rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(19), AKT2(3), AKT3(4), CASP8(10), CD14(2), CD40(1), CD86(2), CHUK(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IKBKB(4), IKBKE(2), IL12A(1), IL12B(1), IL6(2), IRAK1(2), IRAK4(3), IRF3(3), IRF5(1), IRF7(1), JUN(3), LBP(1), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAP3K7(1), MAP3K8(2), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NFKB1(4), NFKB2(3), NFKBIA(1), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), RELA(1), RIPK1(3), SPP1(2), STAT1(1), TBK1(1), TICAM1(5), TIRAP(1), TLR1(1), TLR2(1), TLR3(5), TLR4(13), TLR5(2), TLR7(8), TLR8(3), TLR9(1), TRAF3(2), TRAF6(3)	97377478	517	400	253	42	27	160	56	187	85	2	<1.00e-15	<1.00e-15	<1.76e-14
2	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(5), ABL2(4), AKT1(19), AKT2(3), AKT3(4), ARAF(4), AREG(1), BRAF(3), BTC(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CBL(4), CBLB(10), CBLC(2), CDKN1B(7), CRK(1), CRKL(1), EGF(3), EGFR(5), ELK1(2), ERBB2(12), ERBB3(11), ERBB4(6), GAB1(2), GRB2(1), JUN(3), KRAS(6), MAP2K1(1), MAP2K2(1), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), MYC(1), NCK1(1), NCK2(1), NRAS(1), NRG1(2), NRG3(4), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PLCG1(6), PLCG2(3), PRKCG(2), PTK2(5), RAF1(1), RPS6KB1(2), RPS6KB2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(4), STAT5A(4), STAT5B(5), TGFA(1)	112604599	557	393	289	53	39	160	78	197	83	0	<1.00e-15	<1.00e-15	<1.76e-14
3	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(2), CD36(1), CITED2(2), CPT1B(2), CREBBP(7), EHHADH(3), EP300(7), FABP1(1), HSD17B4(6), JUN(3), LPL(1), MAPK1(1), MAPK3(1), MRPL11(1), MYC(1), NCOA1(2), NCOR1(31), NCOR2(29), NFKBIA(1), NR0B2(2), NR2F1(1), NRIP1(3), PIK3CA(287), PIK3R1(21), PPARA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTGS2(2), RB1(16), RELA(1), RXRA(1), SP1(3), SRA1(1), STAT5A(4), STAT5B(5)	68924350	458	361	195	30	20	120	40	172	105	1	<1.00e-15	<1.00e-15	<1.76e-14
4	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(3), BAK1(2), BAX(2), BID(4), BIRC3(1), CASP2(3), CASP6(2), CASP7(1), CASP8(10), CASP9(1), FAS(1), FASLG(2), JUN(3), MAP2K4(32), MAP3K1(69), MAPK10(2), MCL1(1), MDM2(2), MYC(1), NFKB1(4), NFKBIA(1), PARP1(3), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TP53(261), TRAF1(1)	40657541	419	357	294	14	51	46	53	78	175	16	<1.00e-15	<1.00e-15	<1.76e-14
5	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(19), BCR(3), CRKL(1), GRB2(1), JAK2(5), JUN(3), MAP2K1(1), MAP2K4(32), MAP3K1(69), MAPK3(1), MAPK8(2), MYC(1), PIK3CA(287), PIK3R1(21), RAF1(1), SOS1(4), STAT1(1), STAT5A(4), STAT5B(5)	30563652	461	355	197	16	15	129	31	173	97	16	<1.00e-15	<1.00e-15	<1.76e-14
6	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3E(2), CD3G(2), ELK1(2), GRB2(1), JUN(3), LAT(1), LCK(1), MAP2K1(1), MAP2K4(32), MAP3K1(69), MAPK3(1), MAPK8(2), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKBIA(1), PIK3CA(287), PIK3R1(21), PLCG1(6), PPP3CA(4), PPP3CB(3), PTPN7(2), RAF1(1), RASA1(2), RELA(1), SHC1(1), SOS1(4), VAV1(4), ZAP70(2)	52467488	471	355	224	29	20	123	40	176	96	16	<1.00e-15	<1.00e-15	<1.76e-14
7	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(19), AKT2(3), AKT3(4), CASP9(1), KDR(2), KRAS(6), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NOS3(3), NRAS(1), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(6), PLCG2(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKCG(2), PTGS2(2), PTK2(5), RAF1(1), SH2D2A(1), SHC2(1), SPHK2(2)	77057103	434	354	175	44	18	150	48	173	45	0	<1.00e-15	<1.00e-15	<1.76e-14
8	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(19), AKT2(3), AKT3(4), BCR(3), BLNK(1), BTK(4), CD19(3), CD22(1), CR2(4), DAG1(1), FLOT1(1), FLOT2(2), GRB2(1), GSK3A(3), INPP5D(4), ITPR1(10), ITPR2(7), ITPR3(6), LYN(4), MAP4K1(4), MAPK1(1), MAPK3(1), NFATC2(2), NR0B2(2), PDK1(1), PIK3CA(287), PIK3CD(4), PIK3R1(21), PLCG2(3), PPP1R13B(3), PPP3CA(4), PPP3CB(3), PTPRC(3), RAF1(1), SHC1(1), SOS1(4), SOS2(4), SYK(2), VAV1(4)	80779691	436	353	180	38	23	147	45	179	42	0	<1.00e-15	<1.00e-15	<1.76e-14
9	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(19), AKT2(3), AKT3(4), BRAF(3), EIF4B(1), FIGF(2), HIF1A(1), IGF1(1), MAPK1(1), MAPK3(1), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PRKAA1(1), PRKAA2(3), RHEB(1), RICTOR(3), RPS6(2), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA6(3), RPS6KB1(2), RPS6KB2(4), STK11(2), TSC1(4), TSC2(2), ULK1(1), ULK2(4), ULK3(2)	57150754	403	341	147	27	17	142	31	172	41	0	<1.00e-15	<1.00e-15	<1.76e-14
10	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5(1), CHN1(3), LIMK1(4), MAP3K1(69), MYLK(8), NCF2(4), PAK1(2), PDGFRA(3), PIK3CA(287), PIK3R1(21), PLD1(5), PPP1R12B(1), RALBP1(1), RPS6KB1(2), TRIO(5), VAV1(4), WASF1(5)	39907968	425	336	182	27	10	119	35	175	70	16	<1.00e-15	<1.00e-15	<1.76e-14
11	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(2), AKT1(19), AKT2(3), AKT3(4), BTK(4), GRB2(1), GSK3A(3), IARS(7), INPP5D(4), PDK1(1), PIK3CA(287), PPP1R13B(3), PTEN(29), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SHC1(1), SOS1(4), SOS2(4), TEC(2), YWHAB(1), YWHAG(1), YWHAZ(1)	40211449	393	336	135	16	21	129	32	167	43	1	<1.00e-15	<1.00e-15	<1.76e-14
12	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(19), EIF4A2(6), EIF4B(1), EIF4G1(2), EIF4G2(2), EIF4G3(4), PDK2(2), PIK3CA(287), PIK3R1(21), PPP2CA(2), PTEN(29), RPS6(2), RPS6KB1(2), TSC1(4), TSC2(2)	30835831	385	334	126	11	10	131	24	165	54	1	<1.00e-15	<1.00e-15	<1.76e-14
13	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(19), BCAR1(2), CDKN1B(7), GRB2(1), ILK(2), ITGB1(3), MAPK1(1), MAPK3(1), PDK2(2), PIK3CA(287), PIK3R1(21), PTEN(29), PTK2(5), SHC1(1), SOS1(4)	21125363	385	334	125	11	9	128	21	166	60	1	<1.00e-15	<1.00e-15	<1.76e-14
14	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(19), AKT2(3), AKT3(4), GRB2(1), GSK3A(3), IL4R(4), IRS1(2), JAK1(4), JAK3(5), MAP4K1(4), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(287), PIK3CD(4), PIK3R1(21), PPP1R13B(3), RAF1(1), SHC1(1), SOS1(4), SOS2(4), STAT6(2)	38164816	379	326	123	20	15	131	27	167	39	0	<1.00e-15	<1.00e-15	<1.76e-14
15	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(3), AKT1(19), CAMK2A(2), CAMK2D(4), CAMK2G(1), CREB1(1), GNAS(5), GRB2(1), MAPK1(1), MAPK14(2), MAPK3(1), PIK3CA(287), PIK3R1(21), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RPS6KA1(2), RPS6KA5(4), SOS1(4)	31859914	365	323	109	19	13	131	20	165	36	0	<1.00e-15	<1.00e-15	<1.76e-14
16	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(19), CREB1(1), GRB2(1), MAPK1(1), MAPK3(1), MEF2A(14), MEF2B(1), MEF2C(3), MEF2D(2), NTRK1(4), PIK3CA(287), PIK3R1(21), PLCG1(6), RPS6KA1(2), SHC1(1)	21567933	364	321	97	15	13	124	19	162	46	0	<1.00e-15	<1.00e-15	<1.76e-14
17	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(19), APC(5), AXIN1(1), CCND1(1), CD14(2), CTNNB1(1), DVL1(2), FZD1(1), GJA1(2), GNAI1(1), IRAK1(2), LBP(1), NFKB1(4), PIK3CA(287), PIK3R1(21), PPP2CA(2), RELA(1), TIRAP(1), TLR4(13)	32595702	367	320	110	19	10	130	22	171	34	0	<1.00e-15	<1.00e-15	<1.76e-14
18	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(19), CBL(4), CRKL(1), E2F1(4), GRB2(1), IL2RB(1), IL2RG(1), IRS1(2), JAK1(4), JAK3(5), MAPK1(1), MAPK3(1), MYC(1), PIK3CA(287), PIK3R1(21), RAF1(1), RPS6KB1(2), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5), SYK(2)	38738723	372	320	116	25	13	130	25	166	38	0	<1.00e-15	<1.00e-15	<1.76e-14
19	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(3), AKT1(19), BAX(2), CSF2RB(3), IGF1(1), IGF1R(2), IL3RA(2), KIT(5), KITLG(3), PIK3CA(287), PIK3R1(21), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	24130253	355	314	98	15	9	128	22	161	35	0	<1.00e-15	<1.00e-15	<1.76e-14
20	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), AKT1(19), ANXA1(1), GNAS(5), GNB1(1), NFKB1(4), NOS3(3), NPPA(1), NR3C1(2), PIK3CA(287), PIK3R1(21), RELA(1)	19305687	346	310	90	9	9	127	17	161	32	0	<1.00e-15	<1.00e-15	<1.76e-14
21	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(19), CASP9(1), CHUK(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(4), PIK3CA(287), PIK3R1(21), RAF1(1), RALBP1(1), RALGDS(1), RELA(1), RHOA(2)	21346534	343	309	87	13	10	126	16	161	30	0	<1.00e-15	<1.00e-15	<1.76e-14
22	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(1), GHR(2), GRB2(1), INSR(4), IRS1(2), JAK2(5), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(287), PIK3R1(21), PLCG1(6), RAF1(1), RPS6KA1(2), SHC1(1), SLC2A4(1), SOS1(4), SRF(1), STAT5A(4), STAT5B(5)	36271180	351	306	112	20	15	112	23	162	39	0	<1.00e-15	<1.00e-15	<1.76e-14
23	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(19), GRB2(1), IGF1R(2), IRS1(2), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(287), PIK3R1(21), RAF1(1), SHC1(1), SOS1(4)	20327874	341	306	85	13	7	128	15	160	31	0	<1.00e-15	<1.00e-15	<1.76e-14
