Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.113 0.262 -9999.0 0.0 -0.695 33.0 33.0 IHH -0.212 0.375 -9999.0 0.0 -0.849 118.0 118.0 SHH Np/Cholesterol/GAS1 -0.109 0.208 -9999.0 0.0 -0.52 93.0 93.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.108 0.207 0.516 93.0 -9999.0 0.0 93.0 SMO/beta Arrestin2 -0.101 0.247 -9999.0 0.0 -0.489 121.0 121.0 SMO -0.113 0.26 -9999.0 0.0 -0.52 122.0 122.0 AKT1 -0.029 0.126 -9999.0 0.0 -1.006 1.0 1.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.003 0.116 -9999.0 0.0 -0.827 9.0 9.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.111 0.256 -9999.0 0.0 -0.512 122.0 122.0 STIL -0.082 0.204 -9999.0 0.0 -0.6 19.0 19.0 DHH N/PTCH2 -0.109 0.242 -9999.0 0.0 -0.642 78.0 78.0 DHH N/PTCH1 -0.104 0.231 -9999.0 0.0 -0.46 124.0 124.0 PIK3CA 0.008 0.068 -9999.0 0.0 -0.827 3.0 3.0 DHH 0.008 0.068 -9999.0 0.0 -0.827 3.0 3.0 PTHLH -0.162 0.374 -9999.0 0.0 -1.194 33.0 33.0 determination of left/right symmetry -0.111 0.256 -9999.0 0.0 -0.512 122.0 122.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.159 0.367 -9999.0 0.0 -1.166 33.0 33.0 IHH N/Hhip -0.39 0.406 -9999.0 0.0 -0.748 244.0 244.0 DHH N/Hhip -0.25 0.314 -9999.0 0.0 -0.642 179.0 179.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.111 0.256 -9999.0 0.0 -0.512 122.0 122.0 pancreas development -0.315 0.406 -9999.0 0.0 -0.82 180.0 180.0 HHAT 0.012 0.039 -9999.0 0.0 -0.827 1.0 1.0 PI3K -0.004 0.051 -9999.0 0.0 -0.636 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.154 0.336 -9999.0 0.0 -0.827 92.0 92.0 somite specification -0.111 0.256 -9999.0 0.0 -0.512 122.0 122.0 SHH Np/Cholesterol/PTCH1 -0.093 0.209 -9999.0 0.0 -0.623 18.0 18.0 SHH Np/Cholesterol/PTCH2 -0.091 0.193 -9999.0 0.0 -0.518 77.0 77.0 SHH Np/Cholesterol/Megalin -0.146 0.232 -9999.0 0.0 -0.521 126.0 126.0 SHH 0.007 0.05 -9999.0 0.0 -0.636 1.0 1.0 catabolic process -0.119 0.255 -9999.0 0.0 -0.518 121.0 121.0 SMO/Vitamin D3 -0.096 0.228 -9999.0 0.0 -0.66 18.0 18.0 SHH Np/Cholesterol/Hhip -0.205 0.248 -9999.0 0.0 -0.515 179.0 179.0 LRP2 -0.215 0.374 -9999.0 0.0 -0.827 125.0 125.0 receptor-mediated endocytosis -0.206 0.24 -9999.0 0.0 -0.721 48.0 48.0 SHH Np/Cholesterol/BOC -0.016 0.08 -9999.0 0.0 -0.527 10.0 10.0 SHH Np/Cholesterol/CDO -0.158 0.236 -9999.0 0.0 -0.518 137.0 137.0 mesenchymal cell differentiation 0.203 0.246 0.511 179.0 -9999.0 0.0 179.0 mol:Vitamin D3 -0.092 0.212 -9999.0 0.0 -0.63 18.0 18.0 IHH N/PTCH2 -0.24 0.353 -9999.0 0.0 -0.674 172.0 172.0 CDON -0.235 0.383 -9999.0 0.0 -0.827 136.0 136.0 IHH N/PTCH1 -0.121 0.258 -9999.0 0.0 -0.525 121.0 121.0 Megalin/LRPAP1 -0.172 0.283 -9999.0 0.0 -0.636 125.0 125.0 PTCH2 -0.125 0.312 -9999.0 0.0 -0.827 76.0 76.0 SHH Np/Cholesterol -0.006 0.036 -9999.0 0.0 -0.516 1.0 1.0 PTCH1 -0.12 0.256 -9999.0 0.0 -0.52 121.0 121.0 HHIP -0.316 0.406 -9999.0 0.0 -0.822 180.0 180.0