rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(8), CREM(4), FHL5(4), FSHB(2), FSHR(7), GNAS(6), XPO1(2)	3039066	33	29	33	12	13	9	7	1	3	0	0.00161	0.992
2	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5)	4019457	53	30	53	14	16	19	10	0	7	1	0.00589	1.000
3	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(11), ERBB3(14), NRG1(15), UBE2D1(1)	3378947	44	33	40	7	18	8	11	1	6	0	0.00706	1.000
4	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(4), HLA-DRA(5), HLA-DRB1(2), IL3(3)	949081	14	12	13	4	7	5	0	0	0	2	0.0114	1.000
5	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA6(5), GPX1(1), PRKCE(6)	2175145	38	22	37	6	11	17	6	0	4	0	0.0125	1.000
6	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6)	1762715	24	19	24	9	3	9	11	0	1	0	0.0140	1.000
7	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(4), CFL1(1), GNAQ(4), GNAS(6), GNB1(1), GNGT1(1), LIMK1(5), MAP2K1(4), MAPK1(2), MAPK3(3), MYL2(1), NOX1(1), PIK3C2G(9), PLCB1(8), PPP1R12B(9), PRKCA(4), PTK2(5), RAF1(6), ROCK2(6)	7894259	80	47	78	16	30	21	13	1	15	0	0.0154	1.000
8	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(6), CHKA(4), PCYT1A(5), PDHA1(5), PDHA2(8), PEMT(1), SLC18A3(6)	2214030	37	26	36	17	12	12	10	0	3	0	0.0159	1.000
9	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5), MASP1(12)	6230922	79	39	79	26	26	27	14	0	11	1	0.0160	1.000
10	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(7), GABBR1(6), GPRC5A(2), GPRC5B(2), GPRC5C(2), GPRC5D(1), GRM1(12), GRM2(4), GRM3(7), GRM4(7), GRM5(11), GRM7(12), GRM8(9)	6585022	82	48	80	47	35	23	14	1	9	0	0.0177	1.000
11	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(7), FYN(5), LRP8(4), RELN(33), VLDLR(5)	4557569	55	33	53	19	14	21	12	1	7	0	0.0207	1.000
12	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(4), FMOD(2), KERA(7), LUM(6)	1158397	20	16	20	4	7	4	7	0	2	0	0.0211	1.000
13	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	159	ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRA2A(3), ADRB1(3), ADRB3(1), AGTR1(5), AGTR2(5), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), CCKAR(2), CCKBR(5), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CCR9(6), CCRL1(5), CHML(5), CHRM1(3), CHRM3(4), CHRM4(1), CHRM5(2), CMKLR1(2), CNR1(5), CX3CR1(2), CXCR4(4), DRD1(1), DRD2(5), DRD3(3), DRD5(6), EDNRA(4), F2RL1(1), F2RL2(3), FPR1(2), FSHR(7), GALR1(2), GALT(2), GHSR(5), GPR17(1), GPR173(2), GPR174(3), GPR37(7), GPR37L1(3), GPR4(1), GPR50(5), GPR6(6), GPR63(4), GPR77(2), GPR83(1), GPR85(1), GPR87(5), GRPR(3), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HTR1A(5), HTR1B(5), HTR1D(2), HTR1E(7), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), LHCGR(4), LTB4R(1), MAS1(2), MC3R(1), MC4R(4), MC5R(6), MLNR(3), MTNR1B(3), NMUR1(4), NPY1R(4), NPY2R(5), NPY5R(2), NTSR1(1), NTSR2(5), OPN1SW(3), OPN3(1), OPRD1(1), OPRK1(5), OPRM1(3), OR12D3(4), OR1C1(3), OR1F1(2), OR2H1(5), OR5V1(3), OR7A5(3), OR7C1(6), OR8B8(3), OXTR(3), P2RY1(6), P2RY10(7), P2RY12(4), P2RY13(2), P2RY14(6), P2RY2(3), P2RY6(1), PPYR1(4), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1), RGR(3), RHO(3), RRH(4), SSTR1(5), SSTR2(3), SSTR4(4), SUCNR1(2), TRHR(8)	36703686	441	121	440	154	175	153	78	3	32	0	0.0261	1.000
14	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5), MASP1(12), MASP2(4)	6789042	83	41	83	28	26	29	16	0	11	1	0.0262	1.000
15	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	226	ADCYAP1R1(2), ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(5), ADRA2A(3), ADRA2B(1), ADRB1(3), ADRB3(1), AGTR1(5), AGTR2(5), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), C5AR1(3), CALCR(5), CALCRL(6), CCKAR(2), CCKBR(5), CGA(2), CHRM1(3), CHRM3(4), CHRM4(1), CHRM5(2), CNR1(5), CRHR1(2), CRHR2(5), CTSG(3), CYSLTR1(3), CYSLTR2(4), DRD1(1), DRD2(5), DRD3(3), DRD5(6), EDNRA(4), F2(3), F2RL1(1), F2RL2(3), FPR1(2), FSHB(2), FSHR(7), GABBR1(6), GABBR2(7), GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA6(5), GABRB1(7), GABRB2(7), GABRB3(9), GABRE(5), GABRG2(11), GABRG3(5), GABRP(4), GABRQ(8), GABRR1(2), GABRR2(4), GALR1(2), GH1(2), GH2(3), GHR(6), GHRHR(2), GHSR(5), GLP1R(7), GLP2R(5), GLRA1(2), GLRA2(3), GLRA3(8), GLRB(7), GNRHR(4), GPR156(8), GPR50(5), GPR63(4), GPR83(1), GRIA2(13), GRIA3(8), GRID1(16), GRID2(12), GRIK1(5), GRIK2(14), GRIK4(12), GRIK5(6), GRIN1(1), GRIN2B(10), GRIN2C(4), GRIN2D(5), GRIN3A(6), GRM1(12), GRM2(4), GRM3(7), GRM4(7), GRM5(11), GRM6(10), GRM7(12), GRM8(9), GRPR(3), GZMA(3), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HRH4(2), HTR1A(5), HTR1B(5), HTR1D(2), HTR1E(7), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), LEP(1), LEPR(9), LHB(1), LHCGR(4), LTB4R(1), MAS1(2), MC2R(5), MC3R(1), MC4R(4), MC5R(6), MCHR1(6), MCHR2(3), MLNR(3), MTNR1B(3), NMUR1(4), NPBWR1(3), NPFFR2(4), NPY1R(4), NPY2R(5), NPY5R(2), NR3C1(4), NTSR1(1), NTSR2(5), OPRD1(1), OPRK1(5), OPRM1(3), OXTR(3), P2RX1(1), P2RX2(2), P2RX3(2), P2RX4(3), P2RX5(1), P2RX7(3), P2RY1(6), P2RY10(7), P2RY13(2), P2RY14(6), P2RY2(3), P2RY4(6), P2RY6(1), PARD3(7), PPYR1(4), PRL(3), PRLR(4), PRSS1(3), PRSS2(1), PRSS3(4), PTAFR(1), PTGDR(1), PTGER2(1), PTGER3(7), PTGFR(7), PTGIR(1), PTH2R(7), RXFP1(3), RXFP2(10), SCTR(3), SSTR1(5), SSTR2(3), SSTR4(4), TAAR1(4), TAAR2(2), TAAR5(6), TAAR6(5), TAAR8(2), TAAR9(3), TACR1(2), TACR2(1), TACR3(7), THRA(2), THRB(4), TRHR(8), TRPV1(4), TSHB(1), TSHR(7), VIPR1(4), VIPR2(3)	66109424	869	153	859	328	330	289	170	9	71	0	0.0276	1.000
16	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(9), ARHGEF1(5), GNA12(2), GNA13(2), GNAQ(4), GNB1(1), GNGT1(1), MYL2(1), MYLK(14), PLCB1(8), PPP1R12B(9), PRKCA(4), ROCK1(15)	6663780	75	40	73	19	19	22	15	2	17	0	0.0389	1.000
17	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(7)	663856	11	9	11	2	3	3	4	0	1	0	0.0393	1.000
18	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(8), GNAS(6), GNB1(1), GNGT1(1), PRKACA(1), PRKAR1A(5)	2033110	22	20	22	9	8	7	5	0	2	0	0.0415	1.000
19	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(26), MAP2(25), PPP2CA(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAR2B(3), PRKCE(6)	5791757	66	37	64	20	18	23	13	0	12	0	0.0424	1.000
20	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(6)	240760	6	5	6	0	4	1	0	0	1	0	0.0433	1.000
21	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), CYP19A1(8), CYP1A1(7), CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(6), CYP4B1(9), CYP4F8(4), CYP51A1(3), PON1(6)	9105237	112	52	110	25	40	31	28	0	11	2	0.0441	1.000
22	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	CDH1(5), CREBBP(25), EP300(15), MAP2K1(4), MAP3K7(4), MAPK3(3), SKIL(1), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7)	6512558	83	42	82	21	28	20	19	1	15	0	0.0456	1.000
23	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(2), CD3D(1), CD3G(2), CD80(1), CTLA4(2), GRB2(3), HLA-DRA(5), HLA-DRB1(2), ICOS(1), IL2(4), ITK(11), LCK(3), PTPN11(5)	2918077	42	24	41	10	13	19	5	0	3	2	0.0479	1.000
24	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(8), CAP1(1), CCNB1(2), CDC25C(4), GNAI1(4), GNAS(6), GNB1(1), GNGT1(1), MAPK1(2), MAPK3(3), MYT1(13), PIN1(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RPS6KA1(1), SRC(3)	6423773	67	46	66	21	26	27	10	0	4	0	0.0481	1.000
25	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(5), AGTR2(5), ATP8A1(10), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), CCKAR(2), CCKBR(5), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CX3CR1(2), CXCR4(4), EDNRA(4), FPR1(2), FSHR(7), GALR1(2), GALT(2), GHSR(5), GNRHR(4), GPR77(2), GRPR(3), LHCGR(4), MC2R(5), MC3R(1), MC4R(4), MC5R(6), NPY1R(4), NPY2R(5), NPY5R(2), NTSR1(1), NTSR2(5), OPRD1(1), OPRK1(5), OPRM1(3), OXTR(3), PPYR1(4), SSTR1(5), SSTR2(3), SSTR4(4), TAC4(1), TACR1(2), TACR2(1), TACR3(7), TRHR(8), TSHR(7)	15799674	198	75	198	76	76	67	44	1	10	0	0.0495	1.000
26	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), LTB4R(1), P2RY1(6), P2RY2(3), P2RY6(1)	1775502	28	20	28	4	12	11	3	1	1	0	0.0502	1.000
27	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	CDC25A(2), CDC25B(5), CDC25C(4), CDK2(2), CDK4(3), CHEK1(1), MYT1(13), RB1(7), WEE1(3), YWHAH(1)	3451886	41	27	40	7	12	14	9	2	3	1	0.0505	1.000
28	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(2), CDKN1B(3), CKS1B(1), CUL1(8), NEDD8(1), RB1(7), RBX1(1), SKP2(1), TFDP1(4)	2841873	31	24	31	7	7	4	10	1	8	1	0.0520	1.000
29	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(11), BDKRB2(3), C1QB(1), C1QC(3), C1R(3), C1S(6), C2(4), C3(11), C3AR1(4), C4BPA(7), C5(13), C5AR1(3), C6(13), C7(5), C8A(6), C9(5), CD46(3), CD55(4), CFB(4), CFH(16), CFI(2), CPB2(2), CR1(10), CR2(11), F10(1), F11(4), F12(2), F13A1(10), F13B(5), F2(3), F3(2), F5(21), F7(3), F8(18), F9(6), FGA(13), FGB(2), FGG(4), KLKB1(6), KNG1(4), MASP1(12), MASP2(4), PLAT(5), PLAU(3), PLAUR(4), PLG(9), PROC(1), PROS1(6), SERPINA1(3), SERPINA5(4), SERPINC1(3), SERPIND1(2), SERPINE1(3), SERPING1(5), TFPI(3), THBD(2), VWF(15)	28284547	338	92	333	111	94	137	67	0	39	1	0.0579	1.000
30	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(11), EXTL1(3), EXTL2(6), EXTL3(9), GLCE(6), HS2ST1(4), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), NDST1(4), NDST2(5), NDST3(10), NDST4(4)	6568912	77	45	76	25	31	21	18	1	6	0	0.0642	1.000
31	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(11), C5(13), C6(13), C7(5), ICAM1(2), IL1A(1), IL6(2), IL8(1), ITGA4(8), ITGAL(8), ITGB1(6), ITGB2(5), SELP(6), SELPLG(2), VCAM1(9)	7841280	92	42	90	29	32	30	18	0	11	1	0.0651	1.000
32	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(9), AGT(5), AGTR1(5), AGTR2(5), COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A5(19), COL4A6(15), REN(5)	8157418	95	43	94	19	22	33	22	1	17	0	0.0664	1.000
33	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNAQ(4), GNB1(1), GNGT1(1), HTR2C(8), PLCB1(8), TUB(5)	2324459	30	20	30	9	14	5	6	1	4	0	0.0690	1.000
34	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(5), CBS(3), CTH(2), DNMT1(19), DNMT3A(9), DNMT3B(8), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), MTR(7)	5651874	71	38	66	15	34	18	6	3	10	0	0.0695	1.000
35	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	77	ABL1(4), ABL2(7), AKT1(2), AKT2(6), AKT3(1), ARAF(3), BAD(1), BTC(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CBL(5), CBLB(8), CDKN1A(1), CDKN1B(3), CRKL(2), EGF(3), EGFR(11), ERBB2(10), ERBB3(14), EREG(1), GAB1(6), GRB2(3), GSK3B(8), HBEGF(1), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(7), MAPK9(5), NCK1(1), NRG1(15), NRG2(6), NRG3(7), NRG4(1), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PRKCA(4), PRKCG(10), PTK2(5), RAF1(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SRC(3), STAT5B(3)	29916722	289	99	277	87	104	84	57	4	40	0	0.0750	1.000
36	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD3G(2), CD4(2), CREBBP(25), CSK(3), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(5), HLA-DRB1(2), LCK(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTPRC(17), ZAP70(4)	7239243	93	44	93	25	33	28	18	0	12	2	0.0894	1.000
37	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD3G(2), CD4(2), CREBBP(25), CSK(3), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(5), HLA-DRB1(2), LCK(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTPRC(17), ZAP70(4)	7239243	93	44	93	25	33	28	18	0	12	2	0.0894	1.000
38	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	5	ADAM17(7), NRG2(6), NRG3(7), PRKCA(4), PSEN1(3)	2071174	27	19	26	2	10	8	3	1	5	0	0.0937	1.000
39	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(8), GNAS(6), GNB1(1), GNGT1(1), PPP2CA(1), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	4812682	49	35	48	19	22	15	8	0	4	0	0.0940	1.000
40	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(2), F13A1(10), F2(3), FGA(13), FGB(2), FGG(4), PLAT(5), PLAU(3), PLG(9), SERPINB2(5), SERPINE1(3)	4371403	59	33	59	13	19	22	11	0	7	0	0.0942	1.000
41	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(2), CD80(1), HLA-DRA(5), HLA-DRB1(2), IL10(2), IL2(4), IL4(3)	1278089	21	13	21	8	8	11	0	0	0	2	0.109	1.000
42	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5)	5554949	67	31	67	20	21	23	12	0	10	1	0.113	1.000
43	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	6	CREBBP(25), EP300(15), MAPK1(2), MAPK3(3), PELP1(2), SRC(3)	4279724	50	32	50	15	17	13	13	1	6	0	0.115	1.000
44	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(2), HLA-DRA(5), HLA-DRB1(2)	745262	11	9	11	4	4	5	0	0	0	2	0.117	1.000
45	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(6), NR1I3(3), PTGS1(6), PTGS2(3)	1707532	21	17	21	6	9	7	4	0	1	0	0.117	1.000
46	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	CDC25A(2), CDC25B(5), CDC25C(4), CHEK1(1), MYT1(13), WEE1(3), YWHAH(1)	2427308	29	21	28	4	9	12	5	1	2	0	0.122	1.000
47	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(8), BAD(1), BAK1(1), BAX(1), BCL10(3), BCL2(1), BCL2L1(1), BCL2L11(3), BID(1), CASP8AP2(18), CASP9(2), CES1(5)	3292197	45	28	43	10	13	16	8	0	8	0	0.124	1.000
48	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRA2A(3), ADRB1(3), ADRB3(1), CHRM1(3), CHRM3(4), CHRM4(1), CHRM5(2), DRD1(1), DRD2(5), DRD3(3), DRD5(6), HRH1(1), HRH2(4), HTR1A(5), HTR1B(5), HTR1D(2), HTR1E(7), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7)	7674855	97	50	96	43	47	28	11	1	10	0	0.124	1.000
49	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(3), BFAR(1), CREB1(1), CREB3(3), CREB5(4), MAPK1(2), RAF1(6), SNX13(9), SRC(3), TERF2IP(2)	3128799	34	20	33	12	12	9	7	1	5	0	0.126	1.000
50	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(4), ALDOA(1), ALDOB(5), ALDOC(3), TPI1(1)	1207526	14	13	14	1	4	7	3	0	0	0	0.131	1.000
51	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(6), BCMO1(4), RDH5(1)	1256040	15	13	15	2	6	4	4	0	1	0	0.136	1.000
52	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), ACO2(2), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SDHB(2), SUCLA2(5)	2896732	26	23	26	9	9	8	5	0	4	0	0.139	1.000
53	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), TGDS(1), UGDH(4), UGP2(7), UXS1(7)	1564739	22	16	22	5	7	8	4	0	3	0	0.143	1.000
54	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	20	ADCY1(8), AKT1(2), ASAH1(3), GNAI1(4), GNB1(1), GNGT1(1), ITGAV(5), ITGB3(9), MAPK1(2), MAPK3(3), PDGFA(1), PDGFRA(17), PLCB1(8), PRKCA(4), PTK2(5), SMPD1(6), SPHK1(1), SRC(3)	7667259	83	41	83	31	27	23	20	2	10	1	0.146	1.000
55	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3D(1), CD3G(2), IFNG(1), IL2(4), IL2RA(2), IL4(3), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TGFBR3(8), TOB1(2), TOB2(1)	3453785	52	25	51	15	19	17	7	0	9	0	0.146	1.000
56	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(8), DBH(5), DCT(13), DDC(1), FAH(2), GOT1(6), GOT2(1), GSTZ1(2), HGD(2), HPD(4), MAOA(3), MAOB(1), TAT(5), TPO(11), TYR(3)	9874957	112	52	110	47	39	39	25	1	8	0	0.147	1.000
57	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(6), CCNE1(3), CDK2(2), CUL1(8), RB1(7), SKP2(1), TFDP1(4)	2900493	31	22	31	8	7	5	11	1	6	1	0.149	1.000
58	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), B3GNT1(2), FUT1(4), FUT2(1), FUT9(5), GCNT2(11), ST8SIA1(3)	1933377	28	18	28	7	10	9	5	0	4	0	0.149	1.000
59	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	10	DNM1(11), GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA6(5), NSF(1), SRC(3), UBQLN1(2)	3122862	48	25	46	19	11	23	9	0	5	0	0.152	1.000
60	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ABP1(1), ACAT1(1), ACAT2(2), ACMSD(4), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(8), CAT(3), CYP19A1(8), CYP1A1(7), CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(6), CYP4B1(9), CYP4F8(4), CYP51A1(3), DDC(1), ECHS1(2), EHHADH(2), GCDH(5), HAAO(2), HADHA(3), KMO(5), KYNU(7), MAOA(3), MAOB(1), SDS(2), TDO2(4), TPH1(3), WARS(2), WARS2(3)	17447957	197	68	196	56	68	69	42	1	16	1	0.153	1.000
61	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), AMD1(1), BHMT(5), CBS(3), CTH(2), DNMT1(19), DNMT3A(9), DNMT3B(8), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), MTAP(1), MTFMT(2), MTR(7), TAT(5)	6678265	80	40	75	18	35	25	6	3	11	0	0.158	1.000
62	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), CSAD(2), GAD1(9), GAD2(4), GGT1(3)	1795743	21	17	19	7	8	11	2	0	0	0	0.170	1.000
63	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(9), AGT(5), AGTR1(5), AGTR2(5), ANPEP(8), CPA3(3), CTSA(3), CTSG(3), ENPEP(9), LNPEP(8), MAS1(2), MME(10), NLN(3), REN(5)	6879824	80	42	80	17	22	29	19	0	10	0	0.172	1.000
64	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(4), CD4(2), HLA-DRA(5), HLA-DRB1(2), IL1B(1), IL4(3), IL5RA(6), IL6(2)	1729091	25	15	24	8	11	12	0	0	0	2	0.173	1.000
65	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(7), GBA3(3), LPO(3), MPO(5), PRDX1(1), PRDX6(2), TPO(11), TYR(3)	2979647	35	27	34	16	19	7	4	0	5	0	0.175	1.000
66	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1)	4164218	51	30	51	15	13	20	16	0	2	0	0.178	1.000
67	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(2), HGD(2)	559767	6	5	6	4	1	2	2	0	1	0	0.178	1.000
68	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	BMPR1B(10), CCND2(1), CDK4(3), CDKN1B(3), DAZL(2), DMC1(4), EGR1(3), ESR2(2), FSHR(7), GJA4(2), INHA(2), LHCGR(4), MLH1(8), MSH5(5), NCOR1(12), NRIP1(6), PGR(4), PRLR(4), PTGER2(1), SMPD1(6), VDR(2), ZP2(7)	9276592	98	44	98	31	32	25	23	2	16	0	0.182	1.000
69	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(4), BMPR1A(4), BMPR1B(10), BMPR2(10)	2013511	28	18	28	5	6	7	8	0	7	0	0.183	1.000
70	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(5), ADC(1), ALDH4A1(3), ALDH5A1(4), CAD(11), CPS1(14), EPRS(12), GAD1(9), GAD2(4), GCLC(4), GCLM(1), GFPT1(4), GFPT2(4), GLS2(2), GLUD1(2), GLUD2(6), GLUL(4), GMPS(5), GOT1(6), GOT2(1), GPT2(2), GSR(1), GSS(4), NADSYN1(2), NAGK(2), PPAT(6), QARS(8)	12681561	127	55	126	33	44	42	28	3	10	0	0.185	1.000
71	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), CHAT(6), DBH(5), DDC(1), GAD1(9), GAD2(4), HDC(8), MAOA(3), PAH(4), SLC18A3(6), TPH1(3)	4593955	51	35	51	24	19	20	9	0	3	0	0.186	1.000
72	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(4), ATF2(1), AXIN1(2), BMP10(3), BMP2(1), BMP4(2), BMP5(5), BMP7(6), BMPR1A(4), BMPR2(10), CHRD(5), FZD1(1), GATA4(1), GSK3B(8), MAP3K7(4), MEF2C(9), MYL2(1), NKX2-5(1), NPPA(1), NPPB(1), RFC1(14), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TGFBR3(8), WNT1(1)	9025130	119	48	117	30	41	35	21	0	22	0	0.188	1.000
73	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(5), GAD1(9), HDC(8), TPH1(3)	1907241	25	19	25	8	9	12	3	0	1	0	0.206	1.000
74	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	ARFIP2(2), CDK5R1(1), CFL1(1), CHN1(2), LIMK1(5), MAP3K1(8), MYL2(1), MYLK(14), NCF2(2), PAK1(5), PDGFRA(17), PLD1(11), PPP1R12B(9), RALBP1(6), RPS6KB1(3), TRIO(13), VAV1(13), WASF1(3)	9937426	116	49	114	33	39	36	21	2	17	1	0.206	1.000
75	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(18), CPT1A(6), LEP(1), LEPR(9), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKAG1(1), PRKAG2(3)	4774533	53	29	51	20	20	17	10	0	6	0	0.206	1.000
76	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AKR1C2(4), AKR1C3(2), AKR1C4(3), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), CYP1A1(7), CYP1A2(3), CYP1B1(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2S1(3), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), DHDH(1), EPHX1(5), GSTA1(1), GSTA3(4), GSTA5(2), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), MGST1(2), MGST3(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6)	17326449	190	63	189	45	47	65	52	1	24	1	0.208	1.000
77	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(8), CFTR(12), GNAS(6), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), SLC9A3R1(3)	4057728	42	30	42	13	15	13	9	0	5	0	0.209	1.000
78	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(3), AASS(9), KARS(3)	1568670	16	13	16	4	4	4	5	0	3	0	0.209	1.000
79	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(4), CSK(3), GRB2(3), PRKCA(4), PTPRA(2), SRC(3)	3024185	28	23	28	9	7	14	6	1	0	0	0.214	1.000
80	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(2), B3GNT1(2), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALT1(6), B4GALT2(3), B4GALT3(7), FUT1(4), FUT2(1), FUT3(4), FUT6(1), FUT9(5), GCNT2(11), ST3GAL6(7), ST8SIA1(3)	4995709	61	34	61	14	25	17	12	1	6	0	0.219	1.000
81	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(3), CDK2(2), CUL1(8), RB1(7), TFDP1(4)	2251084	24	18	24	6	5	3	9	1	5	1	0.220	1.000
82	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(3), EPX(7), LPO(3), MPO(5), MTHFR(7), PRDX6(2), SHMT1(2), SHMT2(2), TPO(11)	3611627	43	30	42	16	24	11	5	0	3	0	0.220	1.000
83	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(5), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), DHRS1(1), DHRS2(3), DHRS3(2), ESCO1(11), ESCO2(4), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4)	7785094	88	40	87	31	28	27	26	1	6	0	0.223	1.000
84	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A5(19), COL4A6(15), P4HB(2), SLC23A1(2), SLC23A2(7), SLC2A1(1), SLC2A3(1)	8026105	79	39	78	20	20	25	16	1	17	0	0.224	1.000
85	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(3), ARHGAP4(1), ARHGAP5(9), ARHGAP6(2), ARHGEF1(5), ARHGEF11(11), ARHGEF5(7), ARPC1A(5), ARPC1B(2), ARPC2(2), BAIAP2(1), CFL1(1), DIAPH1(1), LIMK1(5), MYL2(1), MYLK(14), OPHN1(7), PIP5K1A(3), PIP5K1B(2), PPP1R12B(9), ROCK1(15), SRC(3), TLN1(7), VCL(2)	14679953	120	61	118	36	40	32	24	2	22	0	0.229	1.000
86	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(7), GBA3(3), LPO(3), MPO(5), PRDX6(2), TPO(11)	2576917	31	25	30	14	18	7	2	0	4	0	0.232	1.000
87	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(7), PARK2(6), SNCA(1), SNCAIP(3), UBE2E2(1), UBE2F(1), UBE2G1(2), UBE2L3(2)	2093270	23	17	23	8	6	11	5	0	1	0	0.233	1.000
88	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	83	ACVR1(4), ACVR1C(3), ACVR2B(4), ACVRL1(4), AMHR2(2), BMP2(1), BMP4(2), BMP5(5), BMP6(3), BMP7(6), BMP8A(1), BMPR1A(4), BMPR1B(10), BMPR2(10), CHRD(5), COMP(2), CREBBP(25), CUL1(8), DCN(4), E2F4(1), E2F5(2), EP300(15), FST(3), GDF5(2), GDF6(3), IFNG(1), INHBB(1), INHBC(3), INHBE(1), LTBP1(9), MAPK1(2), MAPK3(3), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), RBL1(5), RBL2(8), RBX1(1), RHOA(5), ROCK1(15), ROCK2(6), RPS6KB1(3), RPS6KB2(2), SKP1(1), SMAD1(2), SMAD3(9), SMAD5(1), SMAD9(3), SMURF1(3), SMURF2(2), SP1(2), TFDP1(4), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), THBS1(10), THBS2(15), THBS3(3), THBS4(2), ZFYVE16(12), ZFYVE9(10)	30220065	319	92	314	108	110	102	60	1	46	0	0.244	1.000
89	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	8	JAK1(4), JAK2(9), JAK3(8), PIAS1(4), PIAS3(4), PTPRU(12), SOAT1(1)	4192573	42	28	40	13	20	9	4	0	7	2	0.246	1.000
90	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(3), AKR1D1(1), ARSD(3), ARSE(2), CARM1(2), CYP11B2(5), CYP19A1(8), HSD11B1(1), HSD17B12(2), HSD17B2(2), HSD17B3(2), HSD17B8(1), HSD3B1(3), HSD3B2(1), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SRD5A1(1), SRD5A2(2), STS(7), SULT1E1(2), SULT2A1(2), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), WBSCR22(1)	14685584	143	58	140	31	40	50	29	2	22	0	0.246	1.000
91	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(13), AR(6), ESR2(2), ESRRA(3), HNF4A(6), NPM1(1), NR0B1(3), NR1D1(4), NR1D2(6), NR1H3(4), NR1I2(2), NR1I3(3), NR2C2(4), NR2E1(2), NR2F1(3), NR2F2(5), NR2F6(1), NR3C1(4), NR4A1(2), NR4A2(7), NR5A2(4), PGR(4), PPARA(1), PPARD(2), PPARG(1), RARB(9), RARG(5), ROR1(9), RORA(2), RORC(1), RXRA(1), RXRB(3), RXRG(4), THRA(2), THRB(4), VDR(2)	13151867	135	61	133	53	52	43	26	2	12	0	0.247	1.000