24	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(3), EIF2B1(2), EIF2B2(2), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), ELAVL1(2), FLT1(2), FLT4(1), HIF1A(1), KDR(2), NOS3(3), PIK3CA(287), PIK3R1(21), PLCG1(6), PTK2(5), SHC1(1)	37611320	345	304	106	21	11	113	26	162	33	0	<1.00e-15	<1.00e-15	<1.76e-14
25	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(19), CHRNG(2), MUSK(3), PIK3CA(287), PIK3R1(21), PTK2(5), PTK2B(3)	18112760	340	303	84	12	8	126	19	158	29	0	<1.00e-15	<1.00e-15	<1.76e-14
26	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(18), ATR(6), BRCA1(12), CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(2), CHEK2(3), EP300(7), MDM2(2), MYT1(5), PRKDC(10), RPS6KA1(2), TP53(261), WEE1(2)	49218233	336	298	219	16	45	39	50	76	126	0	<1.00e-15	<1.00e-15	<1.76e-14
27	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(19), AKT2(3), AKT3(4), ELK1(2), GRB2(1), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CA(287), PIK3CD(4), SHC1(1), SOS1(4)	17217995	332	296	77	14	11	123	19	157	22	0	<1.00e-15	<1.00e-15	<1.76e-14
28	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(5), ATM(18), BRCA1(12), CHEK2(3), JUN(3), MAPK8(2), MDM2(2), MRE11A(2), NFKB1(4), NFKBIA(1), RAD50(2), RAD51(2), RBBP8(4), RELA(1), TP53(261), TP73(1)	32808748	323	292	207	8	42	38	47	71	125	0	<1.00e-15	<1.00e-15	<1.76e-14
29	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(2), GRB2(1), IGF1(1), IGF1R(2), IRS1(2), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PIK3CA(287), PIK3R1(21), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1)	26916808	334	292	95	14	10	110	20	159	35	0	<1.00e-15	<1.00e-15	<1.76e-14
30	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), ELK1(2), GRB2(1), INSR(4), IRS1(2), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PIK3CA(287), PIK3R1(21), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SLC2A4(1), SOS1(4), SRF(1)	27715264	336	291	97	16	11	110	20	160	35	0	<1.00e-15	<1.00e-15	<1.76e-14
31	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(3), ATM(18), BAX(2), CCND1(1), CCNE1(1), CDK2(1), CDK4(1), E2F1(4), MDM2(2), RB1(16), TIMP3(1), TP53(261)	20480032	311	291	193	8	41	35	37	70	128	0	<1.00e-15	<1.00e-15	<1.76e-14
32	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(1), ARPC1B(2), ARPC2(2), PAK1(2), PDGFRA(3), PIK3CA(287), PIK3R1(21), WASL(1)	15442304	319	285	80	13	7	108	17	157	30	0	<1.00e-15	<1.00e-15	<1.76e-14
33	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(7), DAXX(2), PAX3(2), PML(1), RARA(2), RB1(16), SIRT1(2), SP100(5), TNFRSF1A(1), TP53(261)	20332854	299	278	182	8	38	33	38	68	122	0	<1.00e-15	<1.00e-15	<1.76e-14
34	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), IFNG(2), IKBKB(4), JAK2(5), NFKB1(4), NFKBIA(1), RB1(16), RELA(1), TNFRSF1A(1), TP53(261), USH1C(5), WT1(2)	19712194	303	277	186	6	40	34	39	66	124	0	<1.00e-15	<1.00e-15	<1.76e-14
35	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(2), CASP2(3), CHUK(1), IKBKB(4), JUN(3), LTA(1), MAP2K3(2), MAP2K4(32), MAP2K6(1), MAP3K1(69), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TANK(2), TNFRSF1A(1)	26087382	134	117	126	6	8	14	19	13	64	16	8.46e-06	<1.00e-15	<1.76e-14
36	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(5), E2F1(4), MDM2(2), MYC(1), PIK3CA(287), PIK3R1(21), POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4), RB1(16), TP53(261)	21722333	611	480	255	16	45	137	49	227	153	0	<1.00e-15	1.22e-15	2.03e-14
37	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(4), MAX(3), MYC(1), SP1(3), SP3(4), TP53(261), WT1(2)	7740759	278	265	162	8	38	30	34	67	109	0	<1.00e-15	1.22e-15	2.03e-14
38	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(19), CABIN1(5), CAMK1(2), CAMK1G(1), HDAC5(3), IGF1(1), IGF1R(2), INSR(4), MAP2K6(1), MAPK14(2), MEF2A(14), MEF2B(1), MEF2C(3), MEF2D(2), NFATC2(2), PIK3CA(287), PIK3R1(21), PPP3CA(4), PPP3CB(3)	37235065	377	325	110	25	8	133	24	166	46	0	<1.00e-15	1.33e-15	2.10e-14
39	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(7), EP300(7), IL2RG(1), IL7R(4), JAK1(4), JAK3(5), LCK(1), PIK3CA(287), PIK3R1(21), PTK2B(3), STAT5A(4), STAT5B(5)	31472946	349	303	109	15	12	109	26	164	38	0	<1.00e-15	1.33e-15	2.10e-14
40	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(19), AKT2(3), AKT3(4), ANGPTL2(1), ARHGAP4(1), ARHGEF11(3), BTK(4), GDI1(4), INPPL1(4), ITPR1(10), ITPR2(7), ITPR3(6), LIMK1(4), MYLK(8), MYLK2(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PDK1(1), PIK3CA(287), PIK3CD(4), PIK3CG(3), PIK3R1(21), PITX2(3), PPP1R13B(3), PTEN(29), RHO(4), ROCK1(4), ROCK2(4), RPS4X(2), SAG(1), WASF1(5), WASL(1)	78418068	462	367	203	41	24	143	46	182	66	1	<1.00e-15	1.44e-15	2.13e-14
41	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(19), AKT2(3), AKT3(4), CDK2(1), CDKN1B(7), CREB1(1), CREB3(1), CREB5(1), EBP(1), ERBB4(6), F2RL2(1), GAB1(2), GRB2(1), GSK3A(3), IFI27(2), IGF1(1), INPPL1(4), IRS1(2), IRS4(6), MET(7), MYC(1), NOLC1(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PARD3(4), PDK1(1), PIK3CA(287), PIK3CD(4), PPP1R13B(3), PREX1(10), PTEN(29), PTK2(5), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SHC1(1), SLC2A4(1), SOS1(4), SOS2(4), TSC1(4), TSC2(2), YWHAB(1), YWHAG(1), YWHAZ(1)	82302068	460	366	200	39	29	142	52	175	61	1	<1.00e-15	1.55e-15	2.13e-14
42	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(19), APC(5), AR(4), ASAH1(1), BRAF(3), CCL13(2), DAG1(1), EGFR(5), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), KCNJ3(1), KCNJ5(1), MAPK1(1), MAPK10(2), MAPK14(2), PHKA2(9), PIK3CA(287), PIK3CD(4), PIK3R1(21), PITX2(3), PTX3(1), RAF1(1)	59419169	406	346	150	32	14	137	34	179	42	0	<1.00e-15	1.55e-15	2.13e-14
43	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(19), ANGPTL2(1), DAG1(1), DGKA(3), ITGA9(2), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), MAP2K1(1), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(8), PDE3B(2), PI3(1), PIK3C2G(3), PIK3CA(287), PIK3CD(4), PIK3R1(21), PLDN(1), RIPK3(2), RPS4X(2), SGCB(1)	54934608	395	336	139	30	13	138	31	175	38	0	<1.00e-15	1.55e-15	2.13e-14
44	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(19), CAT(1), GH1(1), GHR(2), IGF1(1), IGF1R(2), PIK3CA(287), PIK3R1(21), SHC1(1), SOD1(1)	14567090	336	303	80	9	7	124	18	158	29	0	<1.00e-15	1.55e-15	2.13e-14
45	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(19), EGFR(5), IGF1R(2), MYC(1), POLR2A(5), PPP2CA(2), RB1(16), TEP1(11), TP53(261)	31385295	322	292	188	15	40	52	39	71	120	0	<1.00e-15	1.55e-15	2.13e-14
46	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), ELK1(2), GRB2(1), JAK1(4), JUN(3), MAP2K1(1), MAP2K4(32), MAP3K1(69), MAPK3(1), MAPK8(2), PDGFRA(3), PIK3CA(287), PIK3R1(21), PLCG1(6), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(3), STAT5A(4)	39339821	450	341	203	20	17	114	33	173	97	16	<1.00e-15	1.67e-15	2.18e-14
47	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), DNAJC3(4), EIF2S1(1), EIF2S2(2), NFKB1(4), NFKBIA(1), RELA(1), TP53(261)	11349365	275	264	159	3	39	34	35	62	105	0	<1.00e-15	1.67e-15	2.18e-14
48	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(3), EGFR(5), ELK1(2), GRB2(1), JAK1(4), JUN(3), MAP2K1(1), MAP2K4(32), MAP3K1(69), MAPK3(1), MAPK8(2), PIK3CA(287), PIK3R1(21), PLCG1(6), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(3), STAT5A(4)	42278520	455	343	208	24	18	114	34	176	97	16	<1.00e-15	1.78e-15	2.23e-14
49	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PIK3CA(287), PIK3CD(4), PIK3R1(21), TRAF3(2), TRAF5(1), TRAF6(3)	34507674	376	316	133	13	16	113	25	165	55	2	<1.00e-15	1.78e-15	2.23e-14
50	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(19), AKT2(3), AKT3(4), BPNT1(1), GRB2(1), ILK(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(287), PIK3CD(4), PTEN(29), PTK2B(3), RBL2(1), SHC1(1), SOS1(4)	22275594	362	319	104	12	11	126	21	161	42	1	<1.00e-15	1.89e-15	2.24e-14
51	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(4), AKT1(19), ATM(18), BAX(2), CPB2(1), CSNK1A1(1), FHL2(2), HIF1A(1), IGFBP3(1), MAPK8(2), MDM2(2), NQO1(1), TP53(261)	22369922	315	297	181	15	39	53	41	68	114	0	<1.00e-15	1.89e-15	2.24e-14
52	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(18), ATR(6), CDC25C(2), CHEK2(3), TP53(261)	18333592	290	276	174	8	38	34	36	70	112	0	<1.00e-15	1.89e-15	2.24e-14
53	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(19), EIF4A2(6), EIF4G1(2), EIF4G2(2), EIF4G3(4), GHR(2), IRS1(2), MAPK1(1), MAPK14(2), MAPK3(1), PABPC1(3), PDK2(2), PIK3CA(287), PIK3R1(21), PTEN(29), RPS6KB1(2)	31018219	385	334	126	13	10	133	24	162	55	1	<1.00e-15	2.00e-15	2.24e-14
54	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(19), PIK3CA(287), PIK3R1(21), PLCB1(4), PLCG1(6), VAV1(4)	14622804	341	309	85	9	9	125	16	159	32	0	<1.00e-15	2.00e-15	2.24e-14
55	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CRK(1), GNAI1(1), GNAQ(1), GNB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(4), PIK3C2G(3), PIK3CA(287), PIK3R1(21), PLCG1(6), PTK2(5), PTK2B(3), RAF1(1), RELA(1)	31218951	340	301	101	11	9	113	22	163	33	0	<1.00e-15	2.00e-15	2.24e-14
