Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	57.0	2984.0	52.0	-0.132	0.048	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-alpha and p38-beta	48.0	2112.0	44.0	-0.116	0.025	1000.0	-1000.0	-0.021	-1000.0
EPHB forward signaling	42.0	3642.0	85.0	-0.068	0.068	1000.0	-1000.0	-0.045	-1000.0
IL4-mediated signaling events	41.0	3746.0	91.0	-0.554	0.43	1000.0	-1000.0	-0.126	-1000.0
IL23-mediated signaling events	40.0	2457.0	60.0	-0.341	0.025	1000.0	-1000.0	-0.098	-1000.0
Ephrin A  reverse signaling	37.0	261.0	7.0	-0.039	0.017	1000.0	-1000.0	-0.011	-1000.0
Class IB PI3K non-lipid kinase events	36.0	108.0	3.0	-0.002	0.002	1000.0	-1000.0	-0.016	-1000.0
TCR signaling in naïve CD8+ T cells	34.0	3166.0	93.0	-0.098	0.035	1000.0	-1000.0	-0.038	-1000.0
TCGA08_retinoblastoma	32.0	259.0	8.0	-0.021	0.02	1000.0	-1000.0	-0.003	-1000.0
Noncanonical Wnt signaling pathway	31.0	821.0	26.0	-0.064	0.025	1000.0	-1000.0	-0.027	-1000.0
Ephrin B reverse signaling	31.0	1535.0	48.0	-0.076	0.025	1000.0	-1000.0	-0.017	-1000.0
Endothelins	31.0	3011.0	96.0	-0.113	0.053	1000.0	-1000.0	-0.049	-1000.0
Wnt signaling	30.0	210.0	7.0	-0.062	0.008	1000.0	-1000.0	-0.011	-1000.0
LPA receptor mediated events	30.0	3118.0	102.0	-0.079	0.028	1000.0	-1000.0	-0.057	-1000.0
HIF-1-alpha transcription factor network	28.0	2185.0	76.0	-0.148	0.036	1000.0	-1000.0	-0.072	-1000.0
IGF1 pathway	28.0	1598.0	57.0	-0.041	0.039	1000.0	-1000.0	-0.033	-1000.0
FOXA2 and FOXA3 transcription factor networks	27.0	1262.0	46.0	-0.266	0.027	1000.0	-1000.0	-0.094	-1000.0
Glucocorticoid receptor regulatory network	27.0	3153.0	114.0	-0.311	0.16	1000.0	-1000.0	-0.045	-1000.0
Syndecan-1-mediated signaling events	25.0	867.0	34.0	-0.086	0.024	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	25.0	1965.0	78.0	-0.078	0.037	1000.0	-1000.0	-0.038	-1000.0
p75(NTR)-mediated signaling	24.0	3094.0	125.0	-0.086	0.058	1000.0	-1000.0	-0.048	-1000.0
Plasma membrane estrogen receptor signaling	24.0	2118.0	86.0	-0.079	0.074	1000.0	-1000.0	-0.04	-1000.0
Reelin signaling pathway	23.0	1312.0	56.0	-0.053	0.049	1000.0	-1000.0	-0.029	-1000.0
Signaling events regulated by Ret tyrosine kinase	23.0	1919.0	82.0	-0.041	0.026	1000.0	-1000.0	-0.039	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	23.0	1575.0	68.0	-0.173	0.065	1000.0	-1000.0	-0.074	-1000.0
IL12-mediated signaling events	22.0	1959.0	87.0	-0.155	0.025	1000.0	-1000.0	-0.057	-1000.0
Thromboxane A2 receptor signaling	22.0	2405.0	105.0	-0.078	0.035	1000.0	-1000.0	-0.031	-1000.0
BMP receptor signaling	22.0	1782.0	81.0	-0.086	0.048	1000.0	-1000.0	-0.034	-1000.0
Glypican 1 network	22.0	1073.0	48.0	-0.071	0.046	1000.0	-1000.0	-0.022	-1000.0
Nectin adhesion pathway	21.0	1328.0	63.0	-0.039	0.058	1000.0	-1000.0	-0.038	-1000.0
BCR signaling pathway	21.0	2104.0	99.0	-0.09	0.035	1000.0	-1000.0	-0.043	-1000.0
Angiopoietin receptor Tie2-mediated signaling	21.0	1895.0	88.0	-0.083	0.035	1000.0	-1000.0	-0.056	-1000.0
