SOS1(3), STAT5A(1), STAT5B(2) 5337887 73 33 72 21 23 26 1 12 11 0 0.120 1.000 1.000 257 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(2), ELK1(2), FPR1(1), GNA15(2), GNGT1(3), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K6(1), MAP3K1(6), MAPK1(2), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NFKB1(5), PAK1(4), PIK3C2G(3), PLCB1(10), PPP3CA(3), PPP3CB(1), RAF1(5), RELA(1) 6635366 90 40 90 29 28 29 1 18 14 0 0.235 1.000 1.000 258 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CALM1(1), CALM2(2), CALM3(1), CAPN2(2), CAPNS1(1), CAPNS2(1), EP300(13), HDAC1(2), HDAC2(2), MEF2D(5), NFATC1(8), NFATC2(6), PPP3CA(3), PPP3CB(1) 4211893 53 24 53 15 21 17 0 10 5 0 0.106 1.000 1.000 259 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(3), ALOX12(3), ALOX12B(3), ALOX15(2), ALOX15B(1), ALOX5(4), CBR3(3), CYP2B6(2), CYP2C18(3), CYP2C19(6), CYP2E1(3), CYP2J2(2), CYP2U1(2), CYP4A11(1), CYP4A22(1), CYP4F2(4), CYP4F3(3), DHRS4(1), EPHX2(3), GGT1(3), GPX3(1), GPX4(1), GPX6(1), GPX7(2), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PTGES2(4), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(1) 6714782 97 39 96 24 36 26 5 23 7 0 0.0204 1.000 1.000 260 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(4), CRK(1), GNAI1(1), GNAQ(1), GNGT1(3), MAP2K1(2), MAPK1(2), MAPK3(1), NFKB1(5), PIK3C2G(3), PIK3R1(5), PLCG1(10), PTK2(7), PTK2B(5), PXN(1), RAF1(5), RELA(1) 4421258 57 26 56 18 15 15 3 12 12 0 0.378 1.000 1.000 261 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(2), AVP(3), CABIN1(5), CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(2), HDAC5(4), IGF1(2), IGF1R(10), INSR(9), MAP2K6(1), MAPK14(1), MAPK7(6), MEF2B(3), MEF2C(2), MEF2D(5), MYOD1(3), NFATC1(8), NFATC2(6), PIK3R1(5), PPP3CA(3), PPP3CB(1), YWHAH(1) 5619131 87 34 87 28 33 29 2 14 9 0 0.0878 1.000 1.000 262 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(2), APAF1(2), ATM(13), BAD(1), BCL2(1), BID(1), CASP3(1), CASP6(1), CASP7(2), CASP9(1), EIF2S1(1), PTK2(7), PXN(1), STAT1(4), TLN1(11) 4604924 49 26 48 13 19 17 4 4 4 1 0.116 1.000 1.000 263 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22RA1(1), IL22RA2(1), JAK1(2), JAK2(8), JAK3(3), SOCS3(3), STAT1(4), STAT3(6), STAT5A(1), STAT5B(2), TYK2(4) 3177458 35 22 35 12 10 11 1 8 4 1 0.467 1.000 1.000 264 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(3), APC(19), AXIN1(7), BTRC(3), CTNNB1(10), DLL1(3), DVL1(2), FZD1(5), GSK3B(2), NOTCH1(12), PSEN1(1), WNT1(3) 3678052 70 38 68 27 23 14 2 14 15 2 0.602 1.000 1.000 265 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK1(5), HK2(5), HK3(3), IMPA1(3), ISYNA1(2), PGM1(2), PGM3(6), TGDS(2) 2012483 31 18 31 12 12 13 2 2 2 0 0.316 1.000 1.000 266 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(5), ACY3(1), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(3), AOC2(4), AOC3(3), CARM1(2), DDC(3), HAL(1), HARS(3), HARS2(2), HDC(2), HNMT(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(3), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), PRPS1(1), PRPS2(1), UROC1(3), WBSCR22(2) 6852862 82 39 82 24 18 25 3 27 9 0 0.136 1.000 1.000 267 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(12), COL4A2(6), COL4A3(3), COL4A4(5), COL4A5(3), COL4A6(6), P4HB(2), SLC23A1(4), SLC23A2(5), SLC2A1(3), SLC2A3(2) 4383647 51 24 51 22 14 20 0 11 6 0 0.619 1.000 1.000 268 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(2), HLA-A(6), ITGB1(4), KLRC1(2), KLRC2(2), KLRD1(2), MAP2K1(2), MAPK3(1), PAK1(4), PIK3R1(5), PTK2B(5), PTPN6(3), SYK(3), VAV1(6) 2840433 47 34 46 16 7 17 1 12 10 0 0.573 1.000 1.000 269 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(2), CRY1(1), CRY2(1), CSNK1E(6), NPAS2(5), NR1D1(2), PER1(3), PER2(9), PER3(6) 2941956 37 20 37 12 12 7 3 10 5 0 0.423 1.000 1.000 270 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(10), EP300(13), HDAC3(3), IKBKB(3), NFKB1(5), RELA(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF6(4) 3864051 43 24 43 14 12 12 2 7 10 0 0.417 1.000 1.000 271 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(4), AGT(1), AGTR2(1), EDN1(3), EDNRA(1), EGF(4), EGFR(7), JUN(2), NFKB1(5), PLCG1(10), RELA(1) 3404234 39 17 38 14 12 6 2 16 3 0 0.532 1.000 1.000 272 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), BCL2(1), CASP8(5), MAP2K1(2), MAP2K4(5), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8(3), NFKB1(5), NSMAF(8), RAF1(5), RELA(1), SMPD1(3), TNFRSF1A(2), TRAF2(2) 3546801 52 25 52 18 18 14 1 10 9 0 0.376 1.000 1.000 273 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(2), CCR2(2), CCR3(4), CCR5(1), CD4(2), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(2), IL4R(1), TGFB1(3), TGFB2(6), TGFB3(3) 3456099 40 25 40 16 10 9 2 13 6 0 0.669 1.000 1.000 274 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 33 ALDH4A1(2), ARG1(2), ASL(3), ASS1(4), CKB(1), CKMT1A(2), CKMT1B(2), CKMT2(4), DAO(5), EPRS(6), GATM(2), GLUD1(4), GLUD2(6), GOT1(1), GOT2(2), LAP3(1), NOS1(15), NOS3(3), OTC(2), P4HA1(1), P4HA2(6), P4HA3(1), PYCR1(2), RARS(2) 5665484 79 39 78 26 32 21 3 18 5 0 0.239 1.000 1.000 275 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(5), CASP9(1), DFFA(2), DFFB(2), GAS2(1), LMNA(5), MAP3K14(2), NFKB1(5), RELA(1), SPTAN1(10), TNFRSF10A(2), TNFRSF10B(2), TNFRSF25(1), TNFSF10(2), TRAF2(2) 5781027 59 34 59 16 17 14 2 17 9 0 0.263 1.000 1.000 276 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(5), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(3), AOC2(4), AOC3(3), DDC(3), HAL(1), HARS(3), HDC(2), HNMT(1), MAOA(1), MAOB(3), PRPS1(1), PRPS2(1) 4232597 58 32 58 21 15 17 2 19 5 0 0.451 1.000 1.000 277 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREB1(4), CREBBP(10), EP300(13), NCOA3(4), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RARA(1), RXRA(2) 3568668 49 26 49 18 13 20 1 4 11 0 0.382 1.000 1.000 278 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(13), ANAPC11(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), BTRC(3), CDC16(1), CDC20(2), CDC23(4), CDC26(1), CDC27(2), CUL1(8), CUL2(3), CUL3(4), FBXW11(5), FBXW7(8), FZR1(3), ITCH(3), SKP2(3), SMURF1(1), SMURF2(1), TCEB1(1), UBA1(1), UBE2D3(1), UBE2E3(3), WWP1(7), WWP2(8) 6993782 92 33 83 24 26 32 1 19 14 0 0.0840 1.000 1.000 279 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(2), ARFGAP1(1), ARFGAP3(4), ARFGEF2(11), CLTA(2), COPA(4), GBF1(8), GPLD1(8), KDELR1(1) 2798357 41 23 41 14 12 19 1 8 1 0 0.273 1.000 1.000 280 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CDC42(1), CREB1(4), DAXX(3), DDIT3(3), ELK1(2), GRB2(1), HSPB1(1), MAP2K4(5), MAP2K6(1), MAP3K1(6), MAP3K5(3), MAP3K7(6), MAP3K9(5), MAPK14(1), MAPKAPK5(2), MAX(1), MEF2B(3), MEF2C(2), MEF2D(5), MKNK1(1), PLA2G4A(3), SHC1(3), STAT1(4), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TRAF2(2) 6354165 82 34 82 26 27 27 3 13 12 0 0.196 1.000 1.000 281 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(2), ALOX5(4), CYP1A2(3), CYP2C18(3), CYP2C19(6), CYP2E1(3), CYP2J2(2), CYP3A4(1), CYP3A43(3), CYP3A7(2), HSD3B7(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), RDH11(1), RDH12(1) 4138275 52 27 52 16 18 17 2 12 3 0 0.201 1.000 1.000 282 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(1), AP2M1(4), ARF1(2), BAD(1), BTK(2), EEA1(2), GRASP(1), GSK3A(1), GSK3B(2), LYN(2), PDPK1(1), PFKL(4), PFKM(2), PFKP(7), PLCG1(10), PRKCE(5), RAB5A(2), RPS6KB1(2), VAV2(8) 4331992 61 25 60 20 23 21 3 11 3 0 0.209 1.000 1.000 283 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), CDC42(1), CREB1(4), CREB3(2), CREB5(1), DUSP1(1), DUSP10(3), EEF2K(6), EIF4E(1), ELK1(2), HSPB1(1), IL1R1(3), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP3K10(6), MAP3K4(8), MAP3K5(3), MAP3K7(6), MAPK1(2), MAPK13(1), MAPK14(1), MAPKAPK5(2), MKNK1(1), MYEF2(4), NFKB1(5), NR2C2(2), TRAF6(4) 5767065 79 33 78 26 24 27 5 12 11 0 0.228 1.000 1.000 284 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(8), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), PC(5), PCK1(2), SDHA(5), SDHB(3), SUCLA2(3), SUCLG1(1), SUCLG2(3) 3554735 44 23 43 17 20 10 0 10 4 0 0.482 1.000 1.000 285 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRA2A(2), ADRA2C(3), ADRB1(3), ADRB2(3), CHRM1(2), CHRM2(6), CHRM3(5), CHRM4(2), CHRM5(2), DRD1(2), DRD2(5), DRD3(6), DRD4(1), DRD5(7), HRH1(3), HRH2(4), HTR1A(5), HTR1B(4), HTR1D(3), HTR1E(1), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(4) 4432171 103 39 101 33 36 27 7 26 7 0 0.0923 1.000 1.000 286 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(4), CFL1(1), GNAQ(1), GNAS(11), GNGT1(3), LIMK1(3), MAP2K1(2), MAPK1(2), MAPK3(1), MYL2(1), NOX1(4), PIK3C2G(3), PLCB1(10), PPP1R12B(6), PTK2(7), RAF1(5), ROCK2(2) 4386342 67 34 67 20 23 15 3 14 12 0 0.362 1.000 1.000 287 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(2), AKT1(2), ANGPTL2(4), DAG1(5), DGKA(3), ETFA(1), GCA(2), ITGA9(7), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), MAP2K1(2), MAPK1(2), MAPK3(1), NR1I3(3), PAK1(4), PDE3A(6), PDE3B(8), PI3(1), PIK3C2G(3), PIK3CD(8), PIK3R1(5), RIPK3(2), SGCB(2), VASP(2) 8116166 128 47 127 34 41 35 8 25 18 1 0.0247 1.000 1.000 288 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 234 ADCYAP1R1(5), ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(7), ADRA1B(3), ADRA2A(2), ADRA2B(2), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(1), AGTR2(1), AVPR1A(6), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(5), CCKAR(1), CCKBR(4), CHRM1(2), CHRM2(6), CHRM3(5), CHRM4(2), CHRM5(2), CNR1(5), CRHR1(2), CRHR2(3), CTSG(2), CYSLTR1(2), DRD1(2), DRD2(5), DRD3(6), DRD4(1), DRD5(7), EDNRA(1), F2(3), F2R(1), F2RL1(1), F2RL2(1), FPR1(1), FSHB(1), FSHR(12), GABBR1(6), GABBR2(4), GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(4), GABRA6(5), GABRB2(2), GABRB3(3), GABRE(4), GABRG2(8), GABRG3(2), GABRP(3), GABRQ(5), GABRR1(5), GABRR2(4), GALR1(2), GALR2(1), GALR3(1), GH1(1), GH2(2), GHR(3), GHSR(3), GLP1R(1), GLP2R(3), GLRA1(2), GLRA2(1), GLRA3(2), GLRB(5), GNRHR(3), GPR156(2), GPR35(2), GPR50(4), GPR83(4), GRIA1(9), GRIA2(13), GRIA3(5), GRIA4(2), GRID1(12), GRID2(10), GRIK1(6), GRIK2(9), GRIK3(7), GRIK4(5), GRIK5(5), GRIN1(2), GRIN2A(6), GRIN2B(8), GRIN2C(3), GRIN3A(5), GRIN3B(2), GRM1(17), GRM2(10), GRM3(4), GRM4(2), GRM5(12), GRM6(8), GRM7(9), GRM8(9), GRPR(2), HCRTR1(2), HCRTR2(2), HRH1(3), HRH2(4), HRH3(1), HRH4(1), HTR1A(5), HTR1B(4), HTR1D(3), HTR1E(1), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(4), LEPR(6), LHCGR(7), LTB4R(1), LTB4R2(2), MAS1(1), MC2R(2), MC3R(2), MC4R(4), MC5R(5), MCHR1(3), MCHR2(3), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(1), NPBWR1(8), NPBWR2(5), NPFFR1(1), NPFFR2(3), NPY1R(1), NPY2R(1), NR3C1(4), NTSR1(4), OPRD1(2), OPRK1(3), OXTR(4), P2RX2(4), P2RX3(2), P2RX4(1), P2RX5(2), P2RY1(4), P2RY10(3), P2RY13(3), P2RY14(2), P2RY4(2), P2RY6(3), P2RY8(4), PARD3(8), PPYR1(5), PRL(1), PRLHR(2), PRLR(1), PRSS1(2), PRSS3(2), PTAFR(2), PTGDR(4), PTGER2(2), PTGER3(2), PTGER4(1), PTGFR(3), PTH2R(4), RXFP1(4), RXFP2(5), SCTR(2), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(6), SSTR5(2), TAAR1(2), TAAR2(1), TAAR5(2), TAAR6(5), TACR1(3), TACR2(1), TACR3(6), TBXA2R(6), THRA(2), THRB(3), TRHR(3), TRPV1(5), TSHB(1), TSHR(6), UTS2R(1), VIPR1(3), VIPR2(3) 38066156 718 99 713 228 254 217 31 176 40 0 9.57e-05 1.000 1.000 289 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 190 ACTB(4), ACTN1(3), ACTN2(11), ACTN3(1), ACTN4(1), AKT1(2), AKT2(2), AKT3(3), ARHGAP5(5), BAD(1), BCAR1(4), BCL2(1), BIRC2(2), BIRC3(3), BRAF(5), CAPN2(2), CAV1(2), CCND1(1), CCND3(2), CDC42(1), CHAD(1), COL11A1(12), COL11A2(4), COL1A1(5), COL1A2(13), COL2A1(8), COL3A1(6), COL4A1(12), COL4A2(6), COL4A4(5), COL4A6(6), COL5A1(13), COL5A2(5), COL5A3(4), COL6A1(5), COL6A2(8), COL6A3(20), COL6A6(17), COMP(1), CRK(1), CTNNB1(10), DIAPH1(3), DOCK1(10), EGF(4), EGFR(7), ELK1(2), ERBB2(5), FARP2(3), FLNA(10), FLNB(3), FLNC(13), FLT1(5), FN1(18), FYN(5), GRB2(1), GRLF1(7), GSK3B(2), HGF(12), IBSP(2), IGF1(2), IGF1R(10), ILK(1), ITGA1(3), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(4), ITGA8(2), ITGA9(7), ITGAV(3), ITGB1(4), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(1), ITGB7(2), ITGB8(7), JUN(2), KDR(4), LAMA1(16), LAMA2(18), LAMA3(8), LAMA4(9), LAMA5(14), LAMB1(6), LAMB2(9), LAMB3(12), LAMB4(7), LAMC1(5), LAMC2(5), LAMC3(9), MAP2K1(2), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(3), MET(4), MYL2(1), MYL7(1), MYLK(7), MYLK2(2), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PARVB(3), PARVG(1), PDGFA(1), PDGFB(3), PDGFC(3), PDGFD(2), PDGFRA(3), PDGFRB(7), PDPK1(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PIP5K1C(5), PPP1CA(1), PPP1CC(2), PPP1R12A(1), PRKCG(4), PTEN(8), PTK2(7), PXN(1), RAC2(1), RAC3(1), RAF1(5), RAP1A(2), RAP1B(3), RAPGEF1(5), RELN(17), ROCK1(7), ROCK2(2), SHC1(3), SHC2(2), SHC3(4), SOS1(3), SOS2(3), SPP1(1), THBS1(7), THBS2(6), THBS3(4), THBS4(3), TLN1(11), TLN2(18), TNC(10), TNN(11), TNR(12), TNXB(22), VASP(2), VAV1(6), VAV2(8), VAV3(6), VCL(2), VEGFC(3), VTN(3), VWF(9), ZYX(2) 63922767 888 98 879 397 309 277 23 186 90 3 0.936 1.000 1.000 290 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(3), ACTN1(3), ACTN2(11), ACTN3(1), ACTN4(1), APC(19), APC2(6), ARAF(5), ARHGEF1(2), ARHGEF12(3), ARHGEF4(3), ARHGEF6(9), ARHGEF7(8), ARPC1A(3), ARPC4(1), BAIAP2(3), BCAR1(4), BDKRB1(1), BDKRB2(2), BRAF(5), CD14(1), CDC42(1), CFL1(1), CHRM1(2), CHRM2(6), CHRM3(5), CHRM4(2), CHRM5(2), CRK(1), CSK(2), CYFIP1(5), CYFIP2(4), DIAPH1(3), DIAPH2(3), DIAPH3(11), DOCK1(10), EGF(4), EGFR(7), F2(3), F2R(1), FGD1(5), FGD3(7), FGF1(2), FGF10(4), FGF11(1), FGF12(4), FGF13(4), FGF14(4), FGF17(2), FGF18(2), FGF2(1), FGF20(1), FGF21(1), FGF23(1), FGF5(1), FGF6(4), FGF7(1), FGF9(5), FGFR1(8), FGFR2(5), FGFR3(1), FGFR4(6), FN1(18), GIT1(2), GNA12(1), GNG12(1), GRLF1(7), GSN(5), IQGAP1(5), IQGAP2(6), IQGAP3(7), ITGA1(3), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(4), ITGA8(2), ITGA9(7), ITGAD(4), ITGAE(2), ITGAL(5), ITGAM(4), ITGAV(3), ITGAX(5), ITGB1(4), ITGB2(5), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(1), ITGB7(2), ITGB8(7), LIMK1(3), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MOS(3), MSN(3), MYH10(16), MYH14(9), MYH9(13), MYL2(1), MYL7(1), MYLK(7), MYLK2(2), NCKAP1(5), NCKAP1L(7), NRAS(1), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PDGFA(1), PDGFB(3), PDGFRA(3), PDGFRB(7), PFN2(2), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PPP1CA(1), PPP1CC(2), PPP1R12A(1), PPP1R12B(6), PTK2(7), PXN(1), RAC2(1), RAC3(1), RAF1(5), RDX(2), ROCK1(7), ROCK2(2), RRAS(1), RRAS2(1), SCIN(2), SLC9A1(6), SOS1(3), SOS2(3), SSH1(6), SSH2(11), SSH3(2), TIAM1(13), TIAM2(15), TMSL3(1), VAV1(6), VAV2(8), VAV3(6), VCL(2), WASF1(3), WASF2(2), WASL(1) 47330199 684 93 678 283 247 193 20 143 79 2 0.791 1.000 1.000 291 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY7(10), ADCY8(10), ADCY9(5), ADORA2B(1), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRB1(3), ADRB2(3), AGTR1(1), ATP2A1(2), ATP2A2(3), ATP2A3(4), ATP2B1(6), ATP2B2(8), ATP2B3(8), ATP2B4(2), AVPR1A(6), AVPR1B(1), BDKRB1(1), BDKRB2(2), CACNA1A(9), CACNA1B(11), CACNA1C(18), CACNA1D(12), CACNA1E(21), CACNA1F(1), CACNA1G(8), CACNA1H(8), CACNA1I(10), CACNA1S(10), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CAMK4(4), CCKAR(1), CCKBR(4), CD38(1), CHRM1(2), CHRM2(6), CHRM3(5), CHRM5(2), CHRNA7(1), CYSLTR1(2), DRD1(2), EDNRA(1), EGFR(7), ERBB2(5), ERBB3(16), ERBB4(16), F2R(1), GNA11(4), GNA14(2), GNA15(2), GNAQ(1), GNAS(11), GRIN1(2), GRIN2A(6), GRIN2C(3), GRM1(17), GRM5(12), GRPR(2), HRH1(3), HRH2(4), HTR2A(1), HTR2B(4), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(4), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), LHCGR(7), LTB4R2(2), MYLK(7), MYLK2(2), NOS1(15), NOS3(3), NTSR1(4), OXTR(4), P2RX2(4), P2RX3(2), P2RX4(1), P2RX5(2), PDE1A(3), PDE1B(2), PDE1C(2), PDGFRA(3), PDGFRB(7), PHKA1(5), PHKA2(7), PHKG1(2), PHKG2(2), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLCD1(1), PLCD3(6), PLCE1(8), PLCG1(10), PLCG2(6), PLCZ1(2), PPID(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PTAFR(2), PTGER3(2), PTGFR(3), PTK2B(5), RYR1(27), RYR2(35), RYR3(32), SLC25A4(2), SLC25A5(1), SLC25A6(4), SLC8A1(4), SLC8A2(2), SLC8A3(5), SPHK1(3), TACR1(3), TACR2(1), TACR3(6), TBXA2R(6), TNNC1(3), TRHR(3), TRPC1(1), VDAC1(1), VDAC3(1) 46630599 759 92 749 274 287 235 35 136 65 1 0.0162 1.000 1.000 292 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRB1(3), ADRB2(3), ANXA6(2), ARRB1(3), ARRB2(1), ATP1A4(10), ATP1B3(2), ATP2A2(3), ATP2A3(4), ATP2B1(6), ATP2B2(8), ATP2B3(8), CACNA1A(9), CACNA1B(11), CACNA1C(18), CACNA1D(12), CACNA1E(21), CACNA1S(10), CACNB1(1), CALM1(1), CALM2(2), CALM3(1), CALR(3), CAMK1(1), CAMK2A(1), CAMK2G(4), CAMK4(4), CASQ1(2), CASQ2(1), CHRM1(2), CHRM2(6), CHRM3(5), CHRM4(2), CHRM5(2), GJA1(8), GJA4(3), GJA5(2), GJB3(2), GJB6(2), GNA11(4), GNAI2(3), GNAI3(4), GNAO1(1), GNAQ(1), GNAZ(6), GNB2(3), GNB4(3), GNG12(1), GNG7(2), GNGT1(3), GRK4(1), ITPR1(17), ITPR2(14), ITPR3(16), KCNB1(4), KCNJ3(5), KCNJ5(2), MIB1(2), NME7(1), PLCB3(6), PRKACA(1), PRKACB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCQ(2), PRKD1(4), RGS1(1), RGS10(2), RGS11(1), RGS14(1), RGS16(2), RGS17(1), RGS18(2), RGS19(1), RGS2(2), RGS20(1), RGS3(11), RGS5(1), RGS6(7), RGS7(1), RGS9(4), RYR1(27), RYR2(35), RYR3(32), SLC8A1(4), SLC8A3(5), USP5(3), YWHAH(1), YWHAQ(1) 32700480 538 91 534 210 207 153 26 98 54 0 0.180 1.000 1.000 293 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 244 