Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.089 0.209 -9999.0 0.0 -0.631 26.0 26.0 IHH -0.159 0.319 -9999.0 0.0 -0.702 116.0 116.0 SHH Np/Cholesterol/GAS1 -0.055 0.16 -9999.0 0.0 -0.407 74.0 74.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.054 0.159 0.404 74.0 -9999.0 0.0 74.0 SMO/beta Arrestin2 -0.078 0.208 -9999.0 0.0 -0.421 105.0 105.0 SMO -0.098 0.21 -9999.0 0.0 -0.442 109.0 109.0 AKT1 -0.017 0.107 -9999.0 0.0 -0.61 2.0 2.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.015 0.093 -9999.0 0.0 -0.679 8.0 8.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.097 0.207 -9999.0 0.0 -0.436 109.0 109.0 STIL -0.068 0.162 -9999.0 0.0 -0.492 14.0 14.0 DHH N/PTCH2 -0.052 0.206 -9999.0 0.0 -0.51 76.0 76.0 DHH N/PTCH1 -0.078 0.192 -9999.0 0.0 -0.377 119.0 119.0 PIK3CA 0.023 0.057 -9999.0 0.0 -0.679 3.0 3.0 DHH 0.022 0.057 -9999.0 0.0 -0.679 3.0 3.0 PTHLH -0.138 0.31 -9999.0 0.0 -1.049 29.0 29.0 determination of left/right symmetry -0.097 0.207 -9999.0 0.0 -0.436 109.0 109.0 PIK3R1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.137 0.305 -9999.0 0.0 -1.03 29.0 29.0 IHH N/Hhip -0.297 0.337 -9999.0 0.0 -0.598 240.0 240.0 DHH N/Hhip -0.172 0.268 -9999.0 0.0 -0.51 174.0 174.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.097 0.207 -9999.0 0.0 -0.436 109.0 109.0 pancreas development -0.25 0.333 -9999.0 0.0 -0.675 174.0 174.0 HHAT 0.024 0.034 -9999.0 0.0 -0.679 1.0 1.0 PI3K 0.036 0.045 -9999.0 0.0 -0.513 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.103 0.266 -9999.0 0.0 -0.63 90.0 90.0 somite specification -0.097 0.207 -9999.0 0.0 -0.436 109.0 109.0 SHH Np/Cholesterol/PTCH1 -0.073 0.162 -9999.0 0.0 -0.502 13.0 13.0 SHH Np/Cholesterol/PTCH2 -0.045 0.152 -9999.0 0.0 -0.414 61.0 61.0 SHH Np/Cholesterol/Megalin -0.084 0.182 -9999.0 0.0 -0.413 100.0 100.0 SHH -0.005 0.03 -9999.0 0.0 -0.513 1.0 1.0 catabolic process -0.097 0.206 -9999.0 0.0 -0.42 120.0 120.0 SMO/Vitamin D3 -0.079 0.186 -9999.0 0.0 -0.549 12.0 12.0 SHH Np/Cholesterol/Hhip -0.139 0.203 -9999.0 0.0 -0.395 173.0 173.0 LRP2 -0.159 0.309 -9999.0 0.0 -0.667 123.0 123.0 receptor-mediated endocytosis -0.145 0.214 -9999.0 0.0 -0.608 40.0 40.0 SHH Np/Cholesterol/BOC 0.013 0.059 -9999.0 0.0 -0.377 9.0 9.0 SHH Np/Cholesterol/CDO -0.097 0.187 -9999.0 0.0 -0.414 110.0 110.0 mesenchymal cell differentiation 0.138 0.201 0.393 173.0 -9999.0 0.0 173.0 mol:Vitamin D3 -0.067 0.17 -9999.0 0.0 -0.506 13.0 13.0 IHH N/PTCH2 -0.176 0.294 -9999.0 0.0 -0.541 168.0 168.0 CDON -0.181 0.321 -9999.0 0.0 -0.677 135.0 135.0 IHH N/PTCH1 -0.094 0.211 -9999.0 0.0 -0.418 128.0 128.0 Megalin/LRPAP1 -0.106 0.241 -9999.0 0.0 -0.501 123.0 123.0 PTCH2 -0.088 0.26 -9999.0 0.0 -0.675 75.0 75.0 SHH Np/Cholesterol 0.009 0.024 -9999.0 0.0 -0.407 1.0 1.0 PTCH1 -0.098 0.207 -9999.0 0.0 -0.421 120.0 120.0 HHIP -0.251 0.334 -9999.0 0.0 -0.676 174.0 174.0