Fc-epsilon receptor I signaling in mast cells	20.0	1949.0	97.0	-0.072	0.046	1000.0	-1000.0	-0.049	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	20.0	1048.0	52.0	-0.068	0.046	1000.0	-1000.0	-0.034	-1000.0
TCGA08_p53	20.0	145.0	7.0	-0.025	0.021	1000.0	-1000.0	-0.004	-1000.0
Glypican 2 network	20.0	83.0	4.0	-0.003	0.007	1000.0	-1000.0	0.011	-1000.0
Syndecan-4-mediated signaling events	20.0	1382.0	67.0	-0.079	0.035	1000.0	-1000.0	-0.026	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	19.0	2319.0	120.0	-0.078	0.068	1000.0	-1000.0	-0.041	-1000.0
Caspase cascade in apoptosis	18.0	1361.0	74.0	-0.076	0.042	1000.0	-1000.0	-0.031	-1000.0
Retinoic acid receptors-mediated signaling	18.0	1074.0	58.0	-0.065	0.049	1000.0	-1000.0	-0.036	-1000.0
FOXM1 transcription factor network	18.0	940.0	51.0	-0.125	0.032	1000.0	-1000.0	-0.113	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	17.0	606.0	34.0	-0.009	0.037	1000.0	-1000.0	-0.023	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	17.0	1471.0	85.0	-0.037	0.025	1000.0	-1000.0	-0.038	-1000.0
amb2 Integrin signaling	17.0	1412.0	82.0	-0.096	0.034	1000.0	-1000.0	-0.023	-1000.0
PDGFR-alpha signaling pathway	16.0	706.0	44.0	-0.033	0.037	1000.0	-1000.0	-0.03	-1000.0
FAS signaling pathway (CD95)	16.0	776.0	47.0	-0.029	0.037	1000.0	-1000.0	-0.03	-1000.0
Canonical Wnt signaling pathway	16.0	844.0	51.0	-0.109	0.061	1000.0	-1000.0	-0.035	-1000.0
Nongenotropic Androgen signaling	16.0	838.0	52.0	-0.038	0.037	1000.0	-1000.0	-0.022	-1000.0
Arf6 signaling events	15.0	936.0	62.0	-0.019	0.04	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by PTP1B	15.0	1167.0	76.0	-0.053	0.034	1000.0	-1000.0	-0.028	-1000.0
S1P1 pathway	15.0	546.0	36.0	-0.126	0.025	1000.0	-1000.0	-0.025	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	15.0	697.0	45.0	-0.028	0.06	1000.0	-1000.0	-0.038	-1000.0
Calcium signaling in the CD4+ TCR pathway	15.0	475.0	31.0	-0.081	0.025	1000.0	-1000.0	-0.036	-1000.0
Osteopontin-mediated events	14.0	543.0	38.0	-0.037	0.026	1000.0	-1000.0	-0.035	-1000.0
Syndecan-2-mediated signaling events	14.0	1011.0	69.0	-0.071	0.037	1000.0	-1000.0	-0.031	-1000.0
Presenilin action in Notch and Wnt signaling	14.0	893.0	61.0	-0.109	0.051	1000.0	-1000.0	-0.034	-1000.0
Integrins in angiogenesis	14.0	1227.0	84.0	-0.07	0.047	1000.0	-1000.0	-0.043	-1000.0
IL6-mediated signaling events	14.0	1094.0	75.0	-0.116	0.057	1000.0	-1000.0	-0.054	-1000.0
Visual signal transduction: Rods	14.0	779.0	52.0	-0.042	0.041	1000.0	-1000.0	-0.018	-1000.0
Coregulation of Androgen receptor activity	13.0	1028.0	76.0	-0.076	0.044	1000.0	-1000.0	-0.028	-1000.0
Cellular roles of Anthrax toxin	13.0	514.0	39.0	-0.047	0.025	1000.0	-1000.0	-0.02	-1000.0
IL1-mediated signaling events	13.0	850.0	62.0	-0.02	0.048	1000.0	-1000.0	-0.028	-1000.0
EGFR-dependent Endothelin signaling events	13.0	293.0	21.0	-0.025	0.035	1000.0	-1000.0	-0.034	-1000.0
ErbB2/ErbB3 signaling events	12.0	783.0	65.0	-0.027	0.043	1000.0	-1000.0	-0.071	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	12.0	665.0	54.0	-0.053	0.036	1000.0	-1000.0	-0.03	-1000.0