ACVR1B(6), ACVR1C(3), AKT1(2), AKT2(2), AKT3(3), ARRB1(3), ARRB2(1), ATF4(1), BDNF(1), BRAF(5), CACNA1A(9), CACNA1B(11), CACNA1C(18), CACNA1D(12), CACNA1E(21), CACNA1F(1), CACNA1G(8), CACNA1H(8), CACNA1I(10), CACNA1S(10), CACNA2D1(6), CACNA2D2(5), CACNA2D3(6), CACNA2D4(5), CACNB1(1), CACNB2(11), CACNB4(3), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(2), CACNG6(1), CACNG7(4), CASP3(1), CD14(1), CDC25B(2), CDC42(1), CRK(1), DAXX(3), DDIT3(3), DUSP1(1), DUSP10(3), DUSP14(1), DUSP16(3), DUSP2(2), DUSP4(1), DUSP5(3), DUSP6(1), DUSP8(1), DUSP9(2), ECSIT(1), EGF(4), EGFR(7), ELK1(2), ELK4(3), FAS(2), FGF1(2), FGF10(4), FGF11(1), FGF12(4), FGF13(4), FGF14(4), FGF17(2), FGF18(2), FGF2(1), FGF20(1), FGF21(1), FGF23(1), FGF5(1), FGF6(4), FGF7(1), FGF9(5), FGFR1(8), FGFR2(5), FGFR3(1), FGFR4(6), FLNA(10), FLNB(3), FLNC(13), GNA12(1), GNG12(1), GRB2(1), IKBKB(3), IL1B(1), IL1R1(3), IL1R2(1), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAP3K1(6), MAP3K10(6), MAP3K12(4), MAP3K13(3), MAP3K14(2), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAP3K5(3), MAP3K6(5), MAP3K7(6), MAP4K1(2), MAP4K2(3), MAP4K3(1), MAP4K4(4), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3), MAPKAPK3(1), MAPKAPK5(2), MAPT(3), MAX(1), MEF2C(2), MKNK1(1), MOS(3), NF1(9), NFATC2(6), NFATC4(10), NFKB1(5), NFKB2(3), NLK(4), NR4A1(1), NRAS(1), NTF3(1), NTRK1(3), NTRK2(4), PAK1(4), PAK2(5), PDGFA(1), PDGFB(3), PDGFRA(3), PDGFRB(7), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PPM1A(3), PPM1B(8), PPP3CA(3), PPP3CB(1), PPP3R2(1), PPP5C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PTPN5(1), PTPN7(2), PTPRR(2), RAC2(1), RAC3(1), RAF1(5), RAP1A(2), RAP1B(3), RAPGEF2(6), RASA1(9), RASA2(4), RASGRF1(2), RASGRF2(7), RASGRP1(4), RASGRP2(4), RASGRP3(2), RASGRP4(3), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA4(2), RPS6KA6(7), RRAS(1), RRAS2(1), SOS1(3), SOS2(3), STK3(2), STK4(2), STMN1(2), TAOK1(5), TAOK2(8), TAOK3(4), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6), TNF(1), TNFRSF1A(2), TRAF2(2), TRAF6(4), ZAK(3) 49293402 711 89 703 245 251 220 24 138 76 2 0.00885 1.000 1.000 294 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(2), ABLIM1(3), ABLIM2(3), ABLIM3(3), ARHGEF12(3), CDC42(1), CDK5(2), CFL1(1), DCC(16), DPYSL2(1), DPYSL5(4), EFNA1(1), EFNA2(1), EFNA5(2), EFNB1(1), EFNB2(3), EFNB3(3), EPHA1(8), EPHA2(4), EPHA3(10), EPHA4(6), EPHA5(13), EPHA6(12), EPHA7(3), EPHA8(8), EPHB1(13), EPHB2(6), EPHB3(6), EPHB4(4), EPHB6(4), FES(4), FYN(5), GNAI1(1), GNAI2(3), GNAI3(4), GSK3B(2), ITGB1(4), L1CAM(2), LIMK1(3), LRRC4C(3), MAPK1(2), MAPK3(1), MET(4), NCK1(3), NCK2(2), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NGEF(5), NRAS(1), NRP1(8), NTN1(3), NTNG1(6), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PLXNA1(13), PLXNA2(11), PLXNA3(9), PLXNB1(7), PLXNB2(8), PLXNB3(6), PLXNC1(7), PPP3CA(3), PPP3CB(1), PPP3R2(1), PTK2(7), RAC2(1), RAC3(1), RASA1(9), RGS3(11), ROBO1(10), ROBO2(11), ROBO3(4), ROCK1(7), ROCK2(2), SEMA3A(4), SEMA3B(2), SEMA3D(6), SEMA3E(7), SEMA3F(5), SEMA3G(3), SEMA4A(3), SEMA4B(3), SEMA4C(4), SEMA4D(5), SEMA4F(2), SEMA5A(10), SEMA5B(5), SEMA6A(5), SEMA6B(2), SEMA6C(4), SEMA6D(8), SEMA7A(1), SLIT1(5), SLIT2(14), SLIT3(7), SRGAP1(10), SRGAP2(4), SRGAP3(5), UNC5A(6), UNC5B(4), UNC5C(8), UNC5D(4) 33923516 536 88 532 225 161 150 41 126 57 1 0.804 1.000 1.000 295 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(7), CD36(2), CD44(5), CHAD(1), COL11A1(12), COL11A2(4), COL1A1(5), COL1A2(13), COL2A1(8), COL3A1(6), COL4A1(12), COL4A2(6), COL4A4(5), COL4A6(6), COL5A1(13), COL5A2(5), COL5A3(4), COL6A1(5), COL6A2(8), COL6A3(20), COL6A6(17), DAG1(5), FN1(18), FNDC1(8), FNDC3A(5), FNDC4(2), GP5(2), GP6(3), HMMR(4), HSPG2(15), IBSP(2), ITGA1(3), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(4), ITGA8(2), ITGA9(7), ITGAV(3), ITGB1(4), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(1), ITGB7(2), ITGB8(7), LAMA1(16), LAMA2(18), LAMA3(8), LAMA4(9), LAMA5(14), LAMB1(6), LAMB2(9), LAMB3(12), LAMB4(7), LAMC1(5), LAMC2(5), LAMC3(9), RELN(17), SDC1(1), SDC2(1), SDC3(2), SDC4(2), SPP1(1), SV2A(5), SV2C(4), THBS1(7), THBS2(6), THBS3(4), THBS4(3), TNC(10), TNN(11), TNR(12), TNXB(22), VTN(3), VWF(9) 38878552 550 87 546 250 199 149 14 130 57 1 0.941 1.000 1.000 296 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(4), CHAD(1), COL11A1(12), COL11A2(4), COL17A1(4), COL1A1(5), COL1A2(13), COL2A1(8), COL3A1(6), COL4A1(12), COL4A2(6), COL4A4(5), COL4A6(6), COL5A1(13), COL5A2(5), COL5A3(4), COL6A1(5), COL6A2(8), COL6A3(20), COL6A6(17), COMP(1), DSC1(2), DSC2(4), DSC3(4), DSG1(3), DSG2(1), DSG3(6), DSG4(2), FN1(18), GJA1(8), GJA10(1), GJA4(3), GJA5(2), GJA8(1), GJA9(2), GJB3(2), GJB6(2), GJC2(2), GJD2(3), GJD4(4), IBSP(2), INA(3), ITGA6(2), ITGB4(9), KRT1(1), KRT10(3), KRT12(3), KRT13(6), KRT14(1), KRT15(1), KRT16(3), KRT17(1), KRT18(2), KRT2(6), KRT20(2), KRT23(1), KRT24(1), KRT25(2), KRT27(6), KRT28(4), KRT3(2), KRT31(2), KRT32(3), KRT33A(5), KRT33B(3), KRT34(1), KRT35(2), KRT36(3), KRT37(3), KRT38(1), KRT39(2), KRT4(1), KRT40(1), KRT5(2), KRT6A(5), KRT6B(1), KRT6C(2), KRT7(3), KRT71(1), KRT72(5), KRT73(6), KRT74(3), KRT75(2), KRT76(1), KRT77(2), KRT78(3), KRT79(2), KRT8(3), KRT81(2), KRT82(2), KRT83(2), KRT84(3), KRT85(1), KRT86(1), LAMA1(16), LAMA2(18), LAMA3(8), LAMA4(9), LAMA5(14), LAMB1(6), LAMB2(9), LAMB3(12), LAMB4(7), LAMC1(5), LAMC2(5), LAMC3(9), LMNA(5), LMNB1(1), LMNB2(2), NES(3), PRPH(1), RELN(17), SPP1(1), THBS1(7), THBS2(6), THBS3(4), THBS4(3), TNC(10), TNN(11), TNR(12), TNXB(22), VIM(2), VTN(3), VWF(9) 43146495 606 86 603 263 217 173 17 148 50 1 0.819 1.000 1.000 297 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 128 ALCAM(6), CADM1(7), CADM3(4), CD2(2), CD22(1), CD226(2), CD274(1), CD276(3), CD34(2), CD4(2), CD40(1), CD40LG(4), CD58(1), CD6(5), CD80(1), CD86(1), CD8A(2), CD8B(1), CDH15(1), CDH2(8), CDH3(5), CDH4(10), CDH5(4), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(3), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CNTN1(9), CNTN2(4), CNTNAP1(9), CNTNAP2(13), CTLA4(3), ESAM(6), GLG1(5), HLA-A(6), HLA-C(3), HLA-DMA(1), HLA-DMB(2), HLA-DOA(1), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-E(2), HLA-F(4), HLA-G(2), ICAM1(2), ICAM2(2), ICAM3(2), ICOS(1), ITGA4(5), ITGA6(2), ITGA8(2), ITGA9(7), ITGAL(5), ITGAM(4), ITGAV(3), ITGB1(4), ITGB2(5), ITGB7(2), ITGB8(7), JAM3(2), L1CAM(2), MADCAM1(2), MAG(6), MPZ(2), NCAM1(2), NCAM2(9), NEGR1(3), NEO1(7), NFASC(8), NLGN1(7), NLGN2(5), NLGN3(6), NRCAM(5), NRXN1(15), NRXN2(10), NRXN3(10), OCLN(1), PDCD1(1), PDCD1LG2(1), PTPRC(14), PTPRF(8), PTPRM(14), PVR(2), PVRL1(1), PVRL2(3), PVRL3(3), SDC1(1), SDC2(1), SDC3(2), SDC4(2), SELE(3), SELL(4), SELP(2), SELPLG(5), SIGLEC1(9), VCAM1(5), VCAN(20) 25139835 439 83 432 164 141 139 14 105 40 0 0.117 1.000 1.000 298 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(4), ACTN1(3), ACTN2(11), ACTN3(1), ACTN4(1), AKT1(2), AKT2(2), AKT3(3), AMOTL1(3), ASH1L(16), CASK(2), CDC42(1), CGN(7), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(3), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CSDA(4), CSNK2A1(4), CSNK2A2(1), CTNNA1(4), CTNNA2(11), CTNNA3(4), CTNNB1(10), CTTN(2), EPB41(6), EPB41L1(3), EPB41L2(8), EPB41L3(14), EXOC3(3), EXOC4(4), GNAI1(1), GNAI2(3), GNAI3(4), HCLS1(1), IGSF5(2), INADL(5), JAM3(2), LLGL1(7), LLGL2(4), MAGI1(14), MAGI2(9), MAGI3(3), MLLT4(14), MPDZ(14), MPP5(1), MYH1(5), MYH10(16), MYH11(8), MYH13(11), MYH14(9), MYH15(5), MYH2(10), MYH3(13), MYH4(11), MYH6(8), MYH7(11), MYH7B(7), MYH8(8), MYH9(13), MYL2(1), MYL7(1), NRAS(1), OCLN(1), PARD3(8), PARD6B(1), PARD6G(2), PPM1J(2), PPP2CA(3), PPP2CB(2), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(3), PPP2R2C(3), PPP2R3A(5), PPP2R3B(5), PPP2R4(2), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCI(5), PRKCQ(2), PTEN(8), RAB13(2), RAB3B(2), RRAS(1), RRAS2(1), SPTAN1(10), SYMPK(5), TJAP1(1), TJP1(6), TJP2(5), TJP3(2), YES1(2), ZAK(3) 33526160 505 82 502 159 174 152 16 112 50 1 0.00979 1.000 1.000 299 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ACTA2(5), ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ARRB1(3), ARRB2(1), ATF4(1), ATF5(3), ATP2A2(3), ATP2A3(4), CALCA(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CNN1(1), CORIN(7), CREB3(2), CRHR1(2), DGKZ(1), ETS2(1), GABPA(1), GABPB2(1), GBA2(1), GJA1(8), GNAQ(1), GNB2(3), GNB4(3), GNG12(1), GNG7(2), GNGT1(3), GRK4(1), GUCA2A(1), GUCY1A3(9), IGFBP1(2), IGFBP2(1), IGFBP3(4), IL1B(1), ITPR1(17), ITPR2(14), ITPR3(16), JUN(2), MIB1(2), MYL2(1), MYL4(1), MYLK2(2), NFKB1(5), NOS1(15), NOS3(3), OXT(1), OXTR(4), PDE4B(2), PLCB3(6), PLCD1(1), PLCG1(10), PLCG2(6), PRKACA(1), PRKACB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(5), PRKCH(5), PRKCQ(2), PRKD1(4), RAMP2(1), RAMP3(3), RGS1(1), RGS10(2), RGS11(1), RGS14(1), RGS16(2), RGS17(1), RGS18(2), RGS19(1), RGS2(2), RGS20(1), RGS3(11), RGS5(1), RGS6(7), RGS7(1), RGS9(4), RYR1(27), RYR2(35), RYR3(32), SLC8A1(4), SP1(3), TNXB(22), USP5(3), YWHAH(1), YWHAQ(1) 30109693 454 81 451 184 175 117 16 105 41 0 0.478 1.000 1.000 300 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(5), ACTN2(11), ACTN3(1), ACTN4(1), DMD(23), FAM48A(5), MYBPC1(2), MYBPC2(5), MYBPC3(2), MYH3(13), MYH6(8), MYH7(11), MYH8(8), MYL2(1), MYL3(1), MYL4(1), MYOM1(1), NEB(25), TMOD1(1), TNNI2(3), TNNT1(2), TNNT2(2), TPM1(1), TPM3(1), TPM4(2), TTN(234), VIM(2) 23874148 373 81 371 130 102 115 20 113 20 3 0.266 1.000 1.000 301 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(4), ACVR1B(6), ACVR2B(2), AMHR2(2), BMP2(2), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(10), CCL11(1), CCL15(1), CCL18(2), CCL2(1), CCL20(1), CCL23(1), CCL25(1), CCL5(1), CCL7(1), CCL8(2), CCR1(2), CCR2(2), CCR3(4), CCR5(1), CCR8(1), CD27(2), CD40(1), CD40LG(4), CD70(1), CLCF1(1), CNTF(2), CNTFR(1), CSF1R(6), CSF2RA(5), CSF2RB(4), CSF3(1), CSF3R(5), CX3CL1(4), CX3CR1(3), CXCL16(2), CXCL2(1), CXCL9(1), CXCR6(1), EDA(1), EDAR(3), EGF(4), EGFR(7), EPOR(2), FAS(2), FLT1(5), FLT3(6), FLT4(6), GDF5(4), GH1(1), GH2(2), GHR(3), HGF(12), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), IFNAR1(4), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RB(1), IL11(2), IL11RA(2), IL12B(1), IL12RB1(4), IL12RB2(4), IL13(1), IL13RA1(2), IL15RA(1), IL17B(1), IL17RA(4), IL17RB(1), IL18R1(2), IL18RAP(2), IL1B(1), IL1R1(3), IL1R2(1), IL1RAP(3), IL20(1), IL20RA(3), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(3), IL25(1), IL26(1), IL28A(2), IL28B(3), IL2RA(1), IL2RG(3), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6ST(2), IL7R(3), IL8(1), INHBA(5), INHBB(6), INHBC(1), INHBE(1), KDR(4), KIT(6), KITLG(3), LEPR(6), LIF(1), LIFR(5), LTA(2), LTBR(1), MET(4), NGFR(4), OSM(1), OSMR(2), PDGFB(3), PDGFC(3), PDGFRA(3), PDGFRB(7), PF4V1(1), PRL(1), PRLR(1), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6), TNF(1), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF19(3), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFRSF8(2), TNFRSF9(3), TNFSF10(2), TNFSF15(1), TNFSF18(2), TNFSF8(1), TPO(13), TSLP(2), VEGFC(3), XCL1(1), XCR1(3) 30448516 405 80 399 176 124 121 20 96 42 2 0.821 1.000 1.000 302 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(3), ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ADK(1), ADSL(2), ADSS(3), ADSSL1(6), AK5(2), AK7(2), ALLC(3), AMPD1(3), AMPD2(5), AMPD3(7), APRT(2), ATIC(4), CANT1(3), DCK(1), DGUOK(1), ENPP1(1), ENPP3(2), ENTPD1(3), ENTPD3(3), ENTPD4(6), ENTPD6(1), ENTPD8(4), GART(6), GDA(1), GMPR(2), GMPR2(2), GMPS(2), GUCY1A2(3), GUCY1A3(9), GUCY1B3(5), GUCY2C(6), GUCY2D(8), GUCY2F(7), GUK1(2), IMPDH1(1), IMPDH2(1), NME6(2), NME7(1), NPR1(6), NPR2(3), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT2(2), NUDT9(1), PAPSS1(3), PAPSS2(2), PDE10A(1), PDE11A(2), PDE1A(3), PDE1C(2), PDE2A(6), PDE3B(8), PDE4A(3), PDE4B(2), PDE4C(1), PDE5A(3), PDE6G(1), PDE7A(5), PDE7B(2), PDE8A(6), PDE8B(2), PDE9A(2), PFAS(1), PKLR(4), PKM2(2), PNPT1(2), POLA1(4), POLA2(2), POLD1(7), POLD3(1), POLE(12), POLE2(1), POLE3(1), POLE4(1), POLR1A(5), POLR1C(2), POLR1D(1), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(10), POLR3B(3), POLR3G(1), POLR3K(1), PPAT(1), PRIM1(1), PRIM2(3), PRPS1(1), PRPS1L1(1), PRPS2(1), PRUNE(3), RRM1(3), RRM2(2), RRM2B(2), XDH(8) 28328903 364 78 363 128 123 126 13 76 26 0 0.109 1.000 1.000 303 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 141 APC(19), APC2(6), AXIN1(7), AXIN2(3), BTRC(3), CACYBP(1), CAMK2A(1), CAMK2G(4), CCND1(1), CCND3(2), CER1(2), CHD8(7), CREBBP(10), CSNK1A1L(2), CSNK1E(6), CSNK2A1(4), CSNK2A2(1), CTBP1(2), CTBP2(3), CTNNB1(10), CTNNBIP1(1), CUL1(8), CXXC4(1), DAAM1(7), DAAM2(4), DKK1(4), DKK2(2), DKK4(1), DVL1(2), DVL2(2), DVL3(4), EP300(13), FBXW11(5), FZD1(5), FZD10(7), FZD2(2), FZD3(4), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), GSK3B(2), JUN(2), LEF1(4), LRP5(8), LRP6(2), MAP3K7(6), MAPK10(1), MAPK8(3), MAPK9(3), MMP7(1), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NKD1(5), NKD2(1), NLK(4), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PORCN(2), PPARD(4), PPP2CA(3), PPP2CB(2), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(3), PPP2R2C(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRICKLE1(9), PRICKLE2(11), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PSEN1(1), RAC2(1), RAC3(1), ROCK1(7), ROCK2(2), RUVBL1(4), SENP2(2), SFRP1(2), SFRP2(2), SFRP4(2), SIAH1(1), SMAD2(4), SMAD3(2), SOX17(3), TBL1X(2), TBL1XR1(2), TCF7(2), TCF7L1(3), TCF7L2(4), VANGL1(2), WIF1(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(4), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(1), WNT9B(2) 27511843 428 78 422 144 145 133 16 77 54 3 0.0257 1.000 1.000 304 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRA2A(2), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(1), AGTR2(1), AVPR1A(6), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), CCBP2(2), CCKAR(1), CCKBR(4), CCR1(2), CCR10(1), CCR2(2), CCR3(4), CCR5(1), CCR8(1), CCRL1(3), CHML(2), CHRM1(2), CHRM2(6), CHRM3(5), CHRM4(2), CHRM5(2), CMKLR1(1), CNR1(5), CX3CR1(3), DRD1(2), DRD2(5), DRD3(6), DRD4(1), DRD5(7), EDNRA(1), F2R(1), F2RL1(1), F2RL2(1), FPR1(1), FSHR(12), GALR1(2), GALR2(1), GALR3(1), GALT(1), GHSR(3), GPR17(1), GPR173(2), GPR174(1), GPR27(2), GPR3(3), GPR35(2), GPR37(2), GPR37L1(3), GPR4(2), GPR50(4), GPR6(6), GPR83(4), GPR85(1), GPR87(3), GRPR(2), HCRTR1(2), HCRTR2(2), HRH1(3), HRH2(4), HRH3(1), HTR1A(5), HTR1B(4), HTR1D(3), HTR1E(1), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(4), LHCGR(7), LTB4R(1), MAS1(1), MC3R(2), MC4R(4), MC5R(5), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(1), NPY1R(1), NPY2R(1), NTSR1(4), OPN1SW(1), OPN3(2), OPRD1(2), OPRK1(3), OR10A5(1), OR11A1(3), OR12D3(1), OR1F1(1), OR1Q1(4), OR2H1(1), OR5V1(4), OR7C1(2), OR8B8(5), OXTR(4), P2RY1(4), P2RY10(3), P2RY12(7), P2RY13(3), P2RY14(2), P2RY6(3), PPYR1(5), PTAFR(2), PTGDR(4), PTGER2(2), PTGER4(1), PTGFR(3), RGR(2), RHO(2), RRH(2), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(6), SUCNR1(2), TBXA2R(6), TRHR(3) 20796316 368 77 365 138 128 116 16 86 22 0 0.0657 1.000 1.000 305 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 72 ACTB(4), ACTN1(3), ACTN2(11), ACTN3(1), ACTN4(1), ACVR1B(6), ACVR1C(3), BAIAP2(3), CDC42(1), CREBBP(10), CSNK2A1(4), CSNK2A2(1), CTNNA1(4), CTNNA2(11), CTNNA3(4), CTNNB1(10), CTNND1(6), EGFR(7), EP300(13), ERBB2(5), FARP2(3), FER(4), FGFR1(8), FYN(5), IGF1R(10), INSR(9), IQGAP1(5), LEF1(4), LMO7(8), MAP3K7(6), MAPK1(2), MAPK3(1), MET(4), MLLT4(14), NLK(4), PARD3(8), PTPN6(3), PTPRB(10), PTPRF(8), PTPRJ(13), PTPRM(14), PVRL1(1), PVRL2(3), PVRL3(3), PVRL4(4), RAC2(1), RAC3(1), SMAD2(4), SMAD3(2), SNAI1(2), SNAI2(4), SORBS1(5), SSX2IP(3), TCF7(2), TCF7L1(3), TCF7L2(4), TGFBR1(2), TGFBR2(6), TJP1(6), VCL(2), WASF1(3), WASF2(2), WASF3(1), WASL(1), YES1(2) 20173981 318 73 313 108 94 106 11 58 49 0 0.102 1.000 1.000 306 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ADRB1(3), DRD1(2), DRD2(5), EGF(4), EGFR(7), GJA1(8), GJD2(3), GNA11(4), GNAI1(1), GNAI2(3), GNAI3(4), GNAQ(1), GNAS(11), GRB2(1), GRM1(17), GRM5(12), GUCY1A2(3), GUCY1A3(9), GUCY1B3(5), GUCY2C(6), GUCY2D(8), GUCY2F(7), HTR2A(1), HTR2B(4), HTR2C(3), ITPR1(17), ITPR2(14), ITPR3(16), MAP2K1(2), MAP2K2(1), MAP3K2(1), MAPK1(2), MAPK3(1), MAPK7(6), NPR1(6), NPR2(3), NRAS(1), PDGFA(1), PDGFB(3), PDGFC(3), PDGFD(2), PDGFRA(3), PDGFRB(7), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKG1(6), PRKG2(6), PRKX(2), RAF1(5), SOS1(3), SOS2(3), TJP1(6), TUBA1B(1), TUBA1C(2), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA8(3), TUBAL3(3), TUBB1(2), TUBB2A(2), TUBB2C(2), TUBB3(7), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2) 22836567 388 73 386 144 132 117 20 92 27 0 0.258 1.000 1.000 307 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), AKAP1(1), AKAP10(2), AKAP11(4), AKAP12(5), AKAP3(5), AKAP4(7), AKAP6(10), AKAP7(5), AKAP8(6), AKAP9(15), ARHGEF1(2), CALM1(1), CALM2(2), CALM3(1), CHMP1B(1), GNA11(4), GNA12(1), GNA14(2), GNA15(2), GNAI2(3), GNAI3(4), GNAO1(1), GNAQ(1), GNAZ(6), GNB2(3), GNG12(1), GNG7(2), GNGT1(3), GNGT2(1), ITPR1(17), KCNJ3(5), NRAS(1), PDE1A(3), PDE1B(2), PDE1C(2), PDE4A(3), PDE4B(2), PDE4C(1), PDE7A(5), PDE7B(2), PDE8A(6), PDE8B(2), PLCB3(6), PPP3CA(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCI(5), PRKCQ(2), PRKD1(4), PRKD3(1), RRAS(1), SLC9A1(6), USP5(3) 20130624 272 70 267 99 91 85 10 54 32 0 0.189 1.000 1.000 308 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(2), ANAPC1(13), ANAPC11(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), ATM(13), ATR(5), BUB1(5), BUB1B(3), BUB3(2), CCNA1(4), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(6), CCND1(1), CCND3(2), CCNE1(3), CCNE2(1), CCNH(1), CDC14A(6), CDC16(1), CDC20(2), CDC23(4), CDC25A(2), CDC25B(2), CDC25C(2), CDC26(1), CDC27(2), CDC6(2), CDC7(3), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(3), CDKN2D(1), CHEK1(1), CHEK2(5), CREBBP(10), CUL1(8), DBF4(4), E2F2(2), E2F3(1), EP300(13), ESPL1(12), FZR1(3), GSK3B(2), HDAC1(2), HDAC2(2), MAD1L1(5), MCM2(8), MCM3(1), MCM4(6), MCM5(6), MCM7(4), MDM2(3), ORC1L(6), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PKMYT1(3), PLK1(3), PRKDC(19), RB1(7), RBL1(3), SKP2(3), SMAD2(4), SMAD3(2), SMC1A(4), SMC1B(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(3), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 23348013 295 70 287 127 84 95 14 60 41 1 0.923 1.000 1.000 309 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(3), ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADK(1), ADSL(2), ADSS(3), AK5(2), ALLC(3), AMPD1(3), AMPD2(5), AMPD3(7), APRT(2), ATIC(4), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), CANT1(3), DCK(1), DGUOK(1), ENPP1(1), ENPP3(2), ENTPD1(3), GART(6), GDA(1), GMPS(2), GUCY1A2(3), GUCY1A3(9), GUCY1B3(5), GUCY2C(6), GUCY2D(8), GUCY2F(7), GUK1(2), IMPDH1(1), IMPDH2(1), NPR1(6), NPR2(3), NT5C(1), NUDT2(2), PAPSS1(3), PAPSS2(2), PDE1A(3), PDE4A(3), PDE4B(2), PDE4C(1), PDE5A(3), PDE6B(5), PDE6C(2), PDE6G(1), PDE7B(2), PDE8A(6), PDE9A(2), PFAS(1), PKLR(4), PKM2(2), POLD1(7), POLE(12), POLG(3), POLL(1), POLQ(13), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9), PPAT(1), PRPS1(1), PRPS1L1(1), PRPS2(1), PRUNE(3), RRM1(3), RRM2(2) 22198336 285 70 284 115 87 104 11 63 20 0 0.544 1.000 1.000 