This pipeline computes the correlation between significantly recurrent gene mutations and molecular subtypes.
Testing the association between mutation status of 81 genes and 12 molecular subtypes across 771 patients, 56 significant findings detected with P value < 0.05 and Q value < 0.25.
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PIK3CA mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'CN_CNMF', 'METHLYATION_CNMF', 'RPPA_CNMF', 'RPPA_CHIERARCHICAL', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
-
RUNX1 mutation correlated to 'CN_CNMF'.
-
AKT1 mutation correlated to 'MRNASEQ_CNMF'.
-
GATA3 mutation correlated to 'MRNA_CHIERARCHICAL', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
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TP53 mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'CN_CNMF', 'METHLYATION_CNMF', 'RPPA_CNMF', 'RPPA_CHIERARCHICAL', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
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CDH1 mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'CN_CNMF', 'RPPA_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', and 'MIRSEQ_MATURE_CNMF'.
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MAP2K4 mutation correlated to 'MRNASEQ_CHIERARCHICAL'.
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MAP3K1 mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'CN_CNMF', 'RPPA_CNMF', 'RPPA_CHIERARCHICAL', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', and 'MIRSEQ_MATURE_CNMF'.
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CCDC144NL mutation correlated to 'CN_CNMF'.
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TTN mutation correlated to 'CN_CNMF' and 'RPPA_CNMF'.
Clinical Features |
MRNA CNMF |
MRNA CHIERARCHICAL |
CN CNMF |
METHLYATION CNMF |
RPPA CNMF |
RPPA CHIERARCHICAL |
MRNASEQ CNMF |
MRNASEQ CHIERARCHICAL |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRSEQ MATURE CNMF |
MIRSEQ MATURE CHIERARCHICAL |
||
nMutated (%) | nWild-Type | Chi-square test | Fisher's exact test | Chi-square test | Chi-square test | Fisher's exact test | Fisher's exact test | Chi-square test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | |
PIK3CA | 261 (34%) | 510 |
8.9e-15 (7.27e-12) |
3.88e-10 (3.15e-07) |
1.13e-12 (9.19e-10) |
1.67e-09 (1.35e-06) |
1.64e-05 (0.013) |
1.06e-06 (0.000854) |
5.11e-28 (4.2e-25) |
2.61e-12 (2.13e-09) |
8.02e-08 (6.47e-05) |
1.49e-11 (1.21e-08) |
6.4e-05 (0.0502) |
1.9e-10 (1.54e-07) |
TP53 | 257 (33%) | 514 |
7.08e-37 (5.84e-34) |
2.43e-33 (2e-30) |
3.53e-49 (2.93e-46) |
6.18e-23 (5.05e-20) |
1.87e-27 (1.54e-24) |
1.1e-23 (9.03e-21) |
4.17e-55 (3.46e-52) |
4.18e-48 (3.46e-45) |
7.46e-39 (6.16e-36) |
2.32e-44 (1.92e-41) |
1.47e-30 (1.21e-27) |
4.95e-24 (4.06e-21) |
MAP3K1 | 57 (7%) | 714 |
4.33e-06 (0.00344) |
4.38e-05 (0.0344) |
7.22e-05 (0.0566) |
0.00117 (0.891) |
0.000204 (0.159) |
1.99e-06 (0.00159) |
1.08e-05 (0.00855) |
7.51e-05 (0.0587) |
1.96e-05 (0.0155) |
4.16e-05 (0.0327) |
0.00023 (0.179) |
0.00195 (1.00) |
CDH1 | 55 (7%) | 716 |
1.67e-07 (0.000135) |
8.2e-05 (0.0641) |
2.42e-08 (1.96e-05) |
0.000711 (0.545) |
0.000255 (0.198) |
0.000579 (0.444) |
1.29e-06 (0.00103) |
4.23e-07 (0.000339) |
1.67e-06 (0.00133) |
5.92e-08 (4.79e-05) |
0.000244 (0.19) |
0.0104 (1.00) |
GATA3 | 81 (11%) | 690 |
0.000575 (0.442) |
0.000101 (0.079) |
0.00409 (1.00) |
0.00887 (1.00) |
0.00115 (0.879) |
0.000407 (0.314) |
6.27e-06 (0.00498) |
1.22e-09 (9.92e-07) |
4.04e-07 (0.000325) |
1.27e-06 (0.00101) |
3.97e-07 (0.00032) |
1.46e-06 (0.00116) |
TTN | 122 (16%) | 649 |
0.122 (1.00) |
0.0385 (1.00) |
1.02e-05 (0.00805) |
0.0397 (1.00) |
6.23e-05 (0.0489) |
0.052 (1.00) |
0.000335 (0.259) |
