Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.05 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.011 0.06 -9999.0 0.0 -0.514 1.0 1.0 CYFIP2 0.0 0.089 -9999.0 0.0 -0.674 3.0 3.0 ENAH 0.046 0.058 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.027 0.173 -9999.0 0.0 -0.776 9.0 9.0 EPHA2 0.005 0.061 -9999.0 0.0 -0.572 2.0 2.0 MYO6 0.023 0.062 -9999.0 0.0 -0.489 1.0 1.0 CTNNB1 0.007 0.065 -9999.0 0.0 -0.879 1.0 1.0 ABI1/Sra1/Nap1 -0.007 0.056 -9999.0 0.0 -0.429 3.0 3.0 AQP5 -0.207 0.227 -9999.0 0.0 -0.457 79.0 79.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.023 0.061 -9999.0 0.0 -0.48 1.0 1.0 regulation of calcium-dependent cell-cell adhesion 0.01 0.093 -9999.0 0.0 -0.75 1.0 1.0 EGF -0.138 0.294 -9999.0 0.0 -0.69 39.0 39.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.026 0.095 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization -0.011 0.06 -9999.0 0.0 -0.514 1.0 1.0 GO:0000145 0.022 0.058 -9999.0 0.0 -0.458 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.011 0.06 -9999.0 0.0 -0.52 1.0 1.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.013 0.064 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.006 0.051 -9999.0 0.0 -0.547 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.025 0.077 -9999.0 0.0 -0.445 1.0 1.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.023 0.062 -9999.0 0.0 -0.489 1.0 1.0 ARF6/GTP -0.006 0.047 -9999.0 0.0 -0.505 1.0 1.0 CDH1 -0.004 0.095 -9999.0 0.0 -0.572 5.0 5.0 EGFR/EGFR/EGF/EGF -0.102 0.195 -9999.0 0.0 -0.563 20.0 20.0 RhoA/GDP -0.01 0.056 -9999.0 0.0 -0.483 1.0 1.0 actin cytoskeleton organization 0.028 0.059 -9999.0 0.0 -0.451 1.0 1.0 IGF-1R heterotetramer 0.002 0.092 -9999.0 0.0 -0.877 2.0 2.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.002 0.092 -9999.0 0.0 -0.879 2.0 2.0 IGF1 -0.088 0.268 -9999.0 0.0 -0.785 23.0 23.0 DIAPH1 -0.009 0.064 -9999.0 0.0 -0.564 2.0 2.0 Wnt receptor signaling pathway 0.011 0.06 0.514 1.0 -9999.0 0.0 1.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.013 0.064 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.028 0.061 -9999.0 0.0 -0.463 1.0 1.0 EFNA1 0.007 0.065 -9999.0 0.0 -0.879 1.0 1.0 LPP 0.01 0.132 -9999.0 0.0 -0.627 6.0 6.0 Ephrin A1/EPHA2 -0.015 0.074 -9999.0 0.0 -0.506 2.0 2.0 SEC6/SEC8 -0.009 0.049 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.01 0.095 -9999.0 0.0 -0.771 1.0 1.0 HGF/MET -0.046 0.135 -9999.0 0.0 -0.476 15.0 15.0 HGF -0.003 0.113 -9999.0 0.0 -0.879 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.019 0.051 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.056 0.062 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.02 0.063 -9999.0 0.0 -0.467 1.0 1.0 KIFC3 0.023 0.062 -9999.0 0.0 -0.489 1.0 1.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.011 0.098 -9999.0 0.0 -0.496 5.0 5.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.011 0.06 -9999.0 0.0 -0.514 1.0 1.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.023 0.062 -9999.0 0.0 -0.489 1.0 1.0 PIP5K1C 0.023 0.062 -9999.0 0.0 -0.489 1.0 1.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.042 0.067 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.035 0.062 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.066 0.177 -9999.0 0.0 -0.562 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.042 0.211 -9999.0 0.0 -0.879 11.0 11.0 PLEKHA7 0.021 0.066 -9999.0 0.0 -0.489 1.0 1.0 mol:GTP -0.006 0.051 -9999.0 0.0 -0.542 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.045 0.055 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.018 0.05 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.028 0.059 -9999.0 0.0 -0.451 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.019 0.051 -9999.0 0.0 -9999.0 0.0 0.0