310 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(5), BRAF(5), CACNA1A(9), CRHR1(2), GNA11(4), GNA12(1), GNAI1(1), GNAI2(3), GNAI3(4), GNAO1(1), GNAQ(1), GNAS(11), GNAZ(6), GRIA1(9), GRIA2(13), GRIA3(5), GRID2(10), GRM1(17), GRM5(12), GUCY1A2(3), GUCY1A3(9), GUCY1B3(5), GUCY2C(6), GUCY2D(8), GUCY2F(7), IGF1(2), IGF1R(10), ITPR1(17), ITPR2(14), ITPR3(16), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), NOS1(15), NOS3(3), NPR1(6), NPR2(3), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PPP2CA(3), PPP2CB(2), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(3), PPP2R2C(3), PRKCG(4), PRKG1(6), PRKG2(6), RAF1(5), RYR1(27) 19018774 364 69 362 108 131 104 17 86 26 0 0.00907 1.000 1.000 311 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(1), CALM2(2), CALM3(1), CDS1(3), CDS2(1), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKI(5), DGKQ(1), DGKZ(1), FN3K(2), IMPA1(3), INPP4A(1), INPP4B(3), INPP5A(3), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(12), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), OCRL(4), PI4KA(9), PI4KB(3), PIK3C2A(4), PIK3C2B(10), PIK3C2G(3), PIK3C3(6), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLCD1(1), PLCD3(6), PLCE1(8), PLCG1(10), PLCG2(6), PLCZ1(2), PRKCG(4), PTEN(8), SYNJ1(3), SYNJ2(9) 21269212 283 68 278 93 99 88 7 54 34 1 0.0595 1.000 1.000 312 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ATF4(1), CACNA1C(18), CACNA1D(12), CACNA1F(1), CACNA1S(10), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CDC42(1), EGFR(7), ELK1(2), FSHB(1), GNA11(4), GNAQ(1), GNAS(11), GNRH2(1), GNRHR(3), GRB2(1), ITPR1(17), ITPR2(14), ITPR3(16), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAP3K1(6), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(3), MAPK9(3), MMP14(1), MMP2(4), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLD1(7), PLD2(10), PRKACA(1), PRKACB(2), PRKACG(3), PRKCD(3), PRKX(2), PTK2B(5), RAF1(5), SOS1(3), SOS2(3) 22020073 340 68 339 117 117 109 12 64 38 0 0.0649 1.000 1.000 313 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(2), ATM(13), BUB1(5), BUB1B(3), BUB3(2), CCNA1(4), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(6), CCND3(2), CCNE1(3), CCNE2(1), CCNH(1), CDAN1(5), CDC14A(6), CDC20(2), CDC25A(2), CDC25B(2), CDC25C(2), CDC6(2), CDC7(3), CDK2(2), CDKN1A(1), CDKN2A(3), CHEK1(1), CHEK2(5), DTX4(3), E2F2(2), E2F3(1), E2F5(1), EP300(13), ESPL1(12), GSK3B(2), HDAC1(2), HDAC2(2), HDAC3(3), HDAC4(7), HDAC5(4), HDAC6(1), HDAC8(3), MAD1L1(5), MCM2(8), MCM3(1), MCM4(6), MCM5(6), MCM7(4), MDM2(3), MPEG1(4), ORC1L(6), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PLK1(3), PRKDC(19), PTPRA(4), RB1(7), RBL1(3), SKP2(3), TBC1D8(6), TFDP1(2), TGFB1(3) 18534837 244 67 242 96 75 71 14 52 31 1 0.662 1.000 1.000 314 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(2), AKT2(2), AKT3(3), CBL(1), CBLB(2), CBLC(1), CCND1(1), CCND3(2), CISH(1), CLCF1(1), CNTF(2), CNTFR(1), CREBBP(10), CSF2RA(5), CSF2RB(4), CSF3(1), CSF3R(5), EP300(13), EPOR(2), GH1(1), GH2(2), GHR(3), GRB2(1), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), IFNAR1(4), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RB(1), IL11(2), IL11RA(2), IL12B(1), IL12RB1(4), IL12RB2(4), IL13(1), IL13RA1(2), IL13RA2(5), IL15RA(1), IL20(1), IL20RA(3), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(3), IL26(1), IL28A(2), IL28B(3), IL2RA(1), IL2RG(3), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6ST(2), IL7R(3), IRF9(2), JAK1(2), JAK2(8), JAK3(3), LEPR(6), LIF(1), LIFR(5), OSM(1), OSMR(2), PIAS1(3), PIAS2(3), PIAS3(1), PIAS4(4), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PIM1(1), PRL(1), PRLR(1), PTPN11(4), PTPN6(3), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SOCS7(1), SOS1(3), SOS2(3), SPRED1(3), SPRED2(5), SPRY1(2), SPRY3(3), SPRY4(3), STAM(4), STAM2(3), STAT1(4), STAT2(3), STAT3(6), STAT4(3), STAT5A(1), STAT5B(2), TPO(13), TSLP(2), TYK2(4) 24773134 317 67 313 119 97 100 16 71 32 1 0.380 1.000 1.000 315 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(12), BDKRB1(1), BDKRB2(2), C1QA(1), C1QC(3), C1R(2), C1S(3), C2(2), C3(14), C3AR1(2), C5(8), C5AR1(1), C6(6), C7(2), C8A(6), C8B(7), C9(3), CD46(1), CD55(1), CFB(2), CFH(8), CFI(3), CPB2(3), CR1(16), CR2(4), F10(3), F11(3), F12(2), F13A1(7), F13B(8), F2(3), F2R(1), F5(8), F7(6), F8(11), F9(4), FGA(4), FGB(2), KLKB1(4), KNG1(4), MASP1(1), MASP2(2), MBL2(1), PLAT(2), PLAU(2), PLG(8), PROC(3), PROS1(5), SERPINA1(3), SERPINA5(1), SERPINC1(2), SERPIND1(2), SERPINE1(2), SERPINF2(4), SERPING1(2), TFPI(3), THBD(1), VWF(9) 15733189 236 66 233 63 67 67 7 69 25 1 0.0104 1.000 1.000 316 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(3), ACTN2(11), ACTN3(1), ACTN4(1), ARHGAP5(5), BCAR1(4), CDC42(1), CDH5(4), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(3), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CTNNA1(4), CTNNA2(11), CTNNA3(4), CTNNB1(10), CTNND1(6), CYBA(1), CYBB(3), ESAM(6), GNAI1(1), GNAI2(3), GNAI3(4), GRLF1(7), ICAM1(2), ITGA4(5), ITGAL(5), ITGAM(4), ITGB1(4), ITGB2(5), ITK(4), JAM3(2), MAPK13(1), MAPK14(1), MLLT4(14), MMP2(4), MMP9(6), MSN(3), MYL2(1), MYL7(1), NCF1(1), NCF2(1), NOX1(4), NOX3(3), OCLN(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLCG1(10), PLCG2(6), PRKCG(4), PTK2(7), PTK2B(5), PTPN11(4), PXN(1), RAC2(1), RAP1A(2), RAP1B(3), RAPGEF3(1), RAPGEF4(3), RHOH(1), ROCK1(7), ROCK2(2), TXK(1), VASP(2), VAV1(6), VAV2(8), VAV3(6), VCAM1(5), VCL(2) 21064440 314 66 308 134 112 99 11 56 35 1 0.726 1.000 1.000 317 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(2), CD14(1), CD19(1), CD1A(1), CD1B(4), CD1C(2), CD1D(4), CD1E(5), CD2(2), CD22(1), CD33(2), CD34(2), CD36(2), CD37(1), CD38(1), CD3E(2), CD3G(2), CD4(2), CD44(5), CD5(4), CD55(1), CD7(3), CD8A(2), CD8B(1), CR1(16), CR2(4), CSF1R(6), CSF2RA(5), CSF3(1), CSF3R(5), EPOR(2), FCER2(2), FLT3(6), GP5(2), GYPA(1), HLA-DRA(3), HLA-DRB1(1), IL11(2), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(1), IL2RA(1), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL7R(3), ITGA1(3), ITGA2(4), ITGA2B(5), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGAM(4), ITGB3(3), KIT(6), KITLG(3), MME(4), THPO(2), TNF(1), TPO(13) 14134980 193 65 189 79 56 56 8 48 25 0 0.679 1.000 1.000 318 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(3), BCAR1(4), CAPN1(2), CAPN11(3), CAPN2(2), CAPN3(5), CAPN5(2), CAPN6(6), CAPN7(4), CAPN9(2), CAPNS1(1), CAV1(2), CDC42(1), CRK(1), CSK(2), DOCK1(10), FYN(5), GIT2(1), GRB2(1), ILK(1), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(4), ITGA8(2), ITGA9(7), ITGAD(4), ITGAE(2), ITGAL(5), ITGAM(4), ITGAV(3), ITGAX(5), ITGB1(4), ITGB2(5), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(1), ITGB7(2), ITGB8(7), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K6(1), MAPK10(1), MAPK4(4), MAPK6(1), MAPK7(6), MYLK2(2), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PDPK1(1), PIK3R2(4), PTK2(7), PXN(1), RAC2(1), RAC3(1), RAP1B(3), RAPGEF1(5), RHO(2), ROCK1(7), ROCK2(2), SHC1(3), SHC3(4), SORBS1(5), SOS1(3), TLN1(11), TNS1(15), VASP(2), VAV2(8), VAV3(6), VCL(2), ZYX(2) 23272910 296 65 294 132 106 83 11 61 34 1 0.895 1.000 1.000 319 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(4), ACVR1B(6), ACVRL1(2), AKT1(2), AURKB(2), BMPR1A(1), BMPR2(10), BUB1(5), CDKL1(2), CDKL2(2), CDS1(3), CDS2(1), CLK1(3), CLK2(5), CLK4(2), COL4A3BP(1), CSNK2A1(4), CSNK2A2(1), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKQ(1), DGKZ(1), IMPA1(3), INPP4A(1), INPP4B(3), INPP5A(3), INPPL1(12), ITPKA(1), ITPKB(5), MAP3K10(6), MOS(3), NEK1(3), NEK3(1), OCRL(4), PAK4(4), PIK3C2A(4), PIK3C2B(10), PIK3C2G(3), PIK3CB(5), PIK3CG(9), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLCD1(1), PLCG1(10), PLCG2(6), PLK3(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCQ(2), PRKD1(4), PRKG1(6), RAF1(5), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA4(2), RPS6KB1(2), TGFBR1(2), VRK1(1) 19234770 266 65 260 88 82 81 7 58 35 3 0.220 1.000 1.000 320 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(2), ALG1(3), ALG10(5), ALG10B(1), ALG12(1), ALG13(2), ALG3(1), ALG8(1), ALG9(2), B3GNT1(1), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT4(3), B4GALT5(3), B4GALT7(1), C1GALT1C1(3), CHPF(2), CHST1(8), CHST11(1), CHST12(4), CHST13(1), CHST2(7), CHST6(3), CHST7(1), CHSY1(3), EXT1(9), EXT2(3), EXTL1(3), EXTL2(2), EXTL3(5), FUT11(2), FUT8(2), GALNT10(3), GALNT11(4), GALNT12(1), GALNT13(2), GALNT14(4), GALNT2(2), GALNT4(1), GALNT5(4), GALNT6(2), GALNT8(3), GALNT9(2), GALNTL1(2), GALNTL2(4), GALNTL4(5), GALNTL5(2), GANAB(3), GCNT3(1), GCNT4(1), HS3ST1(1), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(4), HS6ST1(1), HS6ST2(1), HS6ST3(4), MAN1A2(1), MAN1B1(2), MAN1C1(3), MAN2A1(2), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(5), MGAT5B(1), NDST1(7), NDST2(5), NDST3(4), NDST4(9), OGT(1), RPN1(1), RPN2(3), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3), ST6GALNAC1(1), STT3B(3), UST(5), XYLT1(7), XYLT2(4) 18849889 247 64 245 113 92 75 8 52 20 0 0.922 1.000 1.000 321 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(10), ADCY8(10), ARAF(5), ATF4(1), BRAF(5), CACNA1C(18), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CAMK4(4), CREBBP(10), EP300(13), GNAQ(1), GRIA1(9), GRIA2(13), GRIN1(2), GRIN2A(6), GRIN2B(8), GRIN2C(3), GRM1(17), GRM5(12), ITPR1(17), ITPR2(14), ITPR3(16), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PPP1CA(1), PPP1CC(2), PPP1R12A(1), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), RAF1(5), RAP1A(2), RAP1B(3), RAPGEF3(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA6(7) 17220927 287 64 286 97 89 100 11 49 38 0 0.0738 1.000 1.000 322 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 77 ABL1(2), ACTN1(3), ACTR2(2), AKT1(2), AKT2(2), AKT3(3), ANGPTL2(4), ARHGEF6(9), ARHGEF7(8), BCAR1(4), BRAF(5), CAV1(2), CDC42(1), CDKN2A(3), CRK(1), DOCK1(10), EPHB2(6), FYN(5), GRB2(1), GRB7(6), GRLF1(7), ILK(1), ITGA1(3), ITGA10(4), ITGA11(6), ITGA2(4), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(4), ITGA8(2), ITGA9(7), ITGB3BP(1), MAP2K4(5), MAP2K7(12), MAP3K11(2), MAPK1(2), MAPK10(1), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3), MYLK(7), MYLK2(2), P4HB(2), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PIK3CB(5), PKLR(4), PLCG1(10), PLCG2(6), PTEN(8), PTK2(7), RAF1(5), RHO(2), ROCK1(7), ROCK2(2), SHC1(3), SOS1(3), SOS2(3), TERF2IP(3), TLN1(11), TLN2(18), VASP(2), ZYX(2) 20847078 303 64 302 103 105 87 10 63 38 0 0.127 1.000 1.000 323 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(16), ASH2L(3), C17orf79(1), CARM1(2), CTCFL(4), DOT1L(7), EED(1), EHMT1(6), EHMT2(3), EZH1(1), EZH2(3), FBXO11(6), HCFC1(9), HSF4(2), JMJD4(1), JMJD6(1), KDM6A(5), MEN1(3), MLL(13), MLL2(28), MLL3(30), MLL4(16), MLL5(10), NSD1(10), OGT(1), PAXIP1(5), PPP1CA(1), PPP1CC(2), PRDM2(14), PRDM9(8), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), RBBP5(1), SATB1(7), SETD1A(6), SETD2(4), SETDB1(8), SETDB2(3), SMYD3(2), STK38(1), SUV39H1(4), SUV39H2(1), SUV420H1(4), SUV420H2(1), SUZ12(1), WHSC1(7), WHSC1L1(6) 20585669 277 63 274 93 82 80 6 55 48 6 0.335 1.000 1.000 324 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(14), ACACB(10), AKT1(2), AKT2(2), AKT3(3), ARAF(5), BAD(1), BRAF(5), CALM1(1), CALM2(2), CALM3(1), CBL(1), CBLB(2), CBLC(1), CRK(1), EIF4EBP1(1), ELK1(2), EXOC7(6), FASN(9), FBP1(1), FBP2(3), FLOT1(1), FLOT2(3), GCK(3), GRB2(1), GSK3B(2), GYS1(4), GYS2(2), IKBKB(3), INPP5D(1), INSR(9), IRS1(6), IRS2(3), IRS4(9), LIPE(4), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(3), MKNK1(1), NRAS(1), PCK1(2), PCK2(5), PDE3A(6), PDE3B(8), PDPK1(1), PFKL(4), PFKM(2), PFKP(7), PHKA1(5), PHKA2(7), PHKG1(2), PHKG2(2), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PKLR(4), PKM2(2), PPARGC1A(4), PPP1CA(1), PPP1CC(2), PPP1R3A(11), PPP1R3B(4), PPP1R3C(3), PPP1R3D(2), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAG3(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKCI(5), PRKX(2), PTPRF(8), PYGB(4), PYGL(3), PYGM(5), RAF1(5), RAPGEF1(5), RHEB(1), RPS6(1), RPS6KB1(2), RPS6KB2(2), SH2B2(2), SHC1(3), SHC2(2), SHC3(4), SLC2A4(1), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SORBS1(5), SOS1(3), SOS2(3), SREBF1(2), TRIP10(4), TSC1(3), TSC2(3) 27214881 370 63 368 159 135 115 11 66 42 1 0.720 1.000 1.000 325 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 97 ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ASIP(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CREB1(4), CREB3(2), CREB3L1(2), CREB3L2(1), CREB3L3(3), CREBBP(10), CTNNB1(10), DCT(6), DVL1(2), DVL2(2), DVL3(4), EDN1(3), EP300(13), FZD1(5), FZD10(7), FZD2(2), FZD3(4), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), GNAI1(1), GNAI2(3), GNAI3(4), GNAO1(1), GNAQ(1), GNAS(11), GSK3B(2), KIT(6), KITLG(3), LEF1(4), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MITF(6), NRAS(1), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), POMC(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), RAF1(5), TCF7(2), TCF7L1(3), TCF7L2(4), TYR(3), TYRP1(5), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(4), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(1), WNT9B(2) 18540068 311 63 308 124 113 92 11 58 36 1 0.339 1.000 1.000 326 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(4), BAD(1), BCL2(1), CABIN1(5), CALM1(1), CALM2(2), CALM3(1), CAMK4(4), CD3E(2), CD3G(2), CDKN1A(1), CNR1(5), CREBBP(10), CSNK2A1(4), CTLA4(3), EGR2(3), EGR3(1), EP300(13), FCGR3A(1), GATA3(3), GATA4(3), GRLF1(7), GSK3A(1), GSK3B(2), ICOS(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL13(1), IL1B(1), IL2RA(1), IL3(1), IL8(1), ITK(4), KPNA5(5), MAP2K7(12), MAPK14(1), MAPK8(3), MAPK9(3), MEF2B(3), MEF2D(5), MYF5(2), NCK2(2), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NFKB2(3), NFKBIB(4), NPPB(1), NUP214(12), OPRD1(2), PAK1(4), PIN1(1), PPP3CB(1), PTPRC(14), RELA(1), RPL13A(1), SLA(1), SP1(3), SP3(3), TGFB1(3), TNF(1), TRAF2(2), TRPV6(3), VAV1(6), VAV2(8), VAV3(6), XPO5(1) 15737448 243 62 241 93 71 82 8 53 29 0 0.439 1.000 1.000 327 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(7), AMY2A(2), AMY2B(3), ASCC3(16), ATP13A2(5), DDX18(7), DDX19A(2), DDX23(5), DDX4(2), DDX41(6), DDX47(1), DDX50(2), DDX51(2), DDX54(6), DDX55(3), DDX56(4), DHX58(4), ENPP1(1), ENPP3(2), ENTPD7(8), EP400(17), ERCC2(4), ERCC3(3), GAA(2), GANC(4), GBA(4), GBA3(1), GBE1(2), GCK(3), GPI(4), GUSB(2), GYS1(4), GYS2(2), HK1(5), HK2(5), HK3(3), IFIH1(2), LYZL1(2), MGAM(6), MOV10L1(3), NUDT8(1), PGM1(2), PGM3(6), PYGB(4), PYGL(3), PYGM(5), RAD54B(3), RAD54L(2), RUVBL2(2), SETX(8), SI(10), SKIV2L2(3), SMARCA2(12), SMARCA5(1), TREH(2), UGDH(4), UGP2(1), UGT1A1(1), UGT1A5(3), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), UXS1(3) 21297805 259 62 259 88 86 87 9 44 33 0 0.160 1.000 1.000 328 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(2), AKT2(2), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN2A(3), CREB1(4), CREB3(2), CREB5(1), EBP(1), ERBB4(16), F2RL2(1), GAB1(1), GRB2(1), GSK3A(1), GSK3B(2), IGF1(2), IGFBP1(2), INPPL1(12), IRS1(6), IRS2(3), IRS4(9), MET(4), NOLC1(6), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PARD3(8), PDK1(1), PIK3CD(8), PPP1R13B(5), PREX1(8), PTEN(8), PTK2(7), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KB1(2), SHC1(3), SLC2A4(1), SOS1(3), SOS2(3), TSC1(3), TSC2(3), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 12982966 186 62 184 67 64 59 10 25 28 0 0.230 1.000 1.000 329 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 89 AKT1(2), AKT2(2), AKT3(3), CARD11(9), CBL(1), CBLB(2), CBLC(1), CD247(2), CD3E(2), CD3G(2), CD4(2), CD40LG(4), CD8A(2), CD8B(1), CDC42(1), CTLA4(3), FYN(5), GRAP2(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(3), IL10(1), ITK(4), JUN(2), LCP2(5), MALT1(4), MAP3K14(2), NCK1(3), NCK2(2), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NFKB1(5), NFKB2(3), NFKBIB(4), NRAS(1), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PDCD1(1), PDK1(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLCG1(10), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKCQ(2), PTPN6(3), PTPRC(14), RASGRP1(4), SOS1(3), SOS2(3), TEC(3), TNF(1), VAV1(6), VAV2(8), VAV3(6), ZAP70(2) 17041774 243 61 239 95 70 76 7 62 28 0 0.611 1.000 1.000 330 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 122 ARAF(5), BID(1), BRAF(5), CASP3(1), CD244(1), CD247(2), FAS(2), FCGR3A(1), FCGR3B(2), FYN(5), GRB2(1), HLA-A(6), HLA-C(3), HLA-E(2), HLA-G(2), ICAM1(2), ICAM2(2), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), IFNAR1(4), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), ITGAL(5), ITGB2(5), KIR2DL1(3), KIR2DL3(1), KIR2DL4(1), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRD1(2), LCP2(5), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MICB(1), NCR1(1), NCR2(3), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NRAS(1), PAK1(4), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLCG1(10), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRF1(1), PRKCG(4), PTK2B(5), PTPN11(4), PTPN6(3), RAC2(1), RAC3(1), RAF1(5), SH2D1A(1), SH3BP2(2), SHC1(3), SHC2(2), SHC3(4), SOS1(3), SOS2(3), SYK(3), TNF(1), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), ULBP1(2), ULBP3(1), VAV1(6), VAV2(8), VAV3(6), ZAP70(2) 18949847 278 60 275 101 81 94 9 57 37 0 0.213 1.000 1.000 331 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 85 ACVR1(4), ACVR1B(6), ACVR1C(3), ACVR2B(2), ACVRL1(2), AMHR2(2), BMP2(2), BMP4(4), BMP5(6), BMP6(5), BMP7(2), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(10), CHRD(1), COMP(1), CREBBP(10), CUL1(8), DCN(2), E2F5(1), EP300(13), FST(1), GDF5(4), GDF6(6), GDF7(1), IFNG(2), INHBA(5), INHBB(6), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(9), MAPK1(2), MAPK3(1), PITX2(2), PPP2CA(3), PPP2CB(2), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(3), PPP2R2C(3), RBL1(3), ROCK1(7), ROCK2(2), RPS6KB1(2), RPS6KB2(2), SMAD1(1), SMAD2(4), SMAD3(2), SMAD5(1), SMAD6(3), SMAD7(2), SMAD9(4), SMURF1(1), SMURF2(1), SP1(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6), THBS1(7), THBS2(6), THBS3(4), THBS4(3), TNF(1), ZFYVE16(6), ZFYVE9(1) 16638882 239 59 236 99 86 66 14 39 32 2 0.636 1.000 1.000 332 