56	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPP5B(5), INPPL1(4), IPMK(1), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(7), MINPP1(1), OCRL(6), PI4KA(5), PI4KB(1), PIK3C3(2), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIP4K2A(1), PIP4K2C(6), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCD3(3), PLCD4(1), PLCE1(12), PLCG1(6), PLCG2(3), PLCZ1(8), PTEN(29), SYNJ1(2), SYNJ2(1)	81472703	444	366	200	36	28	119	52	180	64	1	<1.00e-15	2.11e-15	2.28e-14
57	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	ACTA1(2), AGT(2), AKT1(19), CALR(1), CAMK1(2), CAMK1G(1), CAMK4(3), CREBBP(7), CSNK1A1(1), EDN1(2), ELSPBP1(2), F2(4), HAND2(1), IGF1(1), LIF(3), MAP2K1(1), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MEF2C(3), MYH2(3), NFATC2(2), NFATC3(4), NFATC4(5), NPPA(1), PIK3CA(287), PIK3R1(21), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RAF1(1), RPS6KB1(2)	55486192	401	339	145	34	11	134	43	172	41	0	<1.00e-15	2.11e-15	2.28e-14
58	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(19), AKT2(3), AKT3(4), BTK(4), FCER1A(4), GAB2(2), GRB2(1), INPP5D(4), KRAS(6), LAT(1), LCP2(1), LYN(4), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NRAS(1), PDK1(1), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(6), PLCG2(3), PRKCD(2), PRKCE(2), RAF1(1), SOS1(4), SOS2(4), SYK(2), VAV1(4), VAV2(2), VAV3(4)	79186649	474	375	211	36	26	151	51	180	66	0	<1.00e-15	2.22e-15	2.28e-14
59	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(3), BAK1(2), BAX(2), BCL2L11(4), BID(4), BIRC3(1), CASP1(1), CASP2(3), CASP4(1), CASP6(2), CASP7(1), CASP8(10), CASP9(1), CHUK(1), DFFB(2), FAS(1), FASLG(2), IKBKB(4), IRF1(1), IRF3(3), IRF5(1), IRF6(2), IRF7(1), JUN(3), LTA(1), MAP2K4(32), MAP3K1(69), MAPK10(2), MDM2(2), MYC(1), NFKB1(4), NFKBIA(1), NFKBIE(1), PLEKHG5(3), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TNFRSF21(2), TNFRSF25(1), TP53(261), TP73(1), TRAF1(1), TRAF3(2)	61619955	447	372	322	16	51	55	60	83	181	17	<1.00e-15	2.22e-15	2.28e-14
60	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(19), CASP9(1), CHUK(1), GH1(1), GHR(2), NFKB1(4), NFKBIA(1), PIK3CA(287), PIK3R1(21), PPP2CA(2), RELA(1)	15782104	340	305	84	7	9	127	15	158	31	0	<1.00e-15	2.22e-15	2.28e-14
61	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(18), ATR(6), BRCA1(12), BRCA2(14), CHEK2(3), FANCA(7), FANCC(1), FANCD2(5), FANCE(2), FANCF(1), FANCG(1), HUS1(1), MRE11A(2), RAD1(1), RAD17(2), RAD50(2), RAD51(2), RAD9A(2), TP53(261)	50136815	343	309	227	13	42	39	54	77	131	0	<1.00e-15	2.33e-15	2.35e-14
62	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(19), ATF2(2), DLD(1), DUSP10(2), DUSP4(1), GAB1(2), GCK(2), IL1R1(1), JUN(3), MAP2K4(32), MAP2K5(2), MAP2K7(1), MAP3K1(69), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(7), MAP3K4(18), MAP3K5(2), MAP3K7(1), MAP3K9(4), MAPK10(2), MAPK8(2), MYEF2(3), NFATC3(4), NR2C2(2), PAPPA(9), SHC1(1), TP53(261), TRAF6(3), ZAK(2)	54906707	465	384	311	25	53	60	57	83	196	16	<1.00e-15	2.44e-15	2.35e-14
63	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(19), AKT2(3), AKT3(4), BRD4(2), CAP1(2), CBL(4), F2RL2(1), FLOT1(1), FLOT2(2), GRB2(1), GSK3A(3), INPPL1(4), IRS1(2), IRS4(6), MAPK1(1), MAPK3(1), PARD3(4), PDK1(1), PIK3CA(287), PIK3CD(4), PIK3R1(21), PPYR1(1), PTEN(29), RAF1(1), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SERPINB6(1), SHC1(1), SLC2A4(1), SORBS1(5), SOS1(4), SOS2(4), YWHAB(1), YWHAG(1), YWHAZ(1)	62745024	435	362	176	35	25	135	43	172	59	1	<1.00e-15	2.44e-15	2.35e-14
64	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(4), ELK1(2), FCER1A(4), GRB2(1), JUN(3), LYN(4), MAP2K1(1), MAP2K4(32), MAP2K7(1), MAP3K1(69), MAPK1(1), MAPK3(1), MAPK8(2), NFATC2(2), NFATC3(4), NFATC4(5), PAK2(2), PIK3CA(287), PIK3R1(21), PLA2G4A(7), PLCG1(6), PPP3CA(4), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(4)	46917667	478	359	231	25	19	123	44	179	97	16	<1.00e-15	2.44e-15	2.35e-14
65	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(19), APAF1(3), ATM(18), BAX(2), BID(4), CASP6(2), CASP7(1), CASP9(1), EIF2S1(1), PTK2(5), STAT1(1), TLN1(12), TP53(261)	31095255	330	306	196	10	41	60	41	68	120	0	<1.00e-15	2.55e-15	2.42e-14
66	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(3), ATM(18), ATR(6), BAI1(9), BAX(2), BID(4), CASP8(10), CASP9(1), CCNB1(2), CCNB3(7), CCND1(1), CCND3(2), CCNE1(1), CCNE2(1), CCNG2(2), CDK2(1), CDK4(1), CDK6(1), CHEK2(3), DDB2(1), EI24(1), FAS(1), GTSE1(7), IGF1(1), IGFBP3(1), LRDD(1), MDM2(2), MDM4(3), PERP(2), PPM1D(2), PTEN(29), RCHY1(1), RRM2(1), SERPINE1(3), SESN2(2), SIAH1(3), STEAP3(2), THBS1(4), TP53(261), TP53I3(1), TP73(1), TSC2(2)	71134438	407	333	287	24	56	48	55	92	155	1	<1.00e-15	2.78e-15	2.59e-14
67	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(5), ATM(18), BUB1(1), CCNA1(1), CCNA2(3), CCNB1(2), CCNB3(7), CCND3(2), CCNE1(1), CCNE2(1), CCNH(2), CDAN1(2), CDC14A(2), CDC14B(1), CDC20(1), CDC25A(1), CDC25B(3), CDC25C(2), CDC6(3), CDC7(1), CDH1(56), CDK2(1), CDK4(1), CHEK2(3), DTX4(2), E2F1(4), E2F3(1), E2F4(4), E2F5(1), EP300(7), ESPL1(9), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(3), HDAC6(6), HDAC8(4), MAD2L1(2), MAD2L2(1), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), MDM2(2), MPEG1(2), MPL(1), ORC1L(1), ORC2L(3), ORC3L(2), PLK1(2), PRKDC(10), PTPRA(2), PTTG1(1), PTTG2(1), RB1(16), RBL1(3), SKP2(1), SMAD4(3), TBC1D8(4), TFDP1(2), TGFB1(2), TP53(261), WEE1(2)	125834753	508	398	380	47	58	64	85	92	209	0	1.55e-15	2.89e-15	2.61e-14
68	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(19), AKT2(3), AKT3(4), BCL10(1), BLNK(1), BTK(4), CARD11(4), CD19(3), CD22(1), CD72(1), CD79A(1), CD79B(1), CHUK(1), CR2(4), IFITM1(1), IKBKB(4), INPP5D(4), JUN(3), KRAS(6), LYN(4), MALT1(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NRAS(1), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PLCG2(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), RASGRP3(1), SYK(2), VAV1(4), VAV2(2), VAV3(4)	80961648	445	360	186	43	18	150	52	174	50	1	<1.00e-15	2.89e-15	2.61e-14
69	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(19), CREB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAP3K1(69), MAPK1(1), MAPK14(2), MAPK3(1), NFKB1(4), PIK3CA(287), PIK3R1(21), RB1(16), RELA(1), SP1(3)	22172669	430	345	169	15	9	130	23	172	80	16	<1.00e-15	3.00e-15	2.64e-14
70	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(19), GRB2(1), KLK2(2), NTRK1(4), PIK3CA(287), PIK3R1(21), PLCG1(6), SHC1(1), SOS1(4)	17391534	345	310	89	12	8	126	18	161	32	0	<1.00e-15	3.00e-15	2.64e-14
71	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	ALG2(2), BAK1(2), BAX(2), BFAR(2), BTK(4), CAD(10), CASP8(10), CSNK1A1(1), DAXX(2), EGFR(5), EPHB2(3), IL1A(1), MAP2K4(32), MAP2K7(1), MAP3K1(69), MAP3K5(2), MAPK1(1), MAPK10(2), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MET(7), NFAT5(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NR0B2(2), PTPN13(5), RALBP1(1), RIPK1(3), ROCK1(4), SMPD1(1), TP53(261), TUFM(2)	75893988	461	368	336	27	53	55	68	87	181	17	<1.00e-15	3.11e-15	2.66e-14
72	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), ELK1(2), GRB2(1), JUN(3), KLK2(2), MAP2K1(1), MAPK3(1), MAPK8(2), NGFR(1), PIK3CA(287), PIK3R1(21), PLCG1(6), RAF1(1), SHC1(1), SOS1(4)	20934838	334	293	95	13	11	109	17	161	36	0	<1.00e-15	3.11e-15	2.66e-14
73	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), DIAPH1(4), GSN(1), ITGA1(5), ITGB1(3), MAP2K1(1), MAPK1(1), MAPK3(1), MYLK(8), PIK3CA(287), PIK3R1(21), PTK2(5), RAF1(1), ROCK1(4), SHC1(1), TLN1(12)	42760366	358	313	118	22	11	116	28	166	37	0	<1.00e-15	3.22e-15	2.72e-14
74	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(19), AKT2(3), AKT3(4), CISH(1), GRB2(1), IARS(7), IL13RA1(1), IL2RG(1), IL4R(4), INPP5D(4), JAK1(4), JAK2(5), JAK3(5), NR0B2(2), PI3(1), PIK3CA(287), PPP1R13B(3), RPS6KB1(2), SERPINA4(3), SHC1(1), SOS1(4), SOS2(4), STAT6(2), TYK2(5)	40741575	373	318	118	18	19	129	30	164	31	0	<1.00e-15	3.33e-15	2.74e-14
75	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(5), MAP2K1(1), MAP3K1(69), MAPK14(2), NCOR2(29), RARA(2), RXRA(1), THRA(1), THRB(1)	18567791	114	100	88	11	4	5	12	13	64	16	0.197	3.33e-15	2.74e-14
76	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(19), AKT2(3), AKT3(4), BCR(3), BLNK(1), BTK(4), CD19(3), DAG1(1), EPHB2(3), GRB2(1), ITPKA(1), ITPKB(7), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), NFAT5(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PI3(1), PIK3CA(287), PIK3CD(4), PIK3R1(21), PLCG2(3), PPP1R13B(3), RAF1(1), SERPINA4(3), SHC1(1), SOS1(4), SOS2(4), SYK(2), VAV1(4)	56455652	410	348	154	20	22	138	36	171	42	1	<1.00e-15	3.44e-15	2.75e-14