92	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	12	AXIN1(2), CREBBP(25), EP300(15), FZD1(1), GSK3B(8), HDAC1(2), LDB1(5), LEF1(4), PITX2(2), TRRAP(21), WNT1(1)	8075263	86	46	85	25	37	17	18	1	13	0	0.267	1.000
93	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(3), NFYB(1), NFYC(3), RB1(7), SP1(2), SP3(3)	2204629	19	15	19	4	4	8	5	0	1	1	0.269	1.000
94	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(8), CARM1(2), DBH(5), DCT(13), DDC(1), ECH1(1), ESCO1(11), ESCO2(4), FAH(2), GOT1(6), GOT2(1), GSTZ1(2), HGD(2), HPD(4), LCMT1(3), LCMT2(2), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), MYST3(18), MYST4(10), PNPLA3(4), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SH3GLB1(4), TAT(5), TPO(11), TYR(3), TYRP1(2), WBSCR22(1)	18605814	199	67	195	74	69	66	45	4	15	0	0.270	1.000
95	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), FH(1), IDH2(7), MDH1(1), OGDH(4), SDHA(6), SUCLA2(5)	2979156	26	23	26	10	11	6	5	0	4	0	0.271	1.000
96	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	19	ADCYAP1R1(2), CALCR(5), CALCRL(6), CD97(5), CRHR1(2), CRHR2(5), ELTD1(7), EMR1(8), EMR2(6), GHRHR(2), GLP1R(7), GLP2R(5), GPR64(6), LPHN1(3), LPHN2(13), SCTR(3), VIPR1(4), VIPR2(3)	7963628	92	43	91	31	33	30	19	0	10	0	0.273	1.000
97	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(3), AKT1(2), ASAH1(3), CAV3(3), DAG1(5), DLG4(3), EPHB2(8), GNAI1(4), GNAQ(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), PITX2(2), PTX3(2), RHO(3), RYR1(25)	12186944	131	60	130	54	63	38	17	0	12	1	0.278	1.000
98	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), EGR1(3), KLK2(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), NGFR(3), RAF1(6)	2530557	26	19	23	7	9	7	6	0	4	0	0.279	1.000
99	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(8), ARHGEF1(5), F2(3), GNA12(2), GNA13(2), GNAI1(4), GNAQ(4), GNB1(1), GNGT1(1), MAP3K7(4), PLCB1(8), PPP1R12B(9), PRKCA(4), PTK2B(1), ROCK1(15)	7174036	71	36	70	24	22	19	15	2	13	0	0.280	1.000
100	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(1), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PCYT1A(5), PCYT1B(5), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), WBSCR22(1)	4370535	43	28	42	16	12	14	11	2	4	0	0.280	1.000
101	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(2), PLCB1(8), PLCG1(4), PRKCA(4), VAV1(13)	3004299	31	24	31	12	14	9	5	1	2	0	0.282	1.000
102	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	161	ADCY1(8), ADCY3(2), ADCY4(9), ADCY7(4), ADCY8(12), ADCY9(6), ADORA2A(5), ADORA2B(1), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRB1(3), ADRB3(1), AGTR1(5), ATP2A1(6), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(4), ATP2B4(8), AVPR1A(4), AVPR1B(3), BDKRB2(3), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1F(14), CACNA1G(10), CACNA1H(2), CACNA1I(5), CACNA1S(14), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CCKAR(2), CCKBR(5), CD38(2), CHRM1(3), CHRM3(4), CHRM5(2), CHRNA7(1), CYSLTR1(3), CYSLTR2(4), DRD1(1), EDNRA(4), EGFR(11), ERBB2(10), ERBB3(14), GNA11(1), GNA14(6), GNA15(3), GNAL(4), GNAQ(4), GNAS(6), GRIN1(1), GRIN2C(4), GRIN2D(5), GRM1(12), GRM5(11), GRPR(3), HRH1(1), HRH2(4), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), LHCGR(4), MYLK(14), MYLK2(3), NOS1(11), NOS3(2), NTSR1(1), OXTR(3), P2RX1(1), P2RX2(2), P2RX3(2), P2RX4(3), P2RX5(1), P2RX7(3), PDE1A(4), PDE1B(3), PDE1C(9), PDGFRA(17), PDGFRB(6), PHKA1(8), PHKA2(6), PHKB(6), PHKG2(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PLN(1), PPID(3), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PTAFR(1), PTGER3(7), PTGFR(7), PTK2B(1), RYR1(25), RYR3(42), SLC25A4(1), SLC25A5(1), SLC8A1(13), SLC8A2(4), SLC8A3(7), SPHK1(1), SPHK2(1), TACR1(2), TACR2(1), TACR3(7), TNNC2(1), TRHR(8), TRPC1(6), VDAC1(1), VDAC3(1)	76625483	817	159	801	320	357	243	137	6	71	3	0.282	1.000
103	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	10	IL6(2), IL6R(3), JAK1(4), JAK2(9), JAK3(8), PIAS3(4), PTPRU(12), SRC(3), STAT3(2)	4802325	47	31	45	20	24	13	3	0	5	2	0.296	1.000
104	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(4), MMP2(5), MMP9(11), RECK(5), TIMP1(2), TIMP2(2), TIMP3(3), TIMP4(2)	2420136	34	22	34	8	19	7	7	0	1	0	0.303	1.000
105	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	37	AKT1(2), ASAH1(3), ATF1(2), CREB1(1), CREB3(3), CREB5(4), CREBBP(25), CRKL(2), DAG1(5), EGR1(3), EGR2(8), EGR3(2), FRS2(4), GNAQ(4), MAP1B(30), MAPK1(2), MAPK3(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), NTRK1(6), OPN1LW(1), PIK3C2G(9), PIK3CD(3), PTPN11(5), RPS6KA3(5), SHC1(3), SRC(3), TERF2IP(2)	14001097	156	60	153	54	46	50	32	2	25	1	0.306	1.000
106	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	88	ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADRB1(3), CSNK1D(4), DRD1(1), DRD2(5), EGF(3), EGFR(11), GJA1(7), GJD2(1), GNA11(1), GNAI1(4), GNAQ(4), GNAS(6), GRB2(3), GRM1(12), GRM5(11), GUCY1A2(12), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HTR2A(3), HTR2B(1), HTR2C(8), ITPR1(19), ITPR2(18), ITPR3(12), MAP2K1(4), MAP2K2(1), MAP2K5(4), MAP3K2(3), MAPK1(2), MAPK3(3), MAPK7(3), NPR1(6), NPR2(10), PDGFA(1), PDGFC(3), PDGFD(3), PDGFRA(17), PDGFRB(6), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKG1(9), PRKG2(5), PRKX(2), RAF1(6), SOS1(7), SOS2(11), SRC(3), TJP1(7), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3)	39773626	450	115	447	162	189	145	74	3	36	3	0.311	1.000
107	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(4), FOS(1), GRB2(3), IGF1(2), IGF1R(8), IRS1(8), MAP2K1(4), MAPK3(3), MAPK8(7), PTPN11(5), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3)	6719189	73	39	71	14	22	26	17	1	7	0	0.311	1.000
108	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(8), CREB1(1), FOS(1), GNAI1(4), GNAQ(4), GNAS(6), GNB1(1), GNGT1(1), MAP2K1(4), MAPK3(3), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), RAF1(6), RPS6KA3(5), SYT1(1)	11035083	95	54	94	31	45	21	16	0	13	0	0.316	1.000
109	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	69	ARAF(3), C7orf16(4), CACNA1A(17), CRHR1(2), GNA11(1), GNA12(2), GNA13(2), GNAI1(4), GNAO1(5), GNAQ(4), GNAS(6), GNAZ(1), GRIA2(13), GRIA3(8), GRID2(12), GRM1(12), GRM5(11), GUCY1A2(12), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), IGF1(2), IGF1R(8), ITPR1(19), ITPR2(18), ITPR3(12), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), NOS1(11), NOS3(2), NPR1(6), NPR2(10), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), PRKCA(4), PRKCG(10), PRKG1(9), PRKG2(5), RAF1(6), RYR1(25)	32775580	372	103	365	144	156	119	66	2	28	1	0.319	1.000
110	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(5), DNMT1(19), MTNR1B(3), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1)	3559966	39	26	35	8	18	10	7	3	1	0	0.319	1.000
111	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	136	APC2(1), AXIN1(2), AXIN2(9), BTRC(5), CACYBP(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CCND2(1), CCND3(1), CER1(3), CHD8(6), CREBBP(25), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTBP1(1), CTBP2(2), CTNNBIP1(1), CUL1(8), CXXC4(1), DAAM1(2), DAAM2(9), DKK1(5), DKK2(6), DVL2(9), DVL3(4), EP300(15), FBXW11(8), FZD1(1), FZD10(6), FZD2(2), FZD3(13), FZD4(2), FZD6(6), FZD7(3), FZD8(1), GSK3B(8), LEF1(4), LRP5(5), LRP6(17), MAP3K7(4), MAPK8(7), MAPK9(5), MMP7(5), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NKD1(3), NKD2(1), NLK(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PORCN(2), PPARD(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRICKLE1(11), PRICKLE2(6), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PSEN1(3), RBX1(1), RHOA(5), ROCK1(15), ROCK2(6), RUVBL1(8), SENP2(3), SFRP1(3), SFRP2(3), SFRP4(4), SFRP5(1), SIAH1(1), SKP1(1), SMAD3(9), SOX17(2), TBL1X(6), TBL1XR1(6), TBL1Y(1), TCF7(6), TCF7L1(3), VANGL1(2), VANGL2(5), WIF1(2), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	46509825	493	119	483	144	197	142	87	5	62	0	0.323	1.000
112	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(5), ACTN2(8), ACTN3(3), CSK(3), CTNNA1(12), CTNNA2(12), PECAM1(2), PTK2(5), SRC(3), VCL(2)	5743623	55	35	55	24	31	14	4	1	5	0	0.327	1.000
113	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3G(2), CD4(2), FYN(5), HLA-DRA(5), HLA-DRB1(2), LCK(3), PTPRC(17), ZAP70(4)	2930977	41	22	41	9	10	16	6	0	7	2	0.332	1.000
114	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(4), CREBBP(25), DFFA(3), DFFB(2), GZMA(3), GZMB(2), HMGB2(1)	3289710	41	25	41	11	12	13	9	0	7	0	0.333	1.000
115	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(11), GNAS(6), GNB1(1), GNGT1(1), GRB2(3), IGF1R(8), ITGB1(6), KLK2(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MKNK1(1), MKNK2(3), NGFR(3), PDGFRA(17), PPP2CA(1), PTPRR(5), RAF1(6), RPS6KA1(1), RPS6KA5(6), SHC1(3), SOS1(7), SRC(3), STAT3(2)	10820445	107	54	102	37	37	36	24	0	8	2	0.334	1.000
116	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(2), BAD(1), GRB2(3), IGF1R(8), IRS1(8), MAP2K1(4), MAPK1(2), MAPK3(3), RAF1(6), SHC1(3), SOS1(7), YWHAH(1)	4867967	48	33	46	11	16	17	10	0	5	0	0.337	1.000
117	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	17	HLA-A(3), ITGB1(6), KLRC3(3), KLRC4(1), KLRD1(1), LAT(1), MAP2K1(4), MAPK3(3), PAK1(5), PTK2B(1), PTPN6(4), SYK(3), VAV1(13)	4668301	48	30	48	12	17	13	10	1	7	0	0.341	1.000
118	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS2(2), GLUD1(2), GLUD2(6)	1381929	10	10	10	6	6	3	1	0	0	0	0.341	1.000
119	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(6), CCNA2(3), CCNE1(3), CCNE2(2), CDK2(2), CDK4(3), CDKN1B(3), CDKN2A(1), E2F2(1), E2F4(1), PRB1(1)	2783245	26	20	26	7	7	6	7	1	5	0	0.343	1.000
120	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(5)	673761	7	7	7	3	3	3	0	0	1	0	0.349	1.000
121	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ACAA2(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(2), SOAT2(1), SRD5A1(1), SRD5A2(2)	7443790	80	40	80	23	22	30	23	0	5	0	0.349	1.000
122	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(10), CR2(11), HLA-DRA(5), HLA-DRB1(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	4505311	61	28	61	16	15	26	10	0	8	2	0.350	1.000
123	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(4), LIPT1(4)	494162	8	6	8	1	0	6	1	0	1	0	0.351	1.000
124	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	19	ADCY1(8), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(1), CSF2RB(7), IGF1(2), IGF1R(8), IL3(3), KIT(8), KITLG(2), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), YWHAH(1)	5502988	58	37	57	24	27	18	8	0	5	0	0.357	1.000
125	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), GNAI1(4), GNB1(1), GNGT1(1), ITGA1(3), ITGB1(6), MAP2K1(4), MAPK1(2), MAPK3(3), PLA2G4A(8), PLCB1(8), PRKCA(4), PTGS1(6), PTK2(5), RAF1(6), SRC(3), SYK(3), TBXAS1(5)	8018239	75	40	73	22	29	21	17	1	7	0	0.363	1.000
126	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(6), SPCS1(1), SPCS3(1)	994447	10	9	8	3	6	1	1	0	2	0	0.372	1.000
127	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(4), TPI1(1)	500831	5	5	5	0	0	2	3	0	0	0	0.376	1.000
128	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	CPEB1(5), EGFR(11), ERBB2(10), ETS1(1), ETS2(3), ETV6(5), FMN2(7), GRB2(3), MAP2K1(4), MAPK1(2), MAPK3(3), NOTCH2(13), NOTCH3(15), NOTCH4(7), PIWIL1(8), PIWIL2(10), PIWIL3(10), PIWIL4(8), RAF1(6), SOS1(7), SOS2(11), SPIRE1(3), SPIRE2(1)	15506228	153	65	148	43	54	54	31	2	12	0	0.378	1.000
129	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), TGDS(1), UGDH(4), UXS1(7)	1215803	15	12	15	4	5	6	2	0	2	0	0.378	1.000
130	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(8), G6PD(3), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GSS(4), GSTA1(1), GSTA3(4), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1), PGD(1)	5683259	63	34	61	9	13	28	16	0	6	0	0.378	1.000
131	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(4), ACO2(2), ACSS1(3), ACSS2(6), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SUCLA2(5)	4331110	37	26	37	12	15	11	6	1	4	0	0.384	1.000
132	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(3), EPX(7), LPO(3), MPO(5), PRDX1(1), PRDX6(2), SHMT1(2), SHMT2(2), TPO(11)	3661803	37	28	36	16	22	8	3	0	4	0	0.385	1.000
133	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), XDH(7)	2540963	28	18	28	12	7	11	6	0	4	0	0.389	1.000
134	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(6), MAP3K14(3), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), TNFRSF13B(4), TNFRSF17(2), TNFSF13(2), TNFSF13B(1), TRAF2(1), TRAF3(6), TRAF5(6), TRAF6(4)	4570080	53	29	52	15	21	12	9	3	8	0	0.392	1.000
135	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(13), PPP1R1B(1)	1159240	16	13	15	5	7	3	5	0	1	0	0.392	1.000
136	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(4), AASDHPPT(3), AASS(9), KARS(3)	2302428	20	15	20	8	5	6	6	0	3	0	0.393	1.000
137	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	CALR(1), CANX(2), CD4(2), CD74(1), CD8B(2), CIITA(7), CREB1(1), CTSB(5), CTSL1(4), CTSS(2), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), HSP90AA1(3), HSP90AB1(3), HSPA5(1), IFI30(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(4), KIR3DL2(4), KIR3DL3(4), KLRC3(3), KLRC4(1), KLRD1(1), LGMN(3), NFYA(3), NFYB(1), NFYC(3), PDIA3(2), RFX5(1), RFXAP(1), TAP1(5), TAP2(5), TAPBP(5)	14592901	143	52	140	42	28	60	27	2	20	6	0.397	1.000
138	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(4), AK3(1), CAD(11), CDA(1), CTPS(4), CTPS2(4), DCK(2), DCTD(3), DHODH(4), DPYD(14), DPYS(7), DTYMK(1), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(2), ENTPD6(2), ITPA(2), NME6(4), NME7(5), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), PNPT1(10), POLA1(8), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(11), POLR3GL(1), POLR3H(1), POLR3K(1), RFC5(3), RRM1(2), RRM2(2), TK1(1), TK2(1), TXNRD1(3), TXNRD2(3), TYMS(3), UCK2(1), UMPS(1), UPB1(5), UPP2(2), UPRT(4)	25984357	252	82	248	61	73	96	52	1	30	0	0.398	1.000
139	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	123	ALCAM(2), CADM1(8), CADM3(8), CD2(3), CD22(10), CD226(4), CD274(4), CD28(2), CD34(1), CD4(2), CD40(1), CD40LG(6), CD58(2), CD6(3), CD80(1), CD8B(2), CDH1(5), CDH15(1), CDH3(4), CDH4(11), CDH5(2), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CNTN2(7), CNTNAP1(7), CNTNAP2(12), CTLA4(2), ESAM(3), F11R(1), GLG1(4), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), ICAM1(2), ICAM2(1), ICOS(1), ITGA4(8), ITGA6(4), ITGA8(8), ITGA9(6), ITGAL(8), ITGAM(8), ITGAV(5), ITGB1(6), ITGB2(5), ITGB7(4), ITGB8(5), JAM3(3), L1CAM(4), MAG(7), MPZL1(1), NCAM1(6), NEGR1(4), NEO1(6), NFASC(17), NLGN1(7), NLGN2(2), NLGN3(4), NRCAM(7), NRXN2(6), OCLN(1), PDCD1LG2(1), PECAM1(2), PTPRC(17), PTPRF(9), PVR(1), PVRL1(6), PVRL2(4), PVRL3(2), SDC1(1), SDC2(3), SDC3(3), SDC4(1), SELE(4), SELL(3), SELP(6), SELPLG(2), SIGLEC1(4), SPN(2), VCAM1(9), VCAN(36)	42902410	444	107	434	172	153	150	79	3	55	4	0.416	1.000
140	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A5(19), COL4A6(15), F10(1), F11(4), F12(2), F2(3), F5(21), F8(18), F9(6), FGA(13), FGB(2), FGG(4), KLKB1(6), PROC(1), PROS1(6), SERPINC1(3), SERPING1(5)	14382333	161	54	157	40	34	65	34	1	27	0	0.418	1.000
141	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(2), CAT(3), GH1(2), GHR(6), IGF1(2), IGF1R(8), SHC1(3), SOD2(4)	3059775	30	24	29	13	14	9	5	0	2	0	0.422	1.000
142	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), CSNK1D(4), DRD1(1), DRD2(5), GRM1(12), PLCB1(8), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	5004503	49	32	49	19	22	10	8	2	7	0	0.426	1.000
143	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(5), ACACA(18), ACADL(2), ACADM(6), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), LDHA(2), LDHB(3), LDHC(2), MCEE(2), MLYCD(1), MUT(4), PCCA(9), PCCB(4), SDS(2), SUCLA2(5), SUCLG1(2)	10839687	119	45	117	24	42	38	20	1	18	0	0.428	1.000
144	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(5), GTF2F2(1), GTF2H1(4), GTF2H3(4), GTF2H4(1), GTF2IRD1(9), TAF1(12), TAF1L(22), TAF2(8), TAF4(5), TAF4B(6), TAF5(4), TAF5L(2), TAF6(3), TAF6L(2), TAF7(2), TAF7L(4), TAF9(1), TAF9B(1), TBPL1(1), TBPL2(1)	11708602	106	50	106	24	37	31	25	0	13	0	0.430	1.000
145	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(5), ABP1(1), ACADL(2), ACADM(6), ACADSB(5), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(14), DPYS(7), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), MLYCD(1), SDS(2), SMS(2), UPB1(5)	9373415	114	45	113	28	40	41	19	1	13	0	0.431	1.000
146	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(3), AKR1D1(1), CYP11A1(4), CYP11B2(5), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD3B1(3), HSD3B2(1)	2482465	21	17	21	6	10	7	3	0	1	0	0.435	1.000
147	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(3), AKR1D1(1), CYP11A1(4), CYP11B2(5), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD3B1(3), HSD3B2(1)	2482465	21	17	21	6	10	7	3	0	1	0	0.435	1.000
148	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(6), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(2), CDC25A(2), CDK2(2), CDK4(3), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), RB1(7), RBL1(5), TFDP1(4)	5130899	46	31	46	12	14	10	13	1	7	1	0.438	1.000
149	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(9), DIAPH1(1), FYN(5), ITGA1(3), ITGB1(6), MAP2K1(4), MAPK1(2), MAPK3(3), MYL2(1), MYLK(14), PTK2(5), RAF1(6), ROCK1(15), SHC1(3), SRC(3), TLN1(7)	10755376	87	48	84	24	27	29	18	0	13	0	0.438	1.000
150	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(6), EPHB1(9), FYN(5), ITGA1(3), ITGB1(6), L1CAM(4), LYN(4), RAP1B(2), SELP(6)	4832094	49	28	48	14	19	18	8	0	4	0	0.442	1.000
151	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(8), ARHGAP5(9), ARHGDIB(3), CASP1(2), CASP10(2), CASP3(2), CASP9(2), GZMB(2)	3694553	30	24	29	10	4	11	7	0	8	0	0.447	1.000
152	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(6), GNB1(1), GNGT1(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4)	2987379	26	22	26	7	11	9	4	0	2	0	0.452	1.000
153	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(2), GRB2(3), KLK2(3), NTRK1(6), PLCG1(4), PRKCA(4), SHC1(3), SOS1(7)	3838615	32	26	29	10	6	16	7	0	3	0	0.453	1.000
154	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(2), HLA-DRA(5), HLA-DRB1(2), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL11(1), IL12A(1), IL12B(2), IL13(1), IL15(1), IL1A(1), IL2(4), IL3(3), IL4(3), IL6(2), IL7(2), IL8(1), PDGFA(1), TGFB1(1), TGFB2(9)	4268789	49	24	48	22	18	22	3	0	4	2	0.459	1.000
155	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(7), PRKCA(4), TGM2(6)	1615101	22	14	22	6	9	11	1	0	1	0	0.463	1.000
156	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(3), F3(2), F5(21), F7(3), FGA(13), FGB(2), FGG(4), PROC(1), PROS1(6), SERPINC1(3), TFPI(3)	5318179	62	29	62	17	14	30	12	0	6	0	0.469	1.000
157	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	2599304	30	22	30	6	15	5	7	0	3	0	0.470	1.000
158	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(5), ACTN2(8), ACTN3(3), BCR(7), CAPN1(2), CAPNS1(1), CAPNS2(1), CAV1(1), CRKL(2), CSK(3), FYN(5), GRB2(3), ITGA1(3), ITGB1(6), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(7), PPP1R12B(9), PTK2(5), RAF1(6), RAP1A(2), ROCK1(15), SHC1(3), SOS1(7), SRC(3), TLN1(7), VCL(2), ZYX(1)	14769645	131	60	128	36	51	43	25	1	11	0	0.480	1.000
159	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(5), CARS(6), DARS(4), EPRS(12), FARS2(5), GARS(3), HARS(2), IARS(6), KARS(3), LARS(5), LARS2(3), MARS(6), MARS2(1), NARS(3), QARS(8), RARS(4), SARS(2), TARS(6), WARS(2), WARS2(3), YARS(2)	10503106	91	43	91	16	30	26	23	2	10	0	0.480	1.000
160	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(6), GOT2(1), TAT(5), TYR(3)	1549816	16	12	15	7	6	5	3	0	2	0	0.483	1.000
161	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	106	ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), ARHGAP5(9), CDC42(1), CDH5(2), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTNND1(6), CXCL12(1), CXCR4(4), CYBB(2), ESAM(3), EZR(2), F11R(1), GNAI1(4), GRLF1(12), ICAM1(2), ITGA4(8), ITGAL(8), ITGAM(8), ITGB1(6), ITGB2(5), ITK(11), JAM3(3), MAPK12(2), MAPK13(1), MAPK14(3), MLLT4(6), MMP2(5), MMP9(11), MSN(6), MYL2(1), MYL7(1), MYL9(2), NCF1(1), NCF2(2), NCF4(3), NOX1(1), NOX3(8), OCLN(1), PECAM1(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PRKCA(4), PRKCG(10), PTK2(5), PTK2B(1), PTPN11(5), RAP1A(2), RAP1B(2), RAPGEF3(4), RAPGEF4(7), RASSF5(3), RHOA(5), RHOH(2), ROCK1(15), ROCK2(6), SIPA1(1), TXK(5), VASP(3), VAV1(13), VAV2(4), VAV3(12), VCAM1(9), VCL(2)	37438260	398	104	391	120	164	118	69	1	46	0	0.484	1.000
162	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(4), ACO2(2), CLYBL(6), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), OGDHL(11), PC(6), PCK1(3), PCK2(3), SDHA(6), SDHB(2), SDHD(1), SUCLA2(5), SUCLG1(2)	9500752	80	46	79	30	31	24	16	1	8	0	0.484	1.000
163	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	27	AKT1(2), AKT2(6), AKT3(1), ANKRD6(5), AXIN1(2), AXIN2(9), CER1(3), CSNK1A1(2), DACT1(6), DKK1(5), DKK2(6), DKK3(2), FSTL1(6), GSK3A(2), GSK3B(8), LRP1(17), MVP(4), NKD1(3), NKD2(1), PIN1(1), PSEN1(3), PTPRA(2), SENP2(3), SFRP1(3), TSHB(1), WIF1(2)	10069427	105	52	103	33	48	22	23	0	12	0	0.488	1.000
164	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(2), IL11(1), IL2(4), IL3(3), IL4(3), IL6(2), IL7(2), IL8(1), IL9(2)	2025711	22	14	21	8	9	10	2	0	1	0	0.492	1.000
165	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(8), G6PD(3), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GPX6(3), GSR(1), GSS(4), GSTA1(1), GSTA3(4), GSTA5(2), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1), TXNDC12(2)	6815994	70	37	68	11	14	30	19	0	7	0	0.494	1.000
166	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(2), BAD(1), CREB1(1), CREB3(3), CREB5(4), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(1), GRB2(3), MAP2K1(4), MAP2K2(1), MAP3K8(2), MAPK1(2), MAPK3(3), MKNK1(1), MKNK2(3), MOS(3), NFKB1(6), RAP1A(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), SHC1(3), SOS1(7), SOS2(11), TRAF3(6)	9235448	92	43	91	23	28	32	16	2	14	0	0.497	1.000
167	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(5), CDK7(1), CDKN1A(1), CHEK1(1), NEK1(9), WEE1(3)	2127081	22	14	21	7	7	8	4	2	1	0	0.497	1.000
168	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(7), ADCY4(9), ADCY6(1), ADCY8(12), CACNA1A(17), CACNA1B(11), GNAS(6), GNAT3(2), GNB1(1), GNB3(3), GNG3(2), GRM4(7), ITPR3(12), KCNB1(5), PDE1A(4), PLCB2(3), PRKACA(1), PRKACB(1), PRKACG(3), PRKX(2), SCNN1A(3), SCNN1B(4), SCNN1G(5), TAS1R1(7), TAS1R2(7), TAS2R1(2), TAS2R10(6), TAS2R13(3), TAS2R14(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R39(3), TAS2R4(2), TAS2R41(1), TAS2R46(2), TAS2R5(2), TAS2R50(5), TAS2R60(2), TAS2R7(1), TAS2R8(2), TAS2R9(3)	16976155	177	68	174	67	75	61	29	0	12	0	0.500	1.000
169	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(5), GPD2(4), NDUFA1(1), SDHA(6), SDHB(2), SDHD(1), UQCRC1(2)	2063274	21	15	21	3	6	11	3	0	1	0	0.501	1.000
170	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), NFS1(2), PHPT1(1), THTPA(1), TPK1(3)	2093637	20	15	20	5	8	6	4	0	2	0	0.504	1.000
171	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(3), CYSLTR2(4), GPR161(7), GPR171(4), GPR18(2), GPR34(6), GPR39(3), GPR45(7), GPR65(1), GPR75(2)	3093575	39	23	39	12	17	9	8	0	5	0	0.506	1.000
172	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(4), SNAP25(1), STX1A(2)	1043898	10	10	10	4	6	2	2	0	0	0	0.507	1.000
173	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(5), ABAT(5), ADSL(7), ADSS(2), AGXT2(5), ASL(2), ASNS(1), ASPA(5), CAD(11), CRAT(3), DARS(4), DDO(2), GAD1(9), GAD2(4), GOT1(6), GOT2(1), GPT2(2), NARS(3), PC(6)	8389907	83	44	82	29	38	30	10	0	5	0	0.509	1.000
174	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(8), GNAS(6), PLCE1(9), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RAP2B(1)	4434983	37	27	37	11	15	12	6	0	4	0	0.514	1.000
