Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.008 0.055 -9999.0 0.0 -0.234 6.0 6.0 epithelial cell differentiation 0.038 0.064 -9999.0 0.0 -0.259 6.0 6.0 CYFIP2 0.013 0.084 -9999.0 0.0 -0.486 4.0 4.0 ENAH 0.008 0.106 0.282 11.0 -0.38 2.0 13.0 EGFR -0.006 0.123 -9999.0 0.0 -0.486 9.0 9.0 EPHA2 0.003 0.109 -9999.0 0.0 -0.486 7.0 7.0 MYO6 -0.007 0.076 0.349 1.0 -0.251 6.0 7.0 CTNNB1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.039 0.059 -9999.0 0.0 -0.297 4.0 4.0 AQP5 0.01 0.068 0.26 2.0 -9999.0 0.0 2.0 CTNND1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.01 0.069 -9999.0 0.0 -0.247 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.009 0.09 0.289 2.0 -0.247 11.0 13.0 EGF 0.032 0.055 -9999.0 0.0 -0.486 1.0 1.0 NCKAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.078 0.202 -9999.0 0.0 -0.504 23.0 23.0 cortical microtubule organization 0.038 0.064 -9999.0 0.0 -0.259 6.0 6.0 GO:0000145 -0.01 0.065 -9999.0 0.0 -0.236 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.043 0.066 -9999.0 0.0 -0.261 6.0 6.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.035 0.073 -9999.0 0.0 -0.523 2.0 2.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.073 -9999.0 0.0 -0.339 4.0 4.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.003 0.066 0.343 1.0 -9999.0 0.0 1.0 PVRL2 0.019 0.059 -9999.0 0.0 -0.486 2.0 2.0 ZYX -0.008 0.076 0.349 1.0 -0.249 6.0 7.0 ARF6/GTP 0.048 0.072 -9999.0 0.0 -0.318 4.0 4.0 CDH1 0.006 0.101 -9999.0 0.0 -0.486 6.0 6.0 EGFR/EGFR/EGF/EGF 0.016 0.093 -9999.0 0.0 -0.264 13.0 13.0 RhoA/GDP 0.038 0.063 -9999.0 0.0 -0.249 6.0 6.0 actin cytoskeleton organization -0.009 0.071 0.333 1.0 -0.248 6.0 7.0 IGF-1R heterotetramer 0.012 0.083 -9999.0 0.0 -0.486 4.0 4.0 GIT1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.083 -9999.0 0.0 -0.486 4.0 4.0 IGF1 -0.016 0.167 -9999.0 0.0 -0.486 16.0 16.0 DIAPH1 -0.004 0.174 -9999.0 0.0 -0.59 9.0 9.0 Wnt receptor signaling pathway -0.038 0.064 0.259 6.0 -9999.0 0.0 6.0 RHOA 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.035 0.072 -9999.0 0.0 -0.523 2.0 2.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.009 0.072 0.335 1.0 -0.253 6.0 7.0 EFNA1 0.018 0.06 -9999.0 0.0 -0.486 2.0 2.0 LPP -0.012 0.069 0.341 1.0 -0.243 6.0 7.0 Ephrin A1/EPHA2 0.018 0.097 -9999.0 0.0 -0.318 9.0 9.0 SEC6/SEC8 -0.028 0.048 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.009 0.091 0.291 2.0 -0.251 11.0 13.0 HGF/MET 0.013 0.096 -9999.0 0.0 -0.244 17.0 17.0 HGF -0.009 0.151 -9999.0 0.0 -0.486 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.01 0.051 -9999.0 0.0 -0.236 6.0 6.0 actin cable formation 0.029 0.11 0.297 12.0 -0.289 3.0 15.0 KIAA1543 -0.018 0.101 0.337 1.0 -0.337 9.0 10.0 KIFC3 -0.01 0.077 0.349 1.0 -0.249 7.0 8.0 NCK1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.007 0.076 0.349 1.0 -0.251 6.0 7.0 NCK1/GIT1 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.038 0.064 -9999.0 0.0 -0.259 6.0 6.0 EXOC4 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.005 0.071 0.349 1.0 -0.251 4.0 5.0 PIP5K1C -0.01 0.07 -9999.0 0.0 -0.251 6.0 6.0 LIMA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.01 0.119 0.303 11.0 -0.453 2.0 13.0 adherens junction assembly -0.018 0.113 0.267 1.0 -0.416 6.0 7.0 IGF-1R heterotetramer/IGF1 -0.002 0.117 -9999.0 0.0 -0.253 25.0 25.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.046 -9999.0 0.0 -0.353 2.0 2.0 MET 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.018 0.106 0.349 1.0 -0.353 9.0 10.0 mol:GTP 0.042 0.072 -9999.0 0.0 -0.336 4.0 4.0 establishment of epithelial cell apical/basal polarity 0.017 0.117 0.354 8.0 -9999.0 0.0 8.0 cortical actin cytoskeleton stabilization 0.008 0.055 -9999.0 0.0 -0.234 6.0 6.0 regulation of cell-cell adhesion -0.009 0.071 0.333 1.0 -0.248 6.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.01 0.051 -9999.0 0.0 -0.236 6.0 6.0