0.0009 (0.688) |
0.0434 (1.00) |
0.0193 (1.00) |
0.113 (1.00) |
0.00351 (1.00) |
RUNX1 | 25 (3%) | 746 |
0.00552 (1.00) |
0.0442 (1.00) |
1.85e-05 (0.0146) |
0.0369 (1.00) |
1 (1.00) |
0.252 (1.00) |
0.0299 (1.00) |
0.141 (1.00) |
0.00248 (1.00) |
0.133 (1.00) |
0.106 (1.00) |
0.00803 (1.00) |
AKT1 | 19 (2%) | 752 |
0.0634 (1.00) |
0.925 (1.00) |
0.00312 (1.00) |
0.000363 (0.28) |
0.162 (1.00) |
0.345 (1.00) |
3.09e-05 (0.0244) |
0.288 (1.00) |
0.0167 (1.00) |
0.0756 (1.00) |
0.0813 (1.00) |
0.0402 (1.00) |
MAP2K4 | 32 (4%) | 739 |
0.0292 (1.00) |
0.00313 (1.00) |
0.0323 (1.00) |
0.009 (1.00) |
0.00238 (1.00) |
0.0344 (1.00) |
0.0281 (1.00) |
0.000313 (0.242) |
0.00156 (1.00) |
0.00333 (1.00) |
0.00106 (0.807) |
0.0942 (1.00) |
CCDC144NL | 8 (1%) | 763 |
6.29e-06 (0.00499) |
0.306 (1.00) |
0.705 (1.00) |
0.347 (1.00) |
0.809 (1.00) |
0.216 (1.00) |
0.246 (1.00) |
0.39 (1.00) |
||||
PTEN | 29 (4%) | 742 |
0.226 (1.00) |
0.437 (1.00) |
0.61 (1.00) |
0.603 (1.00) |
0.882 (1.00) |
0.266 (1.00) |
0.268 (1.00) |
0.901 (1.00) |
0.38 (1.00) |
0.886 (1.00) |
0.0597 (1.00) |
0.349 (1.00) |
MLL3 | 56 (7%) | 715 |
0.272 (1.00) |
0.973 (1.00) |
0.585 (1.00) |
0.789 (1.00) |
0.74 (1.00) |
0.935 (1.00) |
0.107 (1.00) |
0.86 (1.00) |
0.0396 (1.00) |
0.281 (1.00) |
0.151 (1.00) |
0.582 (1.00) |
ZNF384 | 14 (2%) | 757 |
0.61 (1.00) |
0.155 (1.00) |
0.535 (1.00) |
1 (1.00) |
0.881 (1.00) |
0.263 (1.00) |
0.466 (1.00) |
0.31 (1.00) |
||||
DCP1B | 5 (1%) | 766 |
0.395 (1.00) |
0.00475 (1.00) |
0.619 (1.00) |
0.719 (1.00) |
0.607 (1.00) |
0.606 (1.00) |
1 (1.00) |
0.667 (1.00) |
||||
NCOA3 | 29 (4%) | 742 |
0.549 (1.00) |
1 (1.00) |
0.993 (1.00) |
0.385 (1.00) |
1 (1.00) |
1 (1.00) |
0.263 (1.00) |
0.287 (1.00) |
0.281 (1.00) |
0.0961 (1.00) |
0.24 (1.00) |
0.132 (1.00) |
AOAH | 19 (2%) | 752 |
0.612 (1.00) |
0.654 (1.00) |
0.481 (1.00) |
0.228 (1.00) |
0.109 (1.00) |
0.503 (1.00) |
0.0498 (1.00) |
0.898 (1.00) |
||||
RBMX | 13 (2%) | 758 |
0.0058 (1.00) |
0.0706 (1.00) |
0.497 (1.00) |
0.127 (1.00) |
0.276 (1.00) |
0.418 (1.00) |
0.647 (1.00) |
0.948 (1.00) |
||||
PIK3R1 | 21 (3%) | 750 |
0.172 (1.00) |
0.616 (1.00) |
0.687 (1.00) |
0.647 (1.00) |
0.538 (1.00) |
0.297 (1.00) |
0.165 (1.00) |
0.913 (1.00) |
1 (1.00) |
0.875 (1.00) |
0.803 (1.00) |
0.786 (1.00) |
MEF2A | 14 (2%) | 757 |
0.659 (1.00) |
0.335 (1.00) |
0.63 (1.00) |
0.149 (1.00) |
0.0531 (1.00) |
0.0127 (1.00) |
0.169 (1.00) |
0.0332 (1.00) |
||||
NCOR2 | 29 (4%) | 742 |
0.676 (1.00) |
1 (1.00) |
0.111 (1.00) |
0.4 (1.00) |
0.839 (1.00) |
0.69 (1.00) |
0.695 (1.00) |
0.549 (1.00) |
0.542 (1.00) |
0.859 (1.00) |
0.413 (1.00) |
0.256 (1.00) |
NR1H2 | 18 (2%) | 753 |
0.326 (1.00) |
0.267 (1.00) |
0.789 (1.00) |
0.0487 (1.00) |
0.064 (1.00) |
0.116 (1.00) |
0.56 (1.00) |
0.0728 (1.00) |
0.739 (1.00) |
0.44 (1.00) |
0.484 (1.00) |
0.0856 (1.00) |
MAP3K4 | 18 (2%) | 753 |
0.108 (1.00) |
0.721 (1.00) |
0.788 (1.00) |
0.0248 (1.00) |
0.0733 (1.00) |
0.69 (1.00) |
0.464 (1.00) |
0.214 (1.00) |
0.398 (1.00) |
0.209 (1.00) |
0.781 (1.00) |
0.765 (1.00) |
TPRX1 | 7 (1%) | 764 |
0.343 (1.00) |
0.561 (1.00) |
0.983 (1.00) |
0.737 (1.00) |
0.694 (1.00) |
1 (1.00) |
0.612 (1.00) |
0.712 (1.00) |
||||
ATN1 | 17 (2%) | 754 |
0.0643 (1.00) |
0.0545 (1.00) |
0.0642 (1.00) |
0.835 (1.00) |
0.169 (1.00) |
0.291 (1.00) |
0.16 (1.00) |
0.569 (1.00) |
0.853 (1.00) |
0.44 (1.00) |
0.0767 (1.00) |
0.353 (1.00) |
CBFB | 16 (2%) | 755 |
0.184 (1.00) |
0.648 (1.00) |
0.0266 (1.00) |
0.0107 (1.00) |
0.35 (1.00) |
0.569 (1.00) |
0.000473 (0.364) |
0.583 (1.00) |
0.0241 (1.00) |
0.00402 (1.00) |
0.0114 (1.00) |
0.000733 (0.56) |
CTCF | 18 (2%) | 753 |
0.0265 (1.00) |
0.32 (1.00) |
0.00297 (1.00) |
0.00459 (1.00) |