175	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	20	AXIN1(2), BTRC(5), CREBBP(25), CSNK1A1(2), CSNK1D(4), CSNK2A1(4), CTBP1(1), FZD1(1), GSK3B(8), HDAC1(2), MAP3K7(4), NLK(1), PPARD(2), PPP2CA(1), TLE1(1), WIF1(2), WNT1(1)	6687693	66	37	66	22	25	12	17	1	11	0	0.516	1.000
176	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	16	ABCB1(11), AKT1(2), BAX(1), CDKN1A(1), CPB2(2), CSNK1A1(2), CSNK1D(4), FHL2(2), HIF1A(3), IGFBP3(4), MAPK8(7), MDM2(4), NFKBIB(1), NQO1(1)	4246304	45	25	45	5	11	14	15	2	3	0	0.516	1.000
177	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), ABP1(1), ACAT1(1), ACAT2(2), ACMSD(4), AFMID(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(8), CARM1(2), CAT(3), CYP1A1(7), CYP1A2(3), CYP1B1(3), DDC(1), ECHS1(2), EHHADH(2), GCDH(5), HAAO(2), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), INMT(2), KMO(5), KYNU(7), LCMT1(3), LCMT2(2), LNX1(11), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), NFX1(8), OGDH(4), OGDHL(11), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), TDO2(4), TPH1(3), TPH2(8), WARS(2), WARS2(3), WBSCR22(1)	19235695	193	68	191	60	66	67	37	3	20	0	0.518	1.000
178	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(5), ACACA(18), ACACB(15), ACADM(6), ACAT1(1), ACAT2(2), ACSS1(3), ACSS2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH7A1(3), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), HIBCH(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), MCEE(2), MLYCD(1), MUT(4), PCCA(9), PCCB(4), SUCLA2(5), SUCLG1(2)	13011901	133	50	131	30	45	46	21	2	19	0	0.524	1.000
179	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	8	IFNG(1), IFNGR1(3), JAK1(4), JAK2(9), PTPRU(12), STAT1(6)	3537238	35	22	33	11	17	6	7	0	3	2	0.527	1.000
180	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(4), FOS(1), GRB2(3), INSR(6), IRS1(8), MAP2K1(4), MAPK3(3), MAPK8(7), PTPN11(5), RAF1(6), RASA1(9), SHC1(3), SLC2A4(4), SOS1(7), SRF(3)	6964964	73	38	71	18	19	27	18	1	8	0	0.533	1.000
181	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH7A1(3), ALDH9A1(1), AMDHD1(4), AOC2(4), AOC3(4), ASPA(5), CARM1(2), CNDP1(3), DDC(1), FTCD(2), HAL(4), HARS(2), HARS2(4), HDC(8), HNMT(4), LCMT1(3), LCMT2(2), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), PRPS1(1), PRPS2(2), UROC1(3), WBSCR22(1)	12414816	118	52	116	43	43	41	23	2	9	0	0.536	1.000
182	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(1), AOC2(4), AOC3(4), CES1(5), ESD(1)	1816825	15	14	15	9	6	7	2	0	0	0	0.540	1.000
183	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	7	IFNAR1(3), IFNB1(1), JAK1(4), PTPRU(12), STAT1(6), STAT2(7), TYK2(1)	3840541	34	24	32	9	19	5	6	0	4	0	0.541	1.000
184	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(1), FARSB(8), GOT1(6), GOT2(1), PAH(4), TAT(5), YARS(2), YARS2(4)	2863003	36	20	35	7	10	13	7	0	6	0	0.541	1.000
185	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(8), CKM(5), FBL(3), LDHA(2), LDHB(3), LDHC(2), MAPK14(3), NCL(3)	2883765	29	21	29	14	12	12	4	0	1	0	0.542	1.000
186	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL12A(1), IL12B(2), IL13(1), IL15(1), IL16(9), IL1A(1), IL2(4), IL3(3), IL4(3), IL6(2), IL8(1), IL9(2)	3122948	35	20	34	20	13	17	3	0	2	0	0.548	1.000
187	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(3), GGT1(3), SHMT1(2), SHMT2(2)	1147546	10	10	8	5	2	5	0	0	3	0	0.552	1.000
188	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(8), CD14(1), CD19(3), CD1A(3), CD1B(1), CD1C(1), CD1D(2), CD2(3), CD22(10), CD33(2), CD34(1), CD36(1), CD37(2), CD38(2), CD3D(1), CD3G(2), CD4(2), CD44(3), CD5(4), CD55(4), CD7(1), CD8B(2), CD9(1), CR1(10), CR2(11), CSF1(2), CSF1R(3), CSF3R(10), DNTT(7), FCER2(1), FCGR1A(1), FLT3(5), FLT3LG(1), GP1BA(1), GP5(6), GYPA(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), IL11(1), IL11RA(1), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), IL2RA(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL7(2), IL7R(3), ITGA1(3), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGAM(8), ITGB3(9), KIT(8), KITLG(2), MME(10), MS4A1(4), TFRC(3), THPO(2), TPO(11)	25212308	260	76	254	87	98	101	36	4	19	2	0.555	1.000
189	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), NCK1(1), NCKAP1(9), NTRK1(6), PIR(1), PSMA7(1), WASF1(3), WASF2(2), WASF3(4), WASL(7)	4931601	52	29	52	11	17	17	12	0	6	0	0.557	1.000
190	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(4), ATR(17), CCNA1(6), CCNE1(3), CDC25A(2), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), DHFR(1), GSK3B(8), HDAC1(2), RB1(7), SKP2(1), TFDP1(4), TGFB1(1), TGFB2(9)	7398859	76	35	76	19	25	17	19	1	13	1	0.559	1.000
191	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(11), ABCB11(11), ABCB4(11), ABCC1(11), ABCC3(5)	4392715	49	26	49	13	9	18	14	1	7	0	0.560	1.000
192	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	50	ADORA3(3), ALG6(3), CCKBR(5), CCR3(4), CCR5(1), CELSR1(8), CELSR2(9), CELSR3(5), CHRM3(4), EDNRA(4), EMR2(6), EMR3(8), FSHR(7), GHRHR(2), GNRHR(4), GPR116(11), GPR132(1), GPR133(8), GPR143(2), GPR17(1), GPR18(2), GPR55(1), GPR56(2), GPR61(4), GPR77(2), GPR84(6), GPR88(1), GRM1(12), GRPR(3), HRH4(2), LPHN2(13), NTSR1(1), OR8G2(1), P2RY13(2), PTGFR(7), SMO(1), SSTR2(3), TAAR5(6), TSHR(7), VN1R1(4)	19511338	176	69	173	76	70	50	35	5	16	0	0.561	1.000
193	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(1), CREBBP(25), EP300(15), NCOA3(11), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RXRA(1)	6607603	68	35	68	16	21	22	15	2	8	0	0.565	1.000
194	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	93	ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3(3), CREB3L1(3), CREB3L2(4), CREB3L3(3), CREB3L4(1), CREBBP(25), DCT(13), DVL2(9), DVL3(4), EDN1(1), EP300(15), FZD1(1), FZD10(6), FZD2(2), FZD3(13), FZD4(2), FZD6(6), FZD7(3), FZD8(1), GNAI1(4), GNAO1(5), GNAQ(4), GNAS(6), GSK3B(8), KIT(8), KITLG(2), LEF1(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MITF(5), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), POMC(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), RAF1(6), TCF7(6), TCF7L1(3), TYR(3), TYRP1(2), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	32279410	335	95	331	126	142	98	54	5	36	0	0.566	1.000
195	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	CXCL12(1), CXCR4(4), GNAI1(4), GNAQ(4), GNB1(1), GNGT1(1), MAP2K1(4), MAPK1(2), MAPK3(3), NFKB1(6), PIK3C2G(9), PLCG1(4), PRKCA(4), PTK2(5), PTK2B(1), RAF1(6), RELA(2)	7530324	61	35	60	19	26	15	10	0	10	0	0.567	1.000
196	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(6), LARS(5), LARS2(3), PDHA1(5), PDHA2(8), PDHB(2)	3238316	30	19	29	7	11	9	6	0	4	0	0.568	1.000
197	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(1), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(7), GOT1(6), GOT2(1), HPD(4), LPO(3), MAOA(3), MAOB(1), MPO(5), PRDX1(1), PRDX6(2), TAT(5), TPO(11)	6918969	71	41	69	26	35	22	8	0	6	0	0.572	1.000
198	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(4), NFKB1(6), PLCB1(8), PRKCA(4), RELA(2)	2716063	24	16	24	9	10	6	3	1	4	0	0.572	1.000
199	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	29	AKT1(2), AR(6), ASAH1(3), CCL13(1), CCL15(1), DAG1(5), EGFR(11), GNA11(1), GNA15(3), GNAI1(4), GNAQ(4), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), MAPK14(3), PHKA2(6), PIK3CD(3), PITX2(2), PTX3(2), RAF1(6), SRC(3)	12757555	134	58	133	54	63	36	23	0	11	1	0.573	1.000
200	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	62	ADCY1(8), ADCY8(12), ARAF(3), ATF4(1), CACNA1C(12), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CREBBP(25), EP300(15), GNAQ(4), GRIA2(13), GRIN1(1), GRIN2B(10), GRIN2C(4), GRIN2D(5), GRM1(12), GRM5(11), ITPR1(19), ITPR2(18), ITPR3(12), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF3(4), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA6(7)	28969395	310	86	308	113	127	83	63	3	33	1	0.573	1.000
201	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(8), BAX(1), BCL2(1), CCNE1(3), CDK2(2), CDK4(3), CDKN1A(1), MDM2(4), PCNA(3), RB1(7), TIMP3(3)	3632136	36	21	36	9	9	12	10	1	3	1	0.578	1.000
202	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(7), APOBEC1(2), APOBEC2(1), APOBEC3A(1), APOBEC3C(3), APOBEC3F(2), APOBEC3G(3), APOBEC4(4)	2333371	23	16	23	5	9	8	3	1	2	0	0.579	1.000
203	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(1), CASP3(2), CFL1(1), CFLAR(3), PDE6D(1)	856153	8	7	8	2	2	4	2	0	0	0	0.579	1.000
204	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(5), ABP1(1), ACADM(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(14), DPYS(7), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), HIBCH(1), MLYCD(1), SMS(2), UPB1(5)	8702151	99	41	98	28	33	37	16	1	12	0	0.583	1.000
205	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAA2(1), ACAD8(1), ACAD9(5), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(2), HSD3B7(2), LIPA(1), RDH11(1), RDH12(3), RDH13(1), SLC27A5(4), SOAT1(1), SOAT2(1), SRD5A1(1), SRD5A2(2)	10111639	93	45	93	33	24	39	23	0	7	0	0.584	1.000
206	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRB1(3), ADRB3(1), ANXA6(3), ARRB1(1), ATP1A4(8), ATP1B1(1), ATP1B2(2), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(4), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1S(14), CACNB1(1), CACNB3(2), CALR(1), CAMK1(3), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CASQ1(2), CASQ2(4), CHRM1(3), CHRM3(4), CHRM4(1), CHRM5(2), GJA1(7), GJA4(2), GJA5(3), GJB1(3), GJB3(4), GJB4(1), GNA11(1), GNAO1(5), GNAQ(4), GNAZ(1), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), GRK4(5), GRK5(4), GRK6(3), ITPR1(19), ITPR2(18), ITPR3(12), KCNB1(5), KCNJ3(6), KCNJ5(4), MIB1(3), MYCBP(1), NME7(5), PEA15(1), PKIA(1), PKIB(1), PLCB3(4), PLN(1), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(2), RGS18(2), RGS2(3), RGS20(4), RGS3(10), RGS4(3), RGS5(1), RGS6(3), RGS7(6), RGS9(7), RYR1(25), RYR3(42), SLC8A1(13), SLC8A3(7), USP5(4), YWHAB(2), YWHAH(1), YWHAQ(1)	53021527	556	132	552	236	258	165	82	0	49	2	0.585	1.000
207	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), ACO2(2), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), PC(6), PCK1(3), SDHA(6), SDHB(2), SUCLA2(5), SUCLG1(2)	6531027	51	34	51	22	20	17	7	0	7	0	0.586	1.000
208	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(1), TAT(5)	873563	12	8	11	2	4	5	1	0	2	0	0.591	1.000
209	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(7), DLG4(3), EPHB2(8), F2(3), F2RL1(1), F2RL2(3), MAP2K5(4), MAPK1(2), MAPK7(3), MAPK8(7), MYEF2(7), PLD1(11), PLD2(2), PLD3(5), PTK2(5), RAF1(6), RASAL1(2), SRC(3), TEC(3), VAV1(13)	8822299	98	43	96	30	46	30	15	1	6	0	0.593	1.000
210	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(1), IL12A(1), IL12B(2), IL2(4)	955184	10	7	10	6	0	10	0	0	0	0	0.593	1.000
211	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CAMK1(3), CAMK1G(5), FPR1(2), GNA15(3), GNB1(1), GNGT1(1), MAP2K1(4), MAP2K2(1), MAP2K6(3), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), NCF1(1), NCF2(2), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), PAK1(5), PIK3C2G(9), PLCB1(8), PPP3CA(3), PPP3CB(5), PPP3CC(4), RAF1(6), RELA(2), SYT1(1)	11915235	108	48	107	36	42	28	17	2	19	0	0.594	1.000
212	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	241	ACVR1(4), ACVR2B(4), AMHR2(2), BMP2(1), BMP7(6), BMPR1A(4), BMPR1B(10), BMPR2(10), CCL13(1), CCL15(1), CCL18(2), CCL22(1), CCL23(2), CCL27(3), CCL7(1), CCL8(1), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CCR9(6), CD27(3), CD40(1), CD40LG(6), CD70(5), CNTF(2), CNTFR(2), CSF1(2), CSF1R(3), CSF2RB(7), CSF3R(10), CX3CL1(1), CX3CR1(2), CXCL10(1), CXCL11(3), CXCL12(1), CXCL14(2), CXCL16(1), CXCL5(2), CXCL6(1), CXCL9(3), CXCR4(4), EDA(2), EDA2R(2), EDAR(3), EGF(3), EGFR(11), FAS(2), FASLG(1), FLT1(12), FLT3(5), FLT3LG(1), FLT4(5), GDF5(2), GH1(2), GH2(3), GHR(6), HGF(8), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), IFNK(1), IL10(2), IL10RA(2), IL10RB(5), IL11(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL13(1), IL13RA1(2), IL15(1), IL15RA(1), IL17A(2), IL17RA(6), IL17RB(1), IL18RAP(4), IL19(1), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), IL1RAP(1), IL2(4), IL20(3), IL20RA(5), IL21(2), IL21R(5), IL22(2), IL22RA1(1), IL23R(3), IL24(2), IL25(1), IL26(3), IL28RA(3), IL2RA(2), IL2RB(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL6ST(3), IL7(2), IL7R(3), IL8(1), IL9(2), INHBB(1), INHBC(3), INHBE(1), KDR(10), KIT(8), KITLG(2), LEP(1), LEPR(9), LTB(1), LTBR(3), MET(5), MPL(2), NGFR(3), OSM(1), OSMR(6), PDGFC(3), PDGFRA(17), PDGFRB(6), PLEKHO2(5), PRL(3), PRLR(4), RELT(2), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(4), TNFRSF13B(4), TNFRSF17(2), TNFRSF19(3), TNFRSF1A(1), TNFRSF21(5), TNFRSF4(1), TNFRSF8(2), TNFRSF9(3), TNFSF10(1), TNFSF11(1), TNFSF12(2), TNFSF13(2), TNFSF13B(1), TNFSF14(3), TNFSF15(3), TNFSF18(1), TNFSF4(1), TNFSF8(1), TPO(11), TSLP(2), VEGFA(2), VEGFB(2), VEGFC(6), XCL2(1), XCR1(1)	54045119	568	118	558	195	183	208	102	0	74	1	0.595	1.000
213	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(3), CARM1(2), CBS(3), CTH(2), GGT1(3), LCMT1(3), LCMT2(2), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), METTL2B(2), METTL6(8), PAPSS1(2), PAPSS2(4), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SCLY(1), SEPHS1(3), SEPHS2(3), WBSCR22(1)	7743173	71	38	67	22	23	27	12	2	7	0	0.597	1.000
214	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), ACAT2(2), HMGCL(1), OXCT1(3)	1112323	7	7	7	3	2	4	1	0	0	0	0.604	1.000
215	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(3), CBS(3), CTH(2), MUT(4)	1606632	13	11	13	1	5	4	0	0	4	0	0.607	1.000
216	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(2), B3GNT2(2), B3GNT7(6), B4GALT1(6), B4GALT2(3), B4GALT3(7), CHST1(7), CHST2(1), FUT8(2), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	3690652	44	27	44	13	25	6	9	1	3	0	0.607	1.000
217	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(5), AGTR1(5), AGTR2(5), BDKRB2(3), KNG1(4), NOS3(2), REN(5)	3134465	31	21	30	9	9	10	6	0	6	0	0.609	1.000
218	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(5), EGF(3), EGFR(11), GRB2(3), MAP2K1(4), MAPK1(2), MAPK3(3), PTPRB(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SPRY1(3), SPRY4(2), SRC(3)	7494984	68	35	66	25	24	21	17	0	6	0	0.614	1.000
219	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(25), EP300(15), LPL(6), NCOA1(8), NCOA2(7), PPARG(1), RXRA(1)	5691962	63	30	63	20	19	19	17	1	7	0	0.617	1.000
220	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(5), ALDH4A1(3), ALDH5A1(4), CAD(11), CPS1(14), EPRS(12), GAD1(9), GAD2(4), GCLC(4), GCLM(1), GFPT1(4), GLS2(2), GLUD1(2), GLUL(4), GMPS(5), GOT1(6), GOT2(1), GPT2(2), GSS(4), NADSYN1(2), PPAT(6), QARS(8)	10683503	113	44	112	23	36	39	26	2	10	0	0.619	1.000
221	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	26	ANXA1(1), ANXA2(2), ANXA3(1), ANXA4(4), ANXA5(1), ANXA6(3), CYP11A1(4), EDN1(1), EDNRA(4), HSD11B1(1), PLA2G4A(8), PRL(3), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	6288225	62	31	61	13	26	20	10	0	6	0	0.624	1.000
222	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH9A1(1), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), HMGCL(1), L2HGDH(3), OXCT1(3), PDHA1(5), PDHA2(8), PDHB(2), SDHB(2), SDS(2)	8448246	95	41	94	25	36	36	15	0	8	0	0.625	1.000
223	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(8), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(6), GRB2(3), MAPK1(2), MAPK14(3), MAPK3(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), RPS6KA1(1), RPS6KA5(6), SOS1(7)	8102424	67	39	66	23	25	23	16	0	3	0	0.629	1.000
224	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYD(14), DPYS(7), ENPP1(4), ENPP3(4), PANK1(2), PANK3(3), PANK4(1), PPCS(2), UPB1(5)	4475160	44	24	43	13	9	21	9	0	5	0	0.630	1.000
225	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(4), FOS(1), GRB2(3), KLK2(3), MAP2K1(4), MAPK3(3), MAPK8(7), NGFR(3), PLCG1(4), RAF1(6), SHC1(3), SOS1(7)	4937387	48	28	44	10	14	18	12	1	3	0	0.630	1.000
226	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AGK(3), AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPAT6(2), AKR1B1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CEL(1), DAK(4), DGAT2(4), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), GK(3), GK2(6), GLA(4), GLB1(3), GPAM(3), LCT(20), LIPA(1), LIPC(4), LIPF(3), LIPG(2), LPL(6), MGLL(1), PNLIP(7), PNLIPRP1(4), PNLIPRP2(2), PNPLA3(4), PPAP2B(1)	18633803	206	66	204	66	69	77	43	0	17	0	0.630	1.000
227	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(2), IL6(2), LDLR(5), LPL(6)	1704920	16	12	16	4	6	4	4	0	2	0	0.630	1.000
228	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), GUSB(2), RPE(2), UGDH(4), UGP2(7), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), XYLB(2)	7852106	82	33	81	17	18	33	17	0	14	0	0.630	1.000
229	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(4), FUT2(1), FUT3(4), FUT6(1), ST3GAL3(4)	1447926	16	12	16	5	10	4	2	0	0	0	0.632	1.000
230	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(7), FCER1A(3), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PAK2(3), PLA2G4A(8), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), RAF1(6), SHC1(3), SOS1(7), SYK(3), SYT1(1), VAV1(13)	12348969	119	50	116	30	46	31	23	1	18	0	0.632	1.000
231	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(2), GOT1(6), GOT2(1), LDHA(2), LDHB(3), LDHC(2)	2221676	22	15	21	4	9	7	3	0	3	0	0.633	1.000
232	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(2), DHRS1(1), DHRS2(3), DHRS3(2), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), WBSCR22(1)	4427815	38	24	37	15	13	10	7	2	6	0	0.634	1.000
233	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), BAD(1), BCL2(1), CABIN1(11), CAMK2B(2), CAMK4(3), CD3G(2), CD69(1), CDKN1A(1), CNR1(5), CREBBP(25), CSNK2A1(4), CSNK2B(2), CTLA4(2), EGR2(8), EGR3(2), EP300(15), FCER1A(3), FCGR3A(1), FOS(1), GATA3(4), GATA4(1), GRLF1(12), GSK3A(2), GSK3B(8), ICOS(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL13(1), IL1B(1), IL2(4), IL2RA(2), IL3(3), IL4(3), IL6(2), IL8(1), ITK(11), KPNA5(4), MAPK14(3), MAPK8(7), MAPK9(5), MEF2A(4), MEF2D(1), MYF5(4), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB2(4), NFKBIB(1), NFKBIE(2), NPPB(1), NUP214(6), OPRD1(1), P2RX7(3), PAK1(5), PIN1(1), PPP3CB(5), PPP3CC(4), PPP3R1(1), PTPRC(17), RELA(2), SLA(4), SP1(2), SP3(3), TGFB1(1), TRAF2(1), TRPV6(11), VAV1(13), VAV2(4), VAV3(12), XPO5(1)	28527793	308	81	304	100	113	90	62	4	39	0	0.635	1.000
234	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(2), CCNE1(3), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN1B(3), MAPK1(2), MAPK3(3), NFKB1(6), PAK1(5), RAF1(6), RB1(7), RELA(2), TFDP1(4)	5401238	50	28	49	12	18	9	13	2	7	1	0.640	1.000
235	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDK2(2), CDK4(3), CDKN1A(1), CDKN1B(3), CDKN2A(1), CFL1(1), E2F2(1), MDM2(4), NXT1(1), PRB1(1)	2219601	18	14	18	5	3	4	6	1	4	0	0.641	1.000
236	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	133	ACTB(2), CHAD(7), COL11A1(24), COL11A2(11), COL17A1(8), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A3(43), COMP(2), DES(1), DSC1(8), DSC2(2), DSC3(4), DSG1(8), DSG2(5), DSG3(8), DSG4(9), FN1(21), GJA1(7), GJA10(9), GJA4(2), GJA5(3), GJA8(5), GJA9(4), GJB1(3), GJB3(4), GJB4(1), GJB7(2), GJC1(4), GJC2(1), GJC3(2), GJD2(1), GJD4(2), IBSP(3), INA(2), ITGA6(4), ITGB4(3), KRT1(4), KRT10(2), KRT12(2), KRT13(4), KRT14(2), KRT15(2), KRT16(2), KRT17(2), KRT18(2), KRT19(2), KRT2(1), KRT20(1), KRT23(1), KRT24(3), KRT25(3), KRT27(2), KRT28(1), KRT3(6), KRT31(4), KRT32(2), KRT33A(2), KRT33B(5), KRT34(4), KRT35(3), KRT36(2), KRT37(6), KRT38(2), KRT4(2), KRT5(4), KRT6A(4), KRT6B(2), KRT6C(2), KRT7(3), KRT71(3), KRT72(5), KRT73(4), KRT74(4), KRT75(6), KRT76(2), KRT77(1), KRT78(4), KRT79(3), KRT8(1), KRT81(1), KRT82(6), KRT83(1), KRT84(9), KRT85(6), KRT9(5), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), LMNB1(4), LMNB2(1), NES(7), PRPH(2), RELN(33), SPP1(1), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TNC(16), TNN(17), TNXB(17), VIM(3), VTN(6), VWF(15)	76258598	802	147	795	319	319	278	122	9	74	0	0.642	1.000
237	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(3), ENO3(4), FARS2(5), GOT1(6), GOT2(1), PAH(4), TAT(5), YARS(2)	2745772	30	19	29	7	8	11	6	0	5	0	0.642	1.000
238	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(5), FOS(1), MAP2K1(4), MAPK1(2), MAPK3(3), NFKB1(6), PLCB1(8), PRKCA(4), RAF1(6), RELA(2)	4978561	41	24	40	14	18	9	8	1	5	0	0.642	1.000
239	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), MIOX(1), UGDH(4)	2724689	31	20	31	6	10	12	5	0	4	0	0.642	1.000
240	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(4), B3GALT5(4), FUT1(4), FUT2(1), FUT9(5), GLA(4), HEXB(3), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST8SIA1(3)	3407123	34	20	33	12	14	8	7	0	5	0	0.643	1.000
241	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), FOS(1), GRB2(3), IL6(2), IL6R(3), IL6ST(3), JAK1(4), JAK2(9), JAK3(8), MAP2K1(4), MAPK3(3), PTPN11(5), RAF1(6), SHC1(3), SOS1(7), SRF(3), STAT3(2)	7723339	70	37	67	16	22	26	12	0	8	2	0.644	1.000
242	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(7), CD79A(3), CD79B(1), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP3K1(8), MAPK14(3), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), RAF1(6), SHC1(3), SOS1(7), SYK(3), SYT1(1), VAV1(13)	12253010	115	50	113	31	46	33	19	1	16	0	0.646	1.000
243	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(11), POLR3GL(1), POLR3H(1), POLR3K(1)	7557555	66	36	66	12	25	24	12	1	4	0	0.646	1.000
244	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPPL1(4), ITPKB(4), MIOX(1), OCRL(9), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3CB(2), PIK3CG(14), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCG1(4), PLCG2(13)	13421216	121	53	119	33	50	38	21	1	11	0	0.647	1.000
245	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(2), ALOX12B(2), ALOX15B(5), ALOX5(4), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2J2(3), CYP2U1(1), CYP4A11(3), CYP4A22(2), CYP4F2(8), CYP4F3(3), EPHX2(1), GGT1(3), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GPX6(3), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	12456242	108	51	105	38	41	39	19	2	7	0	0.647	1.000
246	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(1), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(7), ESCO1(11), ESCO2(4), GOT1(6), GOT2(1), HPD(4), LPO(3), MAOA(3), MAOB(1), MPO(5), MYST3(18), MYST4(10), PNPLA3(4), PRDX6(2), SH3GLB1(4), TAT(5), TPO(11)	10912703	121	49	118	38	55	36	21	1	8	0	0.651	1.000
247	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS1(1), DHRS2(3), DHRS3(2), HSD3B7(2), PON1(6), PON2(2), PON3(2), RDH11(1), RDH12(3), RDH13(1)	2700248	23	18	23	10	10	7	2	0	4	0	0.651	1.000
248	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(1), FOS(1), FYN(5), MAPK14(3), THBS1(10)	2324935	22	16	22	8	7	10	3	0	2	0	0.653	1.000
249	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(9), EGF(3), EGFR(11), TF(11), TFRC(3)	4249140	37	23	37	7	17	9	7	0	3	1	0.654	1.000
250	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(9), AGT(5), AGTR2(5), EDN1(1), EDNRA(4), EGF(3), EGFR(11), FOS(1), NFKB1(6), PLCG1(4), PRKCA(4), RELA(2)	6378173	55	33	55	15	25	15	10	0	5	0	0.657	1.000
251	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(4), AGT(5), AKT1(2), CALR(1), CAMK1(3), CAMK1G(5), CAMK4(3), CREBBP(25), CSNK1A1(2), EDN1(1), ELSPBP1(1), F2(3), GATA4(1), GSK3B(8), HAND1(2), HAND2(2), IGF1(2), MAP2K1(4), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), MEF2C(9), MYH2(12), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NKX2-5(1), NPPA(1), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RAF1(6), RPS6KB1(3), SYT1(1)	14640445	164	57	163	47	63	44	34	1	22	0	0.658	1.000
