Clinical Features Time to Death AGE GENDER HISTOLOGICAL.TYPE RADIATIONS.RADIATION.REGIMENINDICATION DISTANT.METASTASIS LYMPH.NODE.METASTASIS NUMBER.OF.LYMPH.NODES TUMOR.STAGECODE NEOPLASM.DISEASESTAGE nMutated (%) nWild-Type logrank test_P logrank test_Q t-test_P t-test_Q Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q t-test_P t-test_Q t-test_P t-test_Q Chi-square test_P Chi-square test_Q PTEN 29 (4%) 742 0.88949 1 0.45792 1 1 1 0.55381 1 0.82976 1 0.061793 1 0.38721 1 0.22125 1 NA NA 0.02076 1 MLL3 56 (7%) 715 0.52482 1 0.011777 1 1 1 0.9173 1 0.75187 1 0.41817 1 0.31684 1 0.91797 1 NA NA 0.86157 1 ZNF384 14 (2%) 757 0.40805 1 0.012719 1 1 1 0.91592 1 1 1 0.45297 1 0.96396 1 1.1615e-05 0.00832 NA NA 0.4437 1 DCP1B 5 (1%) 766 0.54986 1 0.025035 1 1 1 0.93649 1 0.33529 1 0.37503 1 0.51152 1 0.44004 1 NA NA 1.0785e-07 7.79e-05 PIK3CA 261 (34%) 510 0.92038 1 0.023335 1 1 1 0.021675 1 0.86205 1 0.35699 1 0.43704 1 0.33878 1 NA NA 0.47924 1 NCOA3 29 (4%) 742 0.46385 1 0.87512 1 1 1 0.51377 1 0.66664 1 0.14162 1 0.2206 1 0.17725 1 NA NA 0.47764 1 AOAH 19 (2%) 752 0.2834 1 0.4249 1 1 1 0.79131 1 0.035253 1 0.27551 1 0.91644 1 0.28164 1 NA NA 0.1873 1 RBMX 13 (2%) 758 0.64954 1 0.87351 1 1 1 0.79246 1 0.33717 1 1 1 0.9504 1 0.24084 1 NA NA 0.97197 1 RUNX1 25 (3%) 746 0.44952 1 0.60322 1 1 1 0.053038 1 0.35343 1 1 1 0.88399 1 0.53211 1 NA NA 0.1026 1 PIK3R1 21 (3%) 750 0.1736 1 0.68573 1 1 1 0.84245 1 0.8012 1 0.48417 1 5.689e-05 0.0404 0.080545 1 NA NA 0.2857 1 MEF2A 14 (2%) 757 0.78801 1 0.5219 1 1 1 0.017406 1 0.53733 1 0.71896 1 0.75843 1 0.014186 1 NA NA 0.43552 1 NCOR2 29 (4%) 742 0.81457 1 0.70938 1 1 1 0.86421 1 1 1 0.37531 1 0.93047 1 0.2179 1 NA NA 0.95689 1 AKT1 19 (2%) 752 0.19599 1 0.13261 1 1 1 0.98403 1 0.18266 1 0.59735 1 0.040488 1 0.90221 1 NA NA 0.54115 1 GATA3 81 (11%) 690 0.73937 1 0.00021748 0.154 0.59027 1 0.1471 1 0.13927 1 0.097873 1 0.7807 1 0.59762 1 NA NA 0.2196 1 NR1H2 18 (2%) 753 0.55718 1 0.71377 1 1 1 0.81913 1 1 1 0.002813 1 0.64138 1 0.9544 1 NA NA 0.016298 1 MAP3K4 18 (2%) 753 0.98862 1 0.5425 1 1 1 0.75492 1 0.58535 1 0.0014462 1 0.85375 1 0.91235 1 NA NA 0.80825 1 TP53 257 (33%) 514 0.45577 1 0.038439 1 0.057442 1 1.0256e-06 0.000737 0.43261 1 0.055181 1 0.37858 1 0.41446 1 NA NA 0.73173 1 TPRX1 7 (1%) 764 