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL1(2), ABL2(3), AKT1(2), AKT2(2), AKT3(3), ARAF(5), BAD(1), BRAF(5), BTC(1), CAMK2A(1), CAMK2G(4), CBL(1), CBLB(2), CBLC(1), CDKN1A(1), CRK(1), EGF(4), EGFR(7), EIF4EBP1(1), ELK1(2), ERBB2(5), ERBB3(16), ERBB4(16), EREG(2), GAB1(1), GRB2(1), GSK3B(2), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K4(5), MAP2K7(12), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(3), NCK1(3), NCK2(2), NRAS(1), NRG1(5), NRG2(4), NRG3(9), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLCG1(10), PLCG2(6), PRKCG(4), PTK2(7), RAF1(5), RPS6KB1(2), RPS6KB2(2), SHC1(3), SHC2(2), SHC3(4), SOS1(3), SOS2(3), STAT5A(1), STAT5B(2), TGFA(2) 17333506 257 58 250 100 81 80 10 53 33 0 0.495 1.000 1.000 333 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(2), CCKBR(4), CCR2(2), CCR3(4), CCR5(1), CELSR1(12), CELSR2(15), CELSR3(12), CHRM2(6), CHRM3(5), CIDEB(1), DRD4(1), EDNRA(1), EMR2(1), EMR3(3), F2R(1), FSHR(12), GNRHR(3), GPR116(11), GPR132(1), GPR133(7), GPR135(6), GPR143(1), GPR17(1), GPR55(5), GPR56(1), GPR61(3), GPR84(1), GRM1(17), GRPR(2), HRH4(1), LGR6(4), LPHN2(9), LPHN3(10), LTB4R2(2), NTSR1(4), OR2M4(1), OR8G2(3), P2RY13(3), PTGFR(3), SMO(6), SSTR2(2), TAAR5(2), TSHR(6), VN1R1(3) 11443507 201 57 199 60 60 63 10 56 12 0 0.0215 1.000 1.000 334 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(3), ABCA10(9), ABCA12(18), ABCA13(24), ABCA2(3), ABCA3(7), ABCA4(6), ABCA5(4), ABCA6(3), ABCA7(3), ABCA8(6), ABCA9(7), ABCB1(8), ABCB10(7), ABCB11(4), ABCB4(9), ABCB5(5), ABCB6(3), ABCB7(1), ABCB8(4), ABCB9(2), ABCC1(3), ABCC10(3), ABCC11(10), ABCC12(7), ABCC2(8), ABCC3(6), ABCC4(6), ABCC5(4), ABCC6(5), ABCC8(7), ABCC9(17), ABCD1(2), ABCD2(2), ABCD3(3), ABCD4(4), ABCG1(2), ABCG2(2), ABCG4(3), ABCG5(1), ABCG8(3), CFTR(2), TAP1(3), TAP2(6) 20540815 245 57 244 99 73 82 10 54 26 0 0.479 1.000 1.000 335 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(2), AKT2(2), AKT3(3), CASP8(5), CCL5(1), CD14(1), CD40(1), CD80(1), CD86(1), CXCL9(1), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), IFNAR1(4), IFNAR2(4), IFNB1(2), IKBKB(3), IKBKE(5), IL12B(1), IL1B(1), IL8(1), IRAK1(4), IRAK4(2), IRF5(2), IRF7(1), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAP3K7(6), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(3), MYD88(1), NFKB1(5), NFKB2(3), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), RELA(1), SPP1(1), STAT1(4), TBK1(2), TICAM1(5), TIRAP(2), TLR1(4), TLR2(1), TLR3(2), TLR4(11), TLR5(3), TLR6(1), TLR7(3), TLR8(6), TLR9(10), TNF(1), TOLLIP(1), TRAF3(2), TRAF6(4) 15138171 209 57 203 76 64 57 10 52 26 0 0.370 1.000 1.000 336 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(2), BDKRB2(2), CALM1(1), CALM2(2), CALM3(1), CAV1(2), CHRM1(2), CHRNA1(3), FLT1(5), FLT4(6), KDR(4), NOS3(3), PDE2A(6), PDE3A(6), PDE3B(8), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKG1(6), PRKG2(6), RYR2(35), SLC7A1(2) 7085873 116 56 116 47 33 38 5 34 6 0 0.486 1.000 1.000 337 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(13), CCNA1(4), CCNB1(1), CCND1(1), CCND3(2), CCNE1(3), CCNE2(1), CCNH(1), CDC25A(2), CDK2(2), CDKN1A(1), CDKN2A(3), CDKN2D(1), CREB3(2), CREB3L1(2), CREB3L3(3), E2F2(2), E2F3(1), E2F5(1), GBA2(1), MCM2(8), MCM3(1), MCM4(6), MCM5(6), MCM7(4), MDM2(3), MNAT1(2), MYT1(9), NACA(1), ORC1L(6), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(2), POLE(12), POLE2(1), PRIM1(1), RB1(7), RBL1(3), RPA1(1), RPA2(1), RPA3(1), TFDP1(2), TFDP2(2), TNXB(22) 13173952 162 55 160 72 62 46 6 33 14 1 0.781 1.000 1.000 338 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), AK3(4), CAD(5), CANT1(3), CTPS(1), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(10), DPYS(1), DUT(1), ENTPD1(3), ENTPD3(3), ENTPD4(6), ENTPD6(1), ENTPD8(4), NME6(2), NME7(1), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT2(2), PNPT1(2), POLA1(4), POLA2(2), POLD1(7), POLD3(1), POLE(12), POLE2(1), POLE3(1), POLE4(1), POLR1A(5), POLR1C(2), POLR1D(1), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(10), POLR3B(3), POLR3G(1), POLR3K(1), PRIM1(1), PRIM2(3), RRM1(3), RRM2(2), RRM2B(2), TK1(1), TK2(3), TXNRD1(4), TXNRD2(2), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UPB1(1), UPP2(4), UPRT(1) 14069749 167 54 167 53 57 51 7 32 20 0 0.0815 1.000 1.000 339 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR2(2), AKT1(2), AKT2(2), AKT3(3), ANGPTL2(4), ARHGAP4(2), ARHGEF11(10), BTK(2), CDC42(1), CFL1(1), GDI1(1), INPPL1(12), ITPR1(17), ITPR2(14), ITPR3(16), LIMK1(3), MYLK(7), MYLK2(2), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PDK1(1), PIK3CD(8), PIK3CG(9), PIK3R1(5), PITX2(2), PPP1R13B(5), PTEN(8), RACGAP1(2), RHO(2), ROCK1(7), ROCK2(2), WASF1(3), WASL(1) 11827107 174 54 172 56 64 49 10 28 23 0 0.102 1.000 1.000 340 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(19), AXIN1(7), CCND1(1), CCND3(2), CSNK1E(6), CTNNB1(10), DVL1(2), DVL2(2), DVL3(4), FBXW2(2), FZD1(5), FZD10(7), FZD2(2), FZD3(4), FZD5(1), FZD6(5), FZD7(1), FZD8(2), GSK3B(2), JUN(2), LDLR(4), MAPK10(1), MAPK9(3), PAFAH1B1(3), PLAU(2), PPP2R5C(1), PPP2R5E(4), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCI(5), PRKCQ(2), PRKD1(4), SFRP4(2), TCF7(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(4), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2) 10273823 170 54 167 72 59 33 8 39 28 3 0.668 1.000 1.000 341 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(5), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A3(5), ALDH3A1(3), ALDH3B2(4), AOC2(4), AOC3(3), AOX1(2), CARM1(2), COMT(3), DBH(1), DCT(6), DDC(3), ESCO2(1), FAH(1), GOT1(1), GOT2(2), GSTZ1(3), HGD(2), HPD(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(3), METTL6(1), MYST3(8), MYST4(10), NAT6(2), PNMT(3), PNPLA3(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), SH3GLB1(1), TAT(1), TH(1), TPO(13), TYR(3), TYRP1(5), WBSCR22(2) 10298224 144 53 143 39 39 40 4 42 18 1 0.0359 1.000 1.000 342 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(2), BMP4(4), BMP5(6), BMP6(5), BMP7(2), BMP8B(1), BTRC(3), CSNK1A1L(2), CSNK1E(6), CSNK1G1(1), CSNK1G2(2), CSNK1G3(4), DHH(3), FBXW11(5), GLI1(8), GLI2(6), GLI3(15), GSK3B(2), HHIP(5), IHH(2), LRP2(31), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), PTCH1(8), PTCH2(4), SMO(6), STK36(8), SUFU(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(4), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(1), WNT9B(2) 10422597 190 53 189 69 73 53 8 36 20 0 0.273 1.000 1.000 343 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(2), ADCY4(3), ADCY6(5), ADCY8(10), CACNA1A(9), CACNA1B(11), GNAS(11), GNAT3(2), GRM4(2), ITPR3(16), KCNB1(4), PDE1A(3), PLCB2(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), SCNN1A(2), SCNN1B(5), SCNN1G(3), TAS1R1(4), TAS1R2(3), TAS1R3(5), TAS2R1(1), TAS2R10(1), TAS2R13(2), TAS2R16(3), TAS2R3(2), TAS2R38(3), TAS2R39(3), TAS2R4(2), TAS2R40(2), TAS2R43(1), TAS2R60(3), TAS2R7(2), TAS2R8(1), TAS2R9(2), TRPM5(2) 9857252 141 53 141 61 48 45 6 34 8 0 0.680 1.000 1.000 344 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(4), AR(7), ESR1(4), ESR2(5), HNF4A(5), NR0B1(2), NR1D1(2), NR1D2(3), NR1H2(4), NR1H3(2), NR1I2(3), NR1I3(3), NR2C2(2), NR2F1(3), NR2F2(3), NR2F6(2), NR3C1(4), NR4A1(1), NR4A2(4), NR5A1(5), PGR(6), PPARA(3), PPARD(4), PPARG(1), RARA(1), RARB(5), ROR1(5), RORA(2), RORC(3), RXRA(2), RXRG(3), THRA(2), THRB(3), VDR(3) 7251766 111 53 110 44 38 20 7 34 12 0 0.626 1.000 1.000 345 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 FN3K(2), IMPA1(3), INPP4A(1), INPP4B(3), INPP5A(3), INPP5B(2), INPP5E(2), INPPL1(12), IPMK(1), ISYNA1(2), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), MINPP1(3), OCRL(4), PI4KA(9), PI4KB(3), PIK3C3(6), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLCD1(1), PLCD3(6), PLCE1(8), PLCG1(10), PLCG2(6), PLCZ1(2), PTEN(8), SYNJ1(3), SYNJ2(9) 12462707 177 52 174 51 64 60 1 32 19 1 0.0210 1.000 1.000 346 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(1), AKT1(2), AKT2(2), AKT3(3), APAF1(2), ATM(13), BAD(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(5), CASP9(1), CSF2RB(4), DFFA(2), DFFB(2), ENDOG(1), FAS(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(3), IL3(1), IL3RA(4), IRAK1(4), IRAK2(4), IRAK3(2), IRAK4(2), MAP3K14(2), MYD88(1), NFKB1(5), NFKB2(3), NTRK1(3), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RELA(1), TNF(1), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF1A(2), TNFSF10(2), TRAF2(2) 13957533 168 52 164 57 54 52 5 36 20 1 0.266 1.000 1.000 347 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ADAM17(3), ATP6AP1(3), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), CASP3(1), CCL5(1), CDC42(1), CSK(2), EGFR(7), GIT1(2), IGSF5(2), IKBKB(3), IL8(1), JAM3(2), JUN(2), LYN(2), MAP2K4(5), MAP3K14(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK8(3), MAPK9(3), MET(4), NFKB1(5), NFKB2(3), NOD1(6), PAK1(4), PLCG1(10), PLCG2(6), PTPN11(4), PTPRZ1(13), RELA(1), TCIRG1(4), TJP1(6) 12155383 151 52 150 62 36 47 5 46 17 0 0.738 1.000 1.000 348 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(2), CDC40(4), CLK2(5), CLK3(5), CLK4(2), COL2A1(8), CPSF1(9), CPSF2(2), CPSF3(1), CPSF4(2), CSTF1(4), CSTF2(3), CSTF2T(2), CSTF3(4), DDIT3(3), DDX1(2), DDX20(3), DHX15(8), DHX16(4), DHX38(7), DHX8(4), DHX9(1), DICER1(3), DNAJC8(1), GIPC1(2), METTL3(1), NCBP1(4), NUDT21(1), NXF1(2), PABPN1(2), PAPOLA(2), PHF5A(1), POLR2A(8), PPM1G(2), PRPF3(2), PRPF4(3), PRPF4B(9), PRPF8(9), PSKH1(4), PTBP1(4), PTBP2(1), RBM5(2), RNGTT(1), RNMT(3), SF3A1(2), SF3A2(1), SF3A3(2), SF3B1(4), SF3B2(4), SF3B4(3), SF4(3), SFRS12(3), SFRS14(6), SFRS16(2), SFRS4(2), SFRS5(3), SFRS6(4), SFRS7(2), SFRS8(7), SFRS9(1), SNRPA(4), SNRPA1(2), SNRPB(1), SNRPD1(2), SNRPD2(2), SNRPD3(1), SNRPE(1), SNRPG(1), SNRPN(3), SPOP(2), SRPK1(2), SRPK2(4), SRRM1(3), SUPT5H(6), U2AF1(1), U2AF2(2), XRN2(10) 18250315 248 52 248 77 91 70 14 50 23 0 0.149 1.000 1.000 349 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR1(1), AGTR2(1), ATP8A1(5), AVPR1A(6), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), CCKAR(1), CCKBR(4), CCR1(2), CCR10(1), CCR2(2), CCR3(4), CCR5(1), CCR8(1), CX3CR1(3), CXCR6(1), EDNRA(1), FPR1(1), FSHR(12), GALR1(2), GALR2(1), GALR3(1), GALT(1), GHSR(3), GNRHR(3), GRPR(2), LHCGR(7), MC2R(2), MC3R(2), MC4R(4), MC5R(5), NPY1R(1), NPY2R(1), NTSR1(4), OPRD1(2), OPRK1(3), OXTR(4), PPYR1(5), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(6), TACR1(3), TACR2(1), TACR3(6), TRHR(3), TSHR(6) 8852875 146 52 145 49 51 56 3 29 7 0 0.0314 1.000 1.000 350 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(5), CREB1(4), DAXX(3), ELK1(2), GRB2(1), IKBKB(3), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAP3K1(6), MAP3K10(6), MAP3K11(2), MAP3K12(4), MAP3K13(3), MAP3K14(2), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAP3K5(3), MAP3K6(5), MAP3K7(6), MAP3K9(5), MAP4K1(2), MAP4K2(3), MAP4K3(1), MAP4K4(4), MAP4K5(3), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(4), MAPK6(1), MAPK7(6), MAPK8(3), MAPK9(3), MAPKAPK3(1), MAPKAPK5(2), MAX(1), MEF2B(3), MEF2C(2), MEF2D(5), MKNK1(1), NFKB1(5), PAK1(4), PAK2(5), RAF1(5), RELA(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA4(2), RPS6KB1(2), RPS6KB2(2), SHC1(3), SP1(3), STAT1(4), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TRAF2(2) 16528534 211 51 209 75 76 60 6 37 32 0 0.305 1.000 1.000 351 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT1(2), AKT2(2), AKT3(3), BCR(6), BTK(2), CD19(1), CDKN2A(3), FLOT1(1), FLOT2(3), GAB1(1), ITPR1(17), ITPR2(14), ITPR3(16), LYN(2), NR0B2(1), PDK1(1), PHF11(1), PITX2(2), PLCG2(6), PPP1R13B(5), PREX1(8), PTEN(8), PTPRC(14), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KB1(2), SYK(3), TEC(3), VAV1(6) 9251991 146 51 145 50 52 40 5 31 18 0 0.250 1.000 1.000 352 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(2), BAG4(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(2), CASP3(1), CASP6(1), CASP7(2), CASP8(5), CASP9(1), DAXX(3), DFFA(2), DFFB(2), GSN(5), LMNA(5), LMNB1(1), LMNB2(2), MAP2K7(12), MAP3K1(6), MAP3K14(2), MAP3K5(3), MAPK8(3), MDM2(3), NFKB1(5), NUMA1(10), PAK2(5), PRKCD(3), PRKDC(19), PSEN1(1), PSEN2(2), PTK2(7), RASA1(9), RB1(7), RELA(1), SPTAN1(10), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(2), TRAF2(2) 12066271 158 50 156 51 52 48 8 26 23 1 0.123 1.000 1.000 353 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 63 APAF1(2), ATM(13), ATR(5), BAI1(5), BID(1), CASP3(1), CASP8(5), CASP9(1), CCNB1(1), CCNB2(1), CCNB3(6), CCND1(1), CCND3(2), CCNE1(3), CCNE2(1), CD82(1), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(3), CHEK1(1), CHEK2(5), DDB2(1), FAS(2), GTSE1(2), IGF1(2), IGFBP3(4), LRDD(4), MDM2(3), MDM4(3), PERP(2), PPM1D(3), PTEN(8), RFWD2(3), RPRM(3), RRM2(2), RRM2B(2), SERPINB5(1), SERPINE1(2), SESN1(1), SESN2(1), SESN3(2), SIAH1(1), STEAP3(4), THBS1(7), TNFRSF10B(2), TP73(1), TSC2(3), ZMAT3(2) 11153952 136 50 135 54 42 44 5 26 18 1 0.599 1.000 1.000 354 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(5), CPEB1(2), EGFR(7), ERBB2(5), ERBB4(16), ETS1(4), ETS2(1), ETV6(2), ETV7(1), FMN2(9), GRB2(1), MAP2K1(2), MAPK1(2), MAPK3(1), NOTCH1(12), NOTCH2(8), NOTCH3(8), NOTCH4(6), PIWIL1(4), PIWIL2(4), PIWIL3(1), PIWIL4(2), RAF1(5), SOS1(3), SOS2(3), SPIRE1(2), SPIRE2(1) 8912689 117 50 115 54 43 33 4 27 10 0 0.836 1.000 1.000 355 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(10), ACSL1(2), ACSL3(5), ACSL4(2), ACSL5(2), ACSL6(4), ADIPOQ(2), ADIPOR1(2), ADIPOR2(2), AGRP(1), AKT1(2), AKT2(2), AKT3(3), CAMKK1(3), CD36(2), CPT1A(4), CPT1B(3), CPT1C(2), CPT2(4), IKBKB(3), IRS1(6), IRS2(3), IRS4(9), JAK1(2), JAK2(8), JAK3(3), LEPR(6), MAPK10(1), MAPK8(3), MAPK9(3), NFKB1(5), NFKB2(3), NFKBIB(4), NPY(1), PCK1(2), PCK2(5), POMC(5), PPARA(3), PPARGC1A(4), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2), PRKAG3(2), PRKCQ(2), PTPN11(4), RELA(1), RXRA(2), RXRG(3), SLC2A1(3), SLC2A4(1), SOCS3(3), STAT3(6), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2), TYK2(4) 14327176 182 50 182 71 65 42 6 44 24 1 0.578 1.000 1.000 356 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(2), AKT2(2), AKT3(3), BRD4(5), CAP1(1), CBL(1), CDC42(1), CDKN2A(3), F2RL2(1), FLOT1(1), FLOT2(3), GRB2(1), GSK3A(1), GSK3B(2), IGFBP1(2), INPPL1(12), IRS1(6), IRS2(3), IRS4(9), LNPEP(8), MAPK1(2), MAPK3(1), PARD3(8), PDK1(1), PIK3CD(8), PIK3R1(5), PPYR1(5), PTEN(8), RAF1(5), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KB1(2), SERPINB6(3), SHC1(3), SLC2A4(1), SORBS1(5), SOS1(3), SOS2(3), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 9888332 147 50 145 52 62 46 1 19 19 0 0.257 1.000 1.000 357 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(2), AKT3(3), ASAH1(2), BRAF(5), DAG1(5), DRD2(5), EGFR(7), EPHB2(6), GRB2(1), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), KCNJ3(5), KCNJ5(2), MAPK1(2), PI3(1), PIK3CB(5), PITX2(2), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), RAF1(5), RGS20(1), SHC1(3), SOS1(3), SOS2(3), STAT3(6), TERF2IP(3) 10170656 157 50 157 53 52 50 5 33 16 1 0.204 1.000 1.000 358 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(2), AKT3(3), ANKRD6(1), APC(19), AXIN1(7), AXIN2(3), CER1(2), CTNNB1(10), DACT1(4), DKK1(4), DKK2(2), DKK3(1), DKK4(1), DVL1(2), GSK3A(1), GSK3B(2), LRP1(18), MVP(2), NKD1(5), NKD2(1), PIN1(1), PSEN1(1), PTPRA(4), SENP2(2), SFRP1(2), TSHB(1), WIF1(2) 6992327 105 50 103 38 34 33 2 21 13 2 0.453 1.000 1.000 359 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(4), APC(19), AXIN1(7), BMP10(2), BMP2(2), BMP4(4), BMP5(6), BMP7(2), BMPR1A(1), BMPR2(10), CHRD(1), CTNNB1(10), DVL1(2), FZD1(5), GATA4(3), GSK3B(2), MAP3K7(6), MEF2C(2), MYL2(1), NKX2-5(2), NPPA(1), NPPB(1), RFC1(1), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6), TGFBR3(2), WNT1(3) 6284674 119 49 116 38 30 30 5 31 19 4 0.413 1.000 1.000 360 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(3), ALPP(4), ALPPL2(4), ASCC3(16), ATP13A2(5), DDX18(7), DDX19A(2), DDX23(5), DDX4(2), DDX41(6), DDX47(1), DDX50(2), DDX51(2), DDX54(6), DDX55(3), DDX56(4), DHX58(4), ENTPD7(8), EP400(17), ERCC2(4), ERCC3(3), FPGS(1), GGH(1), IFIH1(2), MOV10L1(3), NUDT8(1), QDPR(1), RAD54B(3), RAD54L(2), RUVBL2(2), SETX(8), SKIV2L2(3), SMARCA2(12), SMARCA5(1), SPR(2) 10858822 153 49 153 54 64 41 5 26 17 0 0.331 1.000 1.000 361 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(1), ACADM(1), ACOX1(2), ACOX2(4), ACOX3(4), ACSL1(2), ACSL3(5), ACSL4(2), ACSL5(2), ACSL6(4), ADIPOQ(2), ANGPTL4(2), APOA1(2), APOA5(5), AQP7(1), CD36(2), CPT1A(4), CPT1B(3), CPT1C(2), CPT2(4), CYP27A1(1), CYP4A11(1), CYP4A22(1), CYP7A1(3), CYP8B1(4), DBI(1), EHHADH(2), FABP3(1), FABP5(2), FABP6(3), FABP7(1), FADS2(3), GK(2), GK2(1), HMGCS2(1), ILK(1), LPL(2), ME1(2), MMP1(2), NR1H3(2), OLR1(1), PCK1(2), PCK2(5), PDPK1(1), PLTP(1), PPARA(3), PPARD(4), PPARG(1), RXRA(2), RXRG(3), SCD(1), SCP2(3), SLC27A1(2), SLC27A2(2), SLC27A4(3), SLC27A5(4), SLC27A6(3), SORBS1(5), UBC(3) 11337128 139 49 139 40 49 32 9 35 14 0 0.0435 1.000 1.000 362 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(2), ACTB(4), ARHGEF2(4), CD14(1), CDC42(1), CLDN1(1), CTNNB1(10), CTTN(2), FYN(5), HCLS1(1), ITGB1(4), KRT18(2), NCK1(3), NCK2(2), NCL(6), OCLN(1), ROCK1(7), ROCK2(2), TLR4(11), TLR5(3), TUBA1B(1), TUBA1C(2), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA8(3), TUBAL3(3), TUBB1(2), TUBB2A(2), TUBB2C(2), TUBB3(7), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2), WASL(1), YWHAQ(1), YWHAZ(1) 8742523 118 49 114 49 37 36 4 33 8 0 0.688 1.000 1.000 363 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(2), ACTB(4), ARHGEF2(4), CD14(1), CDC42(1), CLDN1(1), CTNNB1(10), CTTN(2), FYN(5), HCLS1(1), ITGB1(4), KRT18(2), NCK1(3), NCK2(2), NCL(6), OCLN(1), ROCK1(7), ROCK2(2), TLR4(11), TLR5(3), TUBA1B(1), TUBA1C(2), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA8(3), TUBAL3(3), TUBB1(2), TUBB2A(2), TUBB2C(2), TUBB3(7), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2), WASL(1), YWHAQ(1), YWHAZ(1) 8742523 118 49 114 49 37 36 4 33 8 0 0.688 1.000 1.000 364 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(19), AXIN1(7), CREBBP(10), CTNNB1(10), DVL1(2), EP300(13), FZD1(5), GSK3B(2), HDAC1(2), LDB1(4), LEF1(4), PITX2(2), TRRAP(24), WNT1(3) 5714000 107 49 105 34 39 23 3 18 22 2 0.259 1.000 1.000 365 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(2), APOA1(2), CD36(2), CITED2(1), CPT1B(3), CREBBP(10), DUSP1(1), DUT(1), EHHADH(2), EP300(13), HSD17B4(1), HSPA1A(1), JUN(2), LPL(2), MAPK1(2), MAPK3(1), ME1(2), NCOA1(10), NCOR1(14), NCOR2(13), NR0B2(1), NR1H3(2), NR2F1(3), NRIP1(7), PDGFA(1), PIK3R1(5), PPARA(3), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PTGS2(2), RB1(7), RELA(1), RXRA(2), SP1(3), SRA1(1), STAT5A(1), STAT5B(2), TNF(1) 