Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.175 0.265 -9999.0 0.0 -0.695 56.0 56.0 IHH -0.259 0.27 -9999.0 0.0 -0.523 184.0 184.0 SHH Np/Cholesterol/GAS1 -0.104 0.175 -9999.0 0.0 -0.314 138.0 138.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.103 0.174 0.312 138.0 -9999.0 0.0 138.0 SMO/beta Arrestin2 -0.156 0.219 -9999.0 0.0 -0.519 60.0 60.0 SMO -0.17 0.23 -9999.0 0.0 -0.538 65.0 65.0 AKT1 -0.083 0.153 -9999.0 0.0 -0.554 20.0 20.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.019 0.119 -9999.0 0.0 -0.469 24.0 24.0 ADRBK1 0.011 0.024 -9999.0 0.0 -0.451 1.0 1.0 heart looping -0.168 0.226 -9999.0 0.0 -0.529 65.0 65.0 STIL -0.157 0.204 -9999.0 0.0 -0.497 70.0 70.0 DHH N/PTCH2 -0.026 0.134 -9999.0 0.0 -0.407 38.0 38.0 DHH N/PTCH1 -0.15 0.193 -9999.0 0.0 -0.497 49.0 49.0 PIK3CA 0.01 0.034 -9999.0 0.0 -0.451 2.0 2.0 DHH -0.024 0.132 -9999.0 0.0 -0.514 25.0 25.0 PTHLH -0.204 0.313 -9999.0 0.0 -0.822 52.0 52.0 determination of left/right symmetry -0.168 0.226 -9999.0 0.0 -0.529 65.0 65.0 PIK3R1 -0.018 0.124 -9999.0 0.0 -0.522 21.0 21.0 skeletal system development -0.201 0.309 -9999.0 0.0 -0.811 52.0 52.0 IHH N/Hhip -0.223 0.235 -9999.0 0.0 -0.45 159.0 159.0 DHH N/Hhip -0.088 0.181 -9999.0 0.0 -0.383 97.0 97.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.168 0.226 -9999.0 0.0 -0.529 65.0 65.0 pancreas development -0.099 0.214 -9999.0 0.0 -0.511 78.0 78.0 HHAT -0.004 0.093 -9999.0 0.0 -0.538 11.0 11.0 PI3K -0.006 0.093 -9999.0 0.0 -0.366 23.0 23.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.09 0.203 -9999.0 0.0 -0.491 75.0 75.0 somite specification -0.168 0.226 -9999.0 0.0 -0.529 65.0 65.0 SHH Np/Cholesterol/PTCH1 -0.17 0.214 -9999.0 0.0 -0.511 76.0 76.0 SHH Np/Cholesterol/PTCH2 -0.063 0.148 -9999.0 0.0 -0.298 97.0 97.0 SHH Np/Cholesterol/Megalin -0.158 0.188 -9999.0 0.0 -0.315 197.0 197.0 SHH -0.072 0.169 -9999.0 0.0 -0.374 85.0 85.0 catabolic process -0.154 0.198 -9999.0 0.0 -0.527 39.0 39.0 SMO/Vitamin D3 -0.179 0.232 -9999.0 0.0 -0.565 69.0 69.0 SHH Np/Cholesterol/Hhip -0.11 0.175 -9999.0 0.0 -0.308 147.0 147.0 LRP2 -0.189 0.246 -9999.0 0.0 -0.487 149.0 149.0 receptor-mediated endocytosis -0.237 0.241 -9999.0 0.0 -0.541 108.0 108.0 SHH Np/Cholesterol/BOC -0.065 0.152 -9999.0 0.0 -0.298 100.0 100.0 SHH Np/Cholesterol/CDO -0.058 0.151 -9999.0 0.0 -0.306 89.0 89.0 mesenchymal cell differentiation 0.109 0.174 0.306 147.0 -9999.0 0.0 147.0 mol:Vitamin D3 -0.17 0.216 -9999.0 0.0 -0.513 76.0 76.0 IHH N/PTCH2 -0.163 0.184 -9999.0 0.0 -0.327 192.0 192.0 CDON -0.005 0.092 -9999.0 0.0 -0.485 13.0 13.0 IHH N/PTCH1 -0.155 0.201 -9999.0 0.0 -0.533 39.0 39.0 Megalin/LRPAP1 -0.127 0.178 -9999.0 0.0 -0.342 149.0 149.0 PTCH2 -0.014 0.113 -9999.0 0.0 -0.497 19.0 19.0 SHH Np/Cholesterol -0.056 0.131 -9999.0 0.0 -0.288 85.0 85.0 PTCH1 -0.154 0.199 -9999.0 0.0 -0.529 39.0 39.0 HHIP -0.099 0.214 -9999.0 0.0 -0.511 78.0 78.0