Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.038 0.139 -9999.0 0.0 -0.473 9.0 9.0 IHH -0.042 0.17 -9999.0 0.0 -0.44 27.0 27.0 SHH Np/Cholesterol/GAS1 -0.014 0.096 -9999.0 0.0 -0.235 27.0 27.0 LRPAP1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.014 0.096 0.234 27.0 -9999.0 0.0 27.0 SMO/beta Arrestin2 -0.037 0.157 -9999.0 0.0 -0.421 15.0 15.0 SMO -0.05 0.151 -9999.0 0.0 -0.438 15.0 15.0 AKT1 -0.031 0.139 -9999.0 0.0 -0.458 12.0 12.0 ARRB2 0.028 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.061 -9999.0 0.0 -0.337 5.0 5.0 ADRBK1 0.03 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.049 0.149 -9999.0 0.0 -0.432 15.0 15.0 STIL -0.06 0.14 -9999.0 0.0 -0.377 19.0 19.0 DHH N/PTCH2 0.003 0.096 -9999.0 0.0 -0.219 28.0 28.0 DHH N/PTCH1 -0.02 0.123 -9999.0 0.0 -0.338 11.0 11.0 PIK3CA 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.023 0.051 -9999.0 0.0 -0.364 3.0 3.0 PTHLH -0.053 0.163 -9999.0 0.0 -0.535 10.0 10.0 determination of left/right symmetry -0.049 0.149 -9999.0 0.0 -0.432 15.0 15.0 PIK3R1 0.028 0.009 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.053 0.162 -9999.0 0.0 -0.531 10.0 10.0 IHH N/Hhip -0.08 0.187 -9999.0 0.0 -0.353 54.0 54.0 DHH N/Hhip -0.041 0.143 -9999.0 0.0 -0.284 46.0 46.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.049 0.149 -9999.0 0.0 -0.432 15.0 15.0 pancreas development -0.074 0.181 -9999.0 0.0 -0.397 44.0 44.0 HHAT 0.025 0.045 -9999.0 0.0 -0.397 2.0 2.0 PI3K 0.038 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.008 0.089 -9999.0 0.0 -0.357 10.0 10.0 somite specification -0.049 0.149 -9999.0 0.0 -0.432 15.0 15.0 SHH Np/Cholesterol/PTCH1 -0.048 0.132 -9999.0 0.0 -0.392 14.0 14.0 SHH Np/Cholesterol/PTCH2 -0.033 0.102 -9999.0 0.0 -0.196 48.0 48.0 SHH Np/Cholesterol/Megalin -0.035 0.106 -9999.0 0.0 -0.207 47.0 47.0 SHH -0.029 0.105 -9999.0 0.0 -0.288 25.0 25.0 catabolic process -0.035 0.127 -9999.0 0.0 -0.371 11.0 11.0 SMO/Vitamin D3 -0.054 0.149 -9999.0 0.0 -0.426 15.0 15.0 SHH Np/Cholesterol/Hhip -0.059 0.141 -9999.0 0.0 -0.265 53.0 53.0 LRP2 -0.028 0.133 -9999.0 0.0 -0.332 29.0 29.0 receptor-mediated endocytosis -0.077 0.155 -9999.0 0.0 -0.422 21.0 21.0 SHH Np/Cholesterol/BOC -0.012 0.092 -9999.0 0.0 -0.22 28.0 28.0 SHH Np/Cholesterol/CDO -0.011 0.088 -9999.0 0.0 -0.218 26.0 26.0 mesenchymal cell differentiation 0.059 0.14 0.264 53.0 -9999.0 0.0 53.0 mol:Vitamin D3 -0.045 0.137 0.2 3.0 -0.406 13.0 16.0 IHH N/PTCH2 -0.044 0.136 -9999.0 0.0 -0.252 52.0 52.0 CDON 0.019 0.054 -9999.0 0.0 -0.297 5.0 5.0 IHH N/PTCH1 -0.028 0.131 -9999.0 0.0 -0.374 11.0 11.0 Megalin/LRPAP1 -0.001 0.1 -9999.0 0.0 -0.232 28.0 28.0 PTCH2 -0.017 0.116 -9999.0 0.0 -0.301 26.0 26.0 SHH Np/Cholesterol -0.016 0.082 -9999.0 0.0 -0.217 25.0 25.0 PTCH1 -0.035 0.127 -9999.0 0.0 -0.372 11.0 11.0 HHIP -0.075 0.182 -9999.0 0.0 -0.397 44.0 44.0