10554108 140 49 139 44 29 47 5 35 24 0 0.153 1.000 1.000 366 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(4), CAD(5), CANT1(3), CTPS(1), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(10), DPYS(1), DUT(1), ENTPD1(3), NT5C(1), NUDT2(2), POLD1(7), POLE(12), POLG(3), POLL(1), POLQ(13), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9), RRM1(3), RRM2(2), TK1(1), TK2(3), TXNRD1(4), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UNG(1), UPB1(1) 9906365 117 49 117 48 33 38 5 26 15 0 0.609 1.000 1.000 367 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(2), APC(19), AR(7), ASAH1(2), BRAF(5), CAMP(1), CCL15(1), DAG1(5), EGFR(7), GNA11(4), GNA15(2), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), KCNJ3(5), KCNJ5(2), MAPK1(2), MAPK10(1), MAPK14(1), PHKA2(7), PIK3CD(8), PIK3R1(5), PITX2(2), PTX3(1), RAF1(5) 8883882 149 49 147 48 49 38 10 31 19 2 0.139 1.000 1.000 368 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(1), AGT(1), AKT1(2), CALM1(1), CALM2(2), CALM3(1), CALR(3), CAMK1(1), CAMK1G(2), CAMK4(4), CREBBP(10), EDN1(3), ELSPBP1(1), F2(3), FGF2(1), GATA4(3), GSK3B(2), HAND1(3), HAND2(2), IGF1(2), LIF(1), MAP2K1(2), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(3), MEF2C(2), MYH2(10), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NKX2-5(2), NPPA(1), PIK3R1(5), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RAF1(5), RPS6KB1(2) 8368382 128 48 128 45 39 42 6 21 20 0 0.229 1.000 1.000 369 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(2), AKT2(2), AKT3(3), BAD(1), BCL2(1), BCR(6), BLNK(2), BTK(2), CD19(1), CD22(1), CD81(3), CR2(4), CSK(2), DAG1(5), FLOT1(1), FLOT2(3), GRB2(1), GSK3A(1), GSK3B(2), INPP5D(1), ITPR1(17), ITPR2(14), ITPR3(16), LYN(2), MAP4K1(2), MAPK1(2), MAPK3(1), NFATC1(8), NFATC2(6), NR0B2(1), PDK1(1), PIK3CD(8), PIK3R1(5), PLCG2(6), PPP1R13B(5), PPP3CA(3), PPP3CB(1), PTPRC(14), RAF1(5), SHC1(3), SOS1(3), SOS2(3), SYK(3), VAV1(6) 12480566 179 48 176 55 62 56 5 34 22 0 0.0519 1.000 1.000 370 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CSK(2), CTLA4(3), DAG1(5), EPHB2(6), FBXW7(8), GRAP2(1), GRB2(1), ITK(4), ITPKA(1), ITPKB(5), LCP2(5), MAPK1(2), NCK1(3), NFAT5(4), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PLCG1(10), PTPRC(14), RAF1(5), RASGRP1(4), RASGRP2(4), RASGRP3(2), RASGRP4(3), SOS1(3), SOS2(3), VAV1(6), ZAP70(2) 9698460 143 48 139 54 42 39 5 36 20 1 0.590 1.000 1.000 371 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), AGK(2), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), AKR1B1(5), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), CEL(6), DAK(3), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKI(5), DGKQ(1), DGKZ(1), GK(2), GK2(1), GLB1(2), GPAM(4), LCT(7), LIPA(1), LIPC(2), LIPF(1), LIPG(2), LPL(2), PNLIP(1), PNLIPRP1(2), PNLIPRP2(2), PNPLA3(1), PPAP2C(4) 10193044 118 47 117 46 33 43 2 25 15 0 0.382 1.000 1.000 372 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(2), AKT2(2), AKT3(3), BAD(1), CASP9(1), CDC42(1), KDR(4), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK3(1), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NOS3(3), NRAS(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCG1(10), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKCG(4), PTGS2(2), PTK2(7), PXN(1), RAC2(1), RAC3(1), RAF1(5), SH2D2A(2), SHC2(2), SPHK1(3) 11965424 159 47 156 59 56 53 6 29 15 0 0.278 1.000 1.000 373 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(2), AKT2(2), AKT3(3), BLNK(2), BTK(2), CARD11(9), CD19(1), CD22(1), CD79A(5), CD81(3), CR2(4), FCGR2B(1), GSK3B(2), IFITM1(1), IKBKB(3), INPP5D(1), JUN(2), LILRB3(2), LYN(2), MALT1(4), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NFKB1(5), NFKB2(3), NFKBIB(4), NRAS(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PTPN6(3), RAC2(1), RAC3(1), RASGRP3(2), SYK(3), VAV1(6), VAV2(8), VAV3(6) 12453499 171 47 170 69 58 59 3 31 20 0 0.496 1.000 1.000 374 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(2), AKT2(2), AKT3(3), BTK(2), FYN(5), GRB2(1), IL13(1), IL3(1), INPP5D(1), LCP2(5), LYN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(3), NRAS(1), PDK1(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCG1(10), PLCG2(6), PRKCD(3), PRKCE(5), RAC2(1), RAC3(1), RAF1(5), SOS1(3), SOS2(3), SYK(3), TNF(1), VAV1(6), VAV2(8), VAV3(6) 12013988 175 47 173 63 59 59 2 40 15 0 0.296 1.000 1.000 375 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 ACTA1(1), CRK(1), DOCK1(10), ELK1(2), GAB1(1), GRB2(1), HGF(12), ITGA1(3), ITGB1(4), JUN(2), MAP2K1(2), MAP2K2(1), MAP4K1(2), MAPK1(2), MAPK3(1), MAPK8(3), MET(4), PAK1(4), PIK3R1(5), PTEN(8), PTK2(7), PTK2B(5), PTPN11(4), PXN(1), RAF1(5), RAP1A(2), RAP1B(3), RASA1(9), SOS1(3), STAT3(6) 7316569 114 47 110 38 26 34 4 27 22 1 0.344 1.000 1.000 376 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 BAK1(2), BFAR(1), BTK(2), CAD(5), CASP10(3), CASP3(1), CASP8(5), CASP8AP2(6), CD7(3), DAXX(3), DEDD(1), DEDD2(1), DFFA(2), DIABLO(1), EGFR(7), EPHB2(6), FAF1(4), FAIM2(1), HSPB1(1), IL8(1), MAP2K4(5), MAP2K7(12), MAP3K1(6), MAP3K5(3), MAPK1(2), MAPK10(1), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3), MET(4), NFAT5(4), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), NR0B2(1), PFN2(2), PTPN13(12), RALBP1(4), ROCK1(7), SMPD1(3), TPX2(3), TRAF2(2), TUFM(2) 12550449 162 47 161 61 56 47 5 35 19 0 0.398 1.000 1.000 377 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(3), AKT1(2), APC(19), ASAH1(2), CAMP(1), DAG1(5), DLG4(3), EPHB2(6), GNAI1(1), GNAQ(1), ITPR1(17), ITPR2(14), ITPR3(16), KCNJ3(5), KCNJ5(2), MAPK1(2), PITX2(2), PTX3(1), RHO(2), RYR1(27) 7983844 131 47 130 49 54 29 7 24 16 1 0.331 1.000 1.000 378 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(4), AASS(2), ACAT1(2), ACAT2(2), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), BBOX1(1), DLST(1), DOT1L(7), EHHADH(2), EHMT1(6), EHMT2(3), GCDH(3), HADH(2), HADHA(2), HSD17B4(1), HSD3B7(3), NSD1(10), OGDH(6), OGDHL(3), PIPOX(2), PLOD1(5), PLOD2(3), PLOD3(4), RDH11(1), RDH12(1), SETD1A(6), SETDB1(8), SHMT1(1), SHMT2(3), SPCS3(1), SUV39H1(4), SUV39H2(1), TMLHE(3) 10026846 122 46 120 42 36 42 5 21 18 0 0.204 1.000 1.000 379 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(3), B3GALNT1(1), B3GALT1(2), B3GALT2(5), B3GALT4(2), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALNT1(1), B4GALT1(2), B4GALT2(5), B4GALT4(3), B4GALT6(1), FUT1(1), FUT4(1), FUT7(1), FUT9(2), PIGA(1), PIGB(4), PIGC(2), PIGG(5), PIGK(1), PIGL(1), PIGM(4), PIGN(2), PIGO(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGX(2), PIGZ(2), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3), ST3GAL5(1), ST3GAL6(2), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(2) 8396053 94 46 93 38 35 29 3 21 5 1 0.513 1.000 1.000 380 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(3), ACTN2(11), ACTN3(1), BCAR1(4), BCR(6), CAPN1(2), CAPNS1(1), CAPNS2(1), CAV1(2), CSK(2), FYN(5), GRB2(1), ITGA1(3), ITGB1(4), JUN(2), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(3), PPP1R12B(6), PTK2(7), PXN(1), RAF1(5), RAP1A(2), ROCK1(7), SHC1(3), SOS1(3), TLN1(11), VCL(2), ZYX(2) 8123235 107 46 105 45 38 30 3 26 10 0 0.708 1.000 1.000 381 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(13), BMPR1B(2), DMC1(1), EGR1(3), ESR2(5), FSHR(12), GJA4(3), INHA(2), LHCGR(7), MLH1(3), MSH5(3), NCOR1(14), NR5A1(5), NRIP1(7), PGR(6), PRLR(1), PTGER2(2), SMPD1(3), VDR(3), ZP2(4) 6056457 99 46 96 31 26 34 5 22 11 1 0.168 1.000 1.000 382 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(8), ATP4A(5), ATP4B(1), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), ATP5L(1), ATP6AP1(3), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), COX10(1), COX15(3), COX4I1(3), COX4I2(1), COX6B1(1), COX7A2(2), COX7C(1), LHPP(2), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA3(1), NDUFA6(1), NDUFA8(1), NDUFA9(2), NDUFAB1(1), NDUFB2(1), NDUFB7(1), NDUFB8(1), NDUFB9(1), NDUFC2(2), NDUFS1(4), NDUFS2(2), NDUFS6(1), NDUFS7(1), NDUFS8(3), NDUFV1(1), PPA2(1), SDHA(5), SDHB(3), SDHC(1), TCIRG1(4), UQCRB(1), UQCRC1(2), UQCRC2(2), UQCRFS1(1), UQCRQ(1) 9640904 123 45 123 58 36 45 5 30 7 0 0.876 1.000 1.000 383 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6), AGPAT1(1), AGPAT3(2), AGPAT4(5), AKR1B1(5), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), CEL(6), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKQ(1), DGKZ(1), GK(2), GLB1(2), LCT(7), LIPC(2), LIPF(1), LIPG(2), LPL(2), PNLIP(1), PNLIPRP1(2), PNLIPRP2(2), PPAP2C(4) 8378947 105 44 104 48 32 36 1 22 14 0 0.724 1.000 1.000 384 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(5), AGXT(1), AGXT2(5), ALAS1(1), ALAS2(4), AMT(4), AOC2(4), AOC3(3), BHMT(3), CBS(3), CHDH(3), CHKA(1), CHKB(2), CPT1B(3), CTH(2), DAO(5), DLD(2), DMGDH(5), GARS(1), GATM(2), GCAT(2), GLDC(5), MAOA(1), MAOB(3), PEMT(1), PISD(4), PLCB2(3), PLCG1(10), PLCG2(6), PSPH(2), SARDH(4), SARS(2), SHMT1(1), SHMT2(3), TARS(4) 7269557 110 44 109 39 31 26 7 33 13 0 0.449 1.000 1.000 385 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(7), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), CDS1(3), CDS2(1), CHAT(1), CHKA(1), CHKB(2), CHPT1(1), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKI(5), DGKQ(1), DGKZ(1), ESCO2(1), ETNK2(1), GNPAT(1), GPAM(4), GPD1(3), GPD1L(3), GPD2(3), LCAT(1), LYPLA2(1), MYST3(8), MYST4(10), NAT6(2), PCYT1A(7), PCYT1B(3), PEMT(1), PISD(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLD1(7), PLD2(10), PNPLA3(1), PPAP2C(4), PTDSS1(1), PTDSS2(2), SH3GLB1(1) 11319685 145 44 144 51 52 48 6 28 11 0 0.183 1.000 1.000 386 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(2), AKT2(2), AKT3(3), BRAF(5), EIF4B(2), EIF4EBP1(1), HIF1A(2), IGF1(2), MAPK1(2), MAPK3(1), PDPK1(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PRKAA1(1), PRKAA2(2), RHEB(1), RICTOR(8), RPS6(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA6(7), RPS6KB1(2), RPS6KB2(2), TSC1(3), TSC2(3), ULK1(9), ULK2(4), VEGFC(3) 8827821 117 44 116 50 47 33 6 21 10 0 0.747 1.000 1.000 387 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(2), BAD(1), BCL2(1), CASP1(1), CASP10(3), CASP2(2), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(5), CASP9(1), CD40(1), CD40LG(4), DAXX(3), DFFA(2), DFFB(2), FAS(2), IKBKE(5), LTA(2), NFKB1(5), NGFR(4), NR3C1(4), NTRK1(3), PTPN13(12), SFRS2IP(5), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(2), TRAF2(2), TRAF3(2), TRAF6(4) 7575765 90 43 90 36 20 28 8 26 8 0 0.654 1.000 1.000 388 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(7), CARM1(2), CCND1(1), CREBBP(10), EP300(13), ERCC3(3), ESR1(4), GRIP1(5), GTF2A1(2), GTF2E1(4), GTF2F1(1), HDAC1(2), HDAC2(2), HDAC3(3), HDAC4(7), HDAC5(4), HDAC6(1), MEF2C(2), NCOR2(13), NR0B1(2), NRIP1(7), PELP1(5), POLR2A(8), SRA1(1), TBP(1) 7956617 110 43 109 33 36 30 4 22 18 0 0.104 1.000 1.000 389 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(4), ABAT(3), ACY3(1), ADSL(2), ADSS(3), ADSSL1(6), AGXT(1), AGXT2(5), ASL(3), ASNS(3), ASRGL1(1), ASS1(4), CAD(5), CRAT(3), DARS(1), DDO(2), DLAT(3), DLD(2), GAD1(3), GAD2(3), GOT1(1), GOT2(2), GPT2(2), NARS(3), PC(5), PDHA1(1), PDHA2(4), PDHB(2) 6539234 80 43 79 33 33 21 1 22 3 0 0.643 1.000 1.000 390 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(4), AANAT(1), ABP1(5), ACAT1(2), ACAT2(2), ACMSD(2), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), AOC2(4), AOC3(3), AOX1(2), ASMT(1), CARM1(2), CAT(4), CYP1A1(1), CYP1A2(3), CYP1B1(2), DDC(3), EHHADH(2), GCDH(3), HADH(2), HADHA(2), HSD17B4(1), INMT(1), KYNU(6), LCMT1(1), LCMT2(6), LNX1(4), MAOA(1), MAOB(3), METTL6(1), NFX1(1), OGDH(6), OGDHL(3), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), TDO2(2), TPH1(1), TPH2(1), WARS(3), WARS2(5), WBSCR22(2) 10475349 130 43 126 41 32 42 8 26 21 1 0.105 1.000 1.000 391 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(2), AKT2(2), AKT3(3), BAD(1), BCR(6), BLNK(2), BTK(2), CD19(1), CSK(2), DAG1(5), EPHB2(6), GRB2(1), ITPKA(1), ITPKB(5), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(2), NFAT5(4), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PI3(1), PIK3CD(8), PIK3R1(5), PLCG2(6), PPP1R13B(5), RAF1(5), SERPINA4(2), SHC1(3), SOS1(3), SOS2(3), SYK(3), VAV1(6) 8746556 118 43 117 37 38 37 1 22 19 1 0.173 1.000 1.000 392 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(6), AKT1(2), AKT2(2), AKT3(3), DAG1(5), GNAQ(1), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PDK1(1), PHKA2(7), PIK3CB(5), PITX2(2), PLD1(7), PLD2(10), PLD3(5), VN1R1(3) 7798475 130 43 130 37 41 39 8 29 12 1 0.0550 1.000 1.000 393 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(7), AMY2A(2), AMY2B(3), ENPP1(1), ENPP3(2), GAA(2), GANAB(3), GBA3(1), GBE1(2), GCK(3), GPI(4), GUSB(2), GYS1(4), GYS2(2), HK1(5), HK2(5), HK3(3), MGAM(6), PGM1(2), PGM3(6), PYGB(4), PYGL(3), PYGM(5), SI(10), UCHL1(2), UCHL3(3), UGDH(4), UGT1A1(1), UGT1A5(3), UGT2B15(1), UGT2B4(2), UXS1(3) 9913319 106 43 106 36 30 38 3 16 19 0 0.238 1.000 1.000 394 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(1), CASP2(2), CASP3(1), CASP8(5), DFFA(2), DFFB(2), JUN(2), LMNA(5), LMNB1(1), LMNB2(2), MADD(4), MAP2K4(5), MAP3K1(6), MAP3K7(6), MAPK8(3), PAK1(4), PAK2(5), PRKDC(19), RB1(7), SPTAN1(10), TNF(1), TNFRSF1A(2), TRAF2(2) 6797948 97 43 96 32 26 33 4 20 14 0 0.220 1.000 1.000 395 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 42 ABP1(5), AGMAT(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH4A1(2), ALDH9A1(3), AMD1(2), AOC2(4), AOC3(3), ARG1(2), ASL(3), CKB(1), CKMT1A(2), CKMT1B(2), CKMT2(4), DAO(5), GATM(2), GLUD1(4), GOT1(1), GOT2(2), MAOA(1), MAOB(3), NOS1(15), NOS3(3), ODC1(2), OTC(2), P4HA1(1), P4HA2(6), P4HA3(1), P4HB(2), PYCR1(2), RARS(2), SMS(2) 7108737 114 42 113 34 43 32 3 26 10 0 0.0743 1.000 1.000 396 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(5), DAXX(3), DFFA(2), DFFB(2), FAF1(4), JUN(2), LMNA(5), LMNB1(1), LMNB2(2), MAP2K4(5), MAP3K1(6), MAP3K7(6), MAPK8(3), PAK1(4), PAK2(5), PRKDC(19), PTPN13(12), RB1(7), RIPK2(1), SPTAN1(10) 7204437 111 42 110 33 26 39 4 24 18 0 0.145 1.000 1.000 397 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(6), ACSS2(3), ACYP2(1), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(3), ALDOB(2), ALDOC(2), BPGM(1), DLAT(3), DLD(2), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(3), GALM(1), GAPDH(1), GAPDHS(2), GCK(3), GPI(4), HK1(5), HK2(5), HK3(3), LDHAL6B(2), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKL(4), PFKM(2), PFKP(7), PGAM2(2), PGAM4(1), PGK1(1), PGK2(1), PGM1(2), PGM3(6), PKLR(4), PKM2(2), TPI1(2) 10051406 138 42 137 55 44 43 6 32 13 0 0.422 1.000 1.000 398 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(14), ACACB(10), ACAT1(2), ACAT2(2), ACOT12(4), ACSS1(6), ACSS2(3), ACYP2(1), AKR1B1(5), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), DLAT(3), DLD(2), GRHPR(2), HAGH(1), LDHAL6B(2), LDHB(1), LDHC(1), LDHD(1), MDH1(3), ME1(2), ME2(3), ME3(4), PC(5), PCK1(2), PCK2(5), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2) 8073060 116 42 116 34 38 31 4 29 14 0 0.0852 1.000 1.000 399 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(1), DAXX(3), EGF(4), EGFR(7), ETS1(4), ETS2(1), HOXA7(1), IKBKB(3), JUN(2), MAP2K1(2), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAP3K1(6), MAP3K14(2), MAP3K5(3), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(3), NFKB1(5), PPP2CA(3), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCQ(2), RAF1(5), RELA(1), SP1(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2) 8491769 108 42 107 42 37 29 1 27 14 0 0.464 1.000 1.000 400 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(17), B3GALT4(2), CDR1(4), DGKI(5), IL6ST(2), PIGK(1), RPL10(2), RPL12(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL3(2), RPL31(1), RPL34(1), RPL36(1), RPL5(1), RPL6(1), RPL7A(3), RPL8(2), RPL9(2), RPLP0(3), RPLP1(1), RPS10(1), RPS11(1), RPS13(1), RPS14(2), RPS23(1), RPS27A(1), RPS3(1), RPS3A(1), RPS5(2), RPS6(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA6(7), RPS6KB1(2), RPS6KB2(2), RPSA(3), SLC36A2(4), TBC1D10C(1), TSPAN9(1), UBC(3) 9036834 105 42 105 39 25 38 7 24 10 1 0.565 1.000 1.000 401 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(2), CDC42(1), DLD(2), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(1), GCK(3), IL1R1(3), JUN(2), MAP2K4(5), MAP2K7(12), MAP3K1(6), MAP3K10(6), MAP3K11(2), MAP3K12(4), MAP3K13(3), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAP3K5(3), MAP3K7(6), MAP3K9(5), MAPK10(1), MAPK7(6), MAPK8(3), MAPK9(3), MYEF2(4), NFATC3(2), NR2C2(2), PAPPA(12), SHC1(3), TRAF6(4), ZAK(3) 8570347 125 42 125 38 38 39 6 23 19 0 0.114 1.000 1.000 402 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(5), EEF1B2(1), EEF1D(3), EEF1G(3), EEF2(2), EEF2K(6), EIF1AX(1), EIF1AY(1), EIF2AK1(1), EIF2AK2(2), EIF2AK3(8), EIF2B1(3), EIF2B3(3), EIF2B4(5), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(8), EIF4G3(4), EIF5(3), EIF5A(2), EIF5B(6), ETF1(3), GSPT2(1), KIAA0664(8), PABPC1(3), PABPC3(5), PAIP1(1), SLC35A4(3) 7561690 104 42 102 33 36 35 3 23 7 0 0.146 1.000 1.000 403 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(5), AGXT(1), AGXT2(5), ALAS1(1), ALAS2(4), AMT(4), AOC2(4), AOC3(3), BHMT(3), CBS(3), CHDH(3), CHKA(1), CHKB(2), CTH(2), DAO(5), DLD(2), DMGDH(5), GARS(1), GATM(2), GCAT(2), GLDC(5), GNMT(2), HSD3B7(3), MAOA(1), MAOB(3), PEMT(1), PIPOX(2), PISD(4), PSAT1(2), PSPH(2), RDH11(1), RDH12(1), SARDH(4), SARS(2), SARS2(3), SDS(1), SHMT1(1), SHMT2(3), TARS(4), TARS2(4) 7387435 107 41 107 37 33 25 8 29 12 0 0.328 1.000 1.000 404 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), AKR1C3(3), AKR1C4(3), ALDH1A3(5), ALDH3A1(3), ALDH3B2(4), CYP1A1(1), CYP1A2(3), CYP1B1(2), CYP2B6(2), CYP2C18(3), CYP2C19(6), CYP2E1(3), CYP2F1(1), CYP2S1(2), CYP3A4(1), CYP3A43(3), CYP3A7(2), DHDH(5), EPHX1(3), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTZ1(3), MGST1(1), MGST3(1), UGT1A1(1), UGT1A5(3), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2) 9741758 108 41 107 33 25 37 2 30 14 0 0.134 1.000 1.000 405 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM1(1), CALM2(2), CALM3(1), CD3E(2), CD3G(2), ELK1(2), FYN(5), GRB2(1), JUN(2), MAP2K1(2), MAP2K4(5), MAP3K1(6), MAPK3(1), MAPK8(3), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NFKB1(5), PIK3R1(5), PLCG1(10), PPP3CA(3), PPP3CB(1), PTPN7(2), RAF1(5), RASA1(9), RELA(1), SHC1(3), SOS1(3), VAV1(6), ZAP70(2) 