Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.056 0.017 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.022 0.081 0.46 11.0 -9999.0 0.0 11.0 EGFR 0.02 0.066 -9999.0 0.0 -0.679 4.0 4.0 EPHA2 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.033 0.071 0.431 12.0 -9999.0 0.0 12.0 CTNNB1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.053 0.014 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.003 0.109 -9999.0 0.0 -0.539 16.0 16.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.025 0.054 0.396 8.0 -9999.0 0.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.009 0.059 0.392 6.0 -9999.0 0.0 6.0 EGF -0.076 0.247 -9999.0 0.0 -0.675 66.0 66.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.042 0.172 -9999.0 0.0 -0.535 45.0 45.0 cortical microtubule organization 0.056 0.017 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.013 0.054 0.386 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.061 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.062 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.014 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.021 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.068 0.028 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.01 0.146 -9999.0 0.0 -0.361 67.0 67.0 RhoA/GDP 0.057 0.017 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.022 0.057 0.398 9.0 -9999.0 0.0 9.0 IGF-1R heterotetramer 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.123 0.286 -9999.0 0.0 -0.676 96.0 96.0 DIAPH1 0.051 0.046 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.056 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.022 0.058 0.401 9.0 -9999.0 0.0 9.0 EFNA1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.012 0.05 0.353 3.0 -0.363 4.0 7.0 Ephrin A1/EPHA2 0.047 0.02 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.01 0.059 0.395 6.0 -9999.0 0.0 6.0 HGF/MET -0.003 0.145 -9999.0 0.0 -0.38 56.0 56.0 HGF -0.069 0.241 -9999.0 0.0 -0.679 62.0 62.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.07 0.14 0.497 31.0 -0.328 1.0 32.0 KIAA1543 0.013 0.055 0.366 8.0 -0.356 1.0 9.0 KIFC3 0.021 0.024 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.024 0.039 0.355 4.0 -9999.0 0.0 4.0 NCK1/GIT1 0.039 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.056 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.021 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.054 0.399 8.0 -9999.0 0.0 8.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.045 0.106 0.43 23.0 -9999.0 0.0 23.0 adherens junction assembly 0.027 0.095 0.48 13.0 -0.563 1.0 14.0 IGF-1R heterotetramer/IGF1 -0.034 0.165 -9999.0 0.0 -0.361 90.0 90.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.03 0.072 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.026 0.055 0.376 8.0 -0.373 1.0 9.0 mol:GTP 0.06 0.024 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.032 0.068 0.481 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.022 0.057 0.398 9.0 -9999.0 0.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0