77	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(19), ASAH1(1), ATF1(2), BRAF(3), CREB1(1), CREB3(1), CREB5(1), CREBBP(7), CRKL(1), DAG1(1), EGR1(1), EGR2(2), EGR3(2), ELK1(2), GNAQ(1), JUN(3), MAP1B(3), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), NTRK1(4), OPN1LW(1), PIK3C2G(3), PIK3CA(287), PIK3CD(4), PIK3R1(21), PTPN11(1), RPS6KA3(4), SHC1(1), TERF2IP(3), TH(1)	55610937	427	346	167	24	24	130	37	172	64	0	<1.00e-15	3.44e-15	2.75e-14
78	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(1), AKT1(19), AKT2(3), AKT3(4), APAF1(3), ATM(18), BAX(2), BID(4), BIRC3(1), CAPN1(4), CAPN2(3), CASP6(2), CASP7(1), CASP8(10), CASP9(1), CHUK(1), CSF2RB(3), DFFB(2), FAS(1), FASLG(2), IKBKB(4), IL1A(1), IL1R1(1), IL1RAP(7), IL3RA(2), IRAK1(2), IRAK2(3), IRAK3(1), IRAK4(3), NFKB1(4), NFKB2(3), NFKBIA(1), NTRK1(4), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKACA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RELA(1), RIPK1(3), TNFRSF10D(1), TNFRSF1A(1), TP53(261)	92518165	728	524	355	37	58	184	76	244	165	1	<1.00e-15	3.66e-15	2.84e-14
79	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), GRB2(1), JAK2(5), JUN(3), MAP2K1(1), MAPK3(1), MPL(1), PIK3CA(287), PIK3R1(21), PLCG1(6), RAF1(1), RASA1(2), SHC1(1), SOS1(4), STAT1(1), STAT3(3), STAT5A(4), STAT5B(5)	33766164	348	305	109	15	13	110	21	162	42	0	<1.00e-15	3.66e-15	2.84e-14
80	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(3), HLA-A(4), IL18(1), ITGB1(3), KLRC1(3), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(2), PIK3CA(287), PIK3R1(21), PTK2B(3), SYK(2), VAV1(4)	21179089	337	301	97	11	10	110	23	162	32	0	<1.00e-15	3.77e-15	2.84e-14
81	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3E(2), CD3G(2), CD86(2), CTLA4(1), GRB2(1), HLA-DRB1(8), ICOS(1), IL2(1), ITK(4), LCK(1), PIK3CA(287), PIK3R1(21), PTPN11(1)	14186960	333	294	92	13	8	110	20	160	34	1	<1.00e-15	3.77e-15	2.84e-14
82	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	14	GATA3(84), MAP2K3(2), MAPK14(2), NFATC2(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	11401099	97	93	63	11	0	3	8	5	80	1	0.943	3.77e-15	2.84e-14
83	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPPL1(4), ITPKA(1), ITPKB(7), OCRL(6), PIK3C2A(4), PIK3C2B(6), PIK3C2G(3), PIK3CA(287), PIK3CB(6), PIK3CG(3), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCG1(6), PLCG2(3)	50297732	365	314	127	23	18	117	33	168	29	0	<1.00e-15	3.89e-15	2.85e-14
84	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(5), ATM(18), ATR(6), CCNA1(1), CCND1(1), CCNE1(1), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), CDKN1B(7), E2F1(4), HDAC1(4), RB1(16), SKP2(1), TFDP1(2), TGFB1(2), TGFB3(1), TP53(261)	33266548	334	299	215	14	41	38	41	74	140	0	<1.00e-15	3.89e-15	2.85e-14
85	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(2), CRK(1), CRKL(1), ELK1(2), GAB1(2), GRB2(1), HGF(4), ITGA1(5), ITGB1(3), JUN(3), MAP2K1(1), MAP2K2(1), MAP4K1(4), MAPK1(1), MAPK3(1), MAPK8(2), MET(7), PAK1(2), PIK3CA(287), PIK3R1(21), PTEN(29), PTK2(5), PTK2B(3), PTPN11(1), RAF1(1), RASA1(2), SOS1(4), STAT3(3)	51209672	399	331	157	24	19	121	31	169	58	1	<1.00e-15	4.11e-15	2.98e-14
86	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(19), AKT2(3), AKT3(4), BCR(3), BTK(4), CD19(3), FLOT1(1), FLOT2(2), GAB1(2), ITPR1(10), ITPR2(7), ITPR3(6), LYN(4), NR0B2(2), PDK1(1), PHF11(1), PIK3CA(287), PITX2(3), PLCG2(3), PPP1R13B(3), PREX1(10), PTEN(29), PTPRC(3), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SAG(1), SYK(2), TEC(2), VAV1(4)	62027241	431	354	173	24	26	136	42	177	49	1	<1.00e-15	4.44e-15	3.14e-14
87	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(3), ARHGEF1(7), F2(4), F2R(3), GNAI1(1), GNAQ(1), GNB1(1), MAP3K7(1), PIK3CA(287), PIK3R1(21), PLCB1(4), PPP1R12B(1), PTK2B(3), ROCK1(4)	28432771	341	304	102	14	8	113	27	160	33	0	<1.00e-15	4.44e-15	3.14e-14
88	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(1), CASP2(3), CASP8(10), DFFB(2), JUN(3), LMNA(1), LMNB1(1), MADD(10), MAP2K4(32), MAP3K1(69), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(2), PRKDC(10), RB1(16), RIPK1(3), SPTAN1(4), TNFRSF1A(1)	44093298	174	147	165	13	12	17	24	22	83	16	6.21e-05	4.55e-15	3.19e-14
89	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(3), AKT1(19), ASAH1(1), GNAI1(1), GNB1(1), ITGAV(6), ITGB3(3), MAPK1(1), MAPK3(1), PDGFRA(3), PIK3CA(287), PIK3R1(21), PLCB1(4), PTK2(5), SMPD1(1)	30378210	357	312	101	15	10	130	20	163	34	0	<1.00e-15	4.66e-15	3.23e-14
90	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(1), IFNG(2), IKBKB(4), IL2(1), JUN(3), MAP3K1(69), MAP3K5(2), MAP4K5(1), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF9(2)	22293874	97	82	93	7	6	8	14	10	43	16	0.0118	4.77e-15	3.27e-14
91	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(19), EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), IGF1(1), IGF1R(2), INPPL1(4), PDK2(2), PIK3CA(287), PIK3R1(21), PPP2CA(2), PTEN(29), RPS6(2), RPS6KB1(2)	22037266	377	329	118	13	9	129	23	163	52	1	<1.00e-15	4.88e-15	3.27e-14
92	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1B(7), E2F1(4), MDM2(2), PRB1(2), TP53(261)	8649082	280	273	163	7	40	29	34	64	113	0	<1.00e-15	4.88e-15	3.27e-14
93	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(18), CDC25A(1), CDC25B(3), CDC25C(2), CDK2(1), CDK4(1), MYT1(5), RB1(16), TP53(261), WEE1(2)	20283258	310	287	193	10	38	35	40	71	126	0	<1.00e-15	5.00e-15	3.27e-14
94	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), CHUK(1), ELK1(2), IKBKB(4), IRAK1(2), JUN(3), MAP2K3(2), MAP2K4(32), MAP2K6(1), MAP3K1(69), MAP3K7(1), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), PPARA(2), RELA(1), TIRAP(1), TLR10(1), TLR2(1), TLR3(5), TLR4(13), TLR7(8), TLR9(1), TRAF6(3)	40212497	164	139	155	15	13	16	28	20	71	16	0.000313	5.00e-15	3.27e-14
95	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(19), CCND1(1), CCNE1(1), CDK2(1), CDK4(1), CDK6(1), CDKN1B(7), E2F1(4), MAPK1(1), MAPK3(1), NFKB1(4), NFKBIA(1), PAK1(2), PIK3CA(287), PIK3R1(21), RAF1(1), RB1(16), RELA(1), TFDP1(2)	22478538	372	321	113	10	12	128	17	163	52	0	<1.00e-15	5.22e-15	3.38e-14
96	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAX(2), CASP8(10), MAP2K1(1), MAP2K4(32), MAP3K1(69), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(4), NSMAF(1), RAF1(1), RELA(1), RIPK1(3), SMPD1(1), TNFRSF1A(1)	22374151	130	113	121	6	8	11	15	15	65	16	3.58e-05	5.33e-15	3.42e-14
97	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(18), CCNA1(1), CCNB1(2), CCND1(1), CCND3(2), CCNE1(1), CCNE2(1), CCNG2(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK7(2), CDKN1B(7), CREB3(1), CREB3L1(1), CREB3L3(4), CREB3L4(2), E2F1(4), E2F3(1), E2F4(4), E2F5(1), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), MDM2(2), MNAT1(2), MYC(1), MYT1(5), NACA(3), ORC1L(1), ORC2L(3), ORC3L(2), POLE(7), POLE2(1), RB1(16), RBL1(3), RPA1(1), RPA2(1), RPA3(2), TFDP1(2), TFDP2(4), TNXB(7), TP53(261), WEE1(2)	82474924	399	336	278	28	50	50	66	83	150	0	<1.00e-15	8.33e-15	5.29e-14
98	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(19), AKT2(3), AKT3(4), BCL10(1), CARD11(4), CBL(4), CBLB(10), CBLC(2), CD28(1), CD3E(2), CD3G(2), CD4(4), CD40LG(1), CD8A(2), CDK4(1), CHUK(1), CTLA4(1), GRAP2(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(4), IL2(1), ITK(4), JUN(3), KRAS(6), LAT(1), LCK(1), LCP2(1), MALT1(1), MAP3K8(2), NCK1(1), NCK2(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NRAS(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PDCD1(1), PDK1(1), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKCQ(6), PTPRC(3), RHOA(2), SOS1(4), SOS2(4), TEC(2), VAV1(4), VAV2(2), VAV3(4), ZAP70(2)	110532242	502	386	243	60	28	165	68	186	54	1	<1.00e-15	8.18e-13	5.14e-12
99	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(5), ACTN1(1), AKT1(19), AKT2(3), AKT3(4), ANGPTL2(1), ARHGEF6(4), ARHGEF7(2), BCAR1(2), BRAF(3), CAV1(2), CRK(1), CSE1L(3), EPHB2(3), GRB2(1), GRB7(5), GRLF1(7), ILK(2), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGB3BP(2), MAP2K4(32), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MYLK(8), MYLK2(2), P4HB(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PIK3CA(287), PIK3CB(6), PKLR(3), PLCG1(6), PLCG2(3), PTEN(29), PTK2(5), RAF1(1), RHO(4), ROCK1(4), ROCK2(4), SHC1(1), SOS1(4), SOS2(4), TERF2IP(3), TLN1(12), TLN2(5), WAS(3)	136024563	555	408	293	66	46	155	66	195	92	1	<1.00e-15	1.25e-12	7.75e-12
100	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), CRKL(1), GNAQ(1), GRB2(1), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K4(32), MAP3K1(69), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(6), PTK2B(3), RAF1(1), SHC1(1), SOS1(4)	31463868	136	119	128	15	9	12	19	16	64	16	0.0129	1.04e-11	6.38e-11