JNK signaling in the CD4+ TCR pathway	12.0	212.0	17.0	-0.024	0.043	1000.0	-1000.0	-0.031	-1000.0
ceramide signaling pathway	12.0	624.0	49.0	-0.018	0.037	1000.0	-1000.0	-0.031	-1000.0
HIF-2-alpha transcription factor network	12.0	517.0	43.0	-0.043	0.053	1000.0	-1000.0	-0.046	-1000.0
IL2 signaling events mediated by PI3K	12.0	706.0	58.0	-0.042	0.035	1000.0	-1000.0	-0.042	-1000.0
LPA4-mediated signaling events	11.0	136.0	12.0	-0.035	0.006	1000.0	-1000.0	-0.018	-1000.0
Regulation of nuclear SMAD2/3 signaling	11.0	1529.0	136.0	-0.237	0.073	1000.0	-1000.0	-0.03	-1000.0
EPO signaling pathway	11.0	634.0	55.0	-0.001	0.052	1000.0	-1000.0	-0.028	-1000.0
IFN-gamma pathway	11.0	801.0	68.0	-0.042	0.052	1000.0	-1000.0	-0.044	-1000.0
Ceramide signaling pathway	11.0	838.0	76.0	-0.032	0.068	1000.0	-1000.0	-0.023	-1000.0
Effects of Botulinum toxin	11.0	307.0	26.0	-0.038	0.039	1000.0	-1000.0	-0.003	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	886.0	74.0	-0.051	0.048	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in keratinocytes	11.0	511.0	43.0	-0.014	0.038	1000.0	-1000.0	-0.025	-1000.0
Regulation of Androgen receptor activity	11.0	799.0	70.0	-0.1	0.029	1000.0	-1000.0	-0.042	-1000.0
Ras signaling in the CD4+ TCR pathway	11.0	198.0	17.0	-0.015	0.042	1000.0	-1000.0	-0.023	-1000.0
Hedgehog signaling events mediated by Gli proteins	10.0	668.0	65.0	-0.185	0.058	1000.0	-1000.0	-0.041	-1000.0
E-cadherin signaling in the nascent adherens junction	10.0	784.0	76.0	-0.037	0.055	1000.0	-1000.0	-0.042	-1000.0
mTOR signaling pathway	9.0	490.0	53.0	-0.02	0.028	1000.0	-1000.0	-0.038	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	9.0	351.0	37.0	-0.022	0.052	1000.0	-1000.0	-0.027	-1000.0
S1P5 pathway	9.0	159.0	17.0	-0.001	0.025	1000.0	-1000.0	-0.008	-1000.0
IL27-mediated signaling events	9.0	500.0	51.0	-0.041	0.026	1000.0	-1000.0	-0.039	-1000.0
Regulation of Telomerase	9.0	941.0	102.0	-0.135	0.057	1000.0	-1000.0	-0.038	-1000.0
S1P4 pathway	9.0	235.0	25.0	-0.007	0.038	1000.0	-1000.0	-0.017	-1000.0
Aurora B signaling	9.0	640.0	67.0	-0.152	0.062	1000.0	-1000.0	-0.038	-1000.0
BARD1 signaling events	8.0	470.0	57.0	-0.036	0.046	1000.0	-1000.0	-0.027	-1000.0
a4b1 and a4b7 Integrin signaling	8.0	41.0	5.0	0.011	0.025	1000.0	-1000.0	0.011	-1000.0
TRAIL signaling pathway	8.0	397.0	48.0	-0.005	0.05	1000.0	-1000.0	-0.029	-1000.0
Class I PI3K signaling events	8.0	588.0	73.0	-0.038	0.047	1000.0	-1000.0	-0.041	-1000.0
ErbB4 signaling events	7.0	519.0	69.0	-0.025	0.03	1000.0	-1000.0	-0.028	-1000.0
PLK1 signaling events	7.0	626.0	85.0	-0.006	0.039	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class III	7.0	296.0	40.0	-0.052	0.046	1000.0	-1000.0	-0.02	-1000.0
TCGA08_rtk_signaling	7.0	198.0	26.0	-0.036	0.05	1000.0	-1000.0	-0.006	-1000.0
IL2 signaling events mediated by STAT5	7.0	170.0	22.0	-0.012	0.026	1000.0	-1000.0	-0.038	-1000.0
Insulin Pathway	7.0	564.0	74.0	-0.044	0.059	1000.0	-1000.0	-0.031	-1000.0
