Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.134 0.255 -9999.0 0.0 -0.702 19.0 19.0 IHH -0.119 0.217 -9999.0 0.0 -0.491 35.0 35.0 SHH Np/Cholesterol/GAS1 -0.205 0.253 -9999.0 0.0 -0.517 52.0 52.0 LRPAP1 0.01 0.036 -9999.0 0.0 -0.427 1.0 1.0 dorsoventral neural tube patterning 0.203 0.251 0.513 52.0 -9999.0 0.0 52.0 SMO/beta Arrestin2 -0.124 0.223 -9999.0 0.0 -0.664 13.0 13.0 SMO -0.138 0.235 -9999.0 0.0 -0.616 20.0 20.0 AKT1 -0.042 0.097 -9999.0 0.0 -0.336 1.0 1.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.023 0.12 -9999.0 0.0 -0.427 12.0 12.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.136 0.23 -9999.0 0.0 -0.604 20.0 20.0 STIL -0.155 0.207 -9999.0 0.0 -0.516 24.0 24.0 DHH N/PTCH2 -0.053 0.152 -9999.0 0.0 -0.536 12.0 12.0 DHH N/PTCH1 -0.091 0.173 -9999.0 0.0 -0.459 17.0 17.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.019 0.139 -9999.0 0.0 -0.631 7.0 7.0 PTHLH -0.198 0.386 -9999.0 0.0 -1.085 19.0 19.0 determination of left/right symmetry -0.136 0.23 -9999.0 0.0 -0.604 20.0 20.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.195 0.378 -9999.0 0.0 -1.064 19.0 19.0 IHH N/Hhip -0.155 0.239 -9999.0 0.0 -0.474 46.0 46.0 DHH N/Hhip -0.11 0.204 -9999.0 0.0 -0.431 38.0 38.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.136 0.23 -9999.0 0.0 -0.604 20.0 20.0 pancreas development -0.115 0.245 -9999.0 0.0 -0.556 33.0 33.0 HHAT 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.155 0.293 -9999.0 0.0 -0.645 38.0 38.0 somite specification -0.136 0.23 -9999.0 0.0 -0.604 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.17 0.217 -9999.0 0.0 -0.545 25.0 25.0 SHH Np/Cholesterol/PTCH2 -0.135 0.19 -9999.0 0.0 -0.436 36.0 36.0 SHH Np/Cholesterol/Megalin -0.15 0.2 -9999.0 0.0 -0.476 32.0 32.0 SHH -0.14 0.222 -9999.0 0.0 -0.535 28.0 28.0 catabolic process -0.09 0.172 -9999.0 0.0 -0.476 17.0 17.0 SMO/Vitamin D3 -0.183 0.239 -9999.0 0.0 -0.588 25.0 25.0 SHH Np/Cholesterol/Hhip -0.181 0.227 -9999.0 0.0 -0.484 46.0 46.0 LRP2 -0.062 0.187 -9999.0 0.0 -0.509 21.0 21.0 receptor-mediated endocytosis -0.205 0.227 -9999.0 0.0 -0.561 34.0 34.0 SHH Np/Cholesterol/BOC -0.129 0.176 -9999.0 0.0 -0.433 29.0 29.0 SHH Np/Cholesterol/CDO -0.136 0.191 -9999.0 0.0 -0.442 35.0 35.0 mesenchymal cell differentiation 0.18 0.225 0.481 46.0 -9999.0 0.0 46.0 mol:Vitamin D3 -0.169 0.218 -9999.0 0.0 -0.545 25.0 25.0 IHH N/PTCH2 -0.092 0.179 -9999.0 0.0 -0.43 26.0 26.0 CDON -0.032 0.17 -9999.0 0.0 -0.656 10.0 10.0 IHH N/PTCH1 -0.091 0.173 -9999.0 0.0 -0.482 17.0 17.0 Megalin/LRPAP1 -0.053 0.133 -9999.0 0.0 -0.534 6.0 6.0 PTCH2 -0.03 0.164 -9999.0 0.0 -0.627 10.0 10.0 SHH Np/Cholesterol -0.116 0.17 -9999.0 0.0 -0.425 28.0 28.0 PTCH1 -0.091 0.172 -9999.0 0.0 -0.478 17.0 17.0 HHIP -0.115 0.245 -9999.0 0.0 -0.557 33.0 33.0