101	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(19), AKT2(3), AKT3(4), CBL(4), CBLB(10), CBLC(2), CCND1(1), CCND3(2), CISH(1), CLCF1(1), CNTFR(1), CREBBP(7), CSF2RA(2), CSF2RB(3), CSF3R(3), EP300(7), EPOR(4), GH1(1), GH2(4), GHR(2), GRB2(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNK(1), IL10RA(2), IL10RB(4), IL11(1), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL13RA1(1), IL13RA2(4), IL15(2), IL19(1), IL2(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA1(2), IL22RA2(1), IL23R(3), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(2), IL4R(4), IL5RA(2), IL6(2), IL6R(1), IL6ST(6), IL7R(4), IL9R(1), IRF9(3), JAK1(4), JAK2(5), JAK3(5), LEPR(4), LIF(3), LIFR(7), MPL(1), MYC(1), OSMR(4), PIAS1(2), PIAS2(4), PIAS4(2), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PRLR(1), PTPN11(1), SOCS4(2), SOCS5(1), SOS1(4), SOS2(4), SPRED1(3), SPRED2(1), SPRY1(1), SPRY2(1), SPRY3(3), STAM(2), STAM2(2), STAT1(1), STAT2(2), STAT3(3), STAT4(6), STAT5A(4), STAT5B(5), STAT6(2), TPO(5), TSLP(1), TYK2(5)	162066134	597	422	339	64	51	170	92	200	84	0	<1.00e-15	2.43e-11	1.48e-10
102	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP6(2), CASP7(1), CASP8(10), DAXX(2), DFFB(2), JUN(3), LMNA(1), LMNB1(1), MAP2K4(32), MAP3K1(69), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(2), PRKDC(10), PTPN13(5), RB1(16), SPTAN1(4)	48525804	166	142	157	14	11	15	22	21	81	16	0.000909	2.81e-11	1.70e-10
103	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(19), AKT2(3), AKT3(4), ARHGEF11(3), DLG4(1), LPA(11), MAP2K4(32), MAP3K1(69), MAP3K5(2), MAPK8(2), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(9), PI3(1), PIK3CB(6), PLD1(5), PLD2(2), PLD3(2), PTK2(5), RDX(1), ROCK1(4), ROCK2(4), SERPINA4(3), SRF(1)	54238095	199	166	174	19	18	37	38	17	72	17	7.44e-06	2.92e-11	1.74e-10
104	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(7), IKBKB(4), MAP3K1(69), NFKB1(4), NFKBIA(1), RELA(1), TNFAIP3(2), TRAF3(2), TRAF6(3)	20630196	94	81	90	10	2	9	14	11	41	17	0.0788	7.86e-10	4.65e-09
105	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(4), BID(4), BRAF(3), CD244(1), FAS(1), FASLG(2), FCGR3A(1), FCGR3B(1), GRB2(1), HLA-A(4), HLA-C(2), HLA-E(1), HLA-G(2), ICAM1(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNG(2), ITGAL(1), ITGB2(4), KIR2DL1(1), KIR2DL3(4), KIR2DL4(2), KIR3DL1(1), KIR3DL2(5), KLRC1(3), KLRC3(1), KLRK1(1), KRAS(6), LAT(1), LCK(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MICA(1), NCR1(3), NCR2(3), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NRAS(1), PAK1(2), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PLCG1(6), PLCG2(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRF1(2), PRKCG(2), PTK2B(3), PTPN11(1), RAF1(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(4), SYK(2), TNFRSF10D(1), ULBP1(1), ULBP2(1), ULBP3(2), VAV1(4), VAV2(2), VAV3(4), ZAP70(2)	123245056	491	378	248	59	29	149	71	182	60	0	<1.00e-15	8.23e-10	4.83e-09
106	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDS1(3), CDS2(2), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKI(7), DGKQ(1), FN3K(1), IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPP5B(5), INPP5D(4), INPPL1(4), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), OCRL(6), PI4KA(5), PI4KB(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(3), PIK3C3(2), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PIP4K2A(1), PIP4K2C(6), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCD3(3), PLCD4(1), PLCE1(12), PLCG1(6), PLCG2(3), PLCZ1(8), PRKCG(2), PTEN(29), SYNJ1(2), SYNJ2(1)	139860152	539	416	292	69	41	138	71	202	86	1	1.89e-15	1.28e-08	7.47e-08
107	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(7), IKBKB(4), LTA(1), MAP3K1(69), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TANK(2), TNFAIP3(2), TRAF1(1), TRAF3(2)	24992870	98	85	94	11	3	10	17	9	42	17	0.0521	1.16e-07	6.70e-07
108	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(2), ATF2(2), EGFR(5), ELK1(2), GNAQ(1), GRB2(1), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K4(32), MAP3K1(69), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(14), MEF2B(1), MEF2C(3), MEF2D(2), PAK1(2), PTK2(5), PTK2B(3), RAF1(1), SHC1(1), SOS1(4)	38492648	159	135	140	21	12	11	26	18	76	16	0.0591	1.93e-07	1.10e-06
109	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(1), ACVR1B(6), ACVRL1(1), AKT1(19), AURKB(1), BMPR2(3), BUB1(1), CDKL1(3), CDKL2(1), CDS1(3), CDS2(2), CLK1(2), CLK4(1), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKQ(1), IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPPL1(4), ITPKA(1), ITPKB(7), MAP3K10(4), MOS(3), NEK1(1), NEK3(4), OCRL(6), PAK4(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(3), PIK3CA(287), PIK3CB(6), PIK3CG(3), PIM2(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCG1(6), PLCG2(3), PLK3(1), PRKACA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(6), PRKCZ(1), PRKD1(2), PRKG1(3), RAF1(1), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA4(1), RPS6KB1(2), STK11(2), TGFBR1(2), VRK1(2)	127005581	496	386	238	61	40	145	66	191	54	0	<1.00e-15	2.00e-07	1.13e-06
110	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(2), CREB1(1), DAXX(2), ELK1(2), GRB2(1), MAP2K4(32), MAP2K6(1), MAP3K1(69), MAP3K5(2), MAP3K7(1), MAP3K9(4), MAPK14(2), MAPKAPK2(1), MAX(3), MEF2A(14), MEF2B(1), MEF2C(3), MEF2D(2), MYC(1), PLA2G4A(7), RIPK1(3), RPS6KA5(4), SHC1(1), STAT1(1), TGFB1(2), TGFB3(1), TGFBR1(2)	41225813	165	139	146	20	9	14	30	18	78	16	0.0459	5.35e-07	2.99e-06
111	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(1), IKBKB(4), IL1A(1), IL1R1(1), IRAK1(2), MAP3K1(69), MAP3K7(1), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TLR4(13), TNFAIP3(2), TNFRSF1A(1), TRAF6(3)	26158212	107	88	102	12	4	10	19	16	42	16	0.0476	1.34e-06	7.45e-06
112	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDK2(1), CDKN1B(7), CUL1(2), E2F1(4), NEDD8(1), RB1(16), SKP2(1), TFDP1(2)	9790659	35	33	32	2	4	2	4	3	22	0	0.0366	3.24e-06	1.78e-05
113	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNA1(1), IFNB1(1), IKBKB(4), IL1A(1), IL1R1(1), IL1RAP(7), IL1RN(3), IL6(2), IRAK1(2), IRAK2(3), IRAK3(1), JUN(3), MAP2K3(2), MAP2K6(1), MAP3K1(69), MAP3K7(1), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), RELA(1), TGFB1(2), TGFB3(1), TRAF6(3)	33147193	119	101	115	14	10	16	17	14	46	16	0.0185	1.01e-05	5.49e-05
114	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDK2(1), CUL1(2), E2F1(4), FBXW7(6), RB1(16), TFDP1(2)	9579428	32	30	30	2	5	4	2	5	16	0	0.0195	2.16e-05	0.000117
115	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(2), BCR(3), BLNK(1), ELK1(2), GRB2(1), JUN(3), LYN(4), MAP2K1(1), MAP3K1(69), MAPK1(1), MAPK3(1), MAPK8IP3(3), PAPPA(9), RPS6KA1(2), RPS6KA3(4), SHC1(1), SOS1(4), SYK(2), VAV1(4), VAV2(2), VAV3(4)	34667399	123	107	119	16	16	10	22	16	43	16	0.0162	0.000128	0.000687
116	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(5), ANAPC1(3), ANAPC10(1), ANAPC4(2), ANAPC5(5), ANAPC7(4), ATM(18), ATR(6), BUB1(1), CCNA1(1), CCNA2(3), CCNB1(2), CCNB3(7), CCND1(1), CCND3(2), CCNE1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(1), CDC20(1), CDC23(1), CDC25A(1), CDC25B(3), CDC25C(2), CDC6(3), CDC7(1), CDK2(1), CDK4(1), CDK6(1), CDK7(2), CDKN1B(7), CHEK2(3), CREBBP(7), CUL1(2), E2F1(4), E2F3(1), EP300(7), ESPL1(9), HDAC1(4), HDAC2(3), MAD2L1(2), MAD2L2(1), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), MDM2(2), ORC1L(1), ORC2L(3), ORC3L(2), PLK1(2), PRKDC(10), PTTG1(1), PTTG2(1), RB1(16), RBL1(3), RBL2(1), SKP2(1), SMAD2(4), SMAD3(3), SMAD4(3), SMC1A(5), SMC1B(4), TFDP1(2), TGFB1(2), TGFB3(1), TP53(261), WEE1(2), YWHAB(1), YWHAG(1), YWHAZ(1)	151979238	481	361	361	46	62	61	90	98	170	0	1.84e-14	0.000158	0.000840
117	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CCNE1(1), CDK2(1), CUL1(2), E2F1(4), RB1(16), SKP2(1), TFDP1(2)	9810966	28	26	26	2	4	2	3	3	16	0	0.0527	0.00117	0.00617
118	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), NFYC(2), RB1(16), SP1(3), SP3(4)	7682648	26	24	25	3	0	3	1	6	16	0	0.223	0.00441	0.0230
119	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(4), APAF1(3), ARHGDIB(1), BAG4(1), BID(4), BIRC3(1), CASP2(3), CASP6(2), CASP7(1), CASP8(10), CASP9(1), CHUK(1), DAXX(2), DFFB(2), GSN(1), LMNA(1), LMNB1(1), MAP2K7(1), MAP3K1(69), MAP3K5(2), MAPK8(2), MDM2(2), NFKB1(4), NFKBIA(1), NUMA1(5), PAK2(2), PRKCD(2), PRKDC(10), PSEN1(1), PSEN2(3), PTK2(5), RASA1(2), RB1(16), RELA(1), RIPK1(3), SPTAN1(4), TNFRSF1A(1), TRAF1(1)	77618916	176	148	171	15	16	22	26	25	71	16	3.26e-05	0.00487	0.0252
120	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(1), EGR2(2), EGR3(2), GNAQ(1), MAP3K1(69), MYC(1), NFATC2(2), NFKB1(4), NFKBIA(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RELA(1), VIP(1), VIPR2(1)	30022016	106	93	102	17	4	9	15	16	46	16	0.260	0.00516	0.0265
121	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(1), HLA-DRB1(8)	2916169	10	10	8	2	0	1	1	1	6	1	0.725	0.0105	0.0532
122	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(4), HLA-DRB1(8)	2215028	13	13	11	4	1	1	3	1	6	1	0.786	0.0119	0.0601