252	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(2), ALOX5(4), CYP4F2(8), CYP4F3(3), EPX(7), GGT1(3), LPO(3), MPO(5), PLA2G1B(1), PLA2G4A(8), PLA2G6(4), PRDX1(1), PRDX6(2), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5), TPO(11)	8811080	83	43	79	30	42	25	8	2	6	0	0.659	1.000
253	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(5), DYRK1B(4), GLI2(4), GLI3(13), GSK3B(8), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), SMO(1), SUFU(4)	5184093	52	31	52	24	22	14	8	0	8	0	0.662	1.000
254	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), CDC42(1), PAK1(5), PDGFRA(17), WASL(7)	3126089	44	17	44	14	12	13	10	1	7	1	0.665	1.000
255	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(4), ATG7(1), BECN1(3), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNG(1), PIK3C3(7), PIK3R4(12), PRKAA1(3), PRKAA2(9), ULK1(1), ULK2(4), ULK3(3)	6692708	72	32	71	17	14	32	20	0	6	0	0.666	1.000
256	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	22	AKT1(2), AXIN1(2), CD14(1), FZD1(1), GJA1(7), GNAI1(4), GSK3B(8), IRAK1(1), LBP(1), LEF1(4), LY96(2), MYD88(2), NFKB1(6), PDPK1(1), PPP2CA(1), RELA(2), TIRAP(1), TLR4(10), TOLLIP(1), WNT1(1)	5907469	58	33	58	22	27	11	13	0	7	0	0.670	1.000
257	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	79	ACVR1(4), ACVRL1(4), AKT1(2), AURKB(1), BMPR1A(4), BMPR2(10), BUB1(6), CDKL1(4), CDKL2(4), CDS1(2), CDS2(4), CLK1(6), CLK4(2), COL4A3BP(3), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), IMPA1(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPPL1(4), ITPKB(4), MAP3K10(3), MOS(3), NEK1(9), NEK3(4), OCRL(9), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3CB(2), PIK3CG(14), PIM2(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCG1(4), PLCG2(13), PLK3(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), PRKG1(9), RAF1(6), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), TGFBR1(9), VRK1(4)	34409814	339	93	333	98	136	100	69	2	32	0	0.671	1.000
258	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(1), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), AOC2(4), AOC3(4), ASPA(5), CNDP1(3), DDC(1), HAL(4), HARS(2), HDC(8), HNMT(4), MAOA(3), MAOB(1), PRPS1(1), PRPS2(2)	7765011	80	40	80	27	31	30	16	0	3	0	0.672	1.000
259	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(2), ACTR3(3), AKT1(2), ANGPTL2(8), DAG1(5), DGKA(1), ETFA(3), ITGA9(6), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), MAP2K1(4), MAPK1(2), MAPK3(3), NR1I3(3), PAK1(5), PDE3A(5), PDE3B(3), PI3(1), PIK3C2G(9), PIK3CD(3), PLDN(1), RIPK3(4), RPS4X(2), SGCB(4), VASP(3)	13720481	135	53	135	40	49	37	24	3	20	2	0.674	1.000
260	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(1), COASY(1), DPYD(14), DPYS(7), ENPP1(4), ENPP3(4), ILVBL(2), PANK1(2), PANK3(3), PANK4(1), PPCS(2), UPB1(5), VNN1(6)	5569700	53	29	52	19	13	24	11	0	5	0	0.677	1.000
261	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(5), IGF1(2), IL11(1), IL1A(1), IL3(3), IL6(2), IL9(2), KITLG(2), TGFB1(1), TGFB2(9)	2732522	28	18	27	13	9	11	4	0	4	0	0.679	1.000
262	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(4), FUT2(1), FUT9(5), GLA(4), HEXB(3), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST8SIA1(3)	3201531	28	19	28	11	9	7	7	0	5	0	0.682	1.000
263	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(7), BLNK(1), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8IP3(2), PAPPA(18), RPS6KA1(1), RPS6KA3(5), SHC1(3), SOS1(7), SYK(3), VAV1(13), VAV2(4), VAV3(12)	10292484	102	47	100	23	38	39	16	0	9	0	0.683	1.000
264	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	122	ABL1(4), ABLIM1(6), ABLIM2(4), ABLIM3(5), ARHGEF12(9), CDC42(1), CFL1(1), CXCL12(1), CXCR4(4), DCC(16), DPYSL2(5), DPYSL5(1), EFNA3(1), EFNA4(1), EFNA5(5), EFNB1(3), EFNB2(1), EFNB3(3), EPHA1(6), EPHA2(5), EPHA4(6), EPHA6(5), EPHA7(10), EPHA8(7), EPHB1(9), EPHB2(8), EPHB3(2), EPHB4(5), EPHB6(4), FYN(5), GNAI1(4), GSK3B(8), ITGB1(6), L1CAM(4), LIMK1(5), LIMK2(5), LRRC4C(8), MAPK1(2), MAPK3(3), MET(5), NCK1(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NGEF(1), NRP1(1), NTN1(5), NTN4(6), NTNG1(4), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PLXNA1(2), PLXNA2(8), PLXNA3(2), PLXNB1(5), PLXNB2(2), PLXNB3(3), PLXNC1(9), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PTK2(5), RASA1(9), RGS3(10), RHOA(5), RND1(1), ROBO2(18), ROBO3(5), ROCK1(15), ROCK2(6), SEMA3A(9), SEMA3B(1), SEMA3C(3), SEMA3D(13), SEMA3E(9), SEMA3F(1), SEMA3G(4), SEMA4A(3), SEMA4B(2), SEMA4D(13), SEMA4F(9), SEMA4G(6), SEMA5A(8), SEMA5B(11), SEMA6A(2), SEMA6B(2), SEMA6C(3), SEMA6D(9), SEMA7A(2), SLIT1(11), SLIT2(15), SLIT3(9), SRGAP1(9), SRGAP2(3), SRGAP3(4), UNC5A(2), UNC5B(6), UNC5C(12), UNC5D(9)	58723123	563	127	553	175	232	157	92	6	76	0	0.686	1.000
265	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(7), FOS(1), GRB2(3), IL3(3), JAK2(9), MAP2K1(4), MAPK3(3), PTPN6(4), RAF1(6), SHC1(3), SOS1(7), STAT5B(3)	5354163	53	28	50	11	20	16	9	0	6	2	0.686	1.000
266	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(8), ITGAL(8), ITGB1(6), ITGB2(5), PECAM1(2), SELE(4), SELL(3)	4068317	41	22	39	11	9	19	9	0	4	0	0.686	1.000
267	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMB8(3), PSMB9(4)	2872224	23	18	23	6	6	7	5	2	3	0	0.686	1.000
268	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACAA2(1), ACADL(2), ACADM(6), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH9A1(1), AOX1(8), BCAT1(1), BCKDHA(3), BCKDHB(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HMGCL(1), MCCC1(8), MCCC2(2), MCEE(2), MUT(4), OXCT1(3), PCCA(9), PCCB(4), SDS(2)	11746853	113	48	112	27	41	41	15	0	16	0	0.687	1.000
269	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(8), ITGAL(8), ITGAM(8), ITGB1(6), ITGB2(5), PECAM1(2), SELE(4), SELL(3), SELP(6)	5117927	55	26	53	16	15	24	10	0	6	0	0.689	1.000
270	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(6), ALAS2(6), BLVRA(2), BLVRB(2), COX10(2), COX15(3), CP(6), CPOX(1), EPRS(12), FECH(3), FTMT(4), GUSB(2), HCCS(3), HMBS(2), HMOX1(2), HMOX2(3), MMAB(2), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), UROD(1), UROS(1)	12730971	129	46	126	28	34	59	23	0	13	0	0.690	1.000
271	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(1), CDO1(1), CTH(2), GOT1(6), GOT2(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), SDS(2), SULT1B1(4), SULT1C2(2), SULT1C4(3), SULT4A1(1)	4112439	41	22	38	7	16	14	6	1	4	0	0.691	1.000
272	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(8), ITGAM(8), ITGB2(5), PECAM1(2), SELE(4), SELL(3)	3368409	35	21	35	10	10	16	5	0	4	0	0.691	1.000
273	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(4), ALG1(1), ALG10(3), ALG10B(7), ALG11(1), ALG12(2), ALG13(1), ALG14(1), ALG2(3), ALG3(1), ALG6(3), ALG8(6), ALG9(2), B3GNT1(2), B3GNT2(2), B3GNT7(6), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), C1GALT1C1(2), CHPF(3), CHST1(7), CHST11(3), CHST12(3), CHST13(2), CHST14(1), CHST2(1), CHSY1(5), DAD1(2), DDOST(2), DPAGT1(2), EXT1(11), EXTL1(3), EXTL2(6), EXTL3(9), FUT11(1), FUT8(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(2), GALNT13(5), GALNT2(4), GALNT3(4), GALNT5(10), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GALNTL1(5), GALNTL2(8), GALNTL4(2), GALNTL5(8), GANAB(4), GCNT1(5), GCNT3(4), GCNT4(7), HS2ST1(4), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), MAN1A1(5), MAN1A2(2), MAN1B1(2), MAN1C1(7), MAN2A1(12), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(4), NDST2(5), NDST3(10), NDST4(4), OGT(5), RPN2(1), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(3), STT3B(6), UST(1), XYLT1(6), XYLT2(2)	33996113	332	93	328	105	121	103	72	3	33	0	0.692	1.000
274	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(1), DHRS2(3), DHRS3(2), ESCO1(11), ESCO2(4), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4)	5178628	57	27	56	17	24	14	13	1	5	0	0.692	1.000
275	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	19	BAD(1), BAX(1), BCL2(1), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), NFKB1(6), NSMAF(3), RAF1(6), RELA(2), RIPK1(2), SMPD1(6), TNFRSF1A(1), TRADD(1), TRAF2(1)	5998097	55	29	54	17	25	14	10	2	4	0	0.692	1.000
276	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADH(1), HADHA(3), HADHB(2), HSD17B10(2), HSD17B4(3), MECR(1), PPT2(2)	2809850	17	14	17	9	3	5	2	0	7	0	0.693	1.000
277	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(2), BAD(1), BCL2L1(1), CASP9(2), CDC42(1), CHUK(6), MAP2K1(4), MAPK3(3), NFKB1(6), RAF1(6), RALA(1), RALBP1(6), RALGDS(1), RELA(2), RHOA(5)	5003582	47	28	46	11	23	5	13	0	6	0	0.696	1.000
278	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	69	ACP1(2), ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), ACVR1C(3), BAIAP2(1), CDC42(1), CDH1(5), CREBBP(25), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTNND1(6), EGFR(11), EP300(15), ERBB2(10), FARP2(5), FER(6), FGFR1(4), FYN(5), IGF1R(8), INSR(6), IQGAP1(13), LEF1(4), LMO7(19), MAP3K7(4), MAPK1(2), MAPK3(3), MET(5), MLLT4(6), NLK(1), PARD3(7), PTPN1(5), PTPN6(4), PTPRB(4), PTPRF(9), PTPRJ(4), PVRL1(6), PVRL2(4), PVRL3(2), PVRL4(4), RHOA(5), SMAD3(9), SNAI1(1), SNAI2(2), SORBS1(11), SRC(3), SSX2IP(4), TCF7(6), TCF7L1(3), TGFBR1(9), TGFBR2(7), TJP1(7), VCL(2), WAS(1), WASF1(3), WASF2(2), WASF3(4), WASL(7), YES1(1)	34631735	368	91	361	115	144	116	63	4	40	1	0.696	1.000
279	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(2), CDKN1B(3), GRB2(3), ITGB1(6), MAPK1(2), MAPK3(3), PDK2(2), PDPK1(1), PTK2(5), SHC1(3), SOS1(7)	4737785	37	25	36	11	6	13	11	0	7	0	0.697	1.000
280	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR7(3), CD28(2), CD4(2), CXCR4(4), IFNG(1), IFNGR1(3), IFNGR2(2), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL2(4), IL4(3), IL4R(1), TGFB1(1), TGFB2(9)	5870694	57	29	58	29	15	30	6	0	6	0	0.697	1.000
281	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	28	DUSP1(2), GORASP1(4), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MAPKAPK5(1), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PIK3CD(3), SYT1(1), TRAF2(1), TRAF3(6), TRAF5(6), TRAF6(4)	8885229	68	38	68	25	22	14	14	4	14	0	0.700	1.000
282	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(8), BAD(1), BAX(1), BCL2(1), BCL2A1(3), BCL2L1(1), BOK(1), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP9(2), CD40(1), CD40LG(6), CRADD(2), DAXX(1), DFFA(3), DFFB(2), FAS(2), FASLG(1), IKBKE(4), NFKB1(6), NGFR(3), NR3C1(4), NTRK1(6), PTPN13(17), RIPK1(2), SFRS2IP(3), TFG(6), TNFRSF1A(1), TRADD(1), TRAF1(2), TRAF2(1), TRAF3(6), TRAF6(4)	13447048	118	52	116	53	34	43	22	1	17	1	0.702	1.000
283	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(25), DAXX(1), PAX3(7), PML(4), RB1(7), SIRT1(5), SP100(4), TNFRSF1A(1)	5814876	54	30	53	22	20	12	14	0	7	1	0.703	1.000
284	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(14), ENPP6(2), PAFAH1B1(3), PAFAH1B3(2), PAFAH2(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLD1(11), PLD2(2), PPAP2B(1)	7637810	69	36	66	29	28	24	12	0	5	0	0.705	1.000
285	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), ACO2(2), GRHPR(1), HAO1(5), HAO2(4), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(8)	4158580	33	21	32	13	12	11	5	2	3	0	0.706	1.000
286	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(4), FOS(1), MAPK3(3), OPRK1(5), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	4033965	33	23	33	8	16	7	6	1	3	0	0.706	1.000
287	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(2), CPS1(14), GLUD1(2), GOT1(6)	2484656	25	14	24	6	6	9	4	0	6	0	0.706	1.000
288	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(2), HLA-DRA(5), HLA-DRB1(2), IFNG(1), IFNGR1(3), IFNGR2(2), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL2(4), IL2RA(2), IL4(3), IL4R(1)	3661228	36	19	36	13	13	16	3	0	2	2	0.707	1.000
289	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(2), BLVRB(2), CP(6), CPOX(1), EPRS(12), FECH(3), GUSB(2), HCCS(3), HMBS(2), HMOX1(2), HMOX2(3), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3), UROD(1), UROS(1)	8425939	68	36	67	19	22	27	12	0	7	0	0.708	1.000
290	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(3), AP2M1(4), BAD(1), BTK(7), EEA1(9), GRASP(1), GSK3A(2), GSK3B(8), LYN(4), PDPK1(1), PFKL(1), PFKM(4), PFKP(2), PLCG1(4), PRKCE(6), RPS6KB1(3), VAV2(4)	7958873	66	36	66	19	23	20	12	0	10	1	0.708	1.000
291	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(2), IL8(1)	522441	3	3	3	3	0	2	0	0	1	0	0.712	1.000
292	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(6), CREBBP(25), DUSP1(2), EP300(15), IKBKB(4), IL1B(1), IL8(1), MAP2K6(3), MAP3K14(3), MAP3K7(4), MAPK14(3), MYD88(2), NFKB1(6), NR3C1(4), RELA(2), TGFBR1(9), TGFBR2(7), TLR2(6)	9320381	103	40	102	32	34	29	26	1	13	0	0.726	1.000
293	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(3), AKR1D1(1), ARSB(5), ARSD(3), ARSE(2), CYP11B2(5), HSD11B1(1), HSD17B2(2), HSD17B3(2), HSD17B8(1), HSD3B1(3), HSD3B2(1), SRD5A1(1), SRD5A2(2), STS(7), SULT1E1(2), SULT2A1(2), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3)	8019600	67	35	66	11	29	20	8	0	10	0	0.728	1.000
294	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(3), ADCY3(2), ADCY9(6), ARF4(3), ARF6(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(9), ATP6V1A(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), ERO1L(2), GNAS(6), PDIA4(5), PLCG1(4), PLCG2(13), PRKCA(4), SEC61A1(5), SEC61A2(1), SEC61B(1), TRIM23(9)	11906900	107	49	100	32	50	26	21	1	9	0	0.728	1.000
295	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(1), GNAQ(4), MARCKS(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), SP1(2), SP3(3), SYT1(1)	6651989	49	33	49	17	22	11	5	0	11	0	0.729	1.000
296	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(6), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF5(3), GSK3B(8)	3668538	26	19	26	5	6	6	9	0	5	0	0.730	1.000
297	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15B(5), ALOX5(4), ALOX5AP(1), DPEP1(1), GGT1(3), PLA2G6(4), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	4796011	39	27	37	11	15	16	6	1	1	0	0.731	1.000
298	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	134	ACTA1(4), ACTA2(3), ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADM(2), ARRB1(1), ATF1(2), ATF2(1), ATF3(1), ATF4(1), ATP2A2(6), ATP2A3(4), CACNB3(2), CALCA(4), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(13), CREB3(3), CRHR1(2), DGKZ(3), ETS2(3), FOS(1), GABPA(4), GABPB2(3), GBA2(5), GJA1(7), GNAQ(4), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), GRK4(5), GRK5(4), GRK6(3), GSTO1(1), GUCA2B(2), IGFBP1(2), IGFBP2(1), IGFBP3(4), IGFBP4(2), IL1B(1), IL6(2), ITPR1(19), ITPR2(18), ITPR3(12), MIB1(3), MYL2(1), MYL4(1), MYLK2(3), NFKB1(6), NOS1(11), NOS3(2), OXTR(3), PDE4B(5), PDE4D(4), PKIA(1), PKIB(1), PLCB3(4), PLCD1(7), PLCG1(4), PLCG2(13), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCH(3), PRKCQ(5), RAMP1(1), RAMP3(4), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(2), RGS18(2), RGS2(3), RGS20(4), RGS3(10), RGS4(3), RGS5(1), RGS6(3), RGS7(6), RGS9(7), RLN1(1), RYR1(25), RYR3(42), SLC8A1(13), SP1(2), TNXB(17), USP5(4), YWHAB(2), YWHAH(1), YWHAQ(1)	48533201	492	120	486	175	220	151	71	1	48	1	0.731	1.000
299	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	2584945	33	19	33	5	13	12	7	0	1	0	0.731	1.000
300	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	2584945	33	19	33	5	13	12	7	0	1	0	0.731	1.000
301	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), ACO2(2), AFMID(1), GRHPR(1), HAO1(5), HAO2(4), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(8)	4353426	34	22	33	13	13	11	5	2	3	0	0.734	1.000
302	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	33	AKT1(2), ATF1(2), CDC42(1), CREB1(1), CREB3(3), CREB5(4), DUSP1(2), DUSP10(5), EEF2K(1), IL1R1(4), MAP2K6(3), MAP3K10(3), MAP3K4(18), MAP3K5(6), MAP3K7(4), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MKNK1(1), MKNK2(3), MYEF2(7), NFKB1(6), NR2C2(4), SRF(3), TRAF6(4)	10499406	99	45	98	24	33	31	19	1	15	0	0.735	1.000
303	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP1(1), RANBP2(16), RANGAP1(1)	2416539	20	12	19	4	5	5	6	0	4	0	0.738	1.000
304	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	83	AGRN(1), CD36(1), CD44(3), CD47(3), CHAD(7), COL11A1(24), COL11A2(11), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A3(43), DAG1(5), FN1(21), FNDC3A(7), FNDC4(1), GP1BA(1), GP5(6), GP6(2), HMMR(6), HSPG2(9), IBSP(3), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAV(5), ITGB1(6), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), RELN(33), SDC1(1), SDC2(3), SDC3(3), SDC4(1), SPP1(1), SV2A(5), SV2B(6), SV2C(4), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TNC(16), TNN(17), TNXB(17), VTN(6), VWF(15)	69098796	698	135	691	290	251	240	123	8	76	0	0.739	1.000
305	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), CDC42(1), WASF1(3), WASL(7)	2590052	29	17	29	6	11	9	6	0	3	0	0.745	1.000
306	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(2)	384895	3	2	3	1	1	1	0	0	1	0	0.745	1.000
307	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(5), CD28(2), CD3D(1), CSK(3), CTLA4(2), DAG1(5), DTYMK(1), EPHB2(8), GRAP2(5), GRB2(3), ITK(11), ITPKB(4), LAT(1), LCK(3), LCP2(3), MAPK1(2), NCK1(1), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PLCG1(4), PTPRC(17), RAF1(6), RASGRP1(5), RASGRP2(7), RASGRP3(7), RASGRP4(2), SOS1(7), SOS2(11), VAV1(13), ZAP70(4)	17108213	182	61	178	57	70	64	31	2	15	0	0.746	1.000
308	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPAT6(2), CDS1(2), CDS2(4), CHAT(6), CHKA(4), CHPT1(1), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), ESCO1(11), ESCO2(4), ETNK1(2), ETNK2(2), GNPAT(2), GPAM(3), GPD1(1), GPD1L(3), GPD2(4), LCAT(1), MYST3(18), MYST4(10), PCYT1A(5), PCYT1B(5), PEMT(1), PISD(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLD1(11), PLD2(2), PNPLA3(4), PPAP2B(1), PTDSS1(7), SH3GLB1(4)	21459789	202	68	198	73	73	66	44	1	18	0	0.748	1.000
309	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(4), F12(2), F13B(5), F2(3), F5(21), F7(3), F8(18), F9(6), FGA(13), FGB(2), FGG(4), LPA(10), PLAT(5), PLAU(3), PLG(9), SERPINB2(5), SERPINE1(3), VWF(15)	11308069	132	45	129	44	33	59	23	0	17	0	0.750	1.000
310	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(7), FADS2(4), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4)	3323897	28	18	27	9	14	4	6	1	3	0	0.751	1.000
311	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA4(2), NDUFB2(1), NDUFB6(1), NDUFS1(6), NDUFS2(3), NDUFV1(2)	2257058	18	14	18	6	7	6	3	0	2	0	0.752	1.000
312	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT1(1), B3GALT2(3), B3GALT5(4), B3GNT5(1), FUT1(4), FUT2(1), FUT3(4), ST3GAL3(4), ST3GAL4(2)	2228020	26	16	26	5	13	7	4	0	2	0	0.753	1.000
313	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(6), CREBBP(25), EP300(15), HDAC3(2), IKBKB(4), NFKB1(6), RELA(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF6(4)	7332106	68	34	68	21	26	18	16	1	7	0	0.758	1.000
314	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(8), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIK(1), BIRC2(4), BIRC3(7), CASP3(2), CASP6(2), CASP7(1), CASP9(2), DFFA(3), DFFB(2), DIABLO(1)	4059556	38	24	38	9	11	15	7	0	5	0	0.760	1.000
315	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR2(2), PDE1A(4), PDE1B(3), PLCB1(8), PLCB2(3), PRL(3), TRH(2)	3248579	25	18	25	11	10	8	4	1	2	0	0.762	1.000
316	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(6), IARS2(6), ILVBL(2), LARS(5), LARS2(3), PDHA1(5), PDHA2(8), PDHB(2), VARS(1), VARS2(6)	5948758	46	29	45	14	20	12	8	0	6	0	0.763	1.000
317	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTB(2), ARHGEF2(5), ARPC5(1), ARPC5L(2), CD14(1), CDC42(1), CDH1(5), CTTN(1), EZR(2), FYN(5), HCLS1(8), ITGB1(6), KRT18(2), LY96(2), NCK1(1), NCL(3), OCLN(1), PRKCA(4), RHOA(5), ROCK1(15), ROCK2(6), TLR4(10), TLR5(4), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3), WAS(1), WASL(7), YWHAQ(1)	15727619	157	55	155	54	58	54	26	1	18	0	0.769	1.000
318	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTB(2), ARHGEF2(5), ARPC5(1), ARPC5L(2), CD14(1), CDC42(1), CDH1(5), CTTN(1), EZR(2), FYN(5), HCLS1(8), ITGB1(6), KRT18(2), LY96(2), NCK1(1), NCL(3), OCLN(1), PRKCA(4), RHOA(5), ROCK1(15), ROCK2(6), TLR4(10), TLR5(4), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3), WAS(1), WASL(7), YWHAQ(1)	15727619	157	55	155	54	58	54	26	1	18	0	0.769	1.000
319	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(3), HBXIP(2), PTK2B(1), SHC1(3), SOS1(7), SRC(3)	2861240	20	17	19	7	2	10	5	0	3	0	0.769	1.000
320	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(3), ALG10B(7), ALG11(1), ALG12(2), ALG13(1), ALG14(1), ALG2(3), ALG3(1), ALG5(3), ALG6(3), ALG8(6), ALG9(2), B4GALT1(6), B4GALT2(3), B4GALT3(7), DAD1(2), DDOST(2), DHDDS(1), DPAGT1(2), DPM1(1), FUT8(2), GANAB(4), MAN1A1(5), MAN1A2(2), MAN1B1(2), MAN1C1(7), MAN2A1(12), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), RPN2(1), ST6GAL1(1), STT3B(6)	13404288	112	52	110	28	37	36	30	0	9	0	0.769	1.000
321	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATR(17), CDC25C(4), CHEK1(1), CHEK2(1), YWHAH(1)	2955600	24	15	24	4	9	10	2	0	3	0	0.770	1.000
322	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(4), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(3), HSD3B2(1)	2135345	17	13	17	8	7	7	2	0	1	0	0.771	1.000
323	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CAPNS1(1), CAPNS2(1), CDK5R1(1), CSNK1A1(2), CSNK1D(4), GSK3B(8), MAPT(5), PPP2CA(1)	2721502	26	16	26	8	12	5	5	1	3	0	0.772	1.000
324	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(5), GPI(2), HK1(6), PFKL(1), PGAM1(3), PGK1(3), TPI1(1)	2850475	21	20	20	14	9	7	5	0	0	0	0.773	1.000
325	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(2), CD3D(1), CD3G(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	3430288	40	21	40	14	9	16	7	0	8	0	0.775	1.000
326	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(5), CHIT1(5), CMAS(8), CTBS(4), CYB5R1(3), CYB5R3(1), GFPT1(4), GFPT2(4), GNE(2), GNPDA2(1), HEXB(3), HK1(6), HK2(3), HK3(5), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), NAGK(2), NANS(1), NPL(3), PGM3(5), PHPT1(1), RENBP(1)	9351855	80	41	79	24	32	27	14	1	6	0	0.776	1.000
327	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	39	CD3D(1), CD3G(2), FOS(1), FYN(5), GRB2(3), LAT(1), LCK(3), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), PTPN7(2), RAF1(6), RASA1(9), RELA(2), SHC1(3), SOS1(7), SYT1(1), VAV1(13), ZAP70(4)	13854991	128	52	126	36	53	34	20	1	20	0	0.776	1.000
328	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(6), ACAT1(1), ECHS1(2), HADHA(3)	1767757	14	9	13	5	2	4	1	0	7	0	0.778	1.000
329	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(3), COQ6(2), COQ7(1), NDUFA12(2), NDUFA13(1)	1314043	9	8	9	2	1	4	2	0	2	0	0.780	1.000
330	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), ABP1(1), AOC2(4), AOC3(4), CES1(5), CES7(1), DDHD1(3), ESCO1(11), ESCO2(4), LIPA(1), MYST3(18), MYST4(10), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(2), SH3GLB1(4)	8066733	80	35	79	27	31	24	17	1	7	0	0.781	1.000
331	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(4), GLB1(3), HEXB(3), LCT(20), SLC33A1(2), ST3GAL1(1), ST3GAL2(1), ST6GALNAC3(4), ST6GALNAC4(2), ST6GALNAC5(6), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(6)	5257501	59	31	58	20	27	16	11	0	5	0	0.782	1.000
332	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(5), AGTR2(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), F2(3), FYN(5), GNA11(1), GNAI1(4), GNB1(1), GNGT1(1), GRB2(3), JAK2(9), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), MAPT(5), MYLK(14), PLCG1(4), PRKCA(4), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), STAT1(6), STAT3(2), SYT1(1)	13591354	118	50	116	37	32	43	29	1	11	2	0.782	1.000