7877380 116 41 113 32 33 37 2 19 24 1 0.0796 1.000 1.000 406 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(3), ACTN2(11), ACTN3(1), CAPN1(2), CAPNS1(1), CAPNS2(1), ITGA1(3), ITGB1(4), ITGB3(3), PTK2(7), PXN(1), SPTAN1(10), TLN1(11) 4925910 59 41 57 33 27 13 3 12 4 0 0.933 1.000 1.000 407 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(3), INPP4A(1), INPP4B(3), INPP5A(3), INPPL1(12), ITPKA(1), ITPKB(5), OCRL(4), PIK3C2A(4), PIK3C2B(10), PIK3C2G(3), PIK3CB(5), PIK3CG(9), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLCD1(1), PLCG1(10), PLCG2(6) 7414586 105 40 103 32 34 36 1 21 12 1 0.192 1.000 1.000 408 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(8), ATP4B(1), ATP6AP1(3), ATP6V0A1(4), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), ATP7A(5), ATP7B(8), COX10(1), COX4I1(3), COX6B1(1), COX7A2(2), COX7C(1), NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(4), NDUFS2(2), NDUFV1(1), PPA2(1), SDHA(5), SDHB(3), SHMT1(1), UQCRB(1), UQCRC1(2), UQCRFS1(1) 6589629 93 40 93 35 27 34 3 22 7 0 0.439 1.000 1.000 409 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(6), ACTR2(2), AKT1(2), ANGPTL2(4), CDC42(1), CFL1(1), FLNA(10), FLNC(13), FSCN1(5), FSCN3(8), GDI1(1), LIMK1(3), MYH2(10), MYLK(7), MYLK2(2), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PFN2(2), RHO(2), ROCK1(7), ROCK2(2), VASP(2), WASF1(3), WASL(1) 8284558 112 40 112 37 42 34 5 21 10 0 0.103 1.000 1.000 410 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(2), ASAH1(2), BRAF(5), CAMP(1), CREB1(4), CREB3(2), CREB5(1), CREBBP(10), DAG1(5), EGR1(3), EGR2(3), EGR3(1), EGR4(4), ELK1(2), FRS2(2), GNAQ(1), JUN(2), MAP1B(7), MAP2K4(5), MAP2K7(12), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3), NTRK1(3), OPN1LW(4), PIK3C2G(3), PIK3CD(8), PIK3R1(5), PTPN11(4), RPS6KA3(1), SHC1(3), TERF2IP(3), TH(1) 8510850 128 40 127 49 45 38 1 22 22 0 0.419 1.000 1.000 411 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 32 A1BG(1), AKT1(2), AKT2(2), AKT3(3), BAD(1), BTK(2), CDKN2A(3), GRB2(1), GSK3A(1), GSK3B(2), IARS(6), IGFBP1(2), INPP5D(1), PDK1(1), PPP1R13B(5), PTEN(8), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KB1(2), SHC1(3), SOS1(3), SOS2(3), TEC(3), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 5862380 72 40 72 27 20 25 0 16 11 0 0.558 1.000 1.000 412 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 64 APAF1(2), BAD(1), BAK1(2), BCL2(1), BCL2L11(1), BID(1), BIRC2(2), BIRC3(3), BIRC5(1), CASP1(1), CASP10(3), CASP2(2), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(5), CASP9(1), DFFA(2), DFFB(2), FAS(2), HELLS(3), IKBKB(3), IRF1(1), IRF4(2), IRF5(2), IRF6(2), IRF7(1), JUN(2), LTA(2), MAP2K4(5), MAP3K1(6), MAPK10(1), MDM2(3), NFKB1(5), NFKBIB(4), PLEKHG5(4), PRF1(1), RELA(1), TNF(1), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFSF10(2), TP73(1), TRAF1(2), TRAF2(2), TRAF3(2) 9651170 105 39 105 35 33 31 4 22 15 0 0.224 1.000 1.000 413 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(7), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPS(2), CDS1(3), CDS2(1), CHAT(1), CHKA(1), CHKB(2), CLC(2), CPT1B(3), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKQ(1), DGKZ(1), GNPAT(1), GPD1(3), GPD2(3), LCAT(1), LYPLA2(1), PAFAH1B1(3), PAFAH2(1), PCYT1A(7), PCYT1B(3), PEMT(1), PISD(4), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB2(3), PLCG1(10), PLCG2(6), PPAP2C(4) 8656566 112 39 110 40 46 35 2 21 8 0 0.230 1.000 1.000 414 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(2), ABAT(3), ACADS(1), ACAT1(2), ACAT2(2), ACSM1(1), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH5A1(2), ALDH9A1(3), BDH1(1), DDHD1(7), EHHADH(2), GAD1(3), GAD2(3), HADH(2), HADHA(2), HMGCS1(1), HMGCS2(1), HSD17B4(1), HSD3B7(3), ILVBL(1), L2HGDH(1), OXCT1(3), PDHA1(1), PDHA2(4), PDHB(2), PRDX6(1), RDH11(1), RDH12(1) 7029026 75 39 72 29 25 19 1 23 7 0 0.510 1.000 1.000 415 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(4), CARS(2), CARS2(1), DARS(1), EARS2(1), EPRS(6), FARS2(5), FARSA(2), FARSB(1), GARS(1), HARS(3), HARS2(2), IARS(6), IARS2(3), KARS(2), LARS(2), LARS2(5), MARS(2), MARS2(1), NARS(3), QARS(4), RARS(2), SARS(2), SARS2(3), TARS(4), TARS2(4), VARS(7), VARS2(4), WARS(3), WARS2(5), YARS(1), YARS2(1) 9394027 95 39 95 39 32 32 3 25 3 0 0.738 1.000 1.000 416 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(6), BLNK(2), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(2), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8IP3(7), PAPPA(12), RPS6KA1(6), RPS6KA3(1), SHC1(3), SOS1(3), SYK(3), VAV1(6), VAV2(8), VAV3(6) 5547810 81 39 81 31 26 26 2 16 11 0 0.480 1.000 1.000 417 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(2), AKT3(3), ARHGEF11(10), BCL2(1), CDC42(1), DLG4(3), LPA(10), MAP2K4(5), MAP3K1(6), MAP3K5(3), MAPK8(3), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PDK1(1), PHKA2(7), PI3(1), PIK3CB(5), PLD1(7), PLD2(10), PLD3(5), PTK2(7), RDX(2), ROCK1(7), ROCK2(2), SERPINA4(2), TBXA2R(6) 8507934 129 39 129 40 43 40 8 23 15 0 0.121 1.000 1.000 418 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(3), CDK2(2), CDT1(2), DIAPH2(3), MCM10(5), MCM2(8), MCM3(1), MCM4(6), MCM5(6), MCM7(4), NACA(1), ORC1L(6), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(2), POLD1(7), POLD3(1), POLE(12), POLE2(1), PRIM1(1), RFC1(1), RFC2(1), RFC3(2), RFC4(1), RPA1(1), RPA2(1), RPA3(1), RPS27A(1), UBC(3) 8813560 99 38 99 43 32 24 6 20 17 0 0.790 1.000 1.000 419 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(3), ALDOB(2), ALDOC(2), BPGM(1), DLAT(3), DLD(2), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(3), GAPDH(1), GCK(3), GPI(4), HK1(5), HK2(5), HK3(3), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(2), PFKP(7), PGK1(1), PGM1(2), PGM3(6), PKLR(4), PKM2(2), TPI1(2) 8436122 122 38 121 51 38 37 4 31 12 0 0.589 1.000 1.000 420 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(3), ALDOB(2), ALDOC(2), BPGM(1), DLAT(3), DLD(2), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(3), GAPDH(1), GCK(3), GPI(4), HK1(5), HK2(5), HK3(3), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(2), PFKP(7), PGK1(1), PGM1(2), PGM3(6), PKLR(4), PKM2(2), TPI1(2) 8436122 122 38 121 51 38 37 4 31 12 0 0.589 1.000 1.000 421 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(10), CALM1(1), CALM2(2), CALM3(1), CREB1(4), ELK1(2), GNAI1(1), GNAQ(1), GNAS(11), GNGT1(3), JUN(2), MAP2K1(2), MAPK3(1), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), PLCG1(10), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RAF1(5), RPS6KA3(1) 6022676 100 38 99 31 36 38 0 16 10 0 0.0995 1.000 1.000 422 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 30 ABAT(3), ADC(1), ALDH4A1(2), ALDH5A1(2), CAD(5), EARS2(1), EPRS(6), GAD1(3), GAD2(3), GCLM(2), GFPT1(2), GFPT2(2), GLS(4), GLS2(4), GLUD1(4), GLUD2(6), GLUL(1), GMPS(2), GOT1(1), GOT2(2), GPT2(2), GSR(4), GSS(1), NADSYN1(3), PPAT(1), QARS(4) 6301151 71 38 70 32 23 25 2 18 3 0 0.764 1.000 1.000 423 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(3), ALG10(5), ALG10B(1), ALG12(1), ALG13(2), ALG3(1), ALG8(1), ALG9(2), B4GALT1(2), B4GALT2(5), DOLPP1(2), DPM1(1), FUT8(2), GANAB(3), MAN1A2(1), MAN1B1(2), MAN1C1(3), MAN2A1(2), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(5), MGAT5B(1), RFT1(1), RPN1(1), RPN2(3), STT3B(3) 7362545 65 38 64 38 19 17 4 15 10 0 0.992 1.000 1.000 424 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(3), CREBBP(10), CTBP1(2), CTBP2(3), DLL1(3), DLL3(2), DLL4(1), DTX1(7), DTX2(2), DTX3L(1), DTX4(3), DVL1(2), DVL2(2), DVL3(4), EP300(13), HDAC1(2), HDAC2(2), JAG1(3), JAG2(1), MAML1(4), MAML2(5), MAML3(7), NCOR2(13), NCSTN(2), NOTCH1(12), NOTCH2(8), NOTCH3(8), NOTCH4(6), NUMB(2), NUMBL(2), PSEN1(1), PSEN2(2), PSENEN(1), RBPJ(2), RBPJL(3), RFNG(1) 11912577 145 38 144 67 54 41 6 25 19 0 0.735 1.000 1.000 425 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(2), CALR(3), CANX(1), CD4(2), CD74(1), CD8A(2), CD8B(1), CIITA(5), CREB1(4), CTSL1(2), CTSS(1), HLA-A(6), HLA-C(3), HLA-DMA(1), HLA-DMB(2), HLA-DOA(1), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-E(2), HLA-F(4), HLA-G(2), HSP90AA1(2), HSP90AB1(2), IFI30(1), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), KIR2DL1(3), KIR2DL3(1), KIR2DL4(1), KIR2DS4(1), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRD1(2), LGMN(4), LTA(2), PDIA3(1), PSME2(1), RFX5(2), RFXANK(3), TAP1(3), TAP2(6), TAPBP(1) 7928815 107 38 105 37 17 42 9 25 14 0 0.347 1.000 1.000 426 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 CDK5(2), CDK5R1(1), CFL1(1), CHN1(4), LIMK1(3), MAP3K1(6), MYL2(1), MYLK(7), NCF2(1), PAK1(4), PDGFRA(3), PIK3R1(5), PLD1(7), PPP1R12B(6), RALBP1(4), RPS6KB1(2), TRIO(17), VAV1(6), WASF1(3) 5671547 83 38 82 35 27 25 2 16 12 1 0.753 1.000 1.000 427 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(5), ACAT1(2), ACAT2(2), ACMSD(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), AOC2(4), AOC3(3), AOX1(2), ASMT(1), CAT(4), CYP19A1(5), CYP1A1(1), CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(2), CYP2B6(2), CYP2C18(3), CYP2C19(6), CYP2D6(3), CYP2E1(3), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A7(2), CYP4B1(1), CYP4F8(1), CYP51A1(2), DDC(3), EHHADH(2), GCDH(3), HADHA(2), KYNU(6), MAOA(1), MAOB(3), SDS(1), TDO2(2), TPH1(1), WARS(3), WARS2(5) 9529980 127 37 124 41 37 40 5 29 15 1 0.144 1.000 1.000 428 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3E(2), CD3G(2), CD4(2), CREBBP(10), CSK(2), GNAS(11), GNGT1(3), HLA-DRA(3), HLA-DRB1(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PTPRC(14), ZAP70(2) 3964866 75 36 73 34 18 25 2 16 14 0 0.879 1.000 1.000 429 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3E(2), CD3G(2), CD4(2), CREBBP(10), CSK(2), GNAS(11), GNGT1(3), HLA-DRA(3), HLA-DRB1(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PTPRC(14), ZAP70(2) 3964866 75 36 73 34 18 25 2 16 14 0 0.879 1.000 1.000 430 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(13), ATR(5), BRCA1(7), CCNB1(1), CDC25A(2), CDC25B(2), CDC25C(2), CDC34(1), CDKN1A(1), CDKN2D(1), CHEK1(1), CHEK2(5), EP300(13), MDM2(3), MYT1(9), PRKDC(19), RPS6KA1(6), YWHAH(1), YWHAQ(1) 7212155 93 36 92 31 30 35 2 14 11 1 0.350 1.000 1.000 431 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(3), AKR1D1(1), ARSD(1), ARSE(3), CARM1(2), CYP11B1(2), CYP11B2(2), CYP19A1(5), HSD11B2(2), HSD17B1(3), HSD17B12(2), HSD17B3(1), HSD17B7(1), HSD3B1(1), HSD3B2(1), LCMT1(1), LCMT2(6), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), SRD5A1(2), SRD5A2(2), STS(2), SULT1E1(3), UGT1A1(1), UGT1A5(3), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), WBSCR22(2) 8524209 83 36 83 31 19 30 3 19 12 0 0.408 1.000 1.000 432 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(4), AASDH(3), AASS(2), ACAT1(2), ACAT2(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), BBOX1(1), DLST(1), DOT1L(7), EHHADH(2), EHMT1(6), EHMT2(3), GCDH(3), HADHA(2), PLOD1(5), PLOD2(3), PLOD3(4), SDS(1), SHMT1(1), SHMT2(3), TMLHE(3) 6391636 84 36 83 36 21 32 2 16 13 0 0.569 1.000 1.000 433 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), ELK1(2), IKBKB(3), IRAK1(4), JUN(2), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP3K7(6), MAPK14(1), MAPK8(3), MYD88(1), NFKB1(5), PPARA(3), RELA(1), TIRAP(2), TLR10(3), TLR2(1), TLR3(2), TLR4(11), TLR6(1), TLR7(3), TLR9(10), TOLLIP(1), TRAF6(4) 6316676 85 36 83 29 25 19 5 24 12 0 0.394 1.000 1.000 434 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(15), MAP2(14), PPP1CA(1), PPP2CA(3), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAR2A(1), PRKAR2B(6), PRKCE(5) 3149481 52 35 52 19 9 20 0 17 6 0 0.653 1.000 1.000 435 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), CLOCK(2), CRY1(1), CRY2(1), DAZAP2(3), DNAJA1(2), EIF4G2(1), ETV6(2), G0S2(1), GFRA1(5), GSTM3(1), GSTP1(1), HSPA8(3), KLF9(1), NCKAP1(5), NR1D2(3), PER1(3), PER2(9), PPP1R3C(3), PPP2CB(2), PSMA4(3), PURA(1), SF3A3(2), SUMO3(1), TOB1(1), TUBB3(7), UCP3(1), UGP2(1), ZFR(7) 6299338 75 35 75 33 26 20 3 22 4 0 0.770 1.000 1.000 436 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(5), DIAPH1(3), FYN(5), GSN(5), ITGA1(3), ITGB1(4), MAP2K1(2), MAPK1(2), MAPK3(1), MYL2(1), MYLK(7), PIK3R1(5), PTK2(7), PXN(1), RAF1(5), ROCK1(7), SHC1(3), TLN1(11) 6091274 77 35 76 26 19 26 3 16 12 1 0.368 1.000 1.000 437 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(2), ATM(13), ATR(5), CCNA1(4), CCND1(1), CCNE1(3), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(3), GSK3B(2), HDAC1(2), RB1(7), SKP2(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(3) 5097712 68 35 66 29 17 23 2 17 8 1 0.792 1.000 1.000 438 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ADRBK2(4), ARRB2(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CLCA1(2), CLCA2(4), CLCA4(4), CNGA3(6), CNGA4(9), CNGB1(5), GUCA1A(1), GUCA1C(1), PDC(1), PDE1C(2), PRKACA(1), PRKACB(2), PRKACG(3), PRKG1(6), PRKG2(6), PRKX(2) 5295593 70 35 68 29 24 19 3 17 7 0 0.565 1.000 1.000 439 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(6), ADCY3(1), ADCY9(5), ARF1(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), GNAS(11), PLCG1(10), PLCG2(6), SEC61A1(1), SEC61B(1), SEC61G(1), TRIM23(2) 6400535 78 35 77 30 28 20 3 21 6 0 0.541 1.000 1.000 440 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(14), ACAT1(2), ACAT2(2), ACYP2(1), ADH5(1), AKR1B1(5), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), DLAT(3), DLD(2), GRHPR(2), HAGH(1), LDHB(1), LDHC(1), LDHD(1), MDH1(3), ME1(2), ME2(3), ME3(4), PC(5), PCK1(2), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2) 6378329 94 35 94 31 30 29 2 23 10 0 0.232 1.000 1.000 441 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(2), BAK1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(2), CASP3(1), CASP6(1), CASP7(2), CASP8(5), CASP9(1), FAS(2), JUN(2), MAP2K4(5), MAP3K1(6), MAP3K14(2), MAPK10(1), MDM2(3), NFKB1(5), PARP1(4), PRF1(1), RELA(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFSF10(2), TRAF1(2), TRAF2(2) 6330936 65 34 65 25 20 18 2 15 10 0 0.489 1.000 1.000 442 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(7), ELK1(2), GNAS(11), GNGT1(3), GRB2(1), IGF1R(10), ITGB1(4), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(1), NGFR(4), PDGFRA(3), PPP2CA(3), PTPRR(2), RAF1(5), RPS6KA1(6), SHC1(3), SOS1(3), STAT3(6) 5713159 80 34 79 35 25 27 0 19 9 0 0.800 1.000 1.000 443 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(3), ACAA2(1), ACADM(1), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(3), AOX1(2), AUH(5), BCAT1(1), BCAT2(1), BCKDHA(4), DBT(2), DLD(2), EHHADH(2), HADH(2), HADHA(2), HADHB(2), HIBADH(2), HMGCS1(1), HMGCS2(1), HSD17B4(1), IVD(1), MCCC1(2), MCCC2(1), MCEE(3), MUT(1), OXCT1(3), PCCA(7), PCCB(2) 7452575 80 34 76 27 20 23 1 17 18 1 0.418 1.000 1.000 444 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(1), ARSE(3), ASAH1(2), B4GALT6(1), CERK(3), DEGS1(1), DEGS2(2), ENPP7(2), GAL3ST1(4), GALC(4), GBA(4), GLB1(2), LCT(7), NEU2(2), NEU3(1), NEU4(1), PPAP2C(4), SGMS1(1), SMPD1(3), SMPD3(5), SMPD4(3), SPHK1(3), SPTLC2(2), UGT8(4) 6176481 66 34 66 32 32 23 0 8 3 0 0.696 1.000 1.000 445 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(2), CAPN2(2), CAPNS1(1), CAPNS2(1), EGF(4), EGFR(7), ITGA1(3), ITGB1(4), MAPK1(2), MAPK3(1), MYL2(1), MYLK(7), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PTK2(7), PXN(1), TLN1(11) 5654960 68 34 66 32 25 18 3 15 7 0 0.728 1.000 1.000 446 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ARHGAP4(2), ARHGAP5(5), ARHGAP6(3), ARHGEF1(2), ARHGEF11(10), ARHGEF5(4), ARPC1A(3), ARPC4(1), BAIAP2(3), CFL1(1), DIAPH1(3), GSN(5), LIMK1(3), MYL2(1), MYLK(7), OPHN1(6), PIP5K1A(2), PPP1R12B(6), ROCK1(7), TLN1(11), VCL(2) 7875483 89 34 89 41 33 30 2 15 8 1 0.815 1.000 1.000 447 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 23 ABAT(3), ALDH4A1(2), ALDH5A1(2), CAD(5), EPRS(6), GAD1(3), GAD2(3), GCLM(2), GFPT1(2), GLS(4), GLS2(4), GLUD1(4), GLUL(1), GMPS(2), GOT1(1), GOT2(2), GPT2(2), GSS(1), NADSYN1(3), PPAT(1), QARS(4) 5209346 57 33 56 24 18 22 1 13 3 0 0.675 1.000 1.000 448 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(2), ARSB(3), FUCA1(1), FUCA2(2), GALNS(1), GBA(4), GLB1(2), GNS(3), GUSB(2), HEXA(1), HEXB(2), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(2), IDS(2), IDUA(1), LCT(7), MAN2B1(8), MAN2B2(8), MAN2C1(4), MANBA(2), NAGLU(1), NEU2(2), NEU3(1), NEU4(1), SPAM1(5) 5956106 76 33 75 32 27 29 1 12 7 0 0.620 1.000 1.000 449 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(1), BRAF(5), CREB1(4), CREB3(2), CREB5(1), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(6), EIF4E(1), GRB2(1), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(1), MOS(3), NFKB1(5), RAP1A(2), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), SHC1(3), SOS1(3), SOS2(3), TRAF3(2) 5107721 66 33 65 28 22 19 0 15 10 0 0.744 1.000 1.000 450 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(2), AKT2(2), AKT3(3), CISH(1), GRB2(1), IARS(6), IL13RA1(2), IL2RG(3), IL4R(1), INPP5D(1), JAK1(2), JAK2(8), JAK3(3), NR0B2(1), PI3(1), PPP1R13B(5), RPS6KB1(2), SERPINA4(2), SHC1(3), SOS1(3), SOS2(3), TYK2(4) 6012046 59 33 58 19 13 18 1 14 12 1 0.492 1.000 1.000 451 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(3), ADSL(2), ADSS(3), AGXT(1), AGXT2(5), ASL(3), ASNS(3), CAD(5), CRAT(3), DARS(1), DDO(2), GAD1(3), GAD2(3), GOT1(1), GOT2(2), GPT2(2), NARS(3), PC(5) 4501590 52 32 51 24 23 14 0 14 1 0 0.760 1.000 1.000 452 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(1), CALM1(1), CALM2(2), CALM3(1), EGFR(7), ELK1(2), GNAQ(1), GRB2(1), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K4(5), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8(3), MEF2B(3), MEF2C(2), MEF2D(5), PAK1(4), PTK2(7), PTK2B(5), RAF1(5), SHC1(3), SOS1(3) 5808684 76 32 76 28 22 22 5 16 11 0 0.425 1.000 1.000 453 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(3), ACTN2(11), ACTN3(1), BCAR1(4), CSK(2), CTNNA1(4), CTNNA2(11), CTNNB1(10), PTK2(7), PXN(1), VCL(2) 3290026 56 32 55 26 17 16 4 13 6 0 0.802 1.000 1.000 454 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(10), AKT1(2), ASAH1(2), GNAI1(1), GNGT1(3), ITGAV(3), ITGB3(3), MAPK1(2), MAPK3(1), PDGFA(1), PDGFRA(3), PIK3R1(5), PLCB1(10), PTK2(7), SMPD1(3), SPHK1(3) 