123	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(1), DAXX(2), EGF(3), EGFR(5), ETS1(3), ETS2(5), IKBKB(4), JUN(3), MAP2K1(1), MAP2K3(2), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAP3K1(69), MAP3K5(2), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NFKB1(4), NFKBIA(1), PPP2CA(2), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(6), RAF1(1), RELA(1), RIPK1(3), SP1(3), TNFRSF1A(1)	53987044	170	144	162	27	13	22	23	26	70	16	0.0290	0.0169	0.0847
124	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(2), CD3E(2), CD3G(2), CD4(4), CD58(1), CD8A(2), IL6(2), KITLG(3)	7120299	21	21	21	3	0	7	5	4	5	0	0.122	0.0217	0.108
125	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(10)	4306788	10	10	10	1	2	2	1	3	2	0	0.199	0.0282	0.139
126	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(18), CASP1(1), CASP7(1), CASP8(10), GAPDH(1), INSR(4), ITCH(1), MAGI1(10), MAGI2(9), RERE(7), WWP1(2), WWP2(7)	26139418	71	65	57	8	11	16	9	10	24	1	0.00777	0.0413	0.202
127	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(3), BAK1(2), BAX(2), BID(4), BIK(1), BIRC3(1), CASP6(2), CASP7(1), CASP8(10), CASP9(1), DFFB(2)	15176122	29	28	28	1	5	9	2	3	10	0	0.00434	0.0479	0.232
128	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(5), CBS(2), CTH(3), MUT(3)	5387362	13	13	13	0	2	3	2	2	4	0	0.0276	0.0492	0.237
129	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(2), CD28(1), CD3E(2), CD3G(2), CD4(4)	3744423	11	11	11	2	1	4	2	1	3	0	0.312	0.0939	0.448
130	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), GTF2A1(1), HDAC3(1), NCOA1(2), NCOA2(3), NCOA3(30), NCOR2(29), POLR2A(5), RARA(2), RXRA(1), TBP(1)	27656278	77	64	37	8	5	4	10	7	51	0	0.443	0.116	0.549
131	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(2)	1346070	4	4	4	0	0	3	0	1	0	0	0.208	0.120	0.562
132	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(1), CD4(4), HLA-DRB1(8), IL5RA(2), IL6(2)	5638728	18	18	16	5	1	2	3	2	9	1	0.715	0.121	0.563
133	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(1), CCNB1(2), CCND1(1), CCND3(2), CCNE1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), CDK7(2), CDKN1B(7), E2F1(4), RB1(16), RBL1(3), TFDP1(2)	17395504	47	44	44	6	4	3	8	7	25	0	0.154	0.122	0.567
134	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IFNG(2), IL12A(1), IL12B(1), IL18(1), IL2(1)	3530673	7	7	7	1	1	0	1	4	1	0	0.554	0.128	0.590
135	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2), RAB11A(2), RAB1A(2), RAB27A(1), RAB3A(2), RAB6A(1)	4901601	10	10	10	1	0	4	3	0	3	0	0.192	0.134	0.612
136	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(1), CREBBP(7), EP300(7), NCOA3(30), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RARA(2), RXRA(1)	22904691	57	52	38	7	6	5	9	6	31	0	0.207	0.153	0.691
137	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(19), GRB2(1), IL2RG(1), IL4R(4), IRS1(2), JAK1(4), JAK3(5), RPS6KB1(2), SHC1(1), STAT6(2)	15455493	41	40	24	6	3	22	7	5	4	0	0.00317	0.154	0.692
138	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(4), HLA-DRB1(8), IL2(1)	4035316	14	14	12	5	1	1	3	2	6	1	0.865	0.163	0.729
139	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(3), BAK1(2), BAX(2), BCL10(1), BCL2L11(4), BID(4), CASP9(1), CES1(2)	8480554	19	19	18	2	4	5	4	2	4	0	0.126	0.169	0.747
140	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(5), CDH1(56), CREBBP(7), EP300(7), MAP2K1(1), MAP3K7(1), MAPK3(1), SKIL(3), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3)	29230412	89	85	81	12	7	13	9	8	52	0	0.0616	0.175	0.770
141	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), CREM(2), FHL5(2), FSHR(4), GNAS(5), XPO1(4)	10143105	20	20	19	2	4	4	4	5	3	0	0.105	0.183	0.798
142	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP8(10), CASP9(1), JUN(3), PRF1(2)	14523877	24	24	24	2	6	4	3	5	6	0	0.0275	0.187	0.813
143	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(2), CAMK1G(1), HDAC9(5), MEF2A(14), MEF2B(1), MEF2C(3), MEF2D(2)	9277049	28	27	17	6	2	3	4	3	16	0	0.660	0.210	0.904
144	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(4), ALDOB(2), ALDOC(1), TPI1(2)	4361469	9	9	9	0	0	4	3	1	1	0	0.0405	0.221	0.944
145	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(1), BIRC3(1), CASP8(10), RIPK1(3), TNFRSF1A(1)	8301049	16	16	16	2	2	4	2	3	5	0	0.100	0.225	0.958
146	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), ARHGAP5(3), BCAR1(2), CD99(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(1), CLDN17(2), CLDN19(1), CLDN22(2), CLDN6(1), CTNNA1(4), CTNNA2(8), CTNNA3(6), CTNNB1(1), CTNND1(1), CYBB(1), ESAM(2), EZR(3), F11R(2), GNAI1(1), GNAI2(2), GNAI3(1), GRLF1(7), ICAM1(1), ITGA4(2), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(4), ITK(4), JAM3(1), MAPK13(1), MAPK14(2), MLLT4(12), MMP9(1), MSN(2), MYL5(1), MYLPF(1), NCF1(3), NCF2(4), NCF4(1), NOX1(1), NOX3(1), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PLCG1(6), PLCG2(3), PRKCG(2), PTK2(5), PTK2B(3), PTPN11(1), RAPGEF3(2), RAPGEF4(3), RASSF5(2), RHOA(2), ROCK1(4), ROCK2(4), SIPA1(1), TXK(2), VAV1(4), VAV2(2), VAV3(4), VCAM1(4), VCL(4)	137123035	503	387	264	72	34	140	69	191	69	0	3.59e-13	0.246	1.000
147	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(7)	6140747	11	11	11	0	1	1	4	3	2	0	0.0596	0.285	1.000
148	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(4), CD79A(1), CD79B(1), ELK1(2), GRB2(1), JUN(3), LYN(4), MAP2K1(1), MAP3K1(69), MAPK14(2), MAPK3(1), MAPK8(2), NFATC2(2), NFATC3(4), NFATC4(5), PLCG1(6), PPP3CA(4), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(4)	41683452	128	111	124	22	9	16	22	19	46	16	0.129	0.299	1.000
149	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(2), CD2(3), CD3E(2), CD3G(2), CD4(4), CXCR3(5), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), JAK2(5), STAT4(6), TYK2(5)	16758186	43	39	43	7	5	8	9	8	13	0	0.101	0.317	1.000
150	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), CSAD(2), GAD1(2), GAD2(3), GGT1(3)	6301403	13	13	12	2	2	4	4	1	2	0	0.198	0.357	1.000
151	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(6), FBL(2), GPT(3), LDHC(2), MAPK14(2), NCL(3)	10176986	18	18	18	2	6	5	4	2	1	0	0.0539	0.369	1.000
152	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNA2(3), CCND1(1), CCNE1(1), CCNE2(1), CDK2(1), CDK4(1), CDKN1B(7), E2F1(4), E2F4(4), PRB1(2)	9378610	26	26	23	5	5	2	2	3	14	0	0.498	0.375	1.000
153	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(2)	1932077	3	3	3	1	1	0	0	0	2	0	0.731	0.400	1.000
154	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	9	B3GALT1(1), B3GALT2(1), B3GALT5(2), FUT2(2), FUT3(3), ST3GAL3(3), ST3GAL4(1)	7394854	13	13	12	2	4	4	3	0	2	0	0.0869	0.420	1.000
155	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT2(2), FUT3(3), FUT5(2), FUT6(2), ST3GAL3(3)	4630960	12	12	11	3	4	1	4	0	3	0	0.237	0.423	1.000
156	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	825736	1	1	1	2	0	0	0	0	1	0	0.984	0.436	1.000
157	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(2), ACPP(5), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(1), RFK(1), TYR(6)	11030458	24	24	23	4	3	4	11	3	3	0	0.237	0.442	1.000
158	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(1), GNB1(1), HTR2C(2), PLCB1(4), TUB(2)	7962830	12	12	12	1	4	1	5	1	1	0	0.151	0.443	1.000
159	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(1), NR3C1(2), PPARG(2), RXRA(1)	5923966	8	8	8	1	3	1	3	1	0	0	0.267	0.489	1.000
160	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(4), LRP8(3), RELN(19), VLDLR(4)	15826286	31	29	30	4	5	7	12	3	4	0	0.0568	0.493	1.000
161	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(2), CD3E(2), CD3G(2), CXCR3(5), ETV5(4), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL18(1), IL18R1(2), JAK2(5), JUN(3), MAP2K6(1), MAPK14(2), MAPK8(2), STAT4(6), TYK2(5)	21186549	51	47	51	9	8	9	10	9	15	0	0.0875	0.508	1.000
162	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(3), ESR2(2), ITPKA(1), PDE1A(2), PDE1B(2), PLCB1(4), PLCB2(2), VIP(1)	12098506	17	17	17	2	2	6	3	3	3	0	0.119	0.517	1.000
163	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(4), CPS1(7), GLS(2)	8717627	15	15	15	2	2	4	5	3	1	0	0.154	0.530	1.000
164	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(4), HLCS(1)	3498453	5	5	5	0	1	1	3	0	0	0	0.205	0.536	1.000
165	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(1), ELK1(2), FPR1(1), GNB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAP3K1(69), MAPK1(1), MAPK14(2), MAPK3(1), NCF1(3), NCF2(4), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKBIA(1), PAK1(2), PIK3C2G(3), PLCB1(4), PPP3CA(4), PPP3CB(3), RAF1(1), RELA(1)	42525243	126	110	122	23	10	16	23	18	43	16	0.225	0.537	1.000
166	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(3), DDX20(2), E2F1(4), E2F4(4), ETS1(3), ETS2(5), ETV3(3), HDAC2(3), HDAC5(3), JUN(3), NCOR2(29), RBL1(3), RBL2(1), SIN3A(4), SIN3B(5)	28935517	75	70	51	11	8	12	9	8	38	0	0.207	0.537	1.000
167	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC3(1), CASP7(1), CASP8(10), CASP9(1), DFFB(2), PRF1(2), SCAP(3), SREBF1(1), SREBF2(4)	19330025	28	27	28	2	4	10	5	3	6	0	0.00574	0.548	1.000