0.6947 1 0.12309 1 1 1 0.0017376 1 1 1 0.48262 1 0.97663 1 0.20473 1 NA NA 0.80479 1 CDH1 55 (7%) 716 0.41822 1 0.086132 1 1 1 3.1653e-69 2.3e-66 1 1 0.79896 1 0.02574 1 0.12922 1 NA NA 0.13409 1 ATN1 17 (2%) 754 0.2935 1 0.95926 1 1 1 0.72703 1 0.26359 1 0.104 1 0.98781 1 0.60901 1 NA NA 0.8342 1 MAP2K4 32 (4%) 739 0.18116 1 0.38629 1 1 1 0.52602 1 0.68487 1 0.64718 1 0.33366 1 0.91125 1 NA NA 0.98656 1 MAP3K1 57 (7%) 714 0.78202 1 0.00183 1 1 1 0.61235 1 0.75309 1 0.56491 1 0.10272 1 7.2375e-07 0.000522 NA NA 0.67874 1 CBFB 16 (2%) 755 0.96813 1 0.72482 1 1 1 0.60594 1 1 1 0.20262 1 0.47336 1 0.82134 1 NA NA 0.91585 1 CTCF 18 (2%) 753 0.11715 1 0.93051 1 1 1 0.67066 1 1 1 0.57088 1 0.99071 1 0.049822 1 NA NA 0.36128 1 CCDC144NL 8 (1%) 763 5.1953e-05 0.037 0.050782 1 1 1 0.96896 1 0.12112 1 1 1 0.40982 1 0.29647 1 NA NA 0.4477 1 AKD1 19 (2%) 752 0.80823 1 0.46938 1 1 1 0.066107 1 0.79358 1 0.27551 1 0.37178 1 0.4373 1 NA NA 0.70773 1 RB1 14 (2%) 757 0.88104 1 0.12037 1 0.13695 1 0.91065 1 0.13133 1 0.71896 1 0.071391 1 0.4594 1 NA NA 0.0016907 1 PHLDA1 9 (1%) 762 0.78845 1 0.75169 1 1 1 0.67603 1 0.45969 1 0.19849 1 0.90836 1 0.00081744 0.575 NA NA 0.24923 1 FOXA1 15 (2%) 756 0.078072 1 0.0024907 1 1 1 0.0091698 1 0.37688 1 0.48419 1 0.98977 1 0.83253 1 NA NA 0.095472 1 VEZF1 8 (1%) 763 0.58121 1 0.087893 1 1 1 0.89076 1 0.43205 1 0.52935 1 0.99511 1 0.04249 1 NA NA 0.9434 1 ZFP36L1 10 (1%) 761 0.98104 1 0.012361 1 1 1 0.96206 1 0.071807 1 0.22193 1 0.9428 1 0.41018 1 NA NA 0.66817 1 NCOR1 31 (4%) 740 0.8787 1 0.93421 1 1 1 0.26533 1 1 1 0.34872 1 0.82026 1 0.46214 1 NA NA 0.87817 1 TBX3 18 (2%) 753 0.18463 1 0.015366 1 1 1 0.66856 1 1 1 0.57088 1 0.98868 1 0.47153 1 NA NA 0.67295 1 DSPP 26 (3%) 745 0.8681 1 0.1665 1 1 1 0.95746 1 1 1 1 1 0.47929 1 0.375 1 NA NA 0.83873 1 AQP7 8 (1%) 763 0.012264 1 0.66069 1 1 1 0.96896 1 0.21482 1 1 1 1.6966e-06 0.00122 0.19597 1 NA NA 0.78644 1 BCL6B 8 (1%) 763 0.60693 1 0.74934 1 1 1 0.81215 1 0.12112 1 0.040783 1 0.82369 1 0.80537 1 NA NA 0.93817 1 RPGR 14 (2%) 757 0.86913 1 0.45884 1 1 1 0.85854 1 1 1 0.31795 1 0.88048 1 0.85598 1 NA NA 0.89205 1 TBL1XR1 9 (1%) 762 0.56539 1 0.022342 1 1 1 0.69137 1 0.70184 1 0.19849 1 0.41313 1 0.45371 1 NA NA 0.44657 1 MYB 11 (1%) 760 0.17597 1 0.17983 1 1 1 0.25027 1 