0.0682 (1.00) |
0.369 (1.00) |
0.000386 (0.298) |
0.0891 (1.00) |
0.2 (1.00) |
0.0621 (1.00) |
0.778 (1.00) |
0.532 (1.00) |
AKD1 | 19 (2%) | 752 |
0.926 (1.00) |
0.437 (1.00) |
0.112 (1.00) |
0.176 (1.00) |
0.467 (1.00) |
0.242 (1.00) |
0.415 (1.00) |
0.305 (1.00) |
0.322 (1.00) |
0.0662 (1.00) |
0.114 (1.00) |
0.201 (1.00) |
RB1 | 14 (2%) | 757 |
0.523 (1.00) |
0.172 (1.00) |
0.158 (1.00) |
0.171 (1.00) |
0.483 (1.00) |
0.762 (1.00) |
0.339 (1.00) |
0.231 (1.00) |
0.061 (1.00) |
0.00347 (1.00) |
0.137 (1.00) |
0.137 (1.00) |
PHLDA1 | 9 (1%) | 762 |
0.321 (1.00) |
0.275 (1.00) |
0.395 (1.00) |
0.61 (1.00) |
1 (1.00) |
0.28 (1.00) |
0.89 (1.00) |
0.894 (1.00) |
0.331 (1.00) |
0.436 (1.00) |
0.256 (1.00) |
0.548 (1.00) |
FOXA1 | 15 (2%) | 756 |
0.736 (1.00) |
0.116 (1.00) |
0.175 (1.00) |
0.0334 (1.00) |
1 (1.00) |
0.517 (1.00) |
0.636 (1.00) |
0.167 (1.00) |
0.359 (1.00) |
0.229 (1.00) |
0.456 (1.00) |
0.6 (1.00) |
VEZF1 | 8 (1%) | 763 |
0.48 (1.00) |
0.509 (1.00) |
0.183 (1.00) |
0.88 (1.00) |
0.902 (1.00) |
0.605 (1.00) |
1 (1.00) |
0.904 (1.00) |
||||
ZFP36L1 | 10 (1%) | 761 |
0.839 (1.00) |
0.686 (1.00) |
0.0118 (1.00) |
0.164 (1.00) |
0.0258 (1.00) |
0.392 (1.00) |
0.884 (1.00) |
0.831 (1.00) |
0.841 (1.00) |
0.393 (1.00) |
0.695 (1.00) |
0.126 (1.00) |
NCOR1 | 31 (4%) | 740 |
0.488 (1.00) |
0.33 (1.00) |
0.266 (1.00) |
0.412 (1.00) |
0.723 (1.00) |
0.726 (1.00) |
0.799 (1.00) |
0.484 (1.00) |
0.0941 (1.00) |
0.41 (1.00) |
0.593 (1.00) |
0.455 (1.00) |
TBX3 | 18 (2%) | 753 |
0.612 (1.00) |
0.345 (1.00) |
0.602 (1.00) |
0.0562 (1.00) |
0.16 (1.00) |
0.551 (1.00) |
0.184 (1.00) |
0.444 (1.00) |
0.489 (1.00) |
0.485 (1.00) |
0.651 (1.00) |
1 (1.00) |
DSPP | 26 (3%) | 745 |
0.945 (1.00) |
0.416 (1.00) |
0.647 (1.00) |
0.792 (1.00) |
0.0987 (1.00) |
0.387 (1.00) |
0.703 (1.00) |
0.053 (1.00) |
0.488 (1.00) |
0.311 (1.00) |
0.132 (1.00) |
0.607 (1.00) |
AQP7 | 8 (1%) | 763 |
0.638 (1.00) |
0.0682 (1.00) |
0.0396 (1.00) |
0.662 (1.00) |
0.768 (1.00) |
0.347 (1.00) |
0.474 (1.00) |
0.632 (1.00) |
0.612 (1.00) |
0.412 (1.00) |
||
BCL6B | 8 (1%) | 763 |
0.476 (1.00) |
0.692 (1.00) |
0.304 (1.00) |
1 (1.00) |
0.809 (1.00) |
0.899 (1.00) |
0.49 (1.00) |
0.537 (1.00) |
||||
RPGR | 14 (2%) | 757 |
0.605 (1.00) |
0.392 (1.00) |
0.995 (1.00) |
0.628 (1.00) |
0.745 (1.00) |
0.606 (1.00) |
0.332 (1.00) |
0.51 (1.00) |
0.725 (1.00) |
0.283 (1.00) |
0.902 (1.00) |
0.501 (1.00) |
TBL1XR1 | 9 (1%) | 762 |
0.109 (1.00) |
0.295 (1.00) |
0.0611 (1.00) |
0.455 (1.00) |
0.569 (1.00) |
0.0215 (1.00) |
0.2 (1.00) |
0.0794 (1.00) |
0.482 (1.00) |
0.869 (1.00) |
0.229 (1.00) |
|
MYB | 11 (1%) | 760 |
0.786 (1.00) |
1 (1.00) |
0.086 (1.00) |
0.421 (1.00) |
1 (1.00) |
0.69 (1.00) |
0.758 (1.00) |
0.656 (1.00) |
0.787 (1.00) |
0.687 (1.00) |
0.278 (1.00) |
1 (1.00) |
PABPC3 | 8 (1%) | 763 |
0.163 (1.00) |
0.801 (1.00) |
0.703 (1.00) |
0.73 (1.00) |
0.888 (1.00) |
0.395 (1.00) |
0.641 (1.00) |
0.899 (1.00) |
1 (1.00) |
1 (1.00) |
||
GPS2 | 6 (1%) | 765 |
0.00768 (1.00) |
0.0284 (1.00) |
0.147 (1.00) |
0.293 (1.00) |
1 (1.00) |
1 (1.00) |
0.604 (1.00) |
0.184 (1.00) |
0.752 (1.00) |
1 (1.00) |
||
E2F4 | 4 (1%) | 767 |
0.932 (1.00) |
0.896 (1.00) |
0.817 (1.00) |
0.817 (1.00) |
0.491 (1.00) |
|||||||
DNAH12 | 12 (2%) | 759 |
0.967 (1.00) |
0.266 (1.00) |
0.836 (1.00) |
0.672 (1.00) |
0.689 (1.00) |
0.69 (1.00) |
0.302 (1.00) |
0.532 (1.00) |
0.863 (1.00) |
1 (1.00) |
1 (1.00) |
0.52 (1.00) |
CDKN1B | 7 (1%) | 764 |
0.358 (1.00) |
0.11 (1.00) |
0.00229 (1.00) |
0.0428 (1.00) |
0.331 (1.00) |
0.392 (1.00) |
0.114 (1.00) |
0.306 (1.00) |
0.363 (1.00) |
0.368 (1.00) |
0.453 (1.00) |
0.215 (1.00) |
HNF1A | 9 (1%) | 762 |
0.0661 (1.00) |
0.622 (1.00) |
