Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.086 0.158 -9999.0 0.0 -0.526 4.0 4.0 IHH -0.048 0.131 -9999.0 0.0 -0.307 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.039 0.085 -9999.0 0.0 -0.178 14.0 14.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.039 0.085 0.177 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.1 0.18 -9999.0 0.0 -0.344 13.0 13.0 SMO -0.114 0.178 -9999.0 0.0 -0.354 14.0 14.0 AKT1 -0.057 0.148 -9999.0 0.0 -0.485 4.0 4.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.112 0.176 -9999.0 0.0 -0.349 14.0 14.0 STIL -0.061 0.136 0.19 2.0 -0.298 8.0 10.0 DHH N/PTCH2 0.04 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.063 0.124 -9999.0 0.0 -0.241 9.0 9.0 PIK3CA 0.019 0.05 -9999.0 0.0 -0.341 1.0 1.0 DHH 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.124 0.193 -9999.0 0.0 -0.543 5.0 5.0 determination of left/right symmetry -0.112 0.176 -9999.0 0.0 -0.349 14.0 14.0 PIK3R1 -0.007 0.098 -9999.0 0.0 -0.341 4.0 4.0 skeletal system development -0.123 0.192 -9999.0 0.0 -0.539 5.0 5.0 IHH N/Hhip -0.1 0.137 -9999.0 0.0 -0.247 22.0 22.0 DHH N/Hhip 0.0 0.088 -9999.0 0.0 -0.237 6.0 6.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.112 0.176 -9999.0 0.0 -0.349 14.0 14.0 pancreas development -0.023 0.116 -9999.0 0.0 -0.34 6.0 6.0 HHAT -0.026 0.123 -9999.0 0.0 -0.341 7.0 7.0 PI3K 0.013 0.083 -9999.0 0.0 -0.302 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.047 0.135 -9999.0 0.0 -0.341 9.0 9.0 somite specification -0.112 0.176 -9999.0 0.0 -0.349 14.0 14.0 SHH Np/Cholesterol/PTCH1 -0.075 0.129 -9999.0 0.0 -0.277 11.0 11.0 SHH Np/Cholesterol/PTCH2 -0.005 0.068 -9999.0 0.0 -0.176 7.0 7.0 SHH Np/Cholesterol/Megalin -0.008 0.068 -9999.0 0.0 -0.179 7.0 7.0 SHH -0.018 0.078 -9999.0 0.0 -0.237 6.0 6.0 catabolic process -0.075 0.128 -9999.0 0.0 -0.239 19.0 19.0 SMO/Vitamin D3 -0.077 0.172 -9999.0 0.0 -0.328 12.0 12.0 SHH Np/Cholesterol/Hhip -0.029 0.087 -9999.0 0.0 -0.19 11.0 11.0 LRP2 0.021 0.021 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.078 0.168 -9999.0 0.0 -0.382 8.0 8.0 SHH Np/Cholesterol/BOC -0.005 0.064 -9999.0 0.0 -0.179 6.0 6.0 SHH Np/Cholesterol/CDO -0.007 0.068 -9999.0 0.0 -0.179 7.0 7.0 mesenchymal cell differentiation 0.029 0.087 0.189 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 -0.054 0.152 0.21 2.0 -0.287 10.0 12.0 IHH N/PTCH2 -0.062 0.11 -9999.0 0.0 -0.215 17.0 17.0 CDON 0.023 0.018 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.08 0.134 -9999.0 0.0 -0.24 20.0 20.0 Megalin/LRPAP1 0.033 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.012 0.064 -9999.0 0.0 -0.174 7.0 7.0 PTCH1 -0.076 0.129 -9999.0 0.0 -0.24 19.0 19.0 HHIP -0.023 0.116 -9999.0 0.0 -0.341 6.0 6.0