333	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), GSK3B(8), IGF1(2), IGF1R(8), INPPL1(4), PDK2(2), PDPK1(1), PPP2CA(1), RPS6KB1(3)	4843550	38	28	38	13	15	9	8	0	6	0	0.783	1.000
334	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MAX(1), SP1(2), SP3(3), WT1(6)	1997919	14	12	14	4	8	3	3	0	0	0	0.784	1.000
335	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), AKT2(6), AKT3(1), CDKN1A(1), GRB2(3), MAP2K1(4), MAP2K2(1), NGFR(3), NTRK1(6), PIK3CD(3), SHC1(3), SOS1(7)	4516266	40	26	39	13	11	14	11	0	4	0	0.785	1.000
336	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA1(4), ACTA2(3), ACTN2(8), ACTN3(3), ACTN4(3), DES(1), FAM48A(6), MYBPC1(7), MYBPC2(4), MYBPC3(3), MYH3(14), MYH6(12), MYH7(11), MYH8(20), MYL1(1), MYL2(1), MYL4(1), MYL9(2), MYOM1(12), NEB(54), TMOD1(3), TNNC2(1), TNNI1(2), TNNI3(1), TNNT2(3), TPM1(2), TPM2(6), TPM3(3), TPM4(4), VIM(3)	16216944	198	57	190	69	82	69	25	3	18	1	0.785	1.000
337	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(4), PGLYRP2(2)	579946	6	5	6	2	2	2	1	0	1	0	0.786	1.000
338	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMC2(1), PSMC3(3), PSMD1(8), PSMD11(3), PSMD12(4), PSMD13(2), PSMD2(4), PSMD6(3)	5295327	44	25	43	15	15	14	9	2	4	0	0.786	1.000
339	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(6), ALAS2(6), CPOX(1), FECH(3), HMBS(2), PPOX(3), UROD(1), UROS(1)	2516580	24	15	24	5	13	8	2	0	1	0	0.787	1.000
340	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(6), ATIC(4), DHFR(1), FTCD(2), GART(3), MTFMT(2), MTHFD1(6), MTHFD1L(8), MTHFR(7), MTHFS(1), MTR(7), SHMT1(2), SHMT2(2), TYMS(3)	6082580	54	30	53	15	22	18	7	1	6	0	0.788	1.000
341	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(2), CD3D(1), CD3G(2), CD4(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	3626968	42	22	42	16	9	18	7	0	8	0	0.788	1.000
342	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(2), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), NTAN1(3), SIRT1(5), SIRT2(2), SIRT5(3), SIRT7(1), VNN2(2)	3833366	29	21	29	12	9	7	5	0	8	0	0.790	1.000
343	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	143	AKT1(2), AKT2(6), AKT3(1), BCL2L1(1), CBL(5), CBLB(8), CCND2(1), CCND3(1), CNTF(2), CNTFR(2), CREBBP(25), CSF2RB(7), CSF3R(10), EP300(15), GH1(2), GH2(3), GHR(6), GRB2(3), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), IFNK(1), IL10(2), IL10RA(2), IL10RB(5), IL11(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL13(1), IL13RA1(2), IL13RA2(3), IL15(1), IL15RA(1), IL19(1), IL2(4), IL20(3), IL20RA(5), IL21(2), IL21R(5), IL22(2), IL22RA1(1), IL23R(3), IL24(2), IL26(3), IL28RA(3), IL2RA(2), IL2RB(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL6ST(3), IL7(2), IL7R(3), IL9(2), IRF9(3), JAK1(4), JAK2(9), JAK3(8), LEP(1), LEPR(9), MPL(2), OSM(1), OSMR(6), PIAS1(4), PIAS2(3), PIAS3(4), PIAS4(1), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIM1(1), PRL(3), PRLR(4), PTPN11(5), PTPN6(4), SOCS2(3), SOCS4(1), SOCS5(4), SOS1(7), SOS2(11), SPRED1(7), SPRED2(6), SPRY1(3), SPRY4(2), STAM(2), STAM2(2), STAT1(6), STAT2(7), STAT3(2), STAT4(3), STAT5B(3), STAT6(2), TPO(11), TSLP(2), TYK2(1)	43584132	414	99	406	129	143	149	74	1	45	2	0.790	1.000
344	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(6), HK2(3), HK3(5), IMPA1(2), PGM1(4), PGM3(5), TGDS(1)	3309952	28	20	28	12	9	15	4	0	0	0	0.791	1.000
345	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(1), CREBBP(25), EP300(15), FYN(5), IL7(2), IL7R(3), JAK1(4), JAK3(8), LCK(3), NMI(2), PTK2B(1), STAT5B(3)	7834010	72	35	71	25	24	24	13	1	10	0	0.791	1.000
346	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACAT2(2), ACYP1(2), ECHS1(2), EHHADH(2), GCDH(5), HADHA(3), SDHB(2), SDS(2)	2531762	21	13	21	3	6	7	2	1	5	0	0.792	1.000
347	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(2), BAD(1), CHRNB1(3), CHRNG(3), MUSK(4), PTK2(5), PTK2B(1), RAPSN(2), SRC(3), TERT(2), YWHAH(1)	3942252	27	22	27	16	10	7	2	1	7	0	0.792	1.000
348	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), AGPAT1(2), AGPAT3(3), AGPAT4(8), AKR1B1(3), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), CEL(1), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), GK(3), GLA(4), GLB1(3), LCT(20), LIPC(4), LIPF(3), LIPG(2), LPL(6), PNLIP(7), PNLIPRP1(4), PNLIPRP2(2), PPAP2B(1)	15258034	174	55	172	50	58	60	40	0	16	0	0.792	1.000
349	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), GOT1(6), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME3(5), PGK1(3), PGK2(7), PKM2(2), RPE(2), RPIA(3), TKT(3), TKTL1(5), TKTL2(7), TPI1(1)	5986463	61	34	60	24	21	26	9	0	5	0	0.794	1.000
350	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	13	AKT1(2), CREB1(1), MAP2K1(4), MAP2K2(1), MAP2K6(3), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), NFKB1(6), RB1(7), RELA(2), SP1(2)	4887669	44	22	44	11	16	12	10	0	5	1	0.799	1.000
351	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(3), IFNGR2(2), JAK1(4), JAK2(9), STAT1(6)	2657093	25	15	24	7	8	6	6	0	3	2	0.807	1.000
352	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(2), CDK7(1), ERCC3(7), GTF2B(1), GTF2E1(5), GTF2F2(1), GTF2H1(4), GTF2H4(1), MNAT1(1), POLR1A(10), POLR1B(8), POLR2A(6), POLR2B(8), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3B(11), POLR3D(3), POLR3E(6), POLR3H(1), POLR3K(1), TAF5(4), TAF6(3), TAF7(2), TAF9(1), TBP(1)	11489279	92	44	92	26	33	31	17	1	10	0	0.810	1.000
353	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(5), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), IDS(2), IDUA(1), LCT(20), NAGLU(4)	4683322	48	27	48	13	21	12	10	0	5	0	0.810	1.000
354	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(9), JAK3(8), MAPK1(2), MAPK3(3), STAT3(2), TYK2(1)	3784997	29	20	28	10	9	9	4	0	5	2	0.810	1.000
355	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(4), FOS(1), GRB2(3), JAK1(4), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), PDGFA(1), PDGFRA(17), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3), STAT1(6), STAT3(2)	9711641	96	39	93	26	29	32	23	1	10	1	0.812	1.000
356	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(2), CDC25B(5), CDC25C(4), CDK7(1), MNAT1(1), XPO1(2)	2886991	19	14	19	9	6	8	3	1	1	0	0.815	1.000
357	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(2), CD3D(1), CD3G(2), CD4(2)	938677	8	7	9	5	3	4	0	0	1	0	0.816	1.000
358	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	35	AKT1(2), ATF2(1), CDC42(1), DLD(1), DUSP10(5), DUSP4(1), GAB1(6), GCK(2), IL1R1(4), MAP2K5(4), MAP3K1(8), MAP3K10(3), MAP3K11(4), MAP3K12(6), MAP3K13(9), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAP3K5(6), MAP3K7(4), MAP3K9(4), MAPK7(3), MAPK8(7), MAPK9(5), MYEF2(7), NFATC3(5), NR2C2(4), PAPPA(18), SHC1(3), TRAF6(4), ZAK(6)	15389474	157	56	155	39	58	47	26	1	25	0	0.816	1.000
359	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATR(17), BRCA1(6), CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(4), CDKN1A(1), CHEK1(1), CHEK2(1), EP300(15), MDM2(4), MYT1(13), PRKDC(18), RPS6KA1(1), WEE1(3), YWHAH(1), YWHAQ(1)	10805562	95	41	94	24	30	33	21	2	9	0	0.816	1.000
360	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(3), CAMK1G(5), MEF2A(4), MEF2C(9), MEF2D(1), YWHAH(1)	1700371	23	13	23	10	7	8	6	0	2	0	0.816	1.000
361	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(5), AARS2(6), CARS(6), CARS2(1), DARS(4), DARS2(3), EPRS(12), FARS2(5), FARSA(1), FARSB(8), GARS(3), HARS(2), HARS2(4), IARS(6), IARS2(6), KARS(3), LARS(5), LARS2(3), MARS(6), MARS2(1), MTFMT(2), NARS(3), NARS2(6), QARS(8), RARS(4), RARS2(5), SARS(2), SARS2(2), TARS(6), TARS2(5), VARS(1), VARS2(6), WARS(2), WARS2(3), YARS(2), YARS2(4)	17587056	151	55	150	29	52	44	34	2	19	0	0.818	1.000
362	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(5), AARS2(6), ABAT(5), ADSL(7), ADSS(2), AGXT2(5), ASL(2), ASNS(1), ASPA(5), ASS1(2), CAD(11), CRAT(3), DARS(4), DARS2(3), DDO(2), DLAT(3), DLD(1), GAD1(9), GAD2(4), GOT1(6), GOT2(1), GPT2(2), NARS(3), NARS2(6), PC(6), PDHA1(5), PDHA2(8), PDHB(2)	12212486	119	50	117	38	53	38	17	0	11	0	0.822	1.000
363	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	7	ACLY(4), MDH1(1), PC(6), PDHA1(5), SLC25A11(1)	2536661	17	16	17	7	8	5	2	0	2	0	0.823	1.000
364	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(2), ACTR3(3), AKT1(2), AKT2(6), AKT3(1), ANGPTL2(8), ARHGAP4(1), ARHGEF11(11), BTK(7), CDC42(1), CFL1(1), GDI1(1), GDI2(1), INPPL1(4), ITPR1(19), ITPR2(18), ITPR3(12), LIMK1(5), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDK1(2), PIK3CD(3), PIK3CG(14), PITX2(2), PPP1R13B(6), RACGAP1(2), RHO(3), ROCK1(15), ROCK2(6), RPS4X(2), SAG(1), WASF1(3), WASL(7)	20339134	207	66	207	60	77	68	33	1	27	1	0.826	1.000
365	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	B3GALT4(1), CDR1(2), DGKI(10), FAU(1), IL6ST(3), MRPL19(1), PIGK(4), RPL10(1), RPL11(1), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL24(1), RPL28(2), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL4(2), RPL5(1), RPL6(3), RPL7(1), RPL9(4), RPLP0(2), RPS11(1), RPS13(1), RPS16(2), RPS18(2), RPS2(1), RPS20(1), RPS23(4), RPS3(2), RPS4X(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA6(7), RPS6KB1(3), RPS6KB2(2), RPS9(2), RPSA(1), SLC36A2(2), TBC1D10C(2), TSPAN9(2), UBA52(2), UBB(2)	13653025	110	50	108	30	36	31	24	1	18	0	0.829	1.000
366	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), NFAT5(5), PDE6A(7), PDE6B(5), PDE6C(10), PDE6D(1), SLC6A13(6), TF(11)	10968061	111	44	111	27	44	34	21	0	11	1	0.829	1.000
367	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(6), HK2(3), HK3(5), IMPA1(2), IMPA2(2), PGM1(4), PGM3(5), TGDS(1)	3750919	30	22	30	12	10	15	4	0	1	0	0.831	1.000
368	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), SDS(2)	3957664	42	23	42	8	16	14	7	0	5	0	0.833	1.000
369	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(10), CLOCK(8), CRY1(5), CRY2(1), CSNK1D(4), NPAS2(5), NR1D1(4), PER1(1), PER2(2), PER3(9)	5514844	49	27	47	9	20	13	8	2	5	1	0.835	1.000
370	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCR(7), BLNK(1), BTK(7), CD19(3), CSK(3), DAG1(5), EPHB2(8), GRB2(3), ITPKB(4), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PI3(1), PIK3CD(3), PLCG2(13), PPP1R13B(6), RAF1(6), SERPINA4(5), SHC1(3), SOS1(7), SOS2(11), SYK(3), VAV1(13)	15663225	151	58	146	39	63	43	29	2	14	0	0.835	1.000
371	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(8), PNPO(1), PSAT1(4)	1582845	13	9	13	5	4	5	2	0	2	0	0.839	1.000
372	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	58	AKT1(2), AKT2(6), AKT3(1), BCL10(3), BLNK(1), BTK(7), CARD11(9), CD19(3), CD22(10), CD72(4), CD79A(3), CD79B(1), CHUK(6), CR2(11), FOS(1), GSK3B(8), IFITM1(1), IKBKB(4), INPP5D(4), LILRB3(2), LYN(4), MALT1(7), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PTPN6(4), RASGRP3(7), SYK(3), VAV1(13), VAV2(4), VAV3(12)	22034820	228	70	223	62	101	70	33	1	23	0	0.840	1.000
373	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	CD3D(1), CD3G(2), GZMB(2), HLA-A(3), ICAM1(2), ITGAL(8), ITGB2(5)	2589476	23	17	23	8	7	6	4	0	6	0	0.841	1.000
374	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	88	ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), AKAP10(3), AKAP11(7), AKAP12(14), AKAP3(10), AKAP4(4), AKAP5(3), AKAP6(16), AKAP7(3), AKAP8(3), AKAP9(26), ARHGEF1(5), GNA11(1), GNA12(2), GNA13(2), GNA14(6), GNA15(3), GNAL(4), GNAO1(5), GNAQ(4), GNAZ(1), GNB1(1), GNB3(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), IL18BP(2), ITPR1(19), KCNJ3(6), PDE1A(4), PDE1B(3), PDE1C(9), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE7A(3), PDE7B(4), PDE8A(1), PDE8B(7), PLCB3(4), PPP3CA(3), PPP3CC(4), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), PRKD3(8), RHOA(5), SLC9A1(4), USP5(4)	35425981	339	92	333	122	128	107	55	1	46	2	0.845	1.000
375	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(8), BCL2(1), CASP3(2), CASP9(2), DAXX(1), FAS(2), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK2(3), MAPKAPK3(1)	3627439	28	20	28	11	7	11	6	0	4	0	0.845	1.000
376	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(4), BAIAP2(1), CASP1(2), CASP3(2), CASP7(1), INSR(6), ITCH(3), MAGI1(13), MAGI2(11), RERE(3), WWP1(8), WWP2(4)	7228735	58	37	57	22	20	19	10	0	9	0	0.845	1.000
377	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(4), DHFR(1), GART(3), MTHFD1(6), MTHFD1L(8), MTHFR(7), MTHFS(1), MTR(7), SHMT1(2), SHMT2(2), TYMS(3)	5812891	50	28	49	14	21	17	7	1	4	0	0.848	1.000
378	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(4), IFNG(1), IFNGR1(3), IFNGR2(2), IKBKB(4), JAK2(9), LIN7A(2), NFKB1(6), RB1(7), RELA(2), TNFRSF1A(1), USH1C(8), WT1(6)	5704030	55	25	55	18	18	18	9	0	7	3	0.849	1.000
379	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(5), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), HGSNAT(6), HPSE(2), HPSE2(12), IDS(2), IDUA(1), LCT(20), NAGLU(4), SPAM1(4)	6560742	72	32	70	19	28	20	15	1	8	0	0.849	1.000
380	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(1), ACAT2(2), ACOT11(3), ACYP1(2), DHRS1(1), DHRS2(3), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(11), ESCO2(4), GCDH(5), HADHA(3), ITGB1BP3(1), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4), YOD1(1)	8225211	79	35	78	23	31	21	15	2	10	0	0.850	1.000
381	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CAPN2(6), CAPNS1(1), CAPNS2(1), EP300(15), HDAC1(2), HDAC2(2), MEF2D(1), NFATC1(2), NFATC2(5), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), SYT1(1)	7740630	63	35	63	17	27	13	11	1	11	0	0.850	1.000
382	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(6), ALAS2(6), CPO(3), FECH(3), GATA1(5), HBB(3), HMBS(2), UROD(1), UROS(1)	2662866	31	17	30	6	16	12	2	0	1	0	0.851	1.000
383	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(3), IFNAR2(2), IFNB1(1), JAK1(4), STAT1(6), STAT2(7), TYK2(1)	3420869	25	18	24	6	11	6	5	0	3	0	0.852	1.000
384	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA3(3), GGT1(3), SHMT1(2), SHMT2(2)	1600502	10	10	8	8	2	5	0	0	3	0	0.853	1.000
385	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(5), FUCA1(3), GLB1(3), HEXB(3), LCT(20), MAN2C1(6), MANBA(7), NEU1(1), NEU2(1), NEU3(1)	5256057	50	28	50	15	20	12	14	0	4	0	0.854	1.000
386	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(3), CBS(3), CTH(2), GGT1(3), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), PAPSS1(2), PAPSS2(4), SCLY(1), SEPHS1(3)	3924771	36	21	33	11	13	15	5	0	3	0	0.856	1.000
387	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(7), ADSS(2), DHFR(1), HPRT1(2), IMPDH1(2), POLB(3), POLD1(5), POLG(5), PRPS2(2), RRM1(2)	3985501	31	23	31	12	15	12	2	0	2	0	0.856	1.000
388	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(2), IFNAR1(3), IFNAR2(2), IFNB1(1), MAPK8(7), NFKB1(6), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(4)	3536313	32	17	32	10	12	9	5	1	5	0	0.856	1.000
389	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	63	ADAM10(1), ADAM17(7), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(9), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), CASP3(2), CDC42(1), CHUK(6), CSK(3), EGFR(11), F11R(1), GIT1(3), HBEGF(1), IGSF5(8), IKBKB(4), IL8(1), JAM3(3), LYN(4), MAP3K14(3), MAPK12(2), MAPK13(1), MAPK14(3), MAPK8(7), MAPK9(5), MET(5), NFKB1(6), NFKB2(4), NOD1(4), PAK1(5), PLCG1(4), PLCG2(13), PTPN11(5), PTPRZ1(17), RELA(2), SRC(3), TCIRG1(2), TJP1(7)	21990316	204	65	201	50	75	61	44	2	21	1	0.858	1.000
390	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(2), CASP7(1), DFFA(3), DFFB(2), GZMB(2), HMGB1(1), HMGB2(1), TOP2A(5), TOP2B(9)	2586296	26	14	25	6	4	12	7	0	3	0	0.862	1.000
391	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(4), CYP1A2(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2J2(3), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), HSD3B7(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), RDH11(1), RDH12(3), RDH13(1)	7742821	66	31	65	28	26	19	16	0	4	1	0.863	1.000
392	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX1(3), ACOX3(7), ELOVL2(3), ELOVL5(1), ELOVL6(1), FADS2(4), FASN(1), HADHA(3), HSD17B12(2), SCD(2)	4712836	29	23	29	10	13	7	4	1	4	0	0.864	1.000
393	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST6GALNAC2(2), ST6GALNAC4(2), ST8SIA1(3)	1781248	12	11	12	4	2	3	5	0	2	0	0.864	1.000
394	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(5), AGTR1(5), ATF2(1), EGFR(11), GNAQ(4), GRB2(3), MAP2K1(4), MAP2K2(1), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), MEF2A(4), MEF2C(9), MEF2D(1), PAK1(5), PRKCA(4), PTK2(5), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), SRC(3), SYT1(1)	10506675	103	41	101	29	31	35	22	2	13	0	0.865	1.000
395	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	28	B4GALT5(2), C1GALT1C1(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(2), GALNT13(5), GALNT2(4), GALNT3(4), GALNT5(10), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GALNTL1(5), GALNTL2(8), GALNTL4(2), GALNTL5(8), GCNT1(5), GCNT3(4), GCNT4(7), OGT(5), ST3GAL1(1), ST3GAL2(1), ST6GALNAC1(3)	9692509	99	39	98	27	33	37	15	0	14	0	0.867	1.000
396	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(1), GSS(4), IL8(1), NFKB1(6), NOX1(1), RELA(2), XDH(7)	3276035	23	16	23	8	8	6	6	0	3	0	0.867	1.000
397	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB27A(2), RAB3A(2), RAB4A(1), RAB6A(2), RAB9A(1)	1344186	13	9	13	2	4	6	2	0	1	0	0.868	1.000
398	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(4), CRKL(2), DOCK1(7), FOS(1), GAB1(6), GRB2(3), HGF(8), ITGA1(3), ITGB1(6), MAP2K1(4), MAP2K2(1), MAP4K1(3), MAPK1(2), MAPK3(3), MAPK8(7), MET(5), PAK1(5), PTK2(5), PTK2B(1), PTPN11(5), RAF1(6), RAP1A(2), RAP1B(2), RASA1(9), SOS1(7), SRC(3), STAT3(2)	12523334	112	44	109	30	30	43	27	2	10	0	0.868	1.000
399	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(6), B4GALT2(3), FBP2(3), G6PC(4), GALE(1), GALK2(3), GALT(2), GANAB(4), GCK(2), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(5), LALBA(1), LCT(20), MGAM(13), PFKM(4), PFKP(2), PGM1(4), PGM3(5)	10173859	101	45	101	34	45	35	18	0	3	0	0.873	1.000
400	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(1), CTSD(3), GREB1(12), HSPB2(2), MTA1(1), MTA3(1), PDZK1(1), TUBA8(2)	2935618	23	16	23	10	8	8	4	0	3	0	0.873	1.000
401	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA1(1), CA13(1), CA14(2), CA2(1), CA3(2), CA4(1), CA5A(2), CA6(2), CA8(3), CA9(2), CPS1(14), CTH(2), GLS2(2), GLUD1(2), GLUD2(6), GLUL(4), HAL(4)	6824083	52	30	52	26	20	17	6	0	9	0	0.876	1.000
402	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(5), CSF1R(3), EGF(3), EGFR(11), GRB2(3), MET(5), PDGFRA(17), PRKCA(4), SH3GLB1(4), SH3GLB2(2), SH3KBP1(4), SRC(3)	6320766	64	28	64	29	20	24	15	0	4	1	0.877	1.000
403	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), IDI1(1), SQLE(2)	955191	6	5	6	3	1	2	2	0	1	0	0.878	1.000
404	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(2), CREB1(1), GRB2(3), MAPK1(2), MAPK3(3), MAPK7(3), MEF2A(4), MEF2C(9), MEF2D(1), NTRK1(6), PLCG1(4), RPS6KA1(1), SHC1(3)	4726977	42	25	41	15	15	9	13	0	5	0	0.879	1.000
405	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAA2(1), ACAT1(1), ACAT2(2), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), SDS(2)	2744150	17	13	17	7	3	8	2	0	4	0	0.880	1.000
406	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(1), CXCL12(1), CXCR4(4), FOS(1), GNAQ(4), MAPK14(3), MAPK8(7), PLCG1(4), PRKCA(4), PTK2B(1), SYT1(1)	4306964	31	22	32	12	9	11	5	1	5	0	0.881	1.000
407	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	CRKL(2), GNAQ(4), GRB2(3), MAP2K1(4), MAP2K2(1), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), PAK1(5), PLCG1(4), PRKCA(4), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), SRC(3), SYT1(1)	8732295	71	34	69	22	19	26	15	2	9	0	0.881	1.000
408	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(5), CDKN1A(1), GRIN1(1), HIF1A(3), JAK2(9), NFKB1(6), RELA(2), SOD2(4)	4125705	31	20	31	9	10	9	5	0	5	2	0.881	1.000
409	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2(1), BCR(7), BLNK(1), BTK(7), CD19(3), CD22(10), CR2(11), CSK(3), DAG1(5), FLOT1(3), GRB2(3), GSK3A(2), GSK3B(8), INPP5D(4), ITPR1(19), ITPR2(18), ITPR3(12), LYN(4), MAP4K1(3), MAPK1(2), MAPK3(3), NFATC1(2), NFATC2(5), PDK1(2), PIK3CD(3), PLCG2(13), PPP1R13B(6), PPP3CA(3), PPP3CB(5), PPP3CC(4), PTPRC(17), RAF1(6), SHC1(3), SOS1(7), SOS2(11), SYK(3), VAV1(13)	21704316	242	68	237	57	94	75	38	2	32	1	0.883	1.000
410	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	4956236	40	25	39	10	14	14	8	0	4	0	0.883	1.000
411	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	4956236	40	25	39	10	14	14	8	0	4	0	0.883	1.000
412	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	4956236	40	25	39	10	14	14	8	0	4	0	0.883	1.000
413	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(5), ACTN2(8), ACTN3(3), CAPN1(2), CAPNS1(1), CAPNS2(1), ITGA1(3), ITGB1(6), ITGB3(9), PTK2(5), SPTAN1(13), SRC(3), TLN1(7)	8839041	70	38	70	31	34	22	10	0	3	1	0.885	1.000
414	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), FOS(1), GRB2(3), IL2(4), IL2RA(2), IL2RB(2), JAK1(4), JAK3(8), LCK(3), MAP2K1(4), MAPK3(3), MAPK8(7), RAF1(6), SHC1(3), SOS1(7), STAT5B(3), SYK(3)	7496756	67	33	64	19	19	27	12	1	8	0	0.887	1.000
415	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	25	ARHGDIB(3), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CFLAR(3), DAXX(1), DFFA(3), DFFB(2), FAF1(4), LMNB1(4), LMNB2(1), MAP3K1(8), MAP3K7(4), MAPK8(7), PAK1(5), PAK2(3), PRKDC(18), PTPN13(17), RB1(7), RIPK2(3), SPTAN1(13)	11723246	113	41	111	36	24	42	24	2	18	3	0.887	1.000
416	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACAA2(1), ACADL(2), ACADM(6), ACADSB(5), ACADVL(1), ACAT1(1), ACAT2(2), ACOX1(3), ACOX3(7), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CPT1A(6), CPT1B(5), CPT2(2), CYP4A11(3), CYP4A22(2), ECHS1(2), EHHADH(2), GCDH(5), HADH(1), HADHA(3), HADHB(2), HSD17B10(2), HSD17B4(3), PECI(1)	15682426	143	48	142	45	39	48	35	4	17	0	0.887	1.000
417	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(6), KHK(1), LCT(20), MPI(1), PGM1(4), PYGL(2), PYGM(4), TPI1(1), TREH(2)	4223751	41	26	41	15	18	12	11	0	0	0	0.892	1.000
418	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	54	AXIN1(2), CCND2(1), CCND3(1), DVL2(9), DVL3(4), FBXW2(3), FZD1(1), FZD10(6), FZD2(2), FZD3(13), FZD6(6), FZD7(3), FZD8(1), GSK3B(8), LDLR(5), MAPK9(5), PAFAH1B1(3), PLAU(3), PPP2R5C(3), PPP2R5E(2), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), RHOA(5), SFRP4(4), TCF7(6), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2)	15243816	158	62	154	51	70	41	25	1	21	0	0.892	1.000
419	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(6), DUSP1(2), IKBKAP(2), IKBKB(4), MAP3K1(8), MAP3K14(3), NFKB1(6), RELA(2), TNFAIP3(3), TRAF3(6), TRAF6(4)	5714100	46	25	46	16	20	13	6	1	6	0	0.893	1.000
420	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(4), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAPK3(3), MPL(2), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), STAT1(6), STAT3(2), STAT5B(3), THPO(2)	8485524	72	33	70	19	21	26	15	0	8	2	0.893	1.000
421	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CLCA1(6), CLCA2(7), CLCA4(6), CNGA3(6), CNGA4(6), CNGB1(7), GNAL(4), GUCA1A(2), GUCA1B(3), GUCA1C(1), PDC(2), PDE1C(9), PRKACA(1), PRKACB(1), PRKACG(3), PRKG1(9), PRKG2(5), PRKX(2)	9914066	92	38	90	41	28	38	15	1	10	0	0.894	1.000
422	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	AKT1(2), ANXA1(1), GNAS(6), GNB1(1), GNGT1(1), NFKB1(6), NOS3(2), NPPA(1), NR3C1(4), RELA(2), SYT1(1)	4523503	27	21	27	16	13	6	4	0	4	0	0.895	1.000
423	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(4), EGF(3), EGFR(11), FOS(1), GRB2(3), JAK1(4), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3), STAT1(6), STAT3(2)	10614098	92	41	89	23	34	28	22	1	7	0	0.896	1.000