0.48737 1 1 1 0.98925 1 0.036372 1 NA NA 0.75787 1 PABPC3 8 (1%) 763 0.30201 1 0.94103 1 0.080409 1 0.65522 1 1 1 1 1 0.97264 1 0.16385 1 NA NA 0.88486 1 GPS2 6 (1%) 765 0.21948 1 0.96634 1 1 1 0.69484 1 0.65125 1 1 1 0.3602 1 0.63823 1 NA NA 0.10944 1 E2F4 4 (1%) 767 NA NA 0.36613 1 1 1 0.49187 1 0.57734 1 1 1 0.98724 1 NA NA NA NA 0.98207 1 DNAH12 12 (2%) 759 0.81008 1 0.97961 1 1 1 0.9441 1 0.51793 1 0.67812 1 0.88629 1 0.85962 1 NA NA 0.88119 1 CDKN1B 7 (1%) 764 0.84833 1 0.94501 1 1 1 0.96692 1 1 1 0.02215 1 4.0927e-05 0.0293 0.047824 1 NA NA 0.05124 1 HNF1A 9 (1%) 762 0.53802 1 0.20482 1 1 1 0.0085519 1 0.24699 1 0.065371 1 0.9899 1 0.6364 1 NA NA 0.98016 1 CRIPAK 6 (1%) 765 0.4957 1 0.47328 1 1 1 0.93893 1 1 1 1 1 0.86027 1 0.004915 1 NA NA 0.82032 1 CASP8 10 (1%) 761 0.93045 1 0.58112 1 1 1 0.71381 1 0.46671 1 0.61067 1 0.896 1 5.5688e-05 0.0396 NA NA 0.75303 1 STXBP2 9 (1%) 762 0.25064 1 0.046396 1 1 1 0.96703 1 0.70184 1 1 1 0.99503 1 0.93479 1 NA NA 0.70001 1 CTU2 5 (1%) 766 0.55599 1 0.56896 1 1 1 0.00011406 0.0809 0.33529 1 1 1 0.94586 1 0.057974 1 NA NA 1.5766e-09 1.14e-06 CCDC66 9 (1%) 762 0.69508 1 0.75177 1 1 1 0.70488 1 0.70184 1 0.57191 1 0.8092 1 0.77207 1 NA NA 0.74925 1 HIST1H3B 7 (1%) 764 0.39507 1 0.28526 1 1 1 0.91621 1 0.38251 1 1 1 0.87506 1 0.45151 1 NA NA 0.80479 1 TTN 122 (16%) 649 0.05691 1 0.0074754 1 0.36875 1 0.37231 1 0.91048 1 0.60748 1 0.94862 1 0.39874 1 NA NA 0.026201 1 SLC25A5 3 (0%) 768 NA NA 0.52139 1 1 1 0.11205 1 0.57289 1 0.24546 1 0.94843 1 0.93152 1 NA NA 0.99931 1 SELPLG 7 (1%) 764 0.66159 1 0.26628 1 1 1 0.96692 1 0.38251 1 0.13398 1 0.71047 1 0.00081744 0.575 NA NA 0.79467 1 KRTAP9-9 6 (1%) 765 0.59545 1 0.40808 1 1 1 0.38095 1 0.18171 1 0.43133 1 0.97959 1 0.29265 1 NA NA 0.92979 1 KRTAP4-5 4 (1%) 767 0.59576 1 0.19439 1 1 1 0.26377 1 0.27522 1 0.31325 1 0.97247 1 0.46589 1 NA NA 0.90493 1 SF3B1 14 (2%) 757 0.29136 1 0.7398 1 1 1 0.86193 1 0.36919 1 0.71896 1 0.98246 1 0.77777 1 NA NA 0.29753 1 HLA-A 4 (1%) 767 0.21124 1 0.43666 1 1 1 9.3464e-06 0.0067 0.27522 1 1 1 2.9143e-33 2.11e-30 0.58505 1 NA NA 0.80724 1 FGFR2 7 (1%) 764 0.0004637 0.327 0.75119 1 1 1 0.6273 1 0.68407 1 0.13398 1 0.78906 1 0.047101 1 NA NA 0.75495 1 SHROOM4 11 (1%) 760 0.30197 1 0.61935 1 0.10907 1 0.80445 1 0.16303 1 0.35334 