0.076 (1.00) |
0.0353 (1.00) |
0.406 (1.00) |
0.0699 (1.00) |
0.471 (1.00) |
0.28 (1.00) |
||||
CRIPAK | 6 (1%) | 765 |
0.821 (1.00) |
0.113 (1.00) |
0.285 (1.00) |
0.184 (1.00) |
0.258 (1.00) |
0.569 (1.00) |
0.869 (1.00) |
0.73 (1.00) |
||||
CASP8 | 10 (1%) | 761 |
0.355 (1.00) |
0.197 (1.00) |
0.919 (1.00) |
0.561 (1.00) |
0.402 (1.00) |
1 (1.00) |
0.231 (1.00) |
0.737 (1.00) |
0.772 (1.00) |
0.166 (1.00) |
0.0985 (1.00) |
0.388 (1.00) |
STXBP2 | 9 (1%) | 762 |
0.905 (1.00) |
0.819 (1.00) |
0.876 (1.00) |
0.48 (1.00) |
0.406 (1.00) |
0.917 (1.00) |
0.902 (1.00) |
0.749 (1.00) |
||||
CTU2 | 5 (1%) | 766 |
0.203 (1.00) |
0.542 (1.00) |
0.743 (1.00) |
0.605 (1.00) |
0.847 (1.00) |
0.07 (1.00) |
0.449 (1.00) |
0.213 (1.00) |
||||
CCDC66 | 9 (1%) | 762 |
0.368 (1.00) |
0.197 (1.00) |
0.675 (1.00) |
0.675 (1.00) |
0.0682 (1.00) |
0.157 (1.00) |
0.091 (1.00) |
0.482 (1.00) |
0.484 (1.00) |
0.125 (1.00) |
||
HIST1H3B | 7 (1%) | 764 |
0.383 (1.00) |
1 (1.00) |
0.554 (1.00) |
0.623 (1.00) |
1 (1.00) |
0.827 (1.00) |
0.339 (1.00) |
0.401 (1.00) |
0.474 (1.00) |
0.43 (1.00) |
0.605 (1.00) |
0.0788 (1.00) |
SLC25A5 | 3 (0%) | 768 |
0.329 (1.00) |
0.71 (1.00) |
0.78 (1.00) |
0.354 (1.00) |
0.456 (1.00) |
0.23 (1.00) |
||||||
SELPLG | 7 (1%) | 764 |
0.0783 (1.00) |
0.00372 (1.00) |
0.108 (1.00) |
0.0801 (1.00) |
0.474 (1.00) |
0.304 (1.00) |
1 (1.00) |
0.092 (1.00) |
||||
KRTAP9-9 | 6 (1%) | 765 |
0.249 (1.00) |
0.253 (1.00) |
0.141 (1.00) |
1 (1.00) |
0.298 (1.00) |
0.256 (1.00) |
0.256 (1.00) |
0.156 (1.00) |
||||
KRTAP4-5 | 4 (1%) | 767 |
0.478 (1.00) |
0.251 (1.00) |
0.26 (1.00) |
0.0534 (1.00) |
0.0797 (1.00) |
0.814 (1.00) |
0.154 (1.00) |
0.852 (1.00) |
||||
SF3B1 | 14 (2%) | 757 |
0.629 (1.00) |
0.0949 (1.00) |
0.347 (1.00) |
0.24 (1.00) |
0.253 (1.00) |
0.00499 (1.00) |
0.186 (1.00) |
0.0216 (1.00) |
0.0194 (1.00) |
0.185 (1.00) |
0.369 (1.00) |
0.133 (1.00) |
HLA-A | 4 (1%) | 767 |
0.816 (1.00) |
0.543 (1.00) |
0.339 (1.00) |
1 (1.00) |
0.827 (1.00) |
0.0167 (1.00) |
0.315 (1.00) |
0.671 (1.00) |
0.293 (1.00) |
|||
FGFR2 | 7 (1%) | 764 |
0.602 (1.00) |
0.543 (1.00) |
0.857 (1.00) |
0.188 (1.00) |
1 (1.00) |
0.827 (1.00) |
0.302 (1.00) |
0.515 (1.00) |
0.785 (1.00) |
1 (1.00) |
0.0746 (1.00) |
0.0111 (1.00) |
SHROOM4 | 11 (1%) | 760 |
0.432 (1.00) |
0.182 (1.00) |
0.0315 (1.00) |
0.562 (1.00) |
0.402 (1.00) |
0.633 (1.00) |
0.362 (1.00) |
0.269 (1.00) |
0.618 (1.00) |
0.925 (1.00) |
0.386 (1.00) |
0.904 (1.00) |
MED12 | 20 (3%) | 751 |
0.603 (1.00) |
0.326 (1.00) |
0.304 (1.00) |
0.623 (1.00) |
0.455 (1.00) |
0.803 (1.00) |
0.452 (1.00) |
0.95 (1.00) |
0.835 (1.00) |
0.647 (1.00) |
0.335 (1.00) |
0.0946 (1.00) |
DENND4B | 8 (1%) | 763 |
0.148 (1.00) |
0.0156 (1.00) |
0.0749 (1.00) |
0.631 (1.00) |
0.467 (1.00) |
0.239 (1.00) |
0.587 (1.00) |
0.192 (1.00) |
||||
ODF1 | 5 (1%) | 766 |
0.932 (1.00) |
0.501 (1.00) |
0.454 (1.00) |
0.517 (1.00) |
0.671 (1.00) |
0.491 (1.00) |
0.695 (1.00) |
0.806 (1.00) |
||||
AXL | 6 (1%) | 765 |
0.266 (1.00) |
0.33 (1.00) |
0.887 (1.00) |
0.251 (1.00) |
0.752 (1.00) |
0.384 (1.00) |
1 (1.00) |
0.511 (1.00) |
||||
RPL18 | 4 (1%) | 767 |
0.504 (1.00) |
0.241 (1.00) |
0.119 (1.00) |
0.0917 (1.00) |
0.542 (1.00) |
0.121 (1.00) |
0.456 (1.00) |
0.615 (1.00) |
||||
RAI1 | 7 (1%) | 764 |
0.269 (1.00) |
0.875 (1.00) |
1 (1.00) |
0.782 (1.00) |
0.748 (1.00) |
0.515 (1.00) |
0.474 (1.00) |
0.797 (1.00) |
0.869 (1.00) |
0.6 (1.00) |
||
ERBB2 | 12 (2%) | 759 |
0.287 (1.00) |
0.891 (1.00) |
0.121 (1.00) |
0.0121 (1.00) |
0.451 (1.00) |
0.773 (1.00) |
0.746 (1.00) |
0.294 (1.00) |
0.269 (1.00) |
0.0665 (1.00) |
0.471 (1.00) |
0.402 (1.00) |
KRT38 | 4 (1%) | 767 |
0.602 (1.00) |
0.812 (1.00) |
0.288 (1.00) |