424	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(1), ACY1(2), ADC(1), AGMAT(4), ALDH18A1(5), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(5), ASL(2), ASS1(2), CPS1(14), GATM(1), MAOA(3), MAOB(1), NAGS(1), ODC1(5), OTC(5), SAT1(4), SAT2(2), SMS(2)	9537565	96	40	93	30	31	36	16	0	13	0	0.898	1.000
425	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(1), CD3D(1), CD3G(2), CD4(2), CD58(2), IL3(3), IL6(2), IL8(1), KITLG(2)	2077118	19	11	18	8	6	9	3	0	1	0	0.898	1.000
426	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(1), BMP4(2), BMP5(5), BMP6(3), BMP7(6), BMP8A(1), BTRC(5), CSNK1A1(2), CSNK1A1L(5), CSNK1D(4), CSNK1G1(1), CSNK1G3(3), DHH(1), FBXW11(8), GLI1(4), GLI2(4), GLI3(13), GSK3B(8), HHIP(5), IHH(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKX(2), PTCH1(9), PTCH2(6), RAB23(2), SMO(1), STK36(5), SUFU(4), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2), ZIC2(1)	15968400	151	60	151	68	67	36	25	1	22	0	0.898	1.000
427	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(5), ACAA1(2), ACAA2(1), ACADM(6), ACAT1(1), ACAT2(2), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH7A1(3), ALDH9A1(1), AOX1(8), AUH(1), BCAT1(1), BCAT2(1), BCKDHA(3), BCKDHB(1), DLD(1), ECHS1(2), EHHADH(2), HADH(1), HADHA(3), HADHB(2), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B10(2), HSD17B4(3), MCCC1(8), MCCC2(2), MCEE(2), MUT(4), OXCT1(3), OXCT2(1), PCCA(9), PCCB(4)	14133454	115	50	114	32	44	39	15	0	17	0	0.898	1.000
428	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	40	BCL2(1), CHUK(6), DAXX(1), EGF(3), EGFR(11), ETS1(1), ETS2(3), FOS(1), HOXA7(1), IKBKB(4), MAP2K1(4), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K5(6), MAPK1(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), NFKB1(6), PPP2CA(1), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), RAF1(6), RELA(2), RIPK1(2), SP1(2), TNFRSF1A(1), TRAF2(1)	15163074	124	55	123	39	57	33	28	1	5	0	0.900	1.000
429	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(8), CD2(3), CD33(2), CD5(4), CD7(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL12A(1), IL12B(2), IL13(1), IL3(3), IL4(3), ITGAX(6), TLR2(6), TLR4(10), TLR7(7), TLR9(7)	5849946	69	28	68	22	25	22	19	0	3	0	0.901	1.000
430	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(8), ARHGDIB(3), BIRC2(4), BIRC3(7), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP9(2), DFFA(3), DFFB(2), GZMB(2), LMNB1(4), LMNB2(1)	5883367	52	28	51	15	12	22	10	0	8	0	0.901	1.000
431	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(1), ARG2(5), ASL(2), ASS1(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), DAO(6), EPRS(12), GAMT(1), GATM(1), GLUD1(2), GLUD2(6), GOT1(6), GOT2(1), LAP3(2), NOS1(11), NOS3(2), OAT(1), OTC(5), P4HA1(1), P4HA2(2), P4HA3(2), RARS(4), RARS2(5)	11488760	108	41	107	37	35	35	20	1	17	0	0.902	1.000
432	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	139	ADA(3), ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADK(1), ADSL(7), ADSS(2), AK2(1), AK5(5), AK7(6), ALLC(5), AMPD1(9), AMPD2(5), AMPD3(3), ATIC(4), DCK(2), ENPP1(4), ENPP3(4), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(2), ENTPD6(2), FHIT(1), GART(3), GMPR(2), GMPR2(2), GMPS(5), GUCY1A2(12), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HPRT1(2), IMPDH1(2), IMPDH2(4), ITPA(2), NME6(4), NME7(5), NPR1(6), NPR2(10), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), NUDT9(2), PAICS(1), PAPSS1(2), PAPSS2(4), PDE10A(11), PDE11A(8), PDE1A(4), PDE1C(9), PDE3B(3), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE5A(6), PDE6D(1), PDE7A(3), PDE7B(4), PDE8A(1), PDE8B(7), PDE9A(6), PFAS(1), PKM2(2), PNPT1(10), POLA1(8), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(11), POLR3GL(1), POLR3H(1), POLR3K(1), PPAT(6), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RFC5(3), RRM1(2), RRM2(2), XDH(7)	51324831	479	109	472	151	162	165	84	2	66	0	0.903	1.000
433	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(11), CDA(1), CTPS(4), CTPS2(4), DCK(2), DCTD(3), DHODH(4), DPYD(14), DPYS(7), DTYMK(1), ENTPD1(2), ITPA(2), NT5E(3), NT5M(1), POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12), POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1), RRM1(2), RRM2(2), TK1(1), TK2(1), TXNRD1(3), TYMS(3), UCK2(1), UMPS(1), UNG(1), UPB1(5)	18464641	156	60	153	42	47	59	33	1	16	0	0.904	1.000
434	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(3), ACTR2(2), ACTR3(3), AKT1(2), ANGPTL2(8), CDC42(1), CFL1(1), FLNA(3), FLNC(13), FSCN3(2), GDI1(1), GDI2(1), LIMK1(5), MYH2(12), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PFN2(1), RHO(3), ROCK1(15), ROCK2(6), RPS4X(2), VASP(3), WASF1(3), WASL(7)	15044593	135	53	135	37	45	45	23	1	21	0	0.904	1.000
435	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(5), ASPH(3), COPS5(1), CREB1(1), EDN1(1), EP300(15), HIF1A(3), LDHA(2), NOS3(2), P4HB(2), VHL(1)	5432888	36	24	36	11	12	7	12	1	4	0	0.906	1.000
436	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), G6PD(3), GPI(2), H6PD(4), PFKM(4), PFKP(2), PGD(1), PGM1(4), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3)	6428527	52	34	52	17	21	25	5	0	1	0	0.907	1.000
437	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CCR5(1), CD3D(1), CD3G(2), ETV5(6), IFNG(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), JAK2(9), MAP2K6(3), MAPK14(3), MAPK8(7), STAT4(3), TYK2(1)	5507553	48	24	49	21	8	21	9	1	7	2	0.908	1.000
438	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), GOT1(6), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME2(3), ME3(5), PGK1(3), PKM2(2), RPE(2), RPIA(3), TKT(3), TPI1(1)	5303591	45	28	44	17	15	19	7	0	4	0	0.909	1.000
439	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(18), ATP4A(10), ATP4B(1), ATP5A1(5), ATP5B(4), ATP5C1(4), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), ATP5L(2), ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(9), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), COX10(2), COX15(3), COX17(1), COX4I1(2), COX4I2(3), COX6A2(1), COX6C(1), COX7A1(1), COX7B2(1), COX8C(1), CYC1(1), LHPP(2), NDUFA1(1), NDUFA10(2), NDUFA12(2), NDUFA13(1), NDUFA4(2), NDUFA9(3), NDUFB1(1), NDUFB2(1), NDUFB3(1), NDUFB6(1), NDUFB9(2), NDUFC2(1), NDUFS1(6), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(2), NDUFS6(2), NDUFV1(2), NDUFV3(1), PPA1(2), PPA2(3), SDHA(6), SDHB(2), SDHD(1), TCIRG1(2), UQCRB(2), UQCRC1(2), UQCRC2(3), UQCRFS1(1), UQCRH(1)	18150412	181	61	179	44	72	57	35	0	17	0	0.910	1.000
440	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(2), AKT2(6), AKT3(1), BPNT1(1), GRB2(3), MAPK1(2), MAPK3(3), PDK1(2), PIK3CD(3), PTK2B(1), RBL2(8), SHC1(3), SOS1(7)	5596325	42	26	41	14	11	13	10	0	8	0	0.914	1.000
441	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(4), ANAPC1(4), ANAPC10(2), ANAPC2(1), ANAPC4(4), ANAPC5(3), ANAPC7(4), ATR(17), BUB1(6), BUB1B(6), BUB3(2), CCNA1(6), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDC14A(4), CDC14B(4), CDC16(4), CDC20(3), CDC23(6), CDC25A(2), CDC25B(5), CDC25C(4), CDC27(13), CDC6(1), CDC7(3), CDK2(2), CDK4(3), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), CHEK1(1), CHEK2(1), CREBBP(25), CUL1(8), DBF4(5), E2F2(1), E2F3(2), EP300(15), ESPL1(8), GSK3B(8), HDAC1(2), HDAC2(2), MAD1L1(2), MAD2L1(1), MAD2L2(1), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), PKMYT1(1), PLK1(8), PRKDC(18), PTTG1(1), RB1(7), RBL1(5), RBL2(8), RBX1(1), SKP1(1), SKP2(1), SMAD3(9), SMC1A(10), SMC1B(6), TFDP1(4), TGFB1(1), TGFB2(9), WEE1(3), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	40192157	357	85	351	99	107	108	83	7	51	1	0.916	1.000
442	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(3), IL4R(1), JAK1(4), JAK2(9), TYK2(1)	3317801	21	16	20	9	8	4	5	0	2	2	0.916	1.000
443	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(3), IL4R(1), JAK1(4), JAK2(9), TYK2(1)	3317801	21	16	20	9	8	4	5	0	2	2	0.916	1.000
444	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	GATA3(4), IL13(1), IL4(3), MAF(1), MAPK14(3), NFATC1(2), NFATC2(5), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	3543679	32	22	32	9	20	7	2	0	3	0	0.917	1.000
445	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(22), APOC1(1), APOC2(1), APOE(1), CETP(7), CYP7A1(4), HMGCR(3), LCAT(1), LDLR(5), LIPC(4), LPL(6), LRP1(17), SCARB1(1), SOAT1(1)	8105191	74	36	74	23	31	23	13	1	6	0	0.918	1.000
446	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), DLAT(3), DLD(1), DLST(1), FH(1), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), PC(6), PDHA1(5), PDHA2(8), PDHB(2), PDHX(2), PDK1(2), PDK2(2), PDK3(1), PDK4(3), PDP2(1), SDHA(6), SDHB(2), SDHD(1), SUCLA2(5), SUCLG1(2)	9096358	75	37	74	28	32	20	11	0	12	0	0.918	1.000
447	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(3), CSF1(2), FCGR3A(1), IL1B(1), IL6R(3), SELL(3), SPN(2), TGFB1(1), TGFB2(9), TNFRSF1A(1), TNFRSF8(2), TNFSF8(1)	4271191	31	18	31	14	8	11	5	0	7	0	0.919	1.000
448	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	88	AKT1(2), AKT2(6), AKT3(1), BCL10(3), CARD11(9), CBL(5), CBLB(8), CD247(2), CD28(2), CD3D(1), CD3G(2), CD4(2), CD40LG(6), CD8B(2), CDC42(1), CDK4(3), CHUK(6), CTLA4(2), FOS(1), FYN(5), GRAP2(5), GRB2(3), ICOS(1), IFNG(1), IKBKB(4), IL10(2), IL2(4), IL4(3), ITK(11), LAT(1), LCK(3), LCP2(3), MALT1(7), MAP3K14(3), MAP3K8(2), NCK1(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDK1(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCQ(5), PTPN6(4), PTPRC(17), RASGRP1(5), RHOA(5), SOS1(7), SOS2(11), TEC(3), VAV1(13), VAV2(4), VAV3(12), ZAP70(4)	30904268	314	82	310	104	123	105	52	2	32	0	0.920	1.000
449	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(3), IL4(3), IL4R(1), IRS1(8), JAK1(4), JAK3(8), RPS6KB1(3), SHC1(3), STAT6(2)	4703790	37	24	35	12	11	14	5	0	7	0	0.920	1.000
450	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(4), PRKCA(4), PTK2B(1)	2183401	12	11	12	5	6	3	2	0	1	0	0.921	1.000
451	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	22	ASAH1(3), CASP3(2), CERK(1), CREB1(1), CREB3(3), CREB5(4), DAG1(5), EPHB2(8), FOS(1), GNAQ(4), ITPKB(4), MAPK1(2), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5)	6661420	54	28	53	19	17	14	12	2	9	0	0.921	1.000
452	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(2), HMOX1(2), IL10(2), IL10RA(2), IL10RB(5), IL1A(1), IL6(2), JAK1(4), STAT1(6), STAT3(2)	3894907	30	19	27	18	12	8	7	0	3	0	0.922	1.000
453	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKM(4), PFKP(2), PGAM1(3), PGK1(3), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	15451702	154	54	152	49	51	58	35	0	10	0	0.923	1.000
454	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKM(4), PFKP(2), PGAM1(3), PGK1(3), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	15451702	154	54	152	49	51	58	35	0	10	0	0.923	1.000
455	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(1), BNIP1(1), GOSR1(3), GOSR2(3), SEC22B(3), SNAP23(1), SNAP25(1), SNAP29(3), STX11(2), STX12(3), STX16(3), STX17(1), STX18(1), STX19(2), STX2(3), STX3(3), STX4(2), STX5(3), STX6(1), STX7(3), STX8(4), TSNARE1(1), VAMP1(1), VAMP3(2), VAMP4(3), VAMP5(2), VAMP8(1), VTI1A(1), VTI1B(1), YKT6(1)	5243504	60	26	58	17	23	14	9	0	14	0	0.924	1.000
456	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	AKT1(2), AKT2(6), AKT3(1), BAD(1), BTK(7), CDKN2A(1), DAPP1(2), GRB2(3), GSK3A(2), GSK3B(8), IARS(6), IGFBP1(2), INPP5D(4), PDK1(2), PPP1R13B(6), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SHC1(3), SOS1(7), SOS2(11), TEC(3), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	10444567	103	41	101	27	31	34	24	0	14	0	0.926	1.000
457	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), BCL2(1), EGFR(11), IGF1R(8), POLR2A(6), PPP2CA(1), PRKCA(4), RB1(7), TEP1(7), TERF1(1), TERT(2), TNKS(4), XRCC5(6)	8885698	60	38	60	20	27	16	11	1	4	1	0.928	1.000
458	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ENPP1(4), ENPP3(4), FLAD1(1), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), PHPT1(1), TYR(3)	4911612	35	22	34	19	14	9	8	0	3	1	0.928	1.000
459	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), FDXR(1), SHMT1(2)	5238144	41	25	40	11	14	15	8	0	4	0	0.929	1.000
460	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	67	AKT1(2), AKT2(6), AKT3(1), BTK(7), FCER1A(3), FYN(5), GAB2(1), GRB2(3), IL13(1), IL3(3), IL4(3), INPP5D(4), LAT(1), LCP2(3), LYN(4), MAP2K1(4), MAP2K2(1), MAP2K6(3), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(5), MS4A2(3), PDK1(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCG1(4), PLCG2(13), PRKCA(4), PRKCD(3), PRKCE(6), RAF1(6), SOS1(7), SOS2(11), SYK(3), VAV1(13), VAV2(4), VAV3(12)	20703273	208	64	201	57	83	62	41	1	21	0	0.929	1.000
461	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(3), DAG1(5), GNAQ(4), ITPKB(4)	1941619	16	11	16	6	5	4	4	0	3	0	0.929	1.000
462	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(5), NR1H3(4), NR1H4(2), RXRA(1)	1696750	13	10	13	7	6	3	3	1	0	0	0.929	1.000
463	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(2), RPE(2), UCHL1(2), UCHL3(2), UGDH(4), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3)	5210615	39	22	39	11	15	14	3	0	7	0	0.930	1.000
464	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(2), HADHA(3), SDS(2)	1594865	9	7	9	3	3	2	0	0	4	0	0.931	1.000
465	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(3), ACSS2(6), ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH7A1(3), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), G6PC2(1), GALM(2), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKL(1), PFKM(4), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(7), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	18239599	174	59	172	58	57	68	36	1	12	0	0.932	1.000
466	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(3), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(2), MAN1A1(5), MAN1B1(2), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), RPN2(1), ST6GAL1(1)	6333407	48	31	48	17	20	14	10	0	4	0	0.932	1.000
467	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(2), AKT2(6), AKT3(1), ASAH1(3), DAG1(5), DRD2(5), EGFR(11), EPHB2(8), GRB2(3), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), PI3(1), PIK3CB(2), PITX2(2), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), RAF1(6), RGS20(4), SHC1(3), SOS1(7), SOS2(11), SRC(3), STAT3(2), TERF2IP(2)	17852526	180	61	177	54	76	56	31	1	15	1	0.932	1.000
468	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(10), CLOCK(8), CRY1(5), CRY2(1), PER1(1)	2766349	25	14	24	5	8	7	5	0	4	1	0.932	1.000
469	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	DLG4(3), GRIN1(1), GRIN2B(10), GRIN2C(4), GRIN2D(5), NOS1(11), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), SYT1(1)	7040070	64	31	64	28	30	17	8	0	9	0	0.933	1.000
470	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(5), ALDOC(3), DERA(2), FBP2(3), G6PD(3), GPI(2), H6PD(4), PFKL(1), PFKM(4), PFKP(2), PGD(1), PGM1(4), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3), TKTL1(5), TKTL2(7)	7685403	67	38	67	21	27	29	8	0	3	0	0.936	1.000
471	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(22), ABCA10(10), ABCA13(40), ABCA3(6), ABCA4(14), ABCA5(17), ABCA6(17), ABCA7(5), ABCA8(17), ABCA9(18), ABCB1(11), ABCB10(3), ABCB11(11), ABCB4(11), ABCB5(14), ABCB6(4), ABCB7(4), ABCB8(5), ABCB9(2), ABCC1(11), ABCC10(7), ABCC11(11), ABCC12(11), ABCC2(14), ABCC3(5), ABCC4(9), ABCC5(7), ABCC6(7), ABCC8(8), ABCC9(11), ABCD1(3), ABCD2(9), ABCD3(3), ABCD4(5), ABCG1(6), ABCG2(9), ABCG4(3), ABCG5(1), ABCG8(4), CFTR(12), TAP1(5), TAP2(5)	35610684	397	82	393	115	121	125	94	2	52	3	0.937	1.000
472	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(7), AXIN1(2), BTRC(5), DLL1(4), FZD1(1), GSK3B(8), PSEN1(3), WNT1(1)	4176902	31	19	31	10	13	4	6	0	8	0	0.938	1.000
473	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), DHRS1(1), DHRS2(3), DHRS3(2), PON1(6), PON2(2), PON3(2)	5548920	42	24	41	17	16	12	8	0	4	2	0.939	1.000
474	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(4), BUB1(6), BUB1B(6), BUB3(2), CCNA1(6), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDAN1(3), CDC14A(4), CDC14B(4), CDC20(3), CDC25A(2), CDC25B(5), CDC25C(4), CDC6(1), CDC7(3), CDH1(5), CDK2(2), CDK4(3), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), DTX4(3), E2F2(1), E2F3(2), E2F4(1), E2F5(2), EP300(15), ESPL1(8), GSK3B(8), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(2), HDAC6(6), MAD1L1(2), MAD2L1(1), MAD2L2(1), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), MPEG1(4), MPL(2), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), PLK1(8), PRKDC(18), PTPRA(2), PTTG1(1), RB1(7), RBL1(5), SKP2(1), TBC1D8(5), TFDP1(4), TGFB1(1), WEE1(3)	32096551	245	74	242	70	69	76	62	6	31	1	0.939	1.000
475	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CYP2C19(4), CYP2C9(7), DHRS1(1), DHRS2(3), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(11), ESCO2(4), HADHA(3), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4), YOD1(1)	9865776	105	36	104	28	40	31	22	1	11	0	0.940	1.000
476	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(2), AKT2(6), AKT3(1), ARHGEF11(11), BCL2(1), CDC42(1), DLG4(3), GNA13(2), LPA(10), MAP3K1(8), MAP3K5(6), MAPK8(7), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(6), PI3(1), PIK3CB(2), PLD1(11), PLD2(2), PLD3(5), PTK2(5), RDX(3), ROCK1(15), ROCK2(6), SERPINA4(5), SRF(3)	15320991	137	48	137	44	56	40	21	3	17	0	0.940	1.000
477	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SEC61A2(1), SRP19(1), SRP54(3), SRP68(4), SRP72(4), SRPR(1)	2436731	18	12	18	5	6	8	2	1	1	0	0.941	1.000
478	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD14(1), RPN2(1), UBE2A(2), UBE3A(11)	4205064	34	18	34	12	10	11	9	1	3	0	0.942	1.000
479	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(2)	1313387	8	6	8	5	1	3	2	0	2	0	0.943	1.000
480	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(3), CAMK1G(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), ESRRA(3), HDAC5(2), MEF2A(4), MEF2C(9), MEF2D(1), PPARA(1), PPP3CA(3), PPP3CB(5), PPP3CC(4), SLC2A4(4), SYT1(1), YWHAH(1)	6398760	57	27	56	28	23	13	12	1	8	0	0.943	1.000
481	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(2), AKT2(6), AKT3(1), BCR(7), BTK(7), CD19(3), CDKN2A(1), DAPP1(2), FLOT1(3), GAB1(6), ITPR1(19), ITPR2(18), ITPR3(12), LYN(4), PDK1(2), PHF11(2), PITX2(2), PLCG2(13), PPP1R13B(6), PREX1(16), PTPRC(17), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SAG(1), SYK(3), TEC(3), VAV1(13)	16120845	188	55	185	55	72	58	31	2	24	1	0.943	1.000
482	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(2), GALNT10(5), GALNT2(4), GALNT3(4), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GCNT1(5), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2)	4178917	34	19	34	14	13	9	6	0	6	0	0.944	1.000
483	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	119	ARAF(3), BID(1), CASP3(2), CD244(3), CD247(2), FAS(2), FASLG(1), FCGR3A(1), FYN(5), GRB2(3), GZMB(2), HLA-A(3), HLA-B(3), HLA-C(2), HLA-E(1), HLA-G(2), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), ITGAL(8), ITGB2(5), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(4), KIR3DL2(4), KLRC3(3), KLRD1(1), KLRK1(3), LAT(1), LCK(3), LCP2(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MICB(3), NCR1(1), NCR3(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PAK1(5), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCA(4), PRKCG(10), PTK2B(1), PTPN11(5), PTPN6(4), RAF1(6), SH2D1A(2), SH2D1B(1), SH3BP2(1), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SYK(3), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10D(1), TNFSF10(1), TYROBP(1), ULBP1(2), ULBP2(2), VAV1(13), VAV2(4), VAV3(12), ZAP70(4)	33915555	326	81	320	98	113	111	59	2	39	2	0.945	1.000
484	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(8), C9orf95(1), CD38(2), ENPP1(4), ENPP3(4), NADK(2), NADSYN1(2), NMNAT1(2), NMNAT2(2), NMNAT3(2), NNMT(3), NNT(3), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), NUDT12(2), QPRT(1)	7123081	59	32	59	24	20	20	11	0	8	0	0.945	1.000
485	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2(1), GRB2(3), GSK3A(2), GSK3B(8), IL4R(1), IRS1(8), JAK1(4), JAK3(8), MAP4K1(3), MAPK1(2), MAPK3(3), PDK1(2), PIK3CD(3), PPP1R13B(6), RAF1(6), SHC1(3), SOS1(7), SOS2(11), STAT6(2)	10508492	93	42	90	24	30	30	18	0	15	0	0.948	1.000
486	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(4), CDKN2A(1), MDM2(4), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), RB1(7)	4912867	38	22	38	9	11	12	12	0	2	1	0.948	1.000
487	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ENPP1(4), ENPP3(4), FLAD1(1), TYR(3)	3142807	21	14	20	12	8	5	6	0	1	1	0.948	1.000
488	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(5), EIF2B1(2), EIF2B2(1), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), ELAVL1(3), FLT1(12), FLT4(5), HIF1A(3), KDR(10), NOS3(2), PLCG1(4), PRKCA(4), PTK2(5), SHC1(3), VHL(1)	9742951	69	39	68	27	24	22	13	0	10	0	0.950	1.000
489	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(1), FOS(1), KEAP1(3), MAPK1(2), MAPK14(3), MAPK8(7), NFE2L2(4), PRKCA(4)	2736854	25	13	25	3	6	10	7	1	1	0	0.952	1.000
490	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(18), ACAT1(1), ACAT2(2), ACYP1(2), ADH5(1), AKR1B1(3), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), DLAT(3), DLD(1), GRHPR(1), LDHA(2), LDHB(3), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME2(3), ME3(5), PC(6), PCK1(3), PDHA1(5), PDHA2(8), PDHB(2), PKM2(2)	11484505	109	41	107	36	38	38	20	1	12	0	0.952	1.000
491	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(6), ATF3(1), CYR61(2), HBEGF(1), IFNG(1), IFRD1(5), IL1A(1), IL1R1(4), MYOG(1), NR4A3(4), WDR1(3)	3413847	30	16	30	6	9	11	7	0	3	0	0.953	1.000
492	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(8), ATR(17), BAI1(2), BAX(1), BID(1), CASP3(2), CASP9(2), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNG1(3), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), DDB2(1), EI24(1), FAS(2), GTSE1(2), IGF1(2), IGFBP3(4), MDM2(4), MDM4(3), PPM1D(4), RCHY1(2), RFWD2(5), RPRM(1), RRM2(2), SERPINB5(2), SERPINE1(3), SESN1(2), SESN2(4), SESN3(6), SIAH1(1), STEAP3(1), THBS1(10), TNFRSF10B(6), TP53I3(2), TSC2(2), ZMAT3(5)	17796153	141	57	141	39	43	56	28	1	13	0	0.954	1.000
493	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CDS1(2), CDS2(4), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPP5B(1), INPP5D(4), INPPL1(4), ITGB1BP3(1), ITPK1(2), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), OCRL(9), PI4KA(15), PI4KB(2), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3C3(7), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PRKCA(4), PRKCG(10), PTPMT1(2), SYNJ1(11), SYNJ2(6)	37402429	335	91	330	101	141	95	60	2	36	1	0.954	1.000
494	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(4), ANAPC10(2), ANAPC2(1), ANAPC4(4), ANAPC5(3), ANAPC7(4), BTRC(5), CDC16(4), CDC20(3), CDC23(6), CDC27(13), CUL1(8), CUL2(5), CUL3(1), FBXW11(8), ITCH(3), RBX1(1), SKP1(1), SKP2(1), SMURF1(3), SMURF2(2), UBA1(2), UBE2C(2), UBE2D1(1), UBE2D3(1), UBE2D4(1), UBE2E1(3), UBE2E2(1), VHL(1), WWP1(8), WWP2(4)	12531218	106	45	101	40	31	35	23	0	17	0	0.955	1.000
495	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	89	ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ATF4(1), CACNA1C(12), CACNA1D(8), CACNA1F(14), CACNA1S(14), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CDC42(1), CGA(2), EGFR(11), FSHB(2), GNA11(1), GNAQ(4), GNAS(6), GNRHR(4), GRB2(3), HBEGF(1), ITPR1(19), ITPR2(18), ITPR3(12), LHB(1), MAP2K1(4), MAP2K2(1), MAP2K6(3), MAP3K1(8), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK7(3), MAPK8(7), MAPK9(5), MMP14(4), MMP2(5), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLD1(11), PLD2(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCD(3), PRKX(2), PTK2B(1), RAF1(6), SOS1(7), SOS2(11), SRC(3)	38532651	364	95	360	128	148	110	65	2	38	1	0.955	1.000