4366105 59 32 59 28 17 23 4 5 10 0 0.759 1.000 1.000 455 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(2), ALDOC(2), DLAT(3), DLD(2), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(3), GAPDH(1), GAPDHS(2), GCK(3), GOT1(1), GOT2(2), GPI(4), HK1(5), HK2(5), HK3(3), LDHAL6B(2), LDHB(1), LDHC(1), MDH1(3), PC(5), PCK1(2), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PFKL(4), PFKM(2), PFKP(7), PGAM2(2), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TNFAIP1(1), TPI1(2) 7321282 93 32 93 44 42 27 2 18 4 0 0.748 1.000 1.000 456 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(3), ACACA(14), ACACB(10), ACADM(1), ACAT1(2), ACAT2(2), ACSS1(6), ACSS2(3), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(3), EHHADH(2), HADHA(2), LDHAL6B(2), LDHB(1), LDHC(1), MCEE(3), MLYCD(3), MUT(1), PCCA(7), PCCB(2), SUCLA2(3), SUCLG1(1), SUCLG2(3) 6855104 92 32 88 30 27 24 2 20 19 0 0.312 1.000 1.000 457 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(4), ALAS1(1), ALAS2(4), BLVRA(2), COX10(1), COX15(3), CP(3), EARS2(1), EPRS(6), FECH(4), FTH1(1), FTMT(2), GUSB(2), HCCS(1), HMOX1(3), PPOX(2), UGT1A1(1), UGT1A5(3), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), UROD(1), UROS(3) 7127323 65 32 65 31 11 23 3 20 8 0 0.887 1.000 1.000 458 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(3), ACACA(14), ACADL(1), ACADM(1), ACADSB(3), ACAT1(2), ACAT2(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(3), EHHADH(2), HADHA(2), LDHB(1), LDHC(1), MCEE(3), MLYCD(3), MUT(1), PCCA(7), PCCB(2), SDS(1), SUCLA2(3), SUCLG1(1), SUCLG2(3) 5716483 83 32 79 28 25 28 0 15 15 0 0.355 1.000 1.000 459 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2G(4), DAG1(5), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), NFAT5(4), PDE6A(3), PDE6B(5), PDE6C(2), PDE6G(1), SLC6A13(1), TF(5) 6229824 84 32 84 31 28 25 7 11 12 1 0.326 1.000 1.000 460 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(13), ATR(5), BRCA1(7), BRCA2(14), CHEK1(1), CHEK2(5), FANCA(5), FANCC(2), FANCD2(8), FANCE(1), FANCG(1), HUS1(1), MRE11A(2), RAD1(1), RAD50(6), RAD51(1), RAD9A(1) 7517578 74 31 73 19 16 31 3 14 9 1 0.118 1.000 1.000 461 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(3), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH5A1(2), ALDH9A1(3), EHHADH(2), GAD1(3), GAD2(3), HADHA(2), L2HGDH(1), OXCT1(3), PDHA1(1), PDHA2(4), PDHB(2), SDHB(3), SDS(1) 4454356 63 31 61 27 20 18 0 18 7 0 0.672 1.000 1.000 462 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(2), EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(8), EIF4G2(1), EIF4G3(4), GHR(3), IRS1(6), MAPK1(2), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(3), PDPK1(1), PIK3R1(5), PTEN(8), RPS6KB1(2) 4487437 54 31 54 21 12 18 3 11 10 0 0.721 1.000 1.000 463 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT4(3), CHST1(8), CHST2(7), CHST6(3), FUT8(2), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3) 2152973 44 31 43 18 24 10 1 8 1 0 0.518 1.000 1.000 464 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLA2(2), POLD1(7), POLD3(1), POLE(12), POLE2(1), POLE3(1), POLE4(1), POLG(3), POLG2(3), POLH(2), POLK(1), POLL(1), POLM(3), POLQ(13), PRIM1(1), PRIM2(3), REV1(4), REV3L(16) 7088136 79 31 79 38 19 24 2 17 17 0 0.939 1.000 1.000 465 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(10), CAP1(1), CCNB1(1), CDC25C(2), GNAI1(1), GNAS(11), GNGT1(3), MAPK1(2), MAPK3(1), MYT1(9), PIN1(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RPS6KA1(6) 3546144 62 31 62 29 22 21 0 13 6 0 0.802 1.000 1.000 466 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(2), CALM3(1), DLG4(3), GRIN1(2), GRIN2A(6), GRIN2B(8), GRIN2C(3), NOS1(15), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6) 4410926 58 31 58 23 20 20 1 10 7 0 0.516 1.000 1.000 467 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), DYRK1B(6), GLI2(6), GLI3(15), GSK3B(2), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), SMO(6), SUFU(2) 2856738 54 31 54 27 18 13 2 15 6 0 0.777 1.000 1.000 468 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(4), EGFR(7), GRB2(1), MAP2K1(2), MAPK1(2), MAPK3(1), PTPRB(10), RAF1(5), RASA1(9), SHC1(3), SOS1(3), SPRY1(2), SPRY3(3), SPRY4(3) 4336102 56 31 55 20 13 14 1 17 10 1 0.618 1.000 1.000 469 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 24 EIF2B1(3), EIF2B3(3), EIF2B4(5), EIF2B5(3), EIF2S1(1), EIF2S2(2), ELAVL1(3), FLT1(5), FLT4(6), HIF1A(2), KDR(4), NOS3(3), PIK3R1(5), PLCG1(10), PTK2(7), PXN(1), SHC1(3) 5486922 66 31 64 22 23 21 4 11 7 0 0.256 1.000 1.000 470 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(2), CALM3(1), EGR2(3), EGR3(1), GNAQ(1), MAP3K1(6), NFATC1(8), NFATC2(6), NFKB1(5), PLCG1(10), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RELA(1), VIP(1), VIPR2(3) 4827640 66 31 65 27 26 22 1 12 5 0 0.511 1.000 1.000 471 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(5), B4GALT1(2), B4GALT2(5), GAA(2), GALE(1), GALK1(1), GALK2(2), GALT(1), GANC(4), GCK(3), GLB1(2), HK1(5), HK2(5), HK3(3), HSD3B7(3), LALBA(1), LCT(7), MGAM(6), PFKL(4), PFKM(2), PFKP(7), PGM1(2), PGM3(6), RDH11(1), RDH12(1), UGP2(1) 6694113 82 30 81 39 38 30 2 6 6 0 0.692 1.000 1.000 472 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(3), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), OGDH(6), PC(5), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PDK1(1), PDK3(2), SDHA(5), SDHB(3), SDHC(1), SUCLA2(3), SUCLG1(1), SUCLG2(3) 4894757 56 30 55 28 19 15 1 15 6 0 0.900 1.000 1.000 473 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(4), CALM1(1), CALM2(2), CALM3(1), GNAQ(1), GRB2(1), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP3K1(6), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(3), PAK1(4), PLCG1(10), PTK2B(5), RAF1(5), SHC1(3), SOS1(3) 4905132 64 30 63 22 20 20 0 15 9 0 0.441 1.000 1.000 474 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(2), AKT2(2), AKT3(3), BAD(1), BCL2(1), GRB2(1), GSK3A(1), GSK3B(2), IL4R(1), IRS1(6), IRS2(3), JAK1(2), JAK3(3), MAP4K1(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CD(8), PIK3R1(5), PPP1R13B(5), RAF1(5), SHC1(3), SOCS1(1), SOS1(3), SOS2(3) 5930857 67 30 65 22 25 21 0 12 8 1 0.316 1.000 1.000 475 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(2), ATM(13), BRCA1(7), CDKN1A(1), CHEK1(1), CHEK2(5), JUN(2), MAPK8(3), MDM2(3), MRE11A(2), NFKB1(5), RAD50(6), RAD51(1), RBBP8(3), RELA(1), TP73(1) 5027061 56 29 55 15 11 16 3 15 10 1 0.300 1.000 1.000 476 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(8), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), OGDH(6), OGDHL(3), PC(5), PCK1(2), PCK2(5), SDHA(5), SDHB(3), SDHC(1), SUCLA2(3), SUCLG1(1), SUCLG2(3) 5152016 61 29 59 24 25 17 2 10 7 0 0.486 1.000 1.000 477 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(3), C1GALT1C1(3), GALNT10(3), GALNT11(4), GALNT12(1), GALNT13(2), GALNT14(4), GALNT2(2), GALNT4(1), GALNT5(4), GALNT6(2), GALNT8(3), GALNT9(2), GALNTL1(2), GALNTL2(4), GALNTL4(5), GALNTL5(2), GCNT3(1), GCNT4(1), OGT(1), ST3GAL1(2), ST3GAL2(4), ST6GALNAC1(1) 5378450 57 29 57 31 22 16 1 15 3 0 0.962 1.000 1.000 478 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG7(4), BECN1(1), GABARAPL1(3), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), IFNG(2), PIK3C3(6), PIK3R4(7), PRKAA1(1), PRKAA2(2), ULK1(9), ULK2(4) 3664972 51 29 51 18 11 15 5 13 7 0 0.462 1.000 1.000 479 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(2), EIF4A1(1), EIF4A2(3), EIF4B(2), EIF4E(1), EIF4EBP1(1), EIF4G1(8), EIF4G2(1), EIF4G3(4), MKNK1(1), PDPK1(1), PIK3R1(5), PPP2CA(3), PTEN(8), RPS6(1), RPS6KB1(2), TSC1(3), TSC2(3) 4412307 50 29 50 25 13 17 1 10 9 0 0.953 1.000 1.000 480 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(1), ACADM(1), ACADS(1), ACADSB(3), ACAT1(2), ACAT2(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(3), AOX1(2), BCAT1(1), BCKDHA(4), EHHADH(2), HADHA(2), HADHB(2), HIBADH(2), IVD(1), MCCC1(2), MCCC2(1), MCEE(3), MUT(1), OXCT1(3), PCCA(7), PCCB(2), SDS(1) 6228597 74 29 71 29 15 28 0 15 15 1 0.660 1.000 1.000 481 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(2), DARS(1), EPRS(6), FARS2(5), GARS(1), HARS(3), IARS(6), KARS(2), LARS(2), LARS2(5), MARS(2), MARS2(1), NARS(3), QARS(4), RARS(2), SARS(2), TARS(4), WARS(3), WARS2(5), YARS(1) 5549238 62 28 62 21 18 24 2 16 2 0 0.396 1.000 1.000 482 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(10), AKT1(2), BAD(1), BCL2(1), CSF2RB(4), IGF1(2), IGF1R(10), IL3(1), IL3RA(4), KIT(6), KITLG(3), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), YWHAH(1) 3411804 63 28 63 28 17 29 0 11 6 0 0.587 1.000 1.000 483 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(10), AKT1(2), CAMK2A(1), CAMK2G(4), CREB1(4), GNAS(11), GRB2(1), MAPK1(2), MAPK14(1), MAPK3(1), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RPS6KA1(6), SOS1(3) 4642162 64 28 64 23 20 25 0 9 10 0 0.478 1.000 1.000 484 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD2(2), CD33(2), CD5(4), CD7(3), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(1), IL13(1), IL3(1), ITGAX(5), TLR2(1), TLR4(11), TLR7(3), TLR9(10) 3222776 52 28 49 29 19 9 5 16 3 0 0.956 1.000 1.000 485 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(6), DDX20(3), ETS1(4), ETS2(1), HDAC2(2), HDAC5(4), JUN(2), NCOR2(13), RBL1(3), SIN3A(5), SIN3B(8) 4475723 51 28 51 23 17 10 1 20 3 0 0.805 1.000 1.000 486 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(5), B4GALT1(2), B4GALT2(5), FBP2(3), GAA(2), GALE(1), GALK1(1), GALK2(2), GALT(1), GANAB(3), GCK(3), GLB1(2), HK1(5), HK2(5), HK3(3), LALBA(1), LCT(7), MGAM(6), PFKM(2), PFKP(7), PGM1(2), PGM3(6) 5650923 74 28 73 34 35 23 2 6 8 0 0.687 1.000 1.000 487 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF3(1), HLA-DRA(3), HLA-DRB1(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL11(2), IL12B(1), IL13(1), IL3(1), IL8(1), LTA(2), PDGFA(1), TGFB1(3), TGFB2(6), TGFB3(3), TNF(1) 2312620 35 28 35 14 8 12 1 12 2 0 0.670 1.000 1.000 488 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(10), ARHGEF1(2), F2(3), F2R(1), GNA12(1), GNAI1(1), GNAQ(1), GNGT1(3), MAP3K7(6), PIK3R1(5), PLCB1(10), PPP1R12B(6), PTK2B(5), ROCK1(7) 4087098 61 28 61 29 17 21 1 12 10 0 0.900 1.000 1.000 489 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), ERCC3(3), GTF2B(1), GTF2E1(4), GTF2E2(1), GTF2F2(2), GTF2H1(1), ILK(1), MNAT1(2), POLR1A(5), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3B(3), POLR3D(1), POLR3E(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(4), TAF7(4), TBP(1) 6068132 55 28 55 20 20 17 2 11 5 0 0.475 1.000 1.000 490 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(1), GNAI1(1), GNGT1(3), ITGA1(3), ITGB1(4), MAP2K1(2), MAPK1(2), MAPK3(1), PLA2G4A(3), PLCB1(10), PTGS1(5), PTK2(7), RAF1(5), SYK(3), TBXAS1(1) 4206567 54 28 53 21 15 16 4 10 9 0 0.593 1.000 1.000 491 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(10), GNAS(11), GNGT1(3), PPP2CA(3), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6) 2647346 49 27 49 19 17 17 1 7 7 0 0.608 1.000 1.000 492 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(3), ACPP(2), ACPT(1), ALPI(3), ALPL(3), ALPP(4), ALPPL2(4), CYP19A1(5), CYP1A1(1), CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(2), CYP2B6(2), CYP2C18(3), CYP2C19(6), CYP2D6(3), CYP2E1(3), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A7(2), CYP4B1(1), CYP4F8(1), CYP51A1(2), PON1(1) 5052542 64 27 64 22 26 19 3 11 5 0 0.250 1.000 1.000 493 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(2), CHIT1(2), CMAS(3), CTBS(2), CYB5R1(1), CYB5R3(1), GFPT1(2), GFPT2(2), GNE(3), GNPDA1(3), HEXA(1), HEXB(2), HK1(5), HK2(5), HK3(3), LHPP(2), MTMR1(3), MTMR2(3), MTMR6(3), NPL(1), PGM3(6), PHPT1(2), RENBP(2) 4950502 61 27 61 21 23 21 4 11 2 0 0.250 1.000 1.000 494 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), ACE2(5), AGT(1), AGTR1(1), AGTR2(1), ANPEP(2), CPA3(1), CTSG(2), ENPEP(8), LNPEP(8), MAS1(1), MME(4), NLN(6), REN(2), THOP1(5) 3657265 51 27 51 21 17 21 2 10 1 0 0.495 1.000 1.000 495 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(10), DAXX(3), PAX3(4), PML(3), RARA(1), RB1(7), SIRT1(3), SP100(7), TNF(1), TNFRSF1A(2), TNFRSF1B(1) 3129695 42 27 41 16 14 11 2 8 7 0 0.572 1.000 1.000 496 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(2), BCL2(1), EGFR(7), IGF1R(10), POLR2A(8), PPP2CA(3), RB1(7), TEP1(12), TERF1(1), TERT(2), TNKS(6), XRCC5(3) 4738126 62 27 61 30 19 25 2 11 5 0 0.729 1.000 1.000 497 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(5), ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), FPGT(3), FUK(1), GMDS(1), GMPPA(3), HK1(5), HK2(5), HK3(3), HSD3B7(3), LHPP(2), MTMR1(3), MTMR2(3), MTMR6(3), PFKFB2(4), PFKFB3(2), PFKFB4(1), PFKL(4), PFKM(2), PFKP(7), PHPT1(2), PMM1(1), PMM2(1), RDH11(1), RDH12(1), TPI1(2), TSTA3(4) 6442939 80 26 80 25 35 30 2 9 4 0 0.0612 1.000 1.000 498 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(2), CBS(3), CTH(2), GGT1(3), LCMT1(1), LCMT2(6), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), METTL6(1), PAPSS1(3), PAPSS2(2), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), SCLY(1), SEPHS2(1), WBSCR22(2) 4308136 46 26 46 23 12 16 2 8 8 0 0.815 1.000 1.000 499 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(1), GLB1(2), HEXA(1), HEXB(2), LCT(7), SLC33A1(4), ST3GAL1(2), ST3GAL2(4), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(2) 2840174 39 26 39 17 15 12 1 9 2 0 0.615 1.000 1.000 500 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 BCL2(1), CREBBP(10), EP300(13), FYN(5), IL2RG(3), IL7R(3), JAK1(2), JAK3(3), NMI(1), PIK3R1(5), PTK2B(5), STAT5A(1), STAT5B(2) 4458513 54 26 53 22 11 17 1 11 13 1 0.797 1.000 1.000 501 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), B4GALT1(2), B4GALT2(5), B4GALT5(3), DPM1(1), FUT8(2), MAN1B1(2), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(5), RPN1(1), RPN2(3) 3444284 37 26 36 25 13 9 1 10 4 0 0.992 1.000 1.000 502 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 26 ANXA1(3), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(2), EDN1(3), EDNRA(1), HSD11B2(2), PLA2G4A(3), PRL(1), PTGDR(4), PTGER2(2), PTGER4(1), PTGFR(3), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(1) 3421233 43 26 43 18 7 15 4 12 5 0 0.723 1.000 1.000 503 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A1(4), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1) 2607077 38 25 38 17 6 17 2 11 2 0 0.735 1.000 1.000 504 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(10), CREM(1), FHL5(1), FSHB(1), FSHR(12), GNAS(11), XPO1(3) 1655801 39 25 38 13 13 11 2 11 2 0 0.622 1.000 1.000 505 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A1(4), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1) 2607077 38 25 38 17 6 17 2 11 2 0 0.735 1.000 1.000 506 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(3), ARSD(1), ARSE(3), ASAH1(2), GAL3ST1(4), GALC(4), GBA(4), GLB1(2), LCT(7), NEU2(2), NEU3(1), NEU4(1), PPAP2C(4), SMPD1(3), SPTLC2(2) 4178602 44 25 44 24 22 18 0 2 2 0 0.804 1.000 1.000 507 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(2), FUCA1(1), FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(7), MAN2B1(8), MAN2B2(8), MAN2C1(4), MANBA(2), NEU2(2), NEU3(1), NEU4(1) 3511757 43 25 43 19 19 12 0 6 6 0 0.719 1.000 1.000 508 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(2), BAD(1), BCL2(1), CBL(1), GRB2(1), IL2RA(1), IL2RG(3), IRS1(6), JAK1(2), JAK3(3), MAPK1(2), MAPK3(1), NMI(1), PIK3R1(5), PTPN6(3), RAF1(5), RPS6KB1(2), SHC1(3), SOCS1(1), SOCS3(3), SOS1(3), STAT5A(1), STAT5B(2), SYK(3) 5867062 56 25 55 26 15 20 0 11 9 1 0.877 1.000 1.000 509 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(4), ELK1(2), GRB2(1), IL6ST(2), JAK1(2), JAK2(8), JAK3(3), JUN(2), MAP2K1(2), MAPK3(1), PTPN11(4), RAF1(5), SHC1(3), SOS1(3), STAT3(6) 4130572 48 25 48 17 9 20 0 13 5 1 0.507 1.000 1.000 510 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(7), AP2A1(1), AP2M1(4), CALM1(1), CALM2(2), CALM3(1), DNM1(4), EPN1(2), PPP3CA(3), PPP3CB(1), SYNJ1(3), SYNJ2(9) 3742160 38 25 38 14 16 7 2 10 3 0 0.448 1.000 1.000 511 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(3), ATP6V0A1(4), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), FDXR(2), SHMT1(1) 2772982 40 25 40 18 7 17 2 11 3 0 0.729 1.000 1.000 512 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(10), ADRB2(3), GNAS(11), PLCE1(8), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6) 2548832 45 25 45 20 14 17 0 9 5 0 0.741 1.000 1.000 513 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(2), AKT2(2), AKT3(3), BPNT1(1), GRB2(1), ILK(1), MAPK1(2), MAPK3(1), PDK1(1), PIK3CD(8), PTEN(8), PTK2B(5), SHC1(3), SOS1(3) 3155010 41 25 40 16 14 14 0 7 6 0 0.687 1.000 1.000 514 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(3), APOA1(2), APOA4(1), APOC2(1), CETP(2), CYP7A1(3), HMGCR(4), LCAT(1), LDLR(4), LIPC(2), LPL(2), LRP1(18), SCARB1(3), SOAT1(3) 4736040 49 25 49 30 20 12 4 9 4 0 0.965 1.000 1.000 515 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A1(4), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1) 2607077 38 25 38 17 6 17 2 11 2 0 0.735 1.000 1.000 516 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(4), CCNB1(1), CCND1(1), CCND3(2), CCNE1(3), CCNH(1), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(3), CDKN2D(1), RB1(7), RBL1(3), TFDP1(2) 2778965 37 24 36 19 11 12 1 11 2 0 0.855 1.000 1.000 517 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(6), EPHB1(13), FYN(5), ITGA1(3), ITGB1(4), L1CAM(2), LYN(2), RAP1B(3), SELP(2) 2734111 41 24 40 22 16 7 4 12 2 0 0.882 1.000 1.000 518 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), IL13(1), MAF(2), MAP2K3(1), MAPK14(1), NFATC1(8), NFATC2(6), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6) 2074756 35 24 35 17 12 15 0 7 1 0 0.554 1.000 1.000 519 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(2), BHMT(3), CBS(3), CTH(2), DNMT1(10), DNMT3A(3), DNMT3B(6), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), MTR(9), SRM(1), TAT(1) 3578370 46 24 46 31 15 18 1 10 2 0 0.984 1.000 1.000 520 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(3), GALNS(1), GLB1(2), GNS(3), GUSB(2), HEXA(1), HEXB(2), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(2), IDS(2), IDUA(1), LCT(7), NAGLU(1), SPAM1(5) 3543115 41 24 40 19 11 19 1 8 2 0 0.737 1.000 1.000 521 