0.786 (1.00) |
0.402 (1.00) |
0.633 (1.00) |
0.633 (1.00) |
0.817 (1.00) |
0.817 (1.00) |
1 (1.00) |
||
TICAM1 | 5 (1%) | 766 |
0.774 (1.00) |
0.869 (1.00) |
0.977 (1.00) |
0.605 (1.00) |
1 (1.00) |
0.606 (1.00) |
1 (1.00) |
0.608 (1.00) |
||||
ASXL2 | 8 (1%) | 763 |
0.36 (1.00) |
0.214 (1.00) |
0.799 (1.00) |
0.431 (1.00) |
0.749 (1.00) |
0.305 (1.00) |
0.531 (1.00) |
0.336 (1.00) |
1 (1.00) |
0.468 (1.00) |
||
ASPHD1 | 3 (0%) | 768 |
0.711 (1.00) |
0.886 (1.00) |
0.661 (1.00) |
0.591 (1.00) |
1 (1.00) |
0.626 (1.00) |
1 (1.00) |
1 (1.00) |
||||
FAM171B | 8 (1%) | 763 |
0.925 (1.00) |
0.291 (1.00) |
0.941 (1.00) |
0.047 (1.00) |
0.193 (1.00) |
0.00277 (1.00) |
0.318 (1.00) |
0.0997 (1.00) |
0.0322 (1.00) |
0.188 (1.00) |
||
MUC20 | 10 (1%) | 761 |
0.105 (1.00) |
0.147 (1.00) |
0.000539 (0.414) |
0.193 (1.00) |
0.135 (1.00) |
0.0893 (1.00) |
0.342 (1.00) |
0.109 (1.00) |
||||
PPEF1 | 8 (1%) | 763 |
0.853 (1.00) |
1 (1.00) |
0.354 (1.00) |
0.183 (1.00) |
1 (1.00) |
1 (1.00) |
0.662 (1.00) |
0.711 (1.00) |
0.255 (1.00) |
0.385 (1.00) |
0.203 (1.00) |
0.241 (1.00) |
PRRX1 | 6 (1%) | 765 |
0.577 (1.00) |
0.522 (1.00) |
0.0472 (1.00) |
0.0567 (1.00) |
0.839 (1.00) |
0.392 (1.00) |
0.559 (1.00) |
0.407 (1.00) |
0.866 (1.00) |
0.433 (1.00) |
0.326 (1.00) |
0.73 (1.00) |
ATP13A4 | 9 (1%) | 762 |
0.602 (1.00) |
0.356 (1.00) |
0.157 (1.00) |
0.33 (1.00) |
0.873 (1.00) |
0.428 (1.00) |
0.826 (1.00) |
0.835 (1.00) |
0.789 (1.00) |
0.67 (1.00) |
||
MUC2 | 18 (2%) | 753 |
0.83 (1.00) |
0.259 (1.00) |
0.325 (1.00) |
0.487 (1.00) |
0.778 (1.00) |
0.881 (1.00) |
0.488 (1.00) |
0.288 (1.00) |
0.951 (1.00) |
1 (1.00) |
1 (1.00) |
0.303 (1.00) |
UBC | 8 (1%) | 763 |
0.336 (1.00) |
1 (1.00) |
0.25 (1.00) |
0.35 (1.00) |
0.556 (1.00) |
0.827 (1.00) |
0.29 (1.00) |
0.894 (1.00) |
0.717 (1.00) |
0.741 (1.00) |
||
KCNN3 | 6 (1%) | 765 |
0.968 (1.00) |
1 (1.00) |
0.504 (1.00) |
0.36 (1.00) |
0.143 (1.00) |
0.635 (1.00) |
0.415 (1.00) |
0.769 (1.00) |
0.456 (1.00) |
0.138 (1.00) |
||
RBM23 | 6 (1%) | 765 |
0.693 (1.00) |
0.404 (1.00) |
0.795 (1.00) |
0.0722 (1.00) |
0.415 (1.00) |
0.0581 (1.00) |
0.695 (1.00) |
0.19 (1.00) |
||||
GNRH2 | 3 (0%) | 768 |
0.319 (1.00) |
0.958 (1.00) |
1 (1.00) |
0.125 (1.00) |
1 (1.00) |
P value = 8.9e-15 (Chi-square test), Q value = 7.3e-12
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 21 | 36 | 118 | 95 | 105 | 74 | 20 | 40 |
PIK3CA MUTATED | 7 | 12 | 24 | 7 | 62 | 25 | 9 | 23 |
PIK3CA WILD-TYPE | 14 | 24 | 94 | 88 | 43 | 49 | 11 | 17 |
P value = 3.88e-10 (Fisher's exact test), Q value = 3.2e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 120 | 125 | 264 |
PIK3CA MUTATED | 61 | 16 | 92 |
PIK3CA WILD-TYPE | 59 | 109 | 172 |
P value = 1.13e-12 (Chi-square test), Q value = 9.2e-10
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 261 | 190 | 58 | 203 | 47 |
PIK3CA MUTATED | 122 | 44 | 36 | 47 | 11 |
PIK3CA WILD-TYPE | 139 | 146 | 22 | 156 | 36 |
P value = 1.67e-09 (Chi-square test), Q value = 1.4e-06
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 81 | 121 | 76 | 102 | 28 | 57 |
PIK3CA MUTATED | 9 | 67 | 30 | 24 | 9 | 19 |
PIK3CA WILD-TYPE | 72 | 54 | 46 | 78 | 19 | 38 |
P value = 1.64e-05 (Fisher's exact test), Q value = 0.013
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 144 | 133 | 119 |
PIK3CA MUTATED | 26 | 53 | 49 |
PIK3CA WILD-TYPE | 118 | 80 | 70 |
P value = 1.06e-06 (Fisher's exact test), Q value = 0.00085
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 157 | 114 | 125 |
PIK3CA MUTATED | 55 | 53 | 20 |
PIK3CA WILD-TYPE | 102 | 61 | 105 |
P value = 5.11e-28 (Chi-square test), Q value = 4.2e-25
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 130 | 55 | 196 | 129 | 199 | 34 | 15 |