168	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(4), IL4R(4), JAK1(4), JAK2(5), TYK2(5)	11591288	23	22	23	4	3	2	7	5	6	0	0.304	0.548	1.000
169	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(4), IL4R(4), JAK1(4), JAK2(5), TYK2(5)	11591288	23	22	23	4	3	2	7	5	6	0	0.304	0.548	1.000
170	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1)	6554782	7	7	7	1	3	2	2	0	0	0	0.298	0.573	1.000
171	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), JAK1(4), JAK2(5), STAT1(1)	9460686	12	12	12	1	1	1	3	2	5	0	0.323	0.573	1.000
172	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(4), CD8A(2), CSF1(3), IL11(1), IL2(1), IL6(2)	6806810	13	13	13	3	0	2	6	2	3	0	0.460	0.576	1.000
173	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(1), CDC25B(3), CDC25C(2), CDK7(2), MNAT1(2), XPO1(4)	9760766	18	18	17	3	3	3	9	1	2	0	0.318	0.578	1.000
174	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(4), IARS(7), LARS(2), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1)	11533571	20	18	20	3	3	7	4	4	2	0	0.108	0.622	1.000
175	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(1), FOSB(1), GRIA2(3)	3966413	5	5	5	1	0	2	2	1	0	0	0.469	0.622	1.000
176	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(1), UBE2D2(3), UBE2D3(1), UBE2E1(1), UBE2E3(1), UBE2J1(3), UBE2J2(2), UBE2L6(1), UBE3A(2)	11614960	16	16	16	1	0	5	6	1	4	0	0.137	0.628	1.000
177	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(3), HSD17B2(1), HSD17B4(6), HSD3B1(1), HSD3B2(3)	9142208	15	15	15	3	1	2	8	3	1	0	0.421	0.644	1.000
178	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(2)	1795419	2	2	2	0	0	0	1	0	1	0	0.553	0.649	1.000
179	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), ARHGDIB(1), BIRC3(1), CASP1(1), CASP2(3), CASP4(1), CASP6(2), CASP7(1), CASP8(10), CASP9(1), DFFB(2), LMNA(1), LMNB1(1), PRF1(2)	21356360	30	30	30	3	5	8	5	5	7	0	0.0216	0.662	1.000
180	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB4(1), NDUFB5(3), NDUFS2(2), NDUFV1(3), NDUFV2(1)	8069600	13	13	13	2	4	1	2	4	2	0	0.334	0.673	1.000
181	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(2), UGDH(1), UXS1(2)	4553659	6	5	6	0	1	3	1	1	0	0	0.126	0.685	1.000
182	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(4), PNPO(2)	5353689	6	6	6	1	0	0	3	1	2	0	0.625	0.700	1.000
183	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(1), CYP11B1(2), CYP11B2(5), CYP17A1(1), CYP21A2(2), HSD11B1(2), HSD3B1(1), HSD3B2(3)	9858751	20	20	20	4	6	2	10	2	0	0	0.165	0.700	1.000
184	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(1), CYP11B1(2), CYP11B2(5), CYP17A1(1), CYP21A2(2), HSD11B1(2), HSD3B1(1), HSD3B2(3)	9858751	20	20	20	4	6	2	10	2	0	0	0.165	0.700	1.000
185	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(1), COQ6(2), NDUFA13(1)	4724867	6	6	6	0	0	1	4	1	0	0	0.257	0.707	1.000
186	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(5), ASAH1(1), CERK(1), CREB1(1), CREB3(1), CREB5(1), DAG1(1), EPHB2(3), GNAQ(1), ITPKA(1), ITPKB(7), JUN(3), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3)	30018898	71	67	67	11	11	7	13	12	28	0	0.0627	0.709	1.000
187	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(2), UGDH(1), UGP2(1), UXS1(2)	5760762	7	6	7	0	1	3	2	1	0	0	0.109	0.719	1.000
188	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(19), ATF1(2), CREB1(1), CREB3(1), CREB5(1), DUSP10(2), EEF2K(4), ELK1(2), IL1R1(1), MAP2K3(2), MAP2K4(32), MAP2K6(1), MAP3K10(4), MAP3K4(18), MAP3K5(2), MAP3K7(1), MAPK1(1), MAPK13(1), MAPK14(2), MAPKAPK2(1), MYEF2(3), NFKB1(4), NR2C2(2), SRF(1), TRAF6(3)	36809916	111	103	77	21	10	32	18	9	42	0	0.0549	0.723	1.000
189	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	1750792	1	1	1	1	0	0	0	0	1	0	0.979	0.725	1.000
190	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(1)	5912382	11	11	11	3	2	4	2	2	1	0	0.372	0.737	1.000
191	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(4), NFKBIA(1), PLCB1(4), RELA(1)	9254455	11	11	11	1	3	3	3	0	2	0	0.143	0.738	1.000
192	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(2), ACP6(2), ACPP(5), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(1), MTMR1(1), MTMR2(1), MTMR6(2), RFK(1), TYR(6)	17022927	30	29	29	4	4	6	13	4	3	0	0.0953	0.739	1.000
193	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(4), F2R(3), F5(14), F7(1), FGA(5), FGB(1), FGG(4), PROC(1), PROS1(1), SERPINC1(4), TFPI(2)	18200086	40	38	40	6	4	7	16	7	6	0	0.0884	0.746	1.000
194	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3E(2), CD3G(2), HLA-A(4), ICAM1(1), ITGAL(1), ITGB2(4), PRF1(2)	9271320	19	18	18	4	3	6	2	4	4	0	0.189	0.761	1.000
195	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(1), GPI(2), HK1(1), PFKL(1), PGK1(3), PKLR(3), TPI1(2)	9939461	15	15	15	3	2	3	2	4	4	0	0.161	0.767	1.000
196	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(2)	5976859	9	9	8	2	4	1	3	0	1	0	0.367	0.768	1.000
197	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(2), NFKB1(4), NOX1(1), RELA(1), SOD1(1), XDH(4)	11019907	13	13	13	1	3	2	3	4	1	0	0.0865	0.769	1.000
198	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNAS(5), GNB1(1), PRKACA(2), PRKAR1A(4)	6662977	15	15	15	4	2	2	1	5	5	0	0.648	0.770	1.000
199	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1765846	1	1	1	1	1	0	0	0	0	0	0.933	0.771	1.000
200	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), KHK(1), LCT(11), MPI(2), PGM1(1), PYGL(2), PYGM(5), TPI1(2), TREH(1)	15155437	26	26	26	4	5	2	6	6	7	0	0.0852	0.807	1.000
201	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1), SUCLA2(1)	2360615	2	2	2	1	0	0	0	2	0	0	0.844	0.807	1.000
202	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(1), CREBBP(7), EP300(7), HDAC3(1), IKBKB(4), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TNFRSF1A(1), TRAF6(3)	24286115	33	32	32	2	5	10	7	4	7	0	0.00160	0.814	1.000
203	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(2)	2978435	2	2	2	1	1	0	0	0	1	0	0.900	0.823	1.000
204	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(3), MST1(3), MST1R(2)	6334411	8	7	8	0	2	2	3	0	1	0	0.0888	0.824	1.000
205	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(5), JAK3(5), MAPK1(1), MAPK3(1), STAT3(3), TYK2(5)	12774329	24	22	24	4	5	4	5	3	7	0	0.170	0.827	1.000
206	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(1), GBA3(2), LPO(5), MPO(3), TPO(5)	9401078	20	20	20	4	8	2	3	4	3	0	0.180	0.830	1.000
207	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(1), PCYT1A(2), PDHA1(2), PDHA2(2), SLC18A3(2)	7149740	10	10	10	2	2	4	3	1	0	0	0.246	0.844	1.000
208	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK14(2), MAPK8(2), NFKB1(4), RELA(1), TNFSF13B(1), TRAF3(2), TRAF5(1), TRAF6(3)	16211554	17	17	17	1	2	6	3	2	3	1	0.0193	0.856	1.000
209	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(1), JUN(3), KEAP1(2), MAPK1(1), MAPK14(2), MAPK8(2), NFE2L2(2)	9486454	13	13	13	3	3	2	2	0	5	1	0.331	0.856	1.000
210	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB5(1), PSMB6(2), PSMB8(1)	9269165	11	11	11	2	1	2	3	3	2	0	0.361	0.879	1.000
211	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(1), BCMO1(6), RDH5(1)	4364317	10	11	11	6	1	1	4	1	3	0	0.921	0.885	1.000
212	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(1), ARFGEF2(5), COPA(3), GBF1(7), GPLD1(3), KDELR2(1), KDELR3(1)	18446513	23	23	23	2	2	5	10	3	3	0	0.0258	0.892	1.000
213	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(3), EPOR(4), GRIN1(1), HIF1A(1), JAK2(5), NFKB1(4), NFKBIA(1), RELA(1)	13901350	20	20	20	3	2	5	6	2	5	0	0.189	0.895	1.000
214	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(2), GLS(2), PRODH(1)	6098317	5	5	5	1	2	0	1	0	2	0	0.575	0.900	1.000
215	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(1), HGD(1)	2554068	3	3	3	2	1	0	0	2	0	0	0.894	0.901	1.000
216	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA2A(2), ADORA3(2), P2RY1(3), P2RY2(1), P2RY6(1)	6077131	10	10	10	3	3	2	3	2	0	0	0.370	0.902	1.000
217	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(2), APAF1(3), CASP9(1), DAXX(2), FAS(1), FASLG(2), IL1A(1), MAPKAPK2(1), MAPKAPK3(1)	12000081	14	14	14	2	2	4	5	1	2	0	0.222	0.904	1.000
218	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP54(1), SRP68(3), SRP72(1), SRPR(9)	8615968	14	12	14	3	1	4	3	4	2	0	0.404	0.908	1.000
219	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(6), RANGAP1(2)	9579891	9	9	9	0	0	3	3	1	2	0	0.174	0.908	1.000
220	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(4), ACACB(9), AKT1(19), AKT2(3), AKT3(4), ARAF(4), BRAF(3), CBL(4), CBLB(10), CBLC(2), CRK(1), CRKL(1), ELK1(2), EXOC7(2), FASN(8), FLOT1(1), FLOT2(2), G6PC(1), G6PC2(2), GCK(2), GRB2(1), GYS1(5), GYS2(1), IKBKB(4), INPP5D(4), INSR(4), IRS1(2), IRS4(6), KRAS(6), LIPE(3), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), NRAS(1), PCK1(2), PCK2(3), PDE3A(8), PDE3B(2), PFKL(1), PFKM(4), PFKP(2), PHKA1(4), PHKA2(9), PHKB(2), PHKG2(2), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PKLR(3), PKM2(1), PPARGC1A(5), PPP1R3A(8), PPP1R3B(2), PPP1R3C(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACA(2), PRKACG(1), PRKAG2(1), PRKAG3(3), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(1), PRKX(2), PTPRF(6), PYGB(3), PYGL(2), PYGM(5), RAF1(1), RAPGEF1(4), RHEB(1), RPS6(2), RPS6KB1(2), RPS6KB2(4), SH2B2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS4(2), SORBS1(5), SOS1(4), SOS2(4), SREBF1(1), TRIP10(5), TSC1(4), TSC2(2)	172414895	597	422	338	92	56	174	86	204	77	0	9.55e-15	0.920	1.000
