Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
BRAF	183 (57%)	140	0.019436	1	3.6198e-38	1.01e-35	9.3991e-07	0.000255	2.5141e-11	6.84e-09	3.8796e-49	1.09e-46	7.7593e-49	2.18e-46	2.3538e-40	6.57e-38	3.3175e-43	9.29e-41
EMG1	6 (2%)	317	0.54831	1	1	1	0.3273	1	0.08457	1	1	1	1	1	1	1	1	1
HRAS	12 (4%)	311	0.0002221	0.0586	1.4785e-06	0.000399	9.2268e-05	0.0245	0.0052894	1	1.7051e-05	0.00454	5.2343e-06	0.0014	1.685e-06	0.000453	9.2537e-06	0.00247
NRAS	26 (8%)	297	0.0069154	1	6.06e-14	1.68e-11	1	1	0.00058312	0.153	1.6268e-12	4.47e-10	1.1144e-13	3.08e-11	1.8708e-12	5.13e-10	3.3046e-12	9.02e-10
PTTG1IP	4 (1%)	319	1	1	1	1	NA	NA	NA	NA	0.22255	1	0.45085	1	0.47129	1	0.3963	1
RPTN	8 (2%)	315	0.80523	1	0.44207	1	0.26549	1	0.80127	1	0.026747	1	0.6628	1	0.74024	1	0.67172	1
EIF1AX	5 (2%)	318	0.73075	1	0.027828	1	0.44359	1	0.13207	1	0.065444	1	0.025727	1	0.063412	1	0.19854	1
CCDC15	5 (2%)	318	0.73075	1	0.11479	1	1	1	0.38135	1	0.21101	1	0.32741	1	0.62659	1	0.10808	1
ZNF845	6 (2%)	317	0.4201	1	0.63746	1	0.63895	1	0.1252	1	0.94338	1	0.55233	1	0.87502	1	0.33387	1
ZNF878	4 (1%)	319	1	1	0.48745	1	NA	NA	NA	NA	0.047481	1	0.56093	1	0.6944	1	1	1
TG	16 (5%)	307	1	1	0.020467	1	0.34039	1	0.49163	1	0.14541	1	0.064265	1	0.045313	1	0.021034	1
PRB2	6 (2%)	317	1	1	0.63746	1	0.080108	1	0.85072	1	0.41482	1	0.62344	1	0.52859	1	0.51811	1
R3HDM2	4 (1%)	319	0.012437	1	0.062964	1	NA	NA	NA	NA	0.059824	1	0.065393	1	0.020966	1	0.0069365	1
IL32	3 (1%)	320	1	1	0.74157	1	NA	NA	NA	NA	1	1	1	1	0.20881	1	1	1
TMCO2	3 (1%)	320	1	1	0.4158	1	0.77837	1	0.19981	1	0.50012	1	0.21371	1	0.4183	1	0.77846	1
PPTC7	3 (1%)	320	0.079094	1	0.062683	1	NA	NA	NA	NA	0.17393	1	0.068786	1	0.31178	1	0.29242	1
MUC7	5 (2%)	318	0.73075	1	0.37204	1	0.68309	1	0.26003	1	0.80575	1	0.90775	1	0.86924	1	0.63111	1
LYPD3	3 (1%)	320	0.54697	1	0.4158	1	NA	NA	NA	NA	0.50012	1	0.42684	1	0.65256	1	0.77846	1
TMEM90B	3 (1%)	320	0.13479	1	1	1	NA	NA	NA	NA	1	1	1	1	1	1	1	1
ZNF799	5 (2%)	318	0.4648	1	1	1	0.5049	1	1	1	0.59836	1	0.90775	1	0.45338	1	1	1
PPM1D	5 (2%)	318	1	1	1	1	0.77837	1	0.1252	1	0.69528	1	0.21196	1	0.86924	1	0.32816	1
MAP3K3	4 (1%)	319	0.060961	1	0.22421	1	0.45902	1	0.08457	1	0.11665	1	0.31259	1	0.47129	1	0.55693	1
TROAP	3 (1%)	320	1	1	0.74157	1	0.77837	1	0.53454	1	0.75052	1	0.84961	1	0.53338	1	1	1
SYNPO2L	3 (1%)	320	0.54697	1	1	1	NA	NA	NA	NA	1	1	1	1	1	1	1	1
ATAD2	4 (1%)	319	1	1	0.82341	1	NA	NA	NA	NA	0.8129	1	0.56093	1	0.6944	1	1	1
KRAS	3 (1%)	320	1	1	0.062683	1	NA	NA	NA	NA	0.17393	1	0.097361	1	0.066143	1	0.024316	1
SLC5A11	3 (1%)	320	0.54697	1	0.74157	1	NA	NA	NA	NA	0.65684	1	0.36526	1	0.31178	1	0.29242	1
PRG4	4 (1%)	319	0.22971	1	0.10376	1	NA	NA	NA	NA	0.014304	1	0.028048	1	0.47129	1	0.55693	1
SCUBE2	3 (1%)	320	1	1	0.28125	1	NA	NA	NA	NA	0.31994	1	0.25867	1	0.65256	1	0.64295	1
ZNF479	3 (1%)	320	1	1	0.74157	1	NA	NA	NA	NA	1	1	1	1	0.53338	1	1	1
SREBF2	3 (1%)	320	1	1	0.74157	1	NA	NA	NA	NA	0.57703	1	0.21371	1	0.4183	1	0.77846	1
SLC26A11	3 (1%)	320	0.079094	1	1	1	NA	NA	NA	NA	0.37543	1	1	1	0.77641	1	0.39841	1
TSC22D1	3 (1%)	320	1	1	1	1	NA	NA	NA	NA	0.75052	1	0.84961	1	1	1	0.51215	1
ANKRD30A	5 (2%)	318	0.73075	1	0.46244	1	NA	NA	NA	NA	0.75003	1	0.51394	1	0.74346	1	0.74383	1
FAM155A	4 (1%)	319	0.14362	1	0.15568	1	0.77837	1	0.53454	1	NA	NA	NA	NA	0.036144	1	1	1
SLA	3 (1%)	320	0.54697	1	0.062683	1	0.28597	1	0.28488	1	0.17393	1	0.097361	1	0.066143	1	0.024316	1
ZFHX3	10 (3%)	313	0.17092	1	0.61631	1	0.4801	1	0.63189	1	0.58268	1	0.45886	1	0.61718	1	0.7209	1
ARMCX3	3 (1%)	320	0.54697	1	0.74157	1	NA	NA	NA	NA	0.65684	1	0.13225	1	0.53338	1	0.20044	1
SLC25A45	3 (1%)	320	0.13479	1	1	1	NA	NA	NA	NA	NA	NA	NA	NA	0.20881	1	0.29242	1
COL5A3	6 (2%)	317	0.75178	1	0.31733	1	0.77837	1	0.75837	1	0.051268	1	0.51835	1	0.87502	1	0.59634	1
CDC27	3 (1%)	320	1	1	1	1	NA	NA	NA	NA	0.37543	1	0.17015	1	0.77641	1	0.39841	1