PIK3CA MUTATED | 6 | 20 | 115 | 55 | 35 | 18 | 9 |
PIK3CA WILD-TYPE | 124 | 35 | 81 | 74 | 164 | 16 | 6 |
P value = 2.61e-12 (Fisher's exact test), Q value = 2.1e-09
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 188 | 153 | 417 |
PIK3CA MUTATED | 28 | 77 | 153 |
PIK3CA WILD-TYPE | 160 | 76 | 264 |
P value = 8.02e-08 (Fisher's exact test), Q value = 6.5e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 157 | 378 | 221 |
PIK3CA MUTATED | 67 | 149 | 43 |
PIK3CA WILD-TYPE | 90 | 229 | 178 |
P value = 1.49e-11 (Fisher's exact test), Q value = 1.2e-08
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 347 | 205 | 204 |
PIK3CA MUTATED | 110 | 108 | 41 |
PIK3CA WILD-TYPE | 237 | 97 | 163 |
P value = 6.4e-05 (Fisher's exact test), Q value = 0.05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 207 | 103 | 137 |
PIK3CA MUTATED | 81 | 44 | 27 |
PIK3CA WILD-TYPE | 126 | 59 | 110 |
P value = 1.9e-10 (Fisher's exact test), Q value = 1.5e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 47 | 108 | 114 | 178 |
PIK3CA MUTATED | 23 | 25 | 17 | 87 |
PIK3CA WILD-TYPE | 24 | 83 | 97 | 91 |
P value = 1.85e-05 (Chi-square test), Q value = 0.015
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 261 | 190 | 58 | 203 | 47 |
RUNX1 MUTATED | 10 | 4 | 8 | 2 | 0 |
RUNX1 WILD-TYPE | 251 | 186 | 50 | 201 | 47 |
P value = 3.09e-05 (Chi-square test), Q value = 0.024
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 130 | 55 | 196 | 129 | 199 | 34 | 15 |
AKT1 MUTATED | 0 | 0 | 15 | 3 | 1 | 0 | 0 |
AKT1 WILD-TYPE | 130 | 55 | 181 | 126 | 198 | 34 | 15 |
P value = 0.000101 (Fisher's exact test), Q value = 0.079
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 120 | 125 | 264 |
GATA3 MUTATED | 15 | 2 | 37 |
GATA3 WILD-TYPE | 105 | 123 | 227 |
P value = 6.27e-06 (Chi-square test), Q value = 0.005
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 130 | 55 | 196 | 129 | 199 | 34 | 15 |
GATA3 MUTATED | 1 | 8 | 29 | 6 | 34 | 2 | 0 |
GATA3 WILD-TYPE | 129 | 47 | 167 | 123 | 165 | 32 | 15 |
P value = 1.22e-09 (Fisher's exact test), Q value = 9.9e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 188 | 153 | 417 |
GATA3 MUTATED | 1 | 15 | 64 |
GATA3 WILD-TYPE | 187 | 138 | 353 |
P value = 4.04e-07 (Fisher's exact test), Q value = 0.00032
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 157 | 378 | 221 |
GATA3 MUTATED | 17 | 57 | 5 |
GATA3 WILD-TYPE | 140 | 321 | 216 |
P value = 1.27e-06 (Fisher's exact test), Q value = 0.001
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 347 | 205 | 204 |
GATA3 MUTATED | 48 | 27 | 4 |
GATA3 WILD-TYPE | 299 | 178 | 200 |
P value = 3.97e-07 (Fisher's exact test), Q value = 0.00032
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 207 | 103 | 137 |
GATA3 MUTATED | 39 | 15 | 2 |
GATA3 WILD-TYPE | 168 | 88 | 135 |
P value = 1.46e-06 (Fisher's exact test), Q value = 0.0012
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 47 | 108 | 114 | 178 |
GATA3 MUTATED | 4 | 22 | 1 | 29 |
GATA3 WILD-TYPE | 43 | 86 | 113 | 149 |
P value = 7.08e-37 (Chi-square test), Q value = 5.8e-34
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 21 | 36 | 118 | 95 | 105 | 74 | 20 | 40 |
TP53 MUTATED | 6 | 6 | 23 | 77 | 6 | 50 | 10 | 6 |
TP53 WILD-TYPE | 15 | 30 | 95 | 18 | 99 | 24 | 10 | 34 |
P value = 2.43e-33 (Fisher's exact test), Q value = 2e-30
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 120 | 125 | 264 |
TP53 MUTATED | 16 | 101 | 67 |
TP53 WILD-TYPE | 104 | 24 | 197 |
P value = 3.53e-49 (Chi-square test), Q value = 2.9e-46
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 261 | 190 | 58 | 203 | 47 |
TP53 MUTATED | 32 | 48 | 8 | 154 | 13 |