496	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(6), ACADVL(1), ACSL1(3), ACSL3(6), ACSL4(4), CPT1A(6), CPT2(2), EHHADH(2), HADHA(3), SCP2(3), SLC25A20(2)	5505580	40	22	39	14	11	14	8	0	7	0	0.955	1.000
497	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	64	ACAA1(2), ACADL(2), ACADM(6), ACOX1(3), ACOX2(2), ACOX3(7), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADIPOQ(4), APOA2(1), APOA5(1), AQP7(1), CD36(1), CPT1A(6), CPT1B(5), CPT2(2), CYP27A1(3), CYP4A11(3), CYP4A22(2), CYP7A1(4), CYP8B1(3), EHHADH(2), FABP1(1), FABP2(2), FABP3(1), FABP4(1), FABP5(1), FABP6(1), FABP7(1), FADS2(4), GK(3), GK2(6), HMGCS2(1), LPL(6), MMP1(2), NR1H3(4), OLR1(2), PCK1(3), PCK2(3), PDPK1(1), PLTP(7), PPARA(1), PPARD(2), PPARG(1), RXRA(1), RXRB(3), RXRG(4), SCD(2), SCP2(3), SLC27A1(2), SLC27A2(3), SLC27A4(1), SLC27A5(4), SLC27A6(9), SORBS1(11), UCP1(1)	20506355	181	58	178	58	55	69	33	6	18	0	0.955	1.000
498	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT1(2), AKT2(6), AKT3(1), BAD(1), CASP9(2), CDC42(1), KDR(10), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPKAPK2(3), MAPKAPK3(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NOS3(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCG1(4), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCA(4), PRKCG(10), PTGS2(3), PTK2(5), RAF1(6), SH2D2A(2), SHC2(1), SPHK1(1), SPHK2(1), SRC(3), VEGFA(2)	21590060	175	66	171	65	84	40	27	0	24	0	0.956	1.000
499	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(9), AP2A1(3), AP2M1(4), BIN1(2), DNM1(11), EPN1(2), EPS15(7), PICALM(2), PPP3CA(3), PPP3CB(5), PPP3CC(4), SYNJ1(11), SYNJ2(6), SYT1(1)	7113318	70	30	67	25	22	22	10	0	16	0	0.956	1.000
500	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(1), AGXT2(5), ALAS1(6), ALAS2(6), AOC2(4), AOC3(4), BHMT(5), CBS(3), CHDH(2), CHKA(4), CPT1B(5), CTH(2), DAO(6), DLD(1), DMGDH(7), GAMT(1), GARS(3), GATM(1), GCAT(1), GLDC(3), MAOA(3), MAOB(1), PEMT(1), PISD(2), PLCB2(3), PLCG1(4), PLCG2(13), SARDH(8), SARS(2), SHMT1(2), SHMT2(2), TARS(6)	13440253	117	49	115	43	52	39	12	0	14	0	0.957	1.000
501	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(5), HSD17B2(2), HSD17B3(2), HSD17B4(3), HSD3B1(3), HSD3B2(1)	2656638	18	12	18	4	5	7	4	0	2	0	0.957	1.000
502	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(5), ARG1(1), ARG2(5), ASL(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), GAMT(1), GATM(1), GLUD1(2), NAGS(1), OAT(1), ODC1(5), OTC(5), SMS(2)	5586036	58	26	58	18	19	20	9	0	10	0	0.959	1.000
503	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	CCNA1(6), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDC25A(2), CDK2(2), CDK4(3), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), CREB3(3), CREB3L1(3), CREB3L3(3), CREB3L4(1), E2F2(1), E2F3(2), E2F4(1), E2F5(2), GBA2(5), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), MNAT1(1), MYT1(13), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), POLA2(2), POLE(21), POLE2(1), RB1(7), RBL1(5), RPA1(2), RPA2(1), TFDP1(4), TFDP2(1), TNXB(17), WEE1(3)	21261130	166	59	163	42	50	59	34	2	20	1	0.960	1.000
504	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(8), CYB5R3(1), GCK(2), GFPT1(4), GNE(2), GNPDA2(1), HEXB(3), HK1(6), HK2(3), HK3(5), PGM3(5), RENBP(1)	5551373	41	25	40	13	13	19	8	0	1	0	0.960	1.000
505	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), XYLT1(6), XYLT2(2)	1995965	16	11	15	13	7	4	2	1	2	0	0.960	1.000
506	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), XYLT1(6), XYLT2(2)	1995965	16	11	15	13	7	4	2	1	2	0	0.960	1.000
507	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	39	AGL(9), AMY2B(1), ENPP1(4), ENPP3(4), G6PC(4), GANAB(4), GBA3(3), GBE1(5), GCK(2), GPI(2), GUSB(2), GYS1(2), GYS2(11), HK1(6), HK2(3), HK3(5), MGAM(13), PGM1(4), PGM3(5), PYGB(4), PYGL(2), PYGM(4), SI(15), UCHL1(2), UCHL3(2), UGDH(4), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3), UXS1(7)	17220215	153	54	153	54	52	51	31	0	19	0	0.961	1.000
508	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	184	ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), AKT1(2), AKT2(6), AKT3(1), ARHGAP5(9), BAD(1), BCL2(1), BIRC2(4), BIRC3(7), CAPN2(6), CAV1(1), CAV2(1), CAV3(3), CCND2(1), CCND3(1), CDC42(1), CHAD(7), COL11A1(24), COL11A2(11), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A3(43), COMP(2), CRKL(2), DIAPH1(1), DOCK1(7), EGF(3), EGFR(11), ERBB2(10), FARP2(5), FIGF(2), FLNA(3), FLNB(16), FLNC(13), FLT1(12), FN1(21), FYN(5), GRB2(3), GRLF1(12), GSK3B(8), HGF(8), IBSP(3), IGF1(2), IGF1R(8), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAV(5), ITGB1(6), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), KDR(10), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), MAP2K1(4), MAPK1(2), MAPK3(3), MAPK8(7), MAPK9(5), MET(5), MYL2(1), MYL7(1), MYL9(2), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PARVA(1), PARVB(5), PARVG(3), PDGFA(1), PDGFC(3), PDGFD(3), PDGFRA(17), PDGFRB(6), PDPK1(1), PGF(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP5K1C(4), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PRKCA(4), PRKCG(10), PTK2(5), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF1(6), RELN(33), RHOA(5), ROCK1(15), ROCK2(6), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SPP1(1), SRC(3), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TLN1(7), TLN2(8), TNC(16), TNN(17), TNXB(17), VASP(3), VAV1(13), VAV2(4), VAV3(12), VCL(2), VEGFA(2), VEGFB(2), VEGFC(6), VTN(6), VWF(15), ZYX(1)	112617464	1137	162	1119	427	417	376	205	10	128	1	0.961	1.000
509	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPL13(1), RPL10A(2), RPL10L(2), RPL11(1), RPL18A(1), RPL19(1), RPL21(1), RPL22L1(1), RPL24(1), RPL28(2), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL6(3), RPL7(1), RPL9(4), RPS11(1), RPS13(1), RPS15A(1), RPS16(2), RPS18(2), RPS2(1), RPS20(1), RPS23(4), RPS3(2), RPS9(2), RPSA(1)	6693311	48	28	47	14	14	13	16	1	4	0	0.962	1.000
510	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(2), GHR(6), GRB2(3), INSR(6), IRS1(8), JAK2(9), MAP2K1(4), MAPK1(2), MAPK3(3), PLCG1(4), PRKCA(4), PTPN6(4), RAF1(6), RPS6KA1(1), SHC1(3), SLC2A4(4), SOS1(7), SRF(3), STAT5B(3)	9452536	82	37	80	29	29	29	15	0	7	2	0.963	1.000
511	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CASP9(2), CHUK(6), GH1(2), GHR(6), NFKB1(6), PDPK1(1), PPP2CA(1), RELA(2), YWHAH(1)	3413563	30	16	30	10	13	7	8	0	2	0	0.963	1.000
512	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	88	AKT1(2), AKT3(1), CAPN1(2), CAPN10(3), CAPN11(2), CAPN2(6), CAPN3(6), CAPN5(5), CAPN6(3), CAPN7(4), CAPN9(1), CAPNS1(1), CAV1(1), CAV2(1), CAV3(3), CDC42(1), CSK(3), DOCK1(7), FYN(5), GIT2(7), GRB2(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAD(8), ITGAE(7), ITGAL(8), ITGAM(8), ITGAV(5), ITGAX(6), ITGB1(6), ITGB2(5), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), MAP2K1(4), MAP2K2(1), MAP2K6(3), MAPK12(2), MAPK4(1), MAPK6(3), MAPK7(3), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PDPK1(1), PIK3R2(1), PTK2(5), RAP1B(2), RAPGEF1(6), RHO(3), ROCK1(15), ROCK2(6), SEPP1(1), SHC1(3), SHC3(1), SORBS1(11), SOS1(7), SRC(3), TLN1(7), TNS1(14), VASP(3), VAV2(4), VAV3(12), VCL(2), ZYX(1)	41621372	359	92	351	134	125	124	61	7	42	0	0.964	1.000
513	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(6), AKT3(1), GRB2(3), IARS(6), IL13RA1(2), IL4(3), IL4R(1), INPP5D(4), JAK1(4), JAK2(9), JAK3(8), PI3(1), PPP1R13B(6), RPS6KB1(3), SERPINA4(5), SHC1(3), SOS1(7), SOS2(11), SRC(3), STAT6(2), TYK2(1)	10997865	91	40	88	30	26	33	16	1	13	2	0.964	1.000
514	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(2), CAPN2(6), CAPNS1(1), CAPNS2(1), EGF(3), EGFR(11), ITGA1(3), ITGB1(6), MAPK1(2), MAPK3(3), MYL2(1), MYLK(14), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTK2(5), TLN1(7)	10368336	82	40	82	25	34	24	18	0	6	0	0.965	1.000
515	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), FPGT(5), GCK(2), GMDS(1), GMPPA(7), HK1(6), HK2(3), HK3(5), KHK(1), MPI(1), PFKFB1(7), PFKFB4(2), PFKM(4), PFKP(2), PMM1(3), SORD(2), TPI1(1)	7728760	67	37	67	25	25	32	7	0	3	0	0.966	1.000
516	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(3), CAMK1G(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CAMKK1(1), CAMKK2(1), CREB1(1), SYT1(1)	3810358	23	15	23	14	7	8	6	0	2	0	0.967	1.000
517	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	ACTA1(4), AKT1(2), BDKRB2(3), CAV1(1), CHRM1(3), CHRNA1(4), FLT1(12), FLT4(5), KDR(10), NOS3(2), PDE3A(5), PDE3B(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKG1(9), PRKG2(5), SLC7A1(2), SYT1(1), TNNI1(2)	10148697	86	39	86	39	31	30	15	1	9	0	0.970	1.000
518	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPS(3), CDS1(2), CDS2(4), CHAT(6), CHKA(4), CLC(3), CPT1B(5), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), ETNK1(2), GNPAT(2), GPD1(1), GPD2(4), LCAT(1), PAFAH1B1(3), PAFAH2(1), PCYT1A(5), PCYT1B(5), PEMT(1), PISD(2), PLA2G1B(1), PLA2G4A(8), PLA2G6(4), PLCB2(3), PLCG1(4), PLCG2(13), PPAP2B(1)	16123949	144	54	139	55	58	40	29	0	17	0	0.972	1.000
519	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12)	5395554	48	24	45	14	17	19	6	0	6	0	0.972	1.000
520	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(4), UBE2A(2), UBE2B(2), UBE2C(2), UBE2D1(1), UBE2D3(1), UBE2E1(3), UBE2G1(2), UBE2I(2), UBE2J2(1), UBE2L3(2), UBE3A(11)	3358554	33	15	33	10	9	11	8	0	5	0	0.973	1.000
521	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT1E1(2), SULT2A1(2), SUOX(2)	1968272	14	8	14	1	5	5	1	0	3	0	0.973	1.000
522	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	55	ALG2(3), BAK1(1), BAX(1), BFAR(1), BTK(7), CAD(11), CASP10(2), CASP3(2), CASP8AP2(18), CD7(1), CSNK1A1(2), DAXX(1), DEDD(1), DFFA(3), DIABLO(1), EGFR(11), EPHB2(8), FAF1(4), FAIM2(3), IL1A(1), IL8(1), MAP3K1(8), MAP3K5(6), MAPK1(2), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MET(5), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PFN2(1), PTPN13(17), RALBP1(6), RIPK1(2), ROCK1(15), SMPD1(6), TPX2(8), TRAF2(1), TUFM(1)	21459068	195	57	191	56	65	65	42	3	19	1	0.973	1.000
523	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(3), CD3D(1), CD3G(2), CD4(2), IFNG(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), JAK2(9), STAT4(3), TYK2(1)	4647514	34	18	35	19	5	17	6	0	4	2	0.973	1.000
524	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	73	ABL1(4), ACTN1(5), ACTR2(2), ACTR3(3), AKT1(2), AKT2(6), AKT3(1), ANGPTL2(8), ARHGEF6(10), ARHGEF7(8), CAV1(1), CDC42(1), CDKN2A(1), CSE1L(4), DOCK1(7), EPHB2(8), FYN(5), GRB2(3), GRB7(1), GRLF1(12), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGB3BP(3), MAP3K11(4), MAPK1(2), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MRAS(1), MYLK(14), MYLK2(3), P4HB(2), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PIK3CB(2), PLCG1(4), PLCG2(13), PTK2(5), RAF1(6), RALA(1), RHO(3), ROCK1(15), ROCK2(6), SHC1(3), SOS1(7), SOS2(11), SRC(3), TERF2IP(2), TLN1(7), TLN2(8), VASP(3), WAS(1), ZYX(1)	36688315	322	86	313	125	117	100	55	5	45	0	0.974	1.000
525	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(3), ARSE(2), ASAH1(3), B4GALT6(5), CERK(1), DEGS1(2), ENPP7(2), GAL3ST1(2), GALC(1), GLA(4), GLB1(3), LCT(20), NEU1(1), NEU2(1), NEU3(1), PPAP2B(1), SGMS1(3), SGMS2(6), SGPP1(2), SGPP2(4), SMPD1(6), SMPD3(3), SMPD4(1), SPHK1(1), SPHK2(1), SPTLC1(4), SPTLC2(2), UGCG(2), UGT8(8)	11056697	96	42	94	34	35	26	25	2	7	1	0.974	1.000
526	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(11), ABCC2(14), ABCG2(9), CES1(5), CES2(1), CYP3A4(1), CYP3A5(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6)	7015779	63	25	63	20	23	18	14	1	7	0	0.974	1.000
527	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	196	ABI2(1), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), APC2(1), ARAF(3), ARHGEF1(5), ARHGEF12(9), ARHGEF4(4), ARHGEF6(10), ARHGEF7(8), ARPC1A(5), ARPC1B(2), ARPC2(2), ARPC5(1), ARPC5L(2), BAIAP2(1), BDKRB2(3), CD14(1), CDC42(1), CFL1(1), CHRM1(3), CHRM3(4), CHRM4(1), CHRM5(2), CRKL(2), CSK(3), CYFIP1(6), CYFIP2(5), DIAPH1(1), DIAPH2(12), DIAPH3(5), DOCK1(7), EGF(3), EGFR(11), EZR(2), F2(3), FGD1(8), FGD3(2), FGF1(2), FGF11(3), FGF12(3), FGF13(3), FGF14(5), FGF17(1), FGF19(1), FGF20(2), FGF21(1), FGF23(1), FGF3(1), FGF5(4), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(4), FGFR2(6), FGFR3(2), FGFR4(2), FN1(21), GIT1(3), GNA12(2), GNA13(2), GRLF1(12), IQGAP1(13), IQGAP2(12), IQGAP3(11), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAD(8), ITGAE(7), ITGAL(8), ITGAM(8), ITGAV(5), ITGAX(6), ITGB1(6), ITGB2(5), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), LIMK1(5), LIMK2(5), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MOS(3), MRAS(1), MSN(6), MYH10(10), MYH14(12), MYH9(12), MYL2(1), MYL7(1), MYL9(2), MYLK(14), MYLK2(3), NCKAP1(9), NCKAP1L(11), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDGFA(1), PDGFRA(17), PDGFRB(6), PFN2(1), PFN4(1), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PPP1R12B(9), PTK2(5), RAF1(6), RDX(3), RHOA(5), ROCK1(15), ROCK2(6), RRAS2(2), SCIN(3), SLC9A1(4), SOS1(7), SOS2(11), SSH1(6), SSH2(4), SSH3(1), TIAM1(17), TIAM2(16), TMSL3(1), VAV1(13), VAV2(4), VAV3(12), VCL(2), WAS(1), WASF1(3), WASF2(2), WASL(7)	83276073	800	138	790	270	315	246	143	8	86	2	0.974	1.000
528	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAPK3(3), MAPK8(7), PLCG1(4), PTPN6(4), RAF1(6), SHC1(3), SOS1(7), STAT5B(3)	6907989	58	27	56	13	20	18	12	1	5	2	0.975	1.000
529	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(18), ATP4B(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), ATP7B(4), COX10(2), COX4I1(2), COX6A2(1), COX6C(1), COX7A1(1), NDUFA1(1), NDUFA10(2), NDUFA4(2), NDUFB2(1), NDUFB6(1), NDUFS1(6), NDUFS2(3), NDUFV1(2), PPA2(3), SDHA(6), SDHB(2), SHMT1(2), UQCRB(2), UQCRC1(2), UQCRFS1(1), UQCRH(1)	11349539	105	41	104	30	40	39	17	0	9	0	0.975	1.000
530	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	24	BRCA1(6), CARM1(2), CREBBP(25), EP300(15), ERCC3(7), GRIP1(8), GTF2A1(2), GTF2E1(5), GTF2F1(5), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(2), HDAC6(6), MEF2C(9), NCOR2(2), NR0B1(3), NRIP1(6), PELP1(2), POLR2A(6), TBP(1)	14427162	123	48	122	32	48	32	27	3	13	0	0.976	1.000
531	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(2), AKT2(6), AKT3(1), DAG1(5), GNAQ(4), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(6), PIK3CB(2), PITX2(2), PLD1(11), PLD2(2), PLD3(5), VN1R1(4)	13760204	119	46	119	40	50	35	18	2	13	1	0.976	1.000
532	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(6), NR3C1(4), PPARG(1), RXRA(1)	1860940	13	9	13	10	1	6	3	0	3	0	0.977	1.000
533	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(5), FUCA1(3), GLB1(3), HEXB(3), LCT(20), MAN2B1(5), MAN2B2(1), MAN2C1(6), MANBA(7), NEU1(1), NEU2(1), NEU3(1)	6449743	56	29	56	21	21	16	15	0	4	0	0.978	1.000
534	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(7), DLL1(4), FURIN(3), PSEN1(3)	2908340	17	13	17	3	7	2	2	0	6	0	0.978	1.000
535	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	45	ACOX1(3), APOA2(1), CD36(1), CITED2(1), CPT1B(5), CREBBP(25), DUSP1(2), EHHADH(2), EP300(15), FABP1(1), HSD17B4(3), LPL(6), MAPK1(2), MAPK3(3), NCOA1(8), NCOR1(12), NCOR2(2), NR1H3(4), NR2F1(3), NRIP1(6), PDGFA(1), PPARA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PTGS2(3), RB1(7), RELA(2), RXRA(1), SP1(2), STAT5B(3)	18436068	142	51	142	52	45	43	32	2	19	1	0.978	1.000
536	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	25	BAG4(2), BIRC2(4), BIRC3(7), CASP3(2), CFLAR(3), MAP3K3(3), MAP3K7(4), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), NR2C2(4), RALBP1(6), RIPK1(2), TNFAIP3(3), TNFRSF1A(1), TRADD(1), TRAF2(1)	8099349	56	29	56	14	20	17	14	1	4	0	0.978	1.000
537	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(10), AZIN1(2), BTG1(1), CBX3(3), CLOCK(8), CRY1(5), CRY2(1), DNAJA1(2), EIF4G2(7), ETV6(5), GFRA1(8), GSTM3(3), HERPUD1(1), HSPA8(4), IDI1(1), MYF6(2), NCKAP1(9), NCOA4(4), NR1D2(6), PER1(1), PER2(2), PPP1R3C(4), PPP2CB(2), PSMA4(2), SF3A3(1), SUMO3(1), TOB1(2), TUBB3(2), UCP3(2), UGP2(7), ZFR(6)	11839555	114	40	110	22	38	33	27	1	14	1	0.979	1.000
538	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(3), ABAT(5), ACAT1(1), ACAT2(2), ACSM1(5), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH7A1(3), ALDH9A1(1), BDH1(1), DDHD1(3), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADH(1), HADHA(3), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B10(2), HSD17B4(3), HSD3B7(2), ILVBL(2), L2HGDH(3), OXCT1(3), OXCT2(1), PDHA1(5), PDHA2(8), PDHB(2), PLA1A(3), PPME1(2), PRDX6(2), RDH11(1), RDH12(3), RDH13(1)	13234335	121	45	120	42	49	41	18	0	13	0	0.979	1.000
539	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(8), BIRC2(4), BIRC3(7), CASP10(2), CASP3(2), CASP7(1), CASP9(2), DFFA(3), DFFB(2), GZMB(2), SCAP(2), SREBF1(1), SREBF2(2)	5531504	38	23	38	16	8	16	7	0	7	0	0.980	1.000
540	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(15), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADIPOQ(4), ADIPOR1(1), ADIPOR2(3), AKT1(2), AKT2(6), AKT3(1), CAMKK1(1), CAMKK2(1), CD36(1), CHUK(6), CPT1A(6), CPT1B(5), CPT2(2), G6PC(4), G6PC2(1), IKBKB(4), IRS1(8), IRS4(15), JAK1(4), JAK2(9), JAK3(8), LEP(1), LEPR(9), MAPK8(7), MAPK9(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), NPY(2), PCK1(3), PCK2(3), POMC(2), PPARA(1), PPARGC1A(5), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKAG1(1), PRKAG2(3), PRKAG3(6), PRKCQ(5), PTPN11(5), RELA(2), RXRA(1), RXRB(3), RXRG(4), SLC2A1(1), SLC2A4(4), STAT3(2), TNFRSF1A(1), TRADD(1), TRAF2(1), TYK2(1)	26438223	237	68	235	80	74	86	44	5	26	2	0.980	1.000
541	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), ACAT2(2), BDH1(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(3), OXCT2(1)	2376847	11	10	11	5	6	4	1	0	0	0	0.980	1.000
542	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	19	AKT1(2), BCL2(1), BCR(7), CRKL(2), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), RAF1(6), SOS1(7), STAT1(6), STAT5B(3)	7369204	69	30	68	15	25	20	17	1	4	2	0.982	1.000
543	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(1), AGMAT(4), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH4A1(3), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(5), ASL(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), DAO(6), GAMT(1), GATM(1), GLUD1(2), GOT1(6), GOT2(1), MAOA(3), MAOB(1), NOS1(11), NOS3(2), OAT(1), ODC1(5), OTC(5), P4HA1(1), P4HA2(2), P4HA3(2), P4HB(2), RARS(4), SMS(2)	14048133	141	46	139	48	54	47	21	1	18	0	0.982	1.000
544	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(3), CHST12(3), CHST13(2), PAPSS1(2), PAPSS2(4), SULT1A1(2), SULT1A2(1), SULT1E1(2), SULT2A1(2), SULT2B1(1), SUOX(2)	2963869	25	14	25	5	10	8	4	0	3	0	0.983	1.000
545	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(6), DUSP1(2), IKBKAP(2), IKBKB(4), MAP3K1(8), MAP3K14(3), NFKB1(6), RELA(2), RIPK1(2), TANK(6), TNFAIP3(3), TRAF1(2), TRAF2(1), TRAF3(6)	7081531	53	26	52	18	25	13	9	1	5	0	0.984	1.000
546	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(3), HMGCR(3), IDI1(1), LSS(2), MVK(1), NQO1(1), NQO2(1), PMVK(1), SC5DL(3), SQLE(2)	3542080	20	16	20	8	10	5	4	0	1	0	0.984	1.000
547	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	22	ATF1(2), CASP2(4), CHUK(6), CRADD(2), IKBKB(4), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP4K2(1), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), RIPK1(2), TANK(6), TNFRSF1A(1), TRADD(1), TRAF2(1)	7216074	62	28	61	22	25	19	14	1	3	0	0.984	1.000
548	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), ABO(2), B3GALNT1(4), B3GALT1(1), B3GALT2(3), B3GALT4(1), B3GALT5(4), B3GNT1(2), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALNT1(4), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT6(5), FUT1(4), FUT2(1), FUT3(4), FUT6(1), FUT9(5), GCNT2(11), PIGA(1), PIGB(2), PIGG(3), PIGK(4), PIGM(3), PIGN(2), PIGO(3), PIGQ(1), PIGS(2), PIGT(3), PIGU(1), PIGV(2), PIGX(4), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST3GAL6(7), ST6GALNAC3(4), ST6GALNAC4(2), ST6GALNAC5(6), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(6), UGCG(2)	15361674	148	50	147	44	57	42	29	1	19	0	0.985	1.000
549	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(6), EGR2(8), EGR3(2), GNAQ(4), MAP3K1(8), NFATC1(2), NFATC2(5), NFKB1(6), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RELA(2), SYT1(1), VIPR2(3)	8774038	76	36	75	24	37	15	12	0	12	0	0.985	1.000
550	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(8), GNA12(2), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAR2B(3)	3311365	18	14	18	12	6	6	0	0	6	0	0.986	1.000
551	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(5), ARSD(3), ARSE(2), ASAH1(3), GAL3ST1(2), GALC(1), GLA(4), GLB1(3), LCT(20), NEU1(1), NEU2(1), NEU3(1), PPAP2B(1), SMPD1(6), SPTLC1(4), SPTLC2(2), UGCG(2)	7532229	62	30	62	23	24	18	14	2	4	0	0.987	1.000
552	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(1), AGXT2(5), ALAS1(6), ALAS2(6), AOC2(4), AOC3(4), BHMT(5), CBS(3), CHDH(2), CHKA(4), CTH(2), DAO(6), DLD(1), DMGDH(7), GAMT(1), GARS(3), GATM(1), GCAT(1), GLDC(3), GNMT(1), HSD3B7(2), MAOA(3), MAOB(1), PEMT(1), PHGDH(2), PIPOX(4), PISD(2), PSAT1(4), RDH11(1), RDH12(3), RDH13(1), SARDH(8), SARS(2), SARS2(2), SDS(2), SHMT1(2), SHMT2(2), TARS(6), TARS2(5)	13788345	119	47	119	45	48	44	14	0	13	0	0.987	1.000
553	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	22	POLA1(8), POLA2(2), POLB(3), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLG(5), POLG2(1), POLH(5), POLK(3), POLL(1), POLM(2), POLQ(12), REV1(7), REV3L(22), RFC5(3)	12710241	105	39	100	34	29	42	20	0	13	1	0.987	1.000
554	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	62	APAF1(8), BAD(1), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BCL2L11(3), BID(1), BIRC2(4), BIRC3(7), BNIP3L(3), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP9(2), CHUK(6), DFFA(3), DFFB(2), FAS(2), FASLG(1), GZMB(2), HELLS(5), IKBKB(4), IRF1(1), IRF2(3), IRF3(2), IRF4(3), IRF5(3), IRF6(2), MAP3K1(8), MDM2(4), NFKB1(6), NFKBIB(1), NFKBIE(2), RELA(2), RIPK1(2), TNFRSF10B(6), TNFRSF1A(1), TNFRSF21(5), TNFSF10(1), TRADD(1), TRAF1(2), TRAF2(1), TRAF3(6)	17185411	136	52	135	46	47	44	25	2	18	0	0.987	1.000
555	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), B4GALT1(6), B4GALT2(3), G6PC(4), G6PC2(1), GALE(1), GALK2(3), GALT(2), GANC(3), GCK(2), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(5), HSD3B7(2), LALBA(1), LCT(20), MGAM(13), PFKL(1), PFKM(4), PFKP(2), PGM1(4), PGM3(5), RDH11(1), RDH12(3), RDH13(1), UGP2(7)	12133684	113	43	113	38	50	39	20	0	4	0	0.987	1.000
556	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA1(1), CA14(2), CA2(1), CA3(2), CA4(1), CA5A(2), CA6(2), CA8(3), CA9(2), CPS1(14), CTH(2), GLS2(2), GLUD1(2), GLUL(4), HAL(4)	6113864	45	23	45	23	17	15	5	0	8	0	0.987	1.000
557	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(18), ACACB(15), ACAT1(1), ACAT2(2), ACOT12(9), ACSS1(3), ACSS2(6), ACYP1(2), AKR1B1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), DLAT(3), DLD(1), GRHPR(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME2(3), ME3(5), PC(6), PCK1(3), PCK2(3), PDHA1(5), PDHA2(8), PDHB(2), PKM2(2)	14763737	142	46	140	44	48	52	22	2	18	0	0.987	1.000
558	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22(2), IL22RA1(1), JAK1(4), JAK2(9), JAK3(8), STAT1(6), STAT3(2), STAT5B(3), TYK2(1)	5917795	38	24	37	17	12	12	7	0	5	2	0.988	1.000
