Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.096 0.315 -9999.0 0.0 -0.912 20.0 20.0 IHH -0.089 0.231 -9999.0 0.0 -0.615 29.0 29.0 SHH Np/Cholesterol/GAS1 -0.055 0.171 -9999.0 0.0 -0.657 7.0 7.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.072 0.162 0.65 7.0 -9999.0 0.0 7.0 SMO/beta Arrestin2 -0.057 0.202 -9999.0 0.0 -0.684 8.0 8.0 SMO -0.066 0.213 -9999.0 0.0 -0.726 8.0 8.0 AKT1 -0.011 0.097 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.009 0.127 -9999.0 0.0 -0.756 5.0 5.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.065 0.209 -9999.0 0.0 -0.711 8.0 8.0 STIL -0.127 0.27 -9999.0 0.0 -0.678 24.0 24.0 DHH N/PTCH2 -0.109 0.252 -9999.0 0.0 -0.666 30.0 30.0 DHH N/PTCH1 -0.053 0.185 -9999.0 0.0 -0.648 8.0 8.0 PIK3CA 0.007 0.065 -9999.0 0.0 -0.879 1.0 1.0 DHH 0.0 0.089 -9999.0 0.0 -0.674 3.0 3.0 PTHLH -0.096 0.308 -9999.0 0.0 -1.039 11.0 11.0 determination of left/right symmetry -0.065 0.209 -9999.0 0.0 -0.711 8.0 8.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.095 0.304 -9999.0 0.0 -1.022 11.0 11.0 IHH N/Hhip -0.161 0.269 -9999.0 0.0 -0.528 60.0 60.0 DHH N/Hhip -0.118 0.193 -9999.0 0.0 -0.425 51.0 51.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.065 0.209 -9999.0 0.0 -0.711 8.0 8.0 pancreas development -0.144 0.257 -9999.0 0.0 -0.571 49.0 49.0 HHAT 0.005 0.061 -9999.0 0.0 -0.572 2.0 2.0 PI3K -0.004 0.05 -9999.0 0.0 -0.684 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.027 0.164 -9999.0 0.0 -0.695 10.0 10.0 somite specification -0.065 0.209 -9999.0 0.0 -0.711 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.082 0.215 -9999.0 0.0 -0.625 16.0 16.0 SHH Np/Cholesterol/PTCH2 -0.117 0.231 -9999.0 0.0 -0.578 29.0 29.0 SHH Np/Cholesterol/Megalin -0.111 0.213 -9999.0 0.0 -0.573 22.0 22.0 SHH -0.049 0.167 -9999.0 0.0 -0.435 28.0 28.0 catabolic process -0.059 0.195 -9999.0 0.0 -0.636 9.0 9.0 SMO/Vitamin D3 -0.082 0.227 -9999.0 0.0 -0.656 16.0 16.0 SHH Np/Cholesterol/Hhip -0.119 0.215 -9999.0 0.0 -0.635 16.0 16.0 LRP2 -0.113 0.291 -9999.0 0.0 -0.773 29.0 29.0 receptor-mediated endocytosis -0.152 0.222 -9999.0 0.0 -0.639 22.0 22.0 SHH Np/Cholesterol/BOC -0.045 0.152 -9999.0 0.0 -0.576 6.0 6.0 SHH Np/Cholesterol/CDO -0.048 0.161 -9999.0 0.0 -0.605 7.0 7.0 mesenchymal cell differentiation 0.133 0.204 0.629 16.0 -9999.0 0.0 16.0 mol:Vitamin D3 -0.08 0.217 -9999.0 0.0 -0.628 16.0 16.0 IHH N/PTCH2 -0.154 0.289 -9999.0 0.0 -0.567 54.0 54.0 CDON -0.013 0.145 -9999.0 0.0 -0.879 5.0 5.0 IHH N/PTCH1 -0.059 0.197 -9999.0 0.0 -0.644 9.0 9.0 Megalin/LRPAP1 -0.093 0.221 -9999.0 0.0 -0.59 29.0 29.0 PTCH2 -0.121 0.313 -9999.0 0.0 -0.857 28.0 28.0 SHH Np/Cholesterol -0.052 0.125 -9999.0 0.0 -0.34 28.0 28.0 PTCH1 -0.059 0.196 -9999.0 0.0 -0.639 9.0 9.0 HHIP -0.144 0.258 -9999.0 0.0 -0.572 49.0 49.0