PLK2 and PLK4 events	6.0	20.0	3.0	0.002	0.019	1000.0	-1000.0	-0.008	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	6.0	573.0	83.0	-0.049	0.047	1000.0	-1000.0	-0.024	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	101.0	15.0	-0.015	0.024	1000.0	-1000.0	-0.024	-1000.0
Paxillin-dependent events mediated by a4b1	6.0	242.0	36.0	-0.041	0.043	1000.0	-1000.0	-0.03	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	219.0	33.0	-0.051	0.061	1000.0	-1000.0	-0.027	-1000.0
PDGFR-beta signaling pathway	6.0	638.0	97.0	-0.045	0.062	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by PRL	6.0	209.0	34.0	-0.042	0.037	1000.0	-1000.0	-0.032	-1000.0
Canonical NF-kappaB pathway	5.0	228.0	39.0	-0.017	0.055	1000.0	-1000.0	-0.021	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	144.0	28.0	-0.0	0.045	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	5.0	221.0	38.0	-0.01	0.04	1000.0	-1000.0	-0.008	-1000.0
Class I PI3K signaling events mediated by Akt	5.0	349.0	68.0	-0.032	0.047	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class I	5.0	535.0	104.0	-0.038	0.063	1000.0	-1000.0	-0.025	-1000.0
Syndecan-3-mediated signaling events	5.0	209.0	35.0	-0.034	0.052	1000.0	-1000.0	-0.012	-1000.0
p38 MAPK signaling pathway	5.0	224.0	44.0	-0.042	0.05	1000.0	-1000.0	-0.02	-1000.0
FoxO family signaling	4.0	306.0	64.0	-0.064	0.056	1000.0	-1000.0	-0.05	-1000.0
Regulation of p38-alpha and p38-beta	4.0	265.0	54.0	-0.034	0.058	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	541.0	125.0	-0.008	0.062	1000.0	-1000.0	-0.035	-1000.0
S1P3 pathway	4.0	183.0	42.0	-0.002	0.043	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling events	4.0	20.0	5.0	0.017	0.038	1000.0	-1000.0	0.01	-1000.0
Signaling events mediated by HDAC Class II	3.0	296.0	75.0	-0.03	0.067	1000.0	-1000.0	-0.023	-1000.0
Arf6 downstream pathway	3.0	154.0	43.0	-0.04	0.044	1000.0	-1000.0	-0.026	-1000.0
Insulin-mediated glucose transport	3.0	115.0	32.0	-0.012	0.045	1000.0	-1000.0	-0.018	-1000.0
Atypical NF-kappaB pathway	3.0	122.0	31.0	0.0	0.025	1000.0	-1000.0	-0.017	-1000.0
VEGFR1 specific signals	3.0	221.0	56.0	-0.017	0.049	1000.0	-1000.0	-0.03	-1000.0
Aurora A signaling	2.0	120.0	60.0	-0.0	0.049	1000.0	-1000.0	-0.018	-1000.0
Aurora C signaling	2.0	19.0	7.0	-0.0	0.038	1000.0	-1000.0	-0.01	-1000.0
Arf6 trafficking events	2.0	156.0	71.0	-0.041	0.045	1000.0	-1000.0	-0.025	-1000.0
Arf1 pathway	2.0	146.0	54.0	-0.001	0.038	1000.0	-1000.0	-0.017	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	37.0	23.0	0.004	0.048	1000.0	-1000.0	-0.025	-1000.0
Circadian rhythm pathway	1.0	37.0	22.0	-0.007	0.043	1000.0	-1000.0	-0.034	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	1.0	46.0	27.0	-0.0	0.057	1000.0	-1000.0	-0.026	-1000.0
Rapid glucocorticoid signaling	1.0	33.0	20.0	-0.007	0.029	1000.0	-1000.0	-0.004	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.066	1000.0	-1000.0	0.0	-1000.0
Total	1910	115543	7203	-7.86061883108	5.95090613787	131000	-131000	-4.17236363743	-131000