TP53 WILD-TYPE | 229 | 142 | 50 | 49 | 34 |
P value = 6.18e-23 (Chi-square test), Q value = 5.1e-20
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 81 | 121 | 76 | 102 | 28 | 57 |
TP53 MUTATED | 63 | 11 | 27 | 24 | 5 | 18 |
TP53 WILD-TYPE | 18 | 110 | 49 | 78 | 23 | 39 |
P value = 1.87e-27 (Fisher's exact test), Q value = 1.5e-24
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 144 | 133 | 119 |
TP53 MUTATED | 102 | 12 | 38 |
TP53 WILD-TYPE | 42 | 121 | 81 |
P value = 1.1e-23 (Fisher's exact test), Q value = 9e-21
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 157 | 114 | 125 |
TP53 MUTATED | 35 | 23 | 94 |
TP53 WILD-TYPE | 122 | 91 | 31 |
P value = 4.17e-55 (Chi-square test), Q value = 3.5e-52
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 130 | 55 | 196 | 129 | 199 | 34 | 15 |
TP53 MUTATED | 102 | 8 | 14 | 81 | 34 | 6 | 8 |
TP53 WILD-TYPE | 28 | 47 | 182 | 48 | 165 | 28 | 7 |
P value = 4.18e-48 (Fisher's exact test), Q value = 3.5e-45
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 188 | 153 | 417 |
TP53 MUTATED | 146 | 22 | 85 |
TP53 WILD-TYPE | 42 | 131 | 332 |
P value = 7.46e-39 (Fisher's exact test), Q value = 6.2e-36
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 157 | 378 | 221 |
TP53 MUTATED | 34 | 65 | 152 |
TP53 WILD-TYPE | 123 | 313 | 69 |
P value = 2.32e-44 (Fisher's exact test), Q value = 1.9e-41
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 347 | 205 | 204 |
TP53 MUTATED | 75 | 27 | 149 |
TP53 WILD-TYPE | 272 | 178 | 55 |
P value = 1.47e-30 (Fisher's exact test), Q value = 1.2e-27
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 207 | 103 | 137 |
TP53 MUTATED | 35 | 12 | 98 |
TP53 WILD-TYPE | 172 | 91 | 39 |
P value = 4.95e-24 (Fisher's exact test), Q value = 4.1e-21
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 47 | 108 | 114 | 178 |
TP53 MUTATED | 13 | 25 | 82 | 25 |
TP53 WILD-TYPE | 34 | 83 | 32 | 153 |
P value = 1.67e-07 (Chi-square test), Q value = 0.00013
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 21 | 36 | 118 | 95 | 105 | 74 | 20 | 40 |
CDH1 MUTATED | 0 | 5 | 1 | 0 | 12 | 4 | 1 | 10 |
CDH1 WILD-TYPE | 21 | 31 | 117 | 95 | 93 | 70 | 19 | 30 |
P value = 8.2e-05 (Fisher's exact test), Q value = 0.064
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 120 | 125 | 264 |
CDH1 MUTATED | 18 | 2 | 13 |
CDH1 WILD-TYPE | 102 | 123 | 251 |
P value = 2.42e-08 (Chi-square test), Q value = 2e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 261 | 190 | 58 | 203 | 47 |
CDH1 MUTATED | 26 | 9 | 14 | 2 | 4 |
CDH1 WILD-TYPE | 235 | 181 | 44 | 201 | 43 |
P value = 0.000255 (Fisher's exact test), Q value = 0.2
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 144 | 133 | 119 |
CDH1 MUTATED | 3 | 4 | 16 |
CDH1 WILD-TYPE | 141 | 129 | 103 |
P value = 1.29e-06 (Chi-square test), Q value = 0.001
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 130 | 55 | 196 | 129 | 199 | 34 | 15 |
CDH1 MUTATED | 0 | 11 | 23 | 7 | 7 | 5 | 2 |
CDH1 WILD-TYPE | 130 | 44 | 173 | 122 | 192 | 29 | 13 |
P value = 4.23e-07 (Fisher's exact test), Q value = 0.00034
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 188 | 153 | 417 |
CDH1 MUTATED | 3 | 26 | 26 |
CDH1 WILD-TYPE | 185 | 127 | 391 |
P value = 1.67e-06 (Fisher's exact test), Q value = 0.0013
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 157 | 378 | 221 |
CDH1 MUTATED | 23 | 27 | 3 |
CDH1 WILD-TYPE | 134 | 351 | 218 |
P value = 5.92e-08 (Fisher's exact test), Q value = 4.8e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 347 | 205 | 204 |
CDH1 MUTATED | 18 | 32 | 3 |
CDH1 WILD-TYPE | 329 | 173 | 201 |
P value = 0.000244 (Fisher's exact test), Q value = 0.19
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 207 | 103 | 137 |