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(5), POLR1C(2), POLR1D(1), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(10), POLR3B(3), POLR3G(1), POLR3K(1) 4071009 39 24 39 14 13 14 1 9 2 0 0.454 1.000 1.000 522 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(4), EPX(4), LPO(2), MPO(5), PRDX6(1), SHMT1(1), SHMT2(3), TPO(13) 2036723 34 24 34 12 11 6 1 10 6 0 0.488 1.000 1.000 523 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(5), ARHGEF1(2), GNA12(1), GNAQ(1), GNGT1(3), MYL2(1), MYLK(7), PLCB1(10), PPP1R12B(6), ROCK1(7) 3575651 43 24 43 20 12 12 0 11 7 1 0.883 1.000 1.000 524 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(2), CCND1(1), CCNE1(3), CDK2(2), CDK6(4), CDKN1A(1), MAPK1(2), MAPK3(1), NFKB1(5), PAK1(4), PIK3R1(5), RAF1(5), RB1(7), RELA(1), TFDP1(2) 3127692 45 24 44 15 8 16 1 11 9 0 0.539 1.000 1.000 525 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(13), TYR(3) 1667887 29 24 29 16 11 5 0 10 3 0 0.925 1.000 1.000 526 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(3), AKR1D1(1), ARSB(3), ARSD(1), ARSE(3), CYP11B1(2), CYP11B2(2), HSD11B2(2), HSD17B3(1), HSD3B1(1), HSD3B2(1), SRD5A1(2), SRD5A2(2), STS(2), SULT1E1(3), UGT1A1(1), UGT1A5(3), UGT2B15(1), UGT2B4(2) 4735151 36 23 36 16 11 15 0 5 5 0 0.631 1.000 1.000 527 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(7), MAP2K1(2), MAP3K1(6), MAPK14(1), NCOR2(13), RARA(1), RXRA(2), THRA(2), THRB(3) 2973132 41 23 41 20 17 8 0 11 5 0 0.774 1.000 1.000 528 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA(4), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(13) 1453726 30 23 30 13 13 7 0 8 2 0 0.690 1.000 1.000 529 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(5), ITGAL(5), ITGAM(4), ITGB1(4), ITGB2(5), SELE(3), SELL(4), SELP(2) 2769771 39 23 38 22 14 7 1 10 7 0 0.935 1.000 1.000 530 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(2), CAMK2A(1), CAMK2G(4), CAMK4(4), HDAC5(4), MEF2B(3), MEF2C(2), MEF2D(5), PPARA(3), PPP3CA(3), PPP3CB(1), SLC2A4(1), YWHAH(1) 3501495 39 23 39 15 13 11 2 10 3 0 0.469 1.000 1.000 531 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(4), BLVRA(2), CP(3), EPRS(6), FECH(4), GUSB(2), HCCS(1), HMOX1(3), PPOX(2), UGT1A1(1), UGT1A5(3), UGT2B15(1), UGT2B4(2), UROD(1), UROS(3) 4739103 38 23 38 19 6 15 1 10 6 0 0.877 1.000 1.000 532 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), CD44(5), FCGR3A(1), IL1B(1), SELL(4), TGFB1(3), TGFB2(6), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1) 2292338 31 23 31 16 9 9 0 8 5 0 0.734 1.000 1.000 533 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(5), DNMT1(10), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGDR(4), PTGER2(2), PTGER4(1), PTGFR(3), TBXA2R(6) 1918397 37 23 37 21 12 12 3 8 2 0 0.859 1.000 1.000 534 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(7), CHAT(1), COMT(3), DBH(1), DDC(3), GAD1(3), GAD2(3), HDC(2), MAOA(1), PAH(3), PNMT(3), SLC18A3(5), TH(1), TPH1(1) 2485527 38 22 38 17 16 10 1 10 1 0 0.620 1.000 1.000 535 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), GOT1(1), GOT2(2), GPT2(2), MDH1(3), ME1(2), ME2(3), ME3(4), PGK1(1), PKLR(4), PKM2(2), TPI1(2) 3114534 34 22 34 14 13 9 1 9 2 0 0.622 1.000 1.000 536 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(7), POLE(12), POLG(3), POLL(1), POLQ(13) 2884255 36 22 36 22 10 9 1 9 7 0 0.962 1.000 1.000 537 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALT1(2), B4GALT2(5), B4GALT4(3), FUT1(1), FUT4(1), FUT7(1), FUT9(2), ST3GAL6(2), ST8SIA1(3) 2775393 26 22 25 14 9 8 1 7 1 0 0.871 1.000 1.000 538 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), GOT1(1), GOT2(2), GPT2(2), MDH1(3), ME1(2), ME3(4), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TKTL1(4), TKTL2(4), TPI1(2) 3482436 40 22 40 19 15 12 2 10 1 0 0.767 1.000 1.000 539 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), C9orf95(1), CD38(1), ENPP1(1), ENPP3(2), NADK(2), NADSYN1(3), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(1), NNT(6), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT12(1) 3719540 34 22 34 16 10 12 2 6 3 1 0.774 1.000 1.000 540 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(3), CBS(3), CTH(2), DNMT1(10), DNMT3A(3), DNMT3B(6), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), MTR(9) 3002861 42 22 42 27 15 15 1 9 2 0 0.968 1.000 1.000 541 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(2), AKT2(2), AKT3(3), CDKN1A(1), ELK1(2), GRB2(1), MAP2K1(2), MAP2K2(1), NGFR(4), NTRK1(3), PIK3CD(8), SHC1(3), SOS1(3) 2412380 35 22 34 14 13 13 0 7 2 0 0.565 1.000 1.000 542 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(2), IKBKB(3), JUN(2), LTA(2), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP4K2(3), MAPK14(1), MAPK8(3), NFKB1(5), RELA(1), TANK(2), TNF(1), TNFRSF1A(2), TRAF2(2) 4159826 44 22 44 18 12 13 1 11 7 0 0.660 1.000 1.000 543 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(10), ADRB2(3), CFTR(2), GNAS(11), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6) 2260164 39 21 39 16 15 15 0 6 3 0 0.628 1.000 1.000 544 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), G6PD(2), GPI(4), H6PD(3), PFKL(4), PFKM(2), PFKP(7), PGD(1), PGLS(2), PGM1(2), PGM3(6), PRPS1(1), PRPS1L1(1), PRPS2(1), TALDO1(2), TKTL1(4), TKTL2(4) 4198252 54 21 54 25 16 23 3 9 3 0 0.605 1.000 1.000 545 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(1), IARS(6), IARS2(3), ILVBL(1), LARS(2), LARS2(5), PDHA1(1), PDHA2(4), PDHB(2), VARS(7), VARS2(4) 3221674 37 21 37 12 10 10 2 11 4 0 0.441 1.000 1.000 546 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(2), G6PD(2), GCLM(2), GGT1(3), GPX3(1), GPX4(1), GPX6(1), GPX7(2), GSR(4), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTZ1(3), MGST1(1), MGST3(1), OPLAH(4), TXNDC12(1) 3764629 39 21 39 18 12 12 2 11 2 0 0.744 1.000 1.000 547 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(4), ELK1(2), GRB2(1), IL2RA(1), IL2RG(3), JAK1(2), JAK3(3), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(3), RAF1(5), SHC1(3), SOS1(3), STAT5A(1), STAT5B(2), SYK(3) 4042673 41 21 40 16 8 16 0 11 5 1 0.673 1.000 1.000 548 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(8), ABCB11(4), ABCB4(9), ABCC1(3), ABCC3(6), GSTP1(1) 2483600 31 21 31 14 8 10 1 7 5 0 0.713 1.000 1.000 549 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA1(1), FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(7), MAN2C1(4), MANBA(2), NEU2(2), NEU3(1), NEU4(1) 2847692 27 21 27 15 11 7 0 4 5 0 0.921 1.000 1.000 550 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(2), CD4(2), FYN(5), HLA-DRA(3), HLA-DRB1(1), PTPRC(14), ZAP70(2) 1561630 31 21 29 17 5 10 1 12 3 0 0.956 1.000 1.000 551 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(2), CDKN2A(3), MDM2(3), PIK3R1(5), POLR1A(5), POLR1C(2), POLR1D(1), RB1(7), TBX2(3) 2979685 31 20 30 18 8 11 1 4 7 0 0.914 1.000 1.000 552 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(13), CDC25A(2), CDC25B(2), CDC25C(2), CHEK1(1), MYT1(9), YWHAH(1) 2393987 30 20 29 10 11 11 1 3 3 1 0.436 1.000 1.000 553 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP2(3), ACP6(2), ACPP(2), ACPT(1), ALPI(3), ALPL(3), ALPP(4), ALPPL2(4), CYP3A4(1), CYP3A43(3), CYP3A7(2), DHRS3(1), DHRS7(1), DHRSX(2), PON1(1), PON2(2) 3103023 35 20 35 17 12 13 1 3 6 0 0.721 1.000 1.000 554 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10L(4), RPL12(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL23A(1), RPL3(2), RPL31(1), RPL34(1), RPL36A(1), RPL6(1), RPL8(2), RPL9(2), RPS10(1), RPS11(1), RPS13(1), RPS23(1), RPS3(1), RPS3A(1), RPS5(2), RPS6(1), RPSA(3) 3917473 34 20 34 14 9 15 1 5 4 0 0.689 1.000 1.000 555 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(4), GRB2(1), IL3(1), IL3RA(4), JAK2(8), MAP2K1(2), MAPK3(1), PTPN6(3), RAF1(5), SHC1(3), SOS1(3), STAT5A(1), STAT5B(2) 3059909 38 20 38 16 10 16 0 7 5 0 0.671 1.000 1.000 556 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 20 AMT(4), ASNS(3), CA12(1), CA14(1), CA4(2), CA5B(1), CA6(3), CA7(2), CA8(1), CA9(2), CTH(2), GLS(4), GLS2(4), GLUD1(4), GLUL(1), HAL(1) 2741985 36 20 36 13 10 11 1 9 5 0 0.513 1.000 1.000 557 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), G6PD(2), GPI(4), H6PD(3), PFKM(2), PFKP(7), PGD(1), PGLS(2), PGM1(2), PGM3(6), PRPS1(1), PRPS1L1(1), PRPS2(1), TAL1(1), TALDO1(2) 3526651 43 20 43 21 14 16 2 8 3 0 0.682 1.000 1.000 558 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(2), BAD(1), CHRNG(3), MUSK(4), PIK3R1(5), PTK2(7), PTK2B(5), RAPSN(2), TERT(2), YWHAH(1) 2445280 32 19 32 17 9 9 3 5 6 0 0.896 1.000 1.000 559 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(6), EGF(4), EGFR(7), GRB2(1), MET(4), PDGFRA(3), SH3GLB1(1), SH3GLB2(3), SH3KBP1(5) 3358407 35 19 35 28 14 7 2 7 5 0 0.996 1.000 1.000 560 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(7), ERBB3(16), NRG1(5) 1766190 32 19 29 12 9 8 0 13 2 0 0.641 1.000 1.000 561 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(2), ATM(13), BCL2(1), CCND1(1), CCNE1(3), CDK2(2), CDKN1A(1), MDM2(3), PCNA(2), RB1(7), TIMP3(2) 3004204 37 19 35 13 8 16 2 5 5 1 0.523 1.000 1.000 562 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(1), DAB1(5), FYN(5), LRP8(2), RELN(17), VLDLR(2) 2428428 34 19 34 16 10 13 1 7 3 0 0.756 1.000 1.000 563 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(2), CD3G(2), CD4(2), ICAM1(2), ITGAL(5), ITGB2(5), PTPRC(14) 1952702 34 19 32 15 9 8 1 11 5 0 0.828 1.000 1.000 564 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(2), G6PD(2), GCLM(2), GGT1(3), GPX3(1), GPX4(1), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTM3(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTZ1(3), MGST1(1), MGST3(1), PGD(1) 3111978 27 18 27 15 9 9 1 7 1 0 0.843 1.000 1.000 565 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(3), GALNS(1), GLB1(2), GNS(3), GUSB(2), HEXA(1), HEXB(2), IDS(2), IDUA(1), LCT(7), NAGLU(1) 2476130 25 18 25 15 6 12 0 5 2 0 0.900 1.000 1.000 566 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(5), ITGAL(5), ITGB1(4), ITGB2(5), SELE(3), SELL(4) 2103768 33 18 32 16 12 7 1 7 6 0 0.724 1.000 1.000 567 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(4), GREB1(9), HSPB1(1), MTA1(3), PDZK1(2), TUBA8(3) 1896919 23 18 23 12 8 8 1 2 4 0 0.760 1.000 1.000 568 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(5), ITGAM(4), ITGB2(5), SELE(3), SELL(4) 1811952 28 18 28 16 12 4 1 6 5 0 0.918 1.000 1.000 569 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(4), CCNE1(3), CDC34(1), CDK2(2), CUL1(8), RB1(7), SKP2(3), TFDP1(2) 1487297 30 18 29 12 5 11 1 10 3 0 0.613 1.000 1.000 570 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(1), IKBKAP(2), IKBKB(3), LTA(2), MAP3K1(6), MAP3K14(2), NFKB1(5), RELA(1), TANK(2), TNFAIP3(5), TNFRSF1B(1), TRAF1(2), TRAF2(2), TRAF3(2) 3891280 36 18 36 13 15 9 1 6 5 0 0.478 1.000 1.000 571 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 19 ALDH18A1(4), ARG1(2), ASL(3), CKB(1), CKMT1A(2), CKMT1B(2), CKMT2(4), GATM(2), GLUD1(4), NAGS(1), ODC1(2), OTC(2), PYCR1(2), SMS(2) 2481066 33 18 33 12 17 8 1 7 0 0 0.377 1.000 1.000 572 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDPS(3), HMGCR(4), LSS(3), MVD(2), MVK(4), NQO1(2), NQO2(2), SC5DL(1), SQLE(4), VKORC1(1) 1921701 28 17 28 11 12 8 0 6 2 0 0.555 1.000 1.000 573 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP51A1(2), DHCR24(2), DHCR7(2), EBP(1), FDPS(3), GGPS1(1), HMGCR(4), HSD17B7(1), LSS(3), MVD(2), MVK(4), NQO1(2), NSDHL(2), SC4MOL(2), SC5DL(1), SQLE(4), TM7SF2(1), VKORC1(1) 3349428 38 17 38 19 14 9 2 10 3 0 0.892 1.000 1.000 574 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(4), MBTPS1(5), MBTPS2(2), SCAP(6), SREBF1(2), SREBF2(5) 2036196 25 17 25 14 8 11 0 4 2 0 0.827 1.000 1.000 575 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(4), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(1), CDK2(2), CDKN2A(3), E2F2(2), PRB1(2) 1506602 19 17 19 14 3 8 1 5 2 0 0.965 1.000 1.000 576 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(5), IL4R(1), JAK1(2), JAK2(8), TYK2(4) 1813352 23 17 23 10 6 6 2 4 4 1 0.769 1.000 1.000 577 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(5), IL4R(1), JAK1(2), JAK2(8), TYK2(4) 1813352 23 17 23 10 6 6 2 4 4 1 0.769 1.000 1.000 578 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(2), ARPC1A(3), ARPC4(1), NCK1(3), NCKAP1(5), NTRK1(3), PSMA7(3), WASF1(3), WASF2(2), WASF3(1), WASL(1) 2636308 28 16 28 22 12 9 1 3 3 0 0.987 1.000 1.000 579 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(2), FDPS(3), HMGCR(4), HMGCS1(1), LSS(3), MVD(2), MVK(4), NSDHL(2), SC4MOL(2), SC5DL(1), SQLE(4) 2289128 30 16 30 13 12 7 1 8 2 0 0.718 1.000 1.000 580 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(8), ABCG2(2), BCHE(3), CES1(6), CES2(4), CYP3A4(1), UGT1A1(1), UGT1A5(3) 3957881 31 16 31 18 4 14 2 6 5 0 0.919 1.000 1.000 581 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGT(1), AGTR1(1), AGTR2(1), BDKRB2(2), KNG1(4), NOS3(3), REN(2) 1704505 18 15 18 11 6 6 1 2 3 0 0.819 1.000 1.000 582 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), CDK5R1(1), EGR1(3), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), NGFR(4), RAF1(5) 1411144 21 15 21 12 8 7 0 5 1 0 0.853 1.000 1.000 583 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(5), FARSA(2), FARSB(1), GOT1(1), GOT2(2), PAH(3), TAT(1), YARS(1), YARS2(1) 1506844 17 15 17 10 7 4 0 6 0 0 0.933 1.000 1.000 584 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), GRB2(1), IL2RG(3), IL4R(1), IRS1(6), JAK1(2), JAK3(3), RPS6KB1(2), SHC1(3) 2560727 23 15 22 14 6 8 0 4 4 1 0.967 1.000 1.000 585 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(2), HDAC9(1), MEF2B(3), MEF2C(2), MEF2D(5), MYOD1(3), YWHAH(1) 1362412 18 15 18 11 8 4 2 3 1 0 0.871 1.000 1.000 586 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), CD38(1), ENPP1(1), ENPP3(2), NADSYN1(3), NMNAT1(1), NMNAT2(1), NNMT(1), NNT(6), NT5C(1) 2511644 19 15 19 12 2 6 2 6 2 1 0.968 1.000 1.000 587 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(3), CAPN1(2), CAPNS1(1), CAPNS2(1), CDK5(2), CDK5R1(1), GSK3B(2), MAPT(3), PPP2CA(3) 1607661 18 15 17 10 8 7 0 1 2 0 0.788 1.000 1.000 588 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9) 2320362 25 15 25 11 10 9 0 4 2 0 0.643 1.000 1.000 589 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), HLA-DRA(3), HLA-DRB1(1), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(2), IL2RA(1), IL4R(1) 2195559 23 15 23 11 7 4 2 7 3 0 0.735 1.000 1.000 590 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(3), DLL1(3), FURIN(1), NOTCH1(12), PSEN1(1) 1589085 20 14 20 15 8 6 1 3 2 0 0.934 1.000 1.000 591 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(1), UBE2A(2), UBE2D3(1), UBE2E3(3), UBE2G2(1), UBE2H(1), UBE2I(1), UBE2J2(3), UBE2L3(1), UBE2L6(1), UBE3A(4) 1816230 20 14 20 11 6 7 1 3 3 0 0.790 1.000 1.000 592 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(2), ARPC1A(3), ARPC4(1), CDC42(1), PAK1(4), PDGFRA(3), PIK3R1(5), WASL(1) 1938906 20 13 20 13 4 9 1 1 5 0 0.954 1.000 1.000 593 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(4), EGFR(7), HGS(3), RAB5A(2), TF(5) 2231430 23 13 23 13 4 5 1 10 3 0 0.918 1.000 1.000 594 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2B(1), ADORA3(2), LTB4R(1), P2RY1(4), P2RY6(3) 1026499 15 13 15 8 6 3 0 6 0 0 0.763 1.000 1.000 595 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(15), RANGAP1(4) 1458848 20 13 20 12 1 9 2 6 2 0 0.907 1.000 1.000 596 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(3), CTH(2), GGT1(3), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), PAPSS1(3), PAPSS2(2), SCLY(1) 2136099 20 13 20 14 7 8 1 2 2 0 0.936 1.000 1.000 597 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(1), IL13(1), IL16(1), IL3(1), IL8(1), LTA(2), TNF(1) 1724539 14 12 14 11 3 4 1 6 0 0 0.966 1.000 1.000 598 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(8), GRHPR(2), HAO1(1), MDH1(3), MTHFD1(2), MTHFD1L(2), MTHFD2(1) 2211514 19 12 18 11 5 10 0 2 2 0 0.830 1.000 1.000 599 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(8), GRHPR(2), HAO1(1), MDH1(3), MTHFD1(2), MTHFD1L(2), MTHFD2(1) 2316213 19 12 18 11 5 10 0 2 2 0 0.827 1.000 1.000 600 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(10), PTK2B(5) 1165398 15 12 14 7 8 3 0 4 0 0 0.759 1.000 1.000 601 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), ADSS(3), IMPDH1(1), MTHFD2(1), POLD1(7), POLG(3), PRPS2(1), RRM1(3), SRM(1) 2152171 22 12 22 10 4 13 1 2 2 0 0.608 1.000 1.000 602 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(5), B3GALT5(1), B3GNT5(1), FUT1(1), ST3GAL4(3) 1248240 13 11 13 7 7 2 0 4 0 0 0.850 1.000 1.000 603 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(2), BCL2(1), CASP3(1), CASP9(1), DAXX(3), FAS(2), HSPB1(1), MAPKAPK3(1), TNF(1) 1954967 14 11 14 12 7 4 0 2 1 0 0.970 1.000 1.000 604 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(3), HDC(2), PNMT(3), TH(1), TPH1(1) 1042142 11 10 11 8 4 3 1 3 0 0 0.929 1.000 1.000 605 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), ACAT2(2), BDH1(1), HMGCS1(1), HMGCS2(1), OXCT1(3) 1249587 10 9 10 7 3 4 0 3 0 0 0.941 1.000 1.000 606 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(3), ALDH1A2(4), BCMO1(1), RDH5(2) 673563 10 9 10 11 3 2 0 4 1 0 0.997 1.000 1.000 607 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(4), AASDH(3), AASS(2), KARS(2) 1208101 11 8 11 7 2 7 1 1 0 0 0.881 1.000 1.000 608 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PLCD1(1), TGM2(4) 863842 8 8 8 5 6 1 0 1 0 0 0.793 1.000 1.000 609 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(2), ARPC1A(3), ARPC4(1), CDC42(1), WASF1(3), WASL(1) 1406748 12 7 12 13 4 5 1 1 1 0 0.995 1.000 1.000 610 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(3), RAB27A(3), RAB5A(2), RAB6A(1) 744678 10 6 10 9 2 6 0 2 0 0 0.949 1.000 1.000 611 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), ACAT2(2), OXCT1(3) 584778 7 6 7 5 2 4 0 1 0 0 0.927 1.000 1.000 612 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6) 349972 6 5 6 3 2 1 0 3 0 0 0.835 1.000 1.000 613 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(2), TAT(1) 453569 4 4 4 3 2 1 0 1 0 0 0.886 1.000 1.000 614 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(1) 312759 2 2 2 2 1 1 0 0 0 0 0.910 1.000 1.000 615 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1) 882556 1 1 1 5 1 0 0 0 0 0 1.000 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 87928 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000