559	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(2), APAF1(8), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), CASP3(2), CASP6(2), CASP7(1), CASP9(2), PRKCA(4), PTK2(5), STAT1(6), TLN1(7)	6540877	44	27	44	16	15	15	9	0	5	0	0.988	1.000
560	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(11), MAP2K1(4), MAP3K1(8), MAPK14(3), NCOR2(2), RXRA(1), THRA(2), THRB(4)	5564978	38	22	38	15	18	10	8	0	2	0	0.989	1.000
561	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	26	ARHGDIB(3), BAG4(2), CASP2(4), CASP3(2), CRADD(2), DFFA(3), DFFB(2), LMNB1(4), LMNB2(1), MADD(14), MAP3K1(8), MAP3K7(4), MAPK8(7), PAK1(5), PAK2(3), PRKDC(18), RB1(7), RIPK1(2), SPTAN1(13), TNFRSF1A(1), TRADD(1), TRAF2(1)	11382828	107	39	106	40	32	28	27	2	16	2	0.989	1.000
562	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(18), ACACB(15), FASN(1), MCAT(1), OLAH(1), OXSM(5)	5231151	41	22	40	11	16	13	8	0	4	0	0.989	1.000
563	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	108	ADA(3), ADCY1(8), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADK(1), ADSL(7), ADSS(2), AK2(1), AK5(5), ALLC(5), AMPD1(9), AMPD2(5), AMPD3(3), ATIC(4), ATP1B1(1), ATP5A1(5), ATP5B(4), ATP5C1(4), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), DCK(2), ENPP1(4), ENPP3(4), ENTPD1(2), FHIT(1), GART(3), GMPS(5), GUCY1A2(12), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HPRT1(2), IMPDH1(2), IMPDH2(4), ITPA(2), NPR1(6), NPR2(10), NT5E(3), NT5M(1), PAICS(1), PAPSS1(2), PAPSS2(4), PDE1A(4), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE5A(6), PDE6B(5), PDE6C(10), PDE7B(4), PDE8A(1), PDE9A(6), PFAS(1), PKM2(2), POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12), POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1), PPAT(6), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(2), RRM2(2)	39942605	361	90	355	103	127	120	64	2	48	0	0.989	1.000
564	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(3), ARFGEF2(8), CLTA(2), COPA(2), GBF1(12), GPLD1(6), KDELR1(2), KDELR2(1), KDELR3(1)	5352638	38	22	37	15	16	9	8	1	4	0	0.989	1.000
565	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(3), CDK2(2), DIAPH2(12), GMNN(1), MCM10(8), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), RFC1(14), RFC4(3), RFC5(3), RPA1(2), RPA2(1), RPA4(3), UBA52(2), UBB(2)	16116296	121	47	118	29	29	55	20	1	16	0	0.990	1.000
566	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLUD1(2), OAT(1)	1713924	7	6	7	3	4	1	2	0	0	0	0.990	1.000
567	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(8), CD38(2), ENPP1(4), ENPP3(4), NADSYN1(2), NMNAT1(2), NMNAT2(2), NNMT(3), NNT(3), NT5E(3), NT5M(1), QPRT(1)	4843394	35	19	35	17	11	13	6	0	5	0	0.990	1.000
568	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(3), AASS(9), ACAT1(1), ACAT2(2), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), BBOX1(3), DLST(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(5), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), HSD3B7(2), NSD1(14), OGDH(4), OGDHL(11), PIPOX(4), PLOD1(4), PLOD2(5), PLOD3(4), RDH11(1), RDH12(3), RDH13(1), SETD1A(8), SETD7(3), SETDB1(8), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(1), SUV39H2(3), TMLHE(3)	18717348	157	55	154	43	63	40	29	2	23	0	0.990	1.000
569	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(2), CABIN1(11), CAMK1(3), CAMK1G(5), HDAC5(2), IGF1(2), IGF1R(8), INSR(6), MAP2K6(3), MAPK14(3), MAPK7(3), MEF2A(4), MEF2C(9), MEF2D(1), NFATC1(2), NFATC2(5), PPP3CA(3), PPP3CB(5), PPP3CC(4), SYT1(1), YWHAH(1)	9673636	83	40	82	38	39	21	11	0	12	0	0.992	1.000
570	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	IMPA1(2), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPP5B(1), INPPL1(4), IPMK(2), ITGB1BP3(1), ITPK1(2), ITPKB(4), MINPP1(1), MIOX(1), OCRL(9), PI4KA(15), PI4KB(2), PIK3C3(7), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PTPMT1(2), SYNJ1(11), SYNJ2(6)	22407178	187	61	183	53	75	51	36	2	22	1	0.992	1.000
571	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(2), AKT2(6), AKT3(1), BRD4(4), CAP1(1), CBL(5), CDC42(1), CDKN2A(1), F2RL2(3), FLOT1(3), GRB2(3), GSK3A(2), GSK3B(8), IGFBP1(2), INPPL1(4), IRS1(8), IRS4(15), LNPEP(8), MAPK1(2), MAPK3(3), PARD3(7), PARD6A(2), PDK1(2), PIK3CD(3), PPYR1(4), PTPN1(5), RAF1(6), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SERPINB6(2), SHC1(3), SLC2A4(4), SORBS1(11), SOS1(7), SOS2(11), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	17494559	175	53	171	51	62	59	32	3	19	0	0.992	1.000
572	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(4), AASDHPPT(3), AASS(9), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BBOX1(3), DLST(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(5), HADHA(3), PLOD1(4), PLOD2(5), PLOD3(4), SDS(2), SHMT1(2), SHMT2(2), TMLHE(3)	11886668	99	40	97	25	36	28	18	2	15	0	0.992	1.000
573	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(2), BIRC3(7), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF2(1)	2362139	14	11	14	6	5	5	3	0	1	0	0.992	1.000
574	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(6), IFNA1(1), IFNB1(1), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(1), IL1RN(3), IL6(2), IRAK1(1), IRAK2(8), IRAK3(3), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K7(4), MAPK14(3), MAPK8(7), MYD88(2), NFKB1(6), RELA(2), TGFB1(1), TGFB2(9), TOLLIP(1), TRAF6(4)	9138658	89	31	88	22	35	28	15	1	10	0	0.993	1.000
575	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1)	4332119	28	16	28	4	10	9	7	1	1	0	0.993	1.000
576	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(9), AMY2B(1), ASCC3(19), ATP13A2(3), DDX18(3), DDX19A(3), DDX23(4), DDX4(3), DDX41(2), DDX47(3), DDX50(3), DDX52(2), DDX54(5), DDX55(3), DDX56(5), DHX58(3), ENPP1(4), ENPP3(4), ENTPD7(4), EP400(20), ERCC2(4), ERCC3(7), G6PC(4), G6PC2(1), GANC(3), GBA3(3), GBE1(5), GCK(2), GPI(2), GUSB(2), GYS1(2), GYS2(11), HK1(6), HK2(3), HK3(5), IFIH1(5), MGAM(13), MOV10L1(13), PGM1(4), PGM3(5), PYGB(4), PYGL(2), PYGM(4), RAD54B(8), RAD54L(3), RUVBL2(1), SETX(20), SI(15), SKIV2L2(3), SMARCA2(10), SMARCA5(7), TREH(2), UGDH(4), UGP2(7), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), UXS1(7)	38409596	362	82	358	102	118	115	79	0	49	1	0.994	1.000
577	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(6), IFNG(1), IKBKB(4), IL2(4), IL4(3), MAP3K1(8), MAP3K5(6), MAP4K5(2), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), TNFRSF9(3), TRAF2(1)	6244166	57	23	57	15	21	23	10	1	2	0	0.994	1.000
578	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(5), ARSB(5), FUCA1(3), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), HGSNAT(6), HPSE(2), HPSE2(12), IDS(2), IDUA(1), LCT(20), MAN2B1(5), MAN2B2(1), MAN2C1(6), MANBA(7), NAGLU(4), NEU1(1), NEU2(1), NEU3(1), SPAM1(4)	10922454	102	38	100	35	37	28	24	1	12	0	0.994	1.000
579	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT1(2), AKT2(6), AKT3(1), EIF4B(2), FIGF(2), HIF1A(3), IGF1(2), MAPK1(2), MAPK3(3), PDPK1(1), PGF(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PRKAA1(3), PRKAA2(9), RICTOR(13), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA6(7), RPS6KB1(3), RPS6KB2(2), TSC1(4), TSC2(2), ULK1(1), ULK2(4), ULK3(3), VEGFA(2), VEGFB(2), VEGFC(6)	15328352	128	46	126	39	48	40	20	0	20	0	0.994	1.000
580	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(2), RDH11(1), RDH12(3), RDH13(1)	1535240	8	6	8	4	4	4	0	0	0	0	0.995	1.000
581	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2L1(1), CDC42(1), CDK2(2), CDKN1B(3), CDKN2A(1), CREB1(1), CREB3(3), CREB5(4), EBP(2), F2RL2(3), GAB1(6), GRB2(3), GSK3A(2), GSK3B(8), IGF1(2), IGFBP1(2), INPPL1(4), IRS1(8), IRS4(15), MET(5), NOLC1(8), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PARD3(7), PARD6A(2), PDK1(2), PIK3CD(3), PPP1R13B(6), PREX1(16), PTK2(5), PTPN1(5), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SHC1(3), SLC2A4(4), SOS1(7), SOS2(11), TSC1(4), TSC2(2), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	22769561	218	61	215	77	75	72	37	3	31	0	0.995	1.000
582	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	18	AKT1(2), EIF4G1(9), EIF4G2(7), EIF4G3(11), GHR(6), IRS1(8), MAPK1(2), MAPK14(3), MAPK3(3), MKNK1(1), PABPC1(3), PDK2(2), PDPK1(1), PRKCA(4), RPS6KB1(3)	7261014	65	29	65	20	18	24	16	0	7	0	0.995	1.000
583	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(8), BCL2(1), BID(1), BIRC2(4), BIRC3(7), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CASP9(2), CFLAR(3), CHUK(6), DFFA(3), DFFB(2), GAS2(2), MAP3K14(3), NFKB1(6), RELA(2), RIPK1(2), SPTAN1(13), TNFRSF10A(3), TNFRSF10B(6), TNFSF10(1), TNFSF12(2), TRADD(1), TRAF2(1)	10384045	86	37	86	33	32	31	13	0	9	1	0.995	1.000
584	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	ATR(17), BRCA1(6), BRCA2(22), CHEK1(1), CHEK2(1), FANCA(7), FANCC(3), FANCD2(11), FANCF(2), FANCG(4), HUS1(1), MRE11A(8), RAD1(1), RAD17(4), RAD50(11), TREX1(2)	12002765	101	32	101	16	29	35	23	0	14	0	0.995	1.000
585	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(5), MBTPS1(8), SCAP(2), SREBF1(1), SREBF2(2)	3880001	19	14	19	12	7	6	3	0	3	0	0.996	1.000
586	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	93	AKT1(2), AKT2(6), AKT3(1), CD14(1), CD40(1), CD80(1), CHUK(6), CXCL10(1), CXCL11(3), CXCL9(3), FOS(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IKBKB(4), IKBKE(4), IL12A(1), IL12B(2), IL1B(1), IL6(2), IL8(1), IRAK1(1), IRAK4(4), IRF3(2), IRF5(3), LBP(1), LY96(2), MAP2K1(4), MAP2K2(1), MAP2K6(3), MAP3K7(4), MAP3K8(2), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(5), MYD88(2), NFKB1(6), NFKB2(4), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), RELA(2), RIPK1(2), SPP1(1), STAT1(6), TBK1(6), TICAM1(2), TIRAP(1), TLR1(5), TLR2(6), TLR3(5), TLR4(10), TLR5(4), TLR6(2), TLR7(7), TLR8(6), TLR9(7), TOLLIP(1), TRAF3(6), TRAF6(4)	26300986	240	63	240	70	68	88	55	2	26	1	0.996	1.000
587	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(6), DNAJC3(1), EIF2S2(1), MAP3K14(3), NFKB1(6), RELA(2)	2824571	19	9	19	7	11	2	4	0	2	0	0.996	1.000
588	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(7), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(5), HDAC3(2), NCOA1(8), NCOA2(7), NCOA3(11), NCOR2(2), POLR2A(6), RXRA(1), TBP(1)	7878305	58	30	58	21	19	22	13	1	3	0	0.996	1.000
589	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(3), DDX20(4), E2F4(1), ETS1(1), ETS2(3), ETV3(1), FOS(1), HDAC2(2), HDAC5(2), NCOR2(2), RBL1(5), RBL2(8), SIN3A(10), SIN3B(4)	8409955	49	25	48	27	17	15	9	0	8	0	0.996	1.000
590	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1(1), MST1R(1)	1926083	5	5	5	4	3	2	0	0	0	0	0.997	1.000
591	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDFT1(3), HMGCR(3), HMGCS1(1), IDI1(1), LSS(2), MVK(1), NSDHL(2), PMVK(1), SC4MOL(1), SC5DL(3), SQLE(2)	4214717	25	16	25	10	11	7	5	0	2	0	0.997	1.000
592	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	125	ACACA(18), ACACB(15), AKT1(2), AKT2(6), AKT3(1), ARAF(3), BAD(1), CBL(5), CBLB(8), CRKL(2), EXOC7(2), FASN(1), FBP2(3), FLOT1(3), FOXO1(1), G6PC(4), G6PC2(1), GCK(2), GRB2(3), GSK3B(8), GYS1(2), GYS2(11), IKBKB(4), INPP5D(4), INSR(6), IRS1(8), IRS4(15), LIPE(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(7), MAPK9(5), MKNK1(1), MKNK2(3), PCK1(3), PCK2(3), PDE3A(5), PDE3B(3), PDPK1(1), PFKL(1), PFKM(4), PFKP(2), PHKA1(8), PHKA2(6), PHKB(6), PHKG2(3), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PKM2(2), PPARGC1A(5), PPP1CB(2), PPP1CC(2), PPP1R3A(13), PPP1R3B(1), PPP1R3C(4), PPP1R3D(1), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAG3(6), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCI(4), PRKX(2), PTPN1(5), PTPRF(9), PYGB(4), PYGL(2), PYGM(4), RAF1(6), RAPGEF1(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SLC2A4(4), SOCS2(3), SOCS4(1), SORBS1(11), SOS1(7), SOS2(11), SREBF1(1), TSC1(4), TSC2(2)	49117765	409	98	400	154	150	131	77	5	46	0	0.998	1.000
593	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GOT1(6), GOT2(1), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHAL6B(2), LDHB(3), LDHC(2), MDH1(1), MDH2(1), PC(6), PCK1(3), PDHA1(5), PDHA2(8), PDHB(2), PDHX(2), PFKL(1), PFKM(4), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(7), PKM2(2), TNFAIP1(3), TPI1(1)	13411958	116	44	113	47	47	42	16	0	11	0	0.998	1.000
594	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	29	CD14(1), CHUK(6), FOS(1), IKBKB(4), IRAK1(1), LY96(2), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K7(4), MAPK14(3), MAPK8(7), MYD88(2), NFKB1(6), PPARA(1), RELA(2), TIRAP(1), TLR10(4), TLR2(6), TLR3(5), TLR4(10), TLR6(2), TLR7(7), TLR9(7), TOLLIP(1), TRAF6(4)	10926859	101	35	101	31	34	31	25	1	9	1	0.998	1.000
595	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(24), ASH2L(2), C17orf79(1), CARM1(2), CTCFL(8), DOT1L(3), EED(2), EHMT1(2), EHMT2(3), EZH1(5), EZH2(4), FBXO11(5), HSF4(1), JMJD6(2), KDM6A(1), MEN1(2), MLL(21), MLL2(17), MLL3(16), MLL4(11), MLL5(17), NSD1(14), OGT(5), PAXIP1(6), PPP1CB(2), PPP1CC(2), PRDM2(15), PRDM7(2), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), RBBP5(2), SATB1(2), SETD1A(8), SETD2(16), SETD7(3), SETD8(2), SETDB1(8), SETDB2(3), SETMAR(1), SMYD3(4), STK38(2), SUV39H1(1), SUV39H2(3), SUV420H1(8), SUZ12(3), WHSC1(7), WHSC1L1(4)	36678115	283	72	280	81	106	74	55	2	44	2	0.998	1.000
596	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(7), CREBBP(25), CTBP1(1), CTBP2(2), DLL1(4), DLL3(3), DLL4(2), DTX1(4), DTX2(4), DTX3(1), DTX3L(3), DTX4(3), DVL2(9), DVL3(4), EP300(15), HDAC1(2), HDAC2(2), HES1(1), JAG1(8), MAML1(3), MAML2(3), MAML3(1), NCOR2(2), NCSTN(5), NOTCH2(13), NOTCH3(15), NOTCH4(7), NUMB(2), NUMBL(3), PSEN1(3), PSEN2(2), PTCRA(2), RBPJ(5), RBPJL(3), SNW1(5)	21509568	174	60	171	66	62	53	31	1	27	0	0.998	1.000
597	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	239	ACVR1C(3), AKT1(2), AKT2(6), AKT3(1), ARRB1(1), ATF2(1), ATF4(1), BDNF(1), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1F(14), CACNA1G(10), CACNA1H(2), CACNA1I(5), CACNA1S(14), CACNA2D1(11), CACNA2D2(1), CACNA2D3(6), CACNA2D4(3), CACNB1(1), CACNB2(6), CACNB3(2), CACNB4(2), CACNG1(2), CACNG2(3), CACNG3(8), CACNG4(2), CACNG5(5), CACNG6(1), CACNG7(6), CACNG8(1), CASP3(2), CD14(1), CDC25B(5), CDC42(1), CHUK(6), CRKL(2), DAXX(1), DUSP1(2), DUSP10(5), DUSP16(5), DUSP3(1), DUSP4(1), DUSP5(2), DUSP6(5), DUSP7(2), DUSP9(1), ECSIT(3), EGF(3), EGFR(11), ELK4(2), FAS(2), FASLG(1), FGF1(2), FGF11(3), FGF12(3), FGF13(3), FGF14(5), FGF17(1), FGF19(1), FGF20(2), FGF21(1), FGF23(1), FGF3(1), FGF5(4), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(4), FGFR2(6), FGFR3(2), FGFR4(2), FLNA(3), FLNB(16), FLNC(13), FOS(1), GNA12(2), GRB2(3), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), MAP2K1(4), MAP2K2(1), MAP2K5(4), MAP2K6(3), MAP3K1(8), MAP3K10(3), MAP3K12(6), MAP3K13(9), MAP3K14(3), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAP3K5(6), MAP3K6(6), MAP3K7(4), MAP3K8(2), MAP4K1(3), MAP4K2(1), MAP4K3(4), MAP4K4(8), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK7(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAPT(5), MAX(1), MEF2C(9), MKNK1(1), MKNK2(3), MOS(3), MRAS(1), NF1(9), NFATC2(5), NFATC4(5), NFKB1(6), NFKB2(4), NLK(1), NR4A1(2), NTF3(1), NTRK1(6), NTRK2(4), PAK1(5), PAK2(3), PDGFA(1), PDGFRA(17), PDGFRB(6), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PPM1A(7), PPM1B(2), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PPP5C(3), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PTPN5(1), PTPN7(2), PTPRR(5), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF2(13), RASA1(9), RASA2(3), RASGRF1(12), RASGRF2(9), RASGRP1(5), RASGRP2(7), RASGRP3(7), RASGRP4(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA5(6), RPS6KA6(7), RRAS2(2), SOS1(7), SOS2(11), SRF(3), STK3(3), STK4(3), STMN1(2), TAOK1(5), TAOK2(3), TAOK3(4), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TNFRSF1A(1), TRAF2(1), TRAF6(4), ZAK(6)	86607987	844	134	830	304	347	230	163	6	92	6	0.998	1.000
598	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	74	AIFM1(2), AKT1(2), AKT2(6), AKT3(1), APAF1(8), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(4), BIRC3(7), CAPN1(2), CAPN2(6), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CASP9(2), CFLAR(3), CHUK(6), CSF2RB(7), DFFA(3), DFFB(2), FAS(2), FASLG(1), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(1), IL3(3), IRAK1(1), IRAK2(8), IRAK3(3), IRAK4(4), MAP3K14(3), MYD88(2), NFKB1(6), NFKB2(4), NTRK1(6), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R2(1), PIK3R3(4), PIK3R5(1), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF2(1)	22516833	198	59	196	62	75	62	37	0	24	0	0.999	1.000
599	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(4), CDC40(4), CLK3(3), CLK4(2), COL2A1(9), CPSF1(5), CPSF2(1), CPSF3(2), CPSF4(4), CSTF1(2), CSTF2T(7), CSTF3(4), DDX1(4), DDX20(4), DHX15(3), DHX16(6), DHX38(11), DHX8(6), DHX9(5), DICER1(8), DNAJC8(2), LSM2(1), METTL3(4), NCBP1(6), NCBP2(1), NONO(2), NUDT21(1), NXF1(7), PABPN1(1), PAPOLA(3), PHF5A(1), POLR2A(6), PPM1G(1), PRPF18(4), PRPF3(1), PRPF4(4), PRPF4B(9), PRPF8(11), PSKH1(1), PTBP1(1), PTBP2(4), RBM17(2), RBM5(3), RNGTT(6), RNMT(4), RNPS1(1), SF3A1(3), SF3A2(1), SF3A3(1), SF3B1(10), SF3B2(2), SF3B4(4), SFRS14(2), SFRS4(2), SNRPA(1), SNRPB(1), SNRPB2(1), SNRPD3(1), SNRPE(2), SNRPN(2), SNURF(1), SPOP(2), SRPK1(9), SRPK2(4), SRRM1(11), SUPT5H(11), TXNL4A(1), U2AF1(2), U2AF2(3), XRN2(8)	34021950	266	77	266	73	85	76	62	3	40	0	0.999	1.000
600	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(6), IKBKB(4), IL1A(1), IL1R1(4), IRAK1(1), MAP3K1(8), MAP3K14(3), MAP3K7(4), MYD88(2), NFKB1(6), RELA(2), RIPK1(2), TLR4(10), TNFAIP3(3), TNFRSF1A(1), TRADD(1), TRAF6(4)	7713606	62	25	62	18	23	19	14	0	6	0	0.999	1.000
601	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(3), DHCR24(2), DHCR7(2), EBP(2), FDFT1(3), GGCX(5), GGPS1(1), HMGCR(3), IDI1(1), IDI2(1), LSS(2), MVK(1), NQO1(1), NSDHL(2), PMVK(1), SC4MOL(1), SC5DL(3), SQLE(2)	6166797	39	23	39	14	15	14	6	0	4	0	0.999	1.000
602	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(2), BAD(1), BCL2(1), BCL2L1(1), CBL(5), CFLAR(3), CRKL(2), FOS(1), GRB2(3), IL2RA(2), IL2RB(2), IRS1(8), JAK1(4), JAK3(8), MAPK1(2), MAPK3(3), NMI(2), PTPN6(4), RAF1(6), RPS6KB1(3), SHC1(3), SOS1(7), STAT5B(3), SYK(3)	10321525	79	34	76	29	27	31	10	0	11	0	0.999	1.000
603	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), ASCC3(19), ATP13A2(3), DDX18(3), DDX19A(3), DDX23(4), DDX4(3), DDX41(2), DDX47(3), DDX50(3), DDX52(2), DDX54(5), DDX55(3), DDX56(5), DHFR(1), DHX58(3), ENTPD7(4), EP400(20), ERCC2(4), ERCC3(7), GGH(1), IFIH1(5), MOV10L1(13), RAD54B(8), RAD54L(3), RUVBL2(1), SETX(20), SKIV2L2(3), SMARCA2(10), SMARCA5(7)	20223727	173	52	170	42	66	47	36	0	23	1	0.999	1.000
604	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1A2(1), EEF1B2(1), EEF1G(1), EEF2(3), EEF2K(1), EIF2AK1(6), EIF2AK2(1), EIF2AK3(2), EIF2B1(2), EIF2B2(1), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF4EBP2(1), EIF4G1(9), EIF4G3(11), EIF5(3), EIF5A(2), EIF5B(4), ETF1(5), KIAA0664(4), PABPC1(3), PABPC3(6), PAIP1(4), SLC35A4(2)	13567889	82	39	81	25	26	20	21	2	13	0	0.999	1.000
605	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), AKT1(2), AKT2(6), AKT3(1), AMOTL1(13), ASH1L(24), CASK(4), CDC42(1), CDK4(3), CGN(7), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CSDA(2), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTTN(1), EPB41(3), EPB41L1(9), EPB41L2(6), EPB41L3(18), EXOC4(7), F11R(1), GNAI1(4), HCLS1(8), IGSF5(8), INADL(5), JAM3(3), LLGL1(1), LLGL2(2), MAGI1(13), MAGI2(11), MAGI3(6), MLLT4(6), MPDZ(11), MPP5(3), MRAS(1), MYH1(15), MYH10(10), MYH11(28), MYH13(15), MYH14(12), MYH15(12), MYH2(12), MYH3(14), MYH4(12), MYH6(12), MYH7(11), MYH7B(6), MYH8(20), MYH9(12), MYL2(1), MYL7(1), MYL9(2), OCLN(1), PARD3(7), PARD6A(2), PARD6G(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), PPP2R3A(5), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), RAB3B(1), RHOA(5), RRAS2(2), SPTAN1(13), SRC(3), SYMPK(5), TJAP1(1), TJP1(7), TJP2(5), TJP3(1), YES1(1), ZAK(6)	59567358	596	108	584	198	255	180	91	3	64	3	0.999	1.000
606	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	80	ATF2(1), CHUK(6), CREB1(1), DAXX(1), FOS(1), GRB2(3), IKBKB(4), MAP2K1(4), MAP2K2(1), MAP2K5(4), MAP2K6(3), MAP3K1(8), MAP3K10(3), MAP3K11(4), MAP3K12(6), MAP3K13(9), MAP3K14(3), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAP3K5(6), MAP3K6(6), MAP3K7(4), MAP3K8(2), MAP3K9(4), MAP4K1(3), MAP4K2(1), MAP4K3(4), MAP4K4(8), MAP4K5(2), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK4(1), MAPK6(3), MAPK7(3), MAPK8(7), MAPK9(5), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(4), MEF2C(9), MEF2D(1), MKNK1(1), MKNK2(3), NFKB1(6), PAK1(5), PAK2(3), RAF1(6), RELA(2), RIPK1(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA5(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SP1(2), STAT1(6), TGFB1(1), TGFB2(9), TGFBR1(9), TRADD(1), TRAF2(1)	28907655	263	67	258	72	92	77	55	2	37	0	0.999	1.000
607	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), DHFR(1), GGH(1)	1916656	7	7	7	1	2	4	1	0	0	0	1.000	1.000
608	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(1), B3GAT3(1), CHPF(3), CHST11(3), CHST12(3), CHST13(2), CHST14(1), CHSY1(5), DSE(3), UST(1), XYLT1(6), XYLT2(2)	4439540	31	18	31	24	11	12	6	0	2	0	1.000	1.000
609	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), FPGT(5), FUK(1), GMDS(1), GMPPA(7), HK1(6), HK2(3), HK3(5), HSD3B7(2), KHK(1), LHPP(2), MPI(1), MTMR1(5), MTMR2(2), MTMR6(4), PFKFB1(7), PFKFB4(2), PFKL(1), PFKM(4), PFKP(2), PHPT1(1), PMM1(3), RDH11(1), RDH12(3), RDH13(1), SORD(2), TPI1(1), TSTA3(1)	12055248	89	40	89	39	36	39	9	0	5	0	1.000	1.000
610	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	APAF1(8), ARHGDIB(3), BAG4(2), BCL2(1), BID(1), BIRC2(4), BIRC3(7), CASP2(4), CASP3(2), CASP6(2), CASP7(1), CASP9(2), CFLAR(3), CHUK(6), CRADD(2), DAXX(1), DFFA(3), DFFB(2), LMNB1(4), LMNB2(1), MAP3K1(8), MAP3K14(3), MAP3K5(6), MAPK8(7), MDM2(4), NFKB1(6), NUMA1(10), PAK2(3), PRKCD(3), PRKDC(18), PSEN1(3), PSEN2(2), PTK2(5), RASA1(9), RB1(7), RELA(2), RIPK1(2), SPTAN1(13), TNFRSF1A(1), TRADD(1), TRAF1(2), TRAF2(1)	21151236	175	52	174	54	57	49	45	1	21	2	1.000	1.000
611	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(1), CDC42(1), CREB1(1), DAXX(1), GRB2(3), HSPB2(2), MAP2K6(3), MAP3K1(8), MAP3K5(6), MAP3K7(4), MAP3K9(4), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MAX(1), MEF2A(4), MEF2C(9), MEF2D(1), MKNK1(1), PLA2G4A(8), RIPK1(2), RPS6KA5(6), SHC1(3), STAT1(6), TGFB1(1), TGFB2(9), TGFBR1(9), TRADD(1), TRAF2(1)	11330285	103	33	99	33	38	28	23	0	14	0	1.000	1.000
612	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(6), PGAP1(8), PIGA(1), PIGB(2), PIGG(3), PIGK(4), PIGM(3), PIGN(2), PIGO(3), PIGQ(1), PIGS(2), PIGT(3), PIGU(1), PIGV(2), PIGW(1), PIGX(4)	7610883	49	22	48	19	15	16	12	0	6	0	1.000	1.000
613	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(4), BRCA1(6), CDKN1A(1), CHEK1(1), CHEK2(1), MAPK8(7), MDM2(4), MRE11A(8), NFKB1(6), RAD50(11), RBBP8(2), RELA(2)	7368919	53	20	53	11	16	18	14	1	4	0	1.000	1.000
614	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	37	APAF1(8), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(4), BIRC3(7), CASP2(4), CASP3(2), CASP6(2), CASP7(1), CASP9(2), FAS(2), FASLG(1), GZMB(2), MAP3K1(8), MAP3K14(3), MDM2(4), NFKB1(6), PARP1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF1(2), TRAF2(1)	10635168	75	32	75	30	30	21	17	0	7	0	1.000	1.000
615	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	17	AKT1(2), EIF4B(2), EIF4G1(9), EIF4G2(7), EIF4G3(11), MKNK1(1), PDK2(2), PDPK1(1), PPP2CA(1), RPS6KB1(3), TSC1(4), TSC2(2)	7061404	45	21	45	20	16	12	11	0	6	0	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		169316	0	0	0	1	0	0	0	0	0	0	1.000	1.000