CDH1 MUTATED | 13 | 15 | 2 |
CDH1 WILD-TYPE | 194 | 88 | 135 |
P value = 0.000313 (Fisher's exact test), Q value = 0.24
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 188 | 153 | 417 |
MAP2K4 MUTATED | 0 | 6 | 25 |
MAP2K4 WILD-TYPE | 188 | 147 | 392 |
P value = 4.33e-06 (Chi-square test), Q value = 0.0034
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 21 | 36 | 118 | 95 | 105 | 74 | 20 | 40 |
MAP3K1 MUTATED | 6 | 1 | 11 | 0 | 16 | 1 | 0 | 4 |
MAP3K1 WILD-TYPE | 15 | 35 | 107 | 95 | 89 | 73 | 20 | 36 |
P value = 4.38e-05 (Fisher's exact test), Q value = 0.034
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 120 | 125 | 264 |
MAP3K1 MUTATED | 13 | 0 | 26 |
MAP3K1 WILD-TYPE | 107 | 125 | 238 |
P value = 7.22e-05 (Chi-square test), Q value = 0.057
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 261 | 190 | 58 | 203 | 47 |
MAP3K1 MUTATED | 34 | 7 | 6 | 5 | 5 |
MAP3K1 WILD-TYPE | 227 | 183 | 52 | 198 | 42 |
P value = 0.000204 (Fisher's exact test), Q value = 0.16
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 144 | 133 | 119 |
MAP3K1 MUTATED | 3 | 20 | 13 |
MAP3K1 WILD-TYPE | 141 | 113 | 106 |
P value = 1.99e-06 (Fisher's exact test), Q value = 0.0016
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 157 | 114 | 125 |
MAP3K1 MUTATED | 20 | 16 | 0 |
MAP3K1 WILD-TYPE | 137 | 98 | 125 |
P value = 1.08e-05 (Chi-square test), Q value = 0.0085
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 130 | 55 | 196 | 129 | 199 | 34 | 15 |
MAP3K1 MUTATED | 0 | 4 | 30 | 4 | 17 | 2 | 0 |
MAP3K1 WILD-TYPE | 130 | 51 | 166 | 125 | 182 | 32 | 15 |
P value = 7.51e-05 (Fisher's exact test), Q value = 0.059
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 188 | 153 | 417 |
MAP3K1 MUTATED | 3 | 9 | 45 |
MAP3K1 WILD-TYPE | 185 | 144 | 372 |
P value = 1.96e-05 (Fisher's exact test), Q value = 0.015
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 157 | 378 | 221 |
MAP3K1 MUTATED | 15 | 39 | 3 |
MAP3K1 WILD-TYPE | 142 | 339 | 218 |
P value = 4.16e-05 (Fisher's exact test), Q value = 0.033
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 347 | 205 | 204 |
MAP3K1 MUTATED | 30 | 24 | 3 |
MAP3K1 WILD-TYPE | 317 | 181 | 201 |
P value = 0.00023 (Fisher's exact test), Q value = 0.18
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 207 | 103 | 137 |
MAP3K1 MUTATED | 19 | 12 | 1 |
MAP3K1 WILD-TYPE | 188 | 91 | 136 |
P value = 6.29e-06 (Chi-square test), Q value = 0.005
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 261 | 190 | 58 | 203 | 47 |
CCDC144NL MUTATED | 1 | 3 | 0 | 0 | 4 |
CCDC144NL WILD-TYPE | 260 | 187 | 58 | 203 | 43 |
P value = 1.02e-05 (Chi-square test), Q value = 0.0081
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 261 | 190 | 58 | 203 | 47 |
TTN MUTATED | 27 | 29 | 3 | 53 | 5 |
TTN WILD-TYPE | 234 | 161 | 55 | 150 | 42 |
P value = 6.23e-05 (Fisher's exact test), Q value = 0.049
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 144 | 133 | 119 |
TTN MUTATED | 38 | 10 | 15 |
TTN WILD-TYPE | 106 | 123 | 104 |
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Mutation data file = BRCA-TP.mutsig.cluster.txt
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Molecular subtypes file = BRCA-TP.transferedmergedcluster.txt
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Number of patients = 771
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Number of significantly mutated genes = 81
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Number of Molecular subtypes = 12
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Exclude genes that fewer than K tumors have mutations, K = 3
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.