1 0.89388 1 0.71952 1 NA NA 0.93265 1 MED12 20 (3%) 751 0.60691 1 0.77694 1 1 1 0.98941 1 0.3134 1 0.36632 1 0.95929 1 0.48946 1 NA NA 0.6693 1 DENND4B 8 (1%) 763 0.54558 1 0.73426 1 1 1 0.0035855 1 1 1 0.52935 1 0.99756 1 0.80643 1 NA NA 0.92451 1 ODF1 5 (1%) 766 0.72175 1 0.56876 1 1 1 4.378e-05 0.0313 0.60806 1 0.075083 1 0.69808 1 0.96632 1 NA NA 0.59162 1 AXL 6 (1%) 765 0.43779 1 0.73394 1 1 1 0.0030457 1 0.34732 1 0.43133 1 0.63462 1 0.44669 1 NA NA 0.61446 1 RPL18 4 (1%) 767 0.79397 1 0.85689 1 1 1 0.49187 1 0.27522 1 1 1 0.76695 1 0.027042 1 NA NA 0.7508 1 RAI1 7 (1%) 764 0.67907 1 0.91721 1 1 1 0.96692 1 0.38251 1 1 1 0.96341 1 0.04819 1 NA NA 0.37967 1 ERBB2 12 (2%) 759 0.13887 1 0.54157 1 0.11845 1 0.38332 1 0.74046 1 1 1 0.97639 1 0.52217 1 NA NA 0.93183 1 KRT38 4 (1%) 767 0.4998 1 0.24206 1 1 1 0.97453 1 0.27522 1 1 1 7.549e-15 5.47e-12 0.053852 1 NA NA 0.99082 1 TICAM1 5 (1%) 766 0.56336 1 0.53967 1 1 1 0.95851 1 0.60806 1 0.075083 1 0.037642 1 0.72359 1 NA NA 0.068279 1 ASXL2 8 (1%) 763 0.90577 1 0.94727 1 1 1 0.96896 1 0.43205 1 1 1 7.7251e-07 0.000556 7.0118e-05 0.0498 NA NA 0.97789 1 ASPHD1 3 (0%) 768 0.044313 1 0.78241 1 1 1 0.28778 1 0.57289 1 1 1 0.87937 1 0.72735 1 NA NA 0.96611 1 FAM171B 8 (1%) 763 0.74476 1 0.0037456 1 0.080409 1 0.89076 1 0.43205 1 0.52935 1 0.99876 1 0.38324 1 NA NA 0.88486 1 MUC20 10 (1%) 761 0.42096 1 0.16898 1 1 1 0.069697 1 0.72365 1 0.61067 1 0.81284 1 0.53279 1 NA NA 0.96961 1 PPEF1 8 (1%) 763 0.74798 1 0.70447 1 1 1 0.89076 1 1 1 1 1 0.88548 1 0.16385 1 NA NA 0.98162 1 PRRX1 6 (1%) 765 0.48679 1 0.90032 1 1 1 0.93893 1 0.18171 1 1 1 0.77812 1 0.72185 1 NA NA 0.98769 1 ATP13A4 9 (1%) 762 0.30122 1 0.54526 1 1 1 0.86303 1 0.70184 1 1 1 0.98831 1 0.055769 1 NA NA 0.00039659 0.28 MUC2 18 (2%) 753 0.46572 1 0.78332 1 1 1 0.90038 1 0.097199 1 0.18995 1 0.5475 1 0.44472 1 NA NA 0.52887 1 UBC 8 (1%) 763 0.21583 1 0.67052 1 1 1 0.89076 1 1 1 1 1 0.90582 1 0.84357 1 NA NA 0.93371 1 KCNN3 6 (1%) 765 0.6188 1 0.74417 1 1 1 0.23651 1 0.34732 1 0.43133 1 0.98072 1 0.018978 1 NA NA 0.66935 1 RBM23 6 (1%) 765 0.66325 1 0.74629 1 1 1 0.00040346 0.285 0.18171 1 0.10334 1 0.88981 1 0.79437 1 NA NA 0.79245 1 GNRH2 3 (0%) 768 0.9096 1 0.17785 1 1 1 0.75571 1 0.57289 1 0.24546 1 0.20474 1 0.43363 1 NA NA 0.99931 1