221	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), TAT(2), TYR(6)	5338376	9	9	9	3	1	4	3	0	1	0	0.627	0.922	1.000
222	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), ACO2(3), AFMID(1), CS(1), GRHPR(1), HAO1(4), HAO2(1), MDH2(1), MTHFD1(5), MTHFD1L(4)	15330838	23	21	23	4	4	7	9	2	1	0	0.0972	0.922	1.000
223	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), ACO2(3), CS(1), GRHPR(1), HAO1(4), HAO2(1), MDH2(1), MTHFD1(5), MTHFD1L(4)	14602403	22	20	22	4	3	7	9	2	1	0	0.125	0.925	1.000
224	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(1), EPX(4), LPO(5), MPO(3), PRDX1(1), PRDX5(1), SHMT2(1), TPO(5)	13170415	22	22	22	4	9	4	2	3	4	0	0.100	0.926	1.000
225	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(7), CD44(2), CSF1(3), FCGR3A(1), IL6R(1), SELL(5), SPN(2), TGFB1(2), TNFRSF1A(1), TNFRSF8(2)	14639139	26	26	25	5	1	4	13	3	5	0	0.271	0.927	1.000
226	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS2(4), DHRS7(1), PON1(1), PON2(1), PON3(1), RDH11(2), RDH12(1), RDH14(2)	9990812	13	12	13	3	1	3	2	4	3	0	0.306	0.933	1.000
227	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CAPN1(4), CDK5(1), CSNK1A1(1), MAPT(3), PPP2CA(2)	10344177	14	13	14	2	2	2	6	2	2	0	0.298	0.935	1.000
228	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22(1), IL22RA1(2), IL22RA2(1), JAK1(4), JAK2(5), JAK3(5), STAT1(1), STAT3(3), STAT5A(4), STAT5B(5), TYK2(5)	20295706	38	36	38	6	10	3	11	3	11	0	0.0627	0.937	1.000
229	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(1), HK2(2), HK3(2), IMPA1(1), PGM1(1), PGM3(1), TGDS(2)	11373903	12	12	12	2	3	3	1	4	1	0	0.160	0.937	1.000
230	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(2), IFNAR1(1), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(4), RELA(1), TNFRSF11A(2), TRAF6(3)	11993574	17	17	17	4	4	6	2	3	2	0	0.197	0.940	1.000
231	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(1), CYP11B2(5), CYP17A1(1), HSD11B1(2), HSD3B1(1), HSD3B2(3)	7677187	14	14	14	4	3	0	8	3	0	0	0.457	0.941	1.000
232	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO3(2), FARS2(1), PAH(2), TAT(2)	9415372	8	8	8	1	1	2	3	1	1	0	0.284	0.943	1.000
233	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3E(2), CD3G(2), CD8A(2), ICAM1(1), ITGAL(1), ITGB2(4), PTPRC(3)	11800070	19	18	19	4	1	6	4	5	3	0	0.220	0.946	1.000
234	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFB(2), HMGB1(1), HMGB2(3), TOP2A(2)	12027444	9	9	9	1	0	4	2	2	1	0	0.325	0.949	1.000
235	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(1), AASDHPPT(3), AASS(3)	8023299	7	7	7	2	1	1	3	0	2	0	0.807	0.950	1.000
236	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1B(3), BMPR2(3)	6905501	9	8	8	3	0	2	1	1	5	0	0.579	0.951	1.000
237	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(18), CDC25A(1), CDC25B(3), CDC25C(2), MYT1(5), WEE1(2)	15792073	31	30	31	6	3	6	8	6	8	0	0.260	0.952	1.000
238	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(4), ALDOB(2), ALDOC(1), GPT(3), GPT2(2), MDH2(1), ME2(2), ME3(2), PGK1(3), PKLR(3), PKM2(1), TKT(2), TPI1(2)	19895424	28	28	28	4	8	8	7	4	1	0	0.0189	0.952	1.000
239	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(3), AASS(3)	5472377	6	6	6	2	1	1	3	0	1	0	0.806	0.955	1.000
240	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(1), MTMR6(2), NFS1(1), TPK1(1)	7225673	6	6	6	1	1	3	2	0	0	0	0.392	0.955	1.000
241	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC1(1), APOBEC2(2), APOBEC3A(2), APOBEC3B(1), APOBEC3C(1), APOBEC3G(1), APOBEC4(1)	8405128	11	11	11	3	5	3	0	1	2	0	0.458	0.956	1.000
242	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(2), HLA-DRB1(8), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL18(1), IL18R1(2), IL2(1), IL4R(4)	14027931	28	26	26	8	3	2	9	6	7	1	0.653	0.957	1.000
243	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CTH(3), LDHC(2)	7384720	5	5	5	0	0	1	1	0	3	0	0.272	0.960	1.000
244	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(2), JAK1(4), JAK2(5), PTPRU(5), REG1A(1), STAT1(1)	12909586	19	19	19	4	3	3	3	3	7	0	0.507	0.960	1.000
245	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(6), CS(1), PC(5), PDHA1(2), SLC25A1(1), SLC25A11(1)	10127063	16	14	16	3	2	5	4	3	2	0	0.177	0.961	1.000
246	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(3), CDK7(2), NEK1(1), WEE1(2)	8668966	9	9	9	2	1	2	5	1	0	0	0.596	0.963	1.000
247	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(4), GALNS(1), GLB1(2), GUSB(3), HEXA(1), HEXB(3), IDS(3), IDUA(1), LCT(11), NAGLU(1)	15710499	30	28	30	6	6	8	5	9	2	0	0.0915	0.964	1.000
248	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(4), GALNS(1), GLB1(2), GUSB(3), HEXA(1), HEXB(3), HGSNAT(4), HPSE(5), HPSE2(1), HYAL2(2), IDS(3), IDUA(1), LCT(11), NAGLU(1), SPAM1(2)	22538440	44	41	44	9	7	9	11	11	6	0	0.113	0.964	1.000
249	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(5), METTL2B(2), PCYT1A(2), PCYT1B(3), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), WBSCR22(2)	15343038	33	28	33	6	5	10	11	3	4	0	0.0716	0.970	1.000
250	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH11(2), RDH12(1), RDH14(2)	5260243	5	5	5	2	0	1	1	2	1	0	0.683	0.972	1.000
251	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(1), IFNAR2(1), IFNB1(1), JAK1(4), STAT1(1), STAT2(2), TYK2(5)	12075678	16	16	16	4	3	4	3	2	4	0	0.420	0.973	1.000
252	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(3), GAD1(2), TH(1)	6117601	6	6	6	2	1	1	2	1	1	0	0.732	0.973	1.000
253	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(4), COASY(5), DPYS(1), ENPP1(5), ENPP3(2), PANK1(1), PANK2(1), PANK4(3), UPB1(3)	15106402	25	24	25	5	2	5	6	6	6	0	0.315	0.974	1.000
254	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(7), DFFB(2), GZMA(2), HMGB2(3), PRF1(2), SET(1)	11943688	18	18	18	4	3	3	4	4	4	0	0.393	0.974	1.000
255	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), GBA3(2), LPO(5), MPO(3), PRDX1(1), PRDX5(1), TPO(5), TYR(6)	10820109	27	26	27	6	8	6	5	4	4	0	0.169	0.975	1.000
256	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	6	B3GNT1(1), FUT2(2), GCNT2(1), ST8SIA1(1)	6057719	5	5	4	5	0	0	1	1	3	0	0.966	0.975	1.000
257	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), FPGS(1), GCH1(1)	6316184	10	9	9	4	4	1	4	0	1	0	0.615	0.976	1.000
258	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(4), F2(4), F2R(3), FGA(5), FGB(1), FGG(4), PLAT(3), PLAU(2), PLG(4), SERPINE1(3)	15433587	34	33	34	8	1	5	19	5	4	0	0.450	0.977	1.000
259	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(1), DBH(3), DDC(1), GAD1(2), GAD2(3), MAOA(2), PAH(2), SLC18A3(2), TH(1)	14866107	18	18	18	3	3	5	6	2	2	0	0.171	0.978	1.000
260	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(18), BMPR1B(3), CDK4(1), CDKN1B(7), DMC1(2), EGR1(1), ESR2(2), FSHR(4), GJA4(1), INHA(1), LHCGR(5), MLH1(3), MSH5(2), NCOR1(31), NRIP1(3), PGR(4), PRLR(1), SMPD1(1), ZP2(2)	37888549	92	86	91	16	5	14	17	14	41	1	0.0818	0.978	1.000
261	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(1), FARSB(3), PAH(2), TAT(2), YARS2(1)	9847716	10	10	10	2	2	3	4	0	1	0	0.320	0.978	1.000
262	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(1), HK2(2), HK3(2), IMPA1(1), PGM1(1), PGM3(1), TGDS(2)	12672542	12	12	12	2	3	3	1	4	1	0	0.153	0.978	1.000
263	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(2), ICAM1(1), ITGAL(1), ITGAM(3), ITGB2(4), SELE(1), SELL(5)	12183341	17	16	17	4	0	2	7	4	4	0	0.460	0.980	1.000
264	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(4), ESR1(3), GREB1(3), MTA3(2)	10821293	12	12	12	3	1	5	3	1	2	0	0.301	0.982	1.000
265	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(7), EP300(7), ESR1(3), MAPK1(1), MAPK3(1), PELP1(2)	16649156	21	21	20	4	4	5	4	2	6	0	0.222	0.982	1.000
266	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(4), CSF1(3), HLA-DRB1(8), IFNA1(1), IFNB1(1), IFNG(2), IL11(1), IL12A(1), IL12B(1), IL15(2), IL1A(1), IL2(1), IL6(2), LTA(1), TGFB1(2), TGFB3(1)	14216177	32	30	30	9	3	6	9	4	9	1	0.543	0.983	1.000
267	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(6), PTK2B(3)	7527227	10	10	10	3	1	3	3	1	2	0	0.444	0.984	1.000
268	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(3), IL6(2), LDLR(1), LPL(1)	5878014	9	9	9	4	0	3	3	1	2	0	0.781	0.986	1.000
269	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(2), GGT1(3), SHMT2(1)	4620006	6	6	5	3	1	4	0	1	0	0	0.685	0.986	1.000
270	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS2(2), CDO1(1), CTH(3), LDHC(2), SULT1B1(1), SULT1C2(1)	13787147	10	10	10	1	0	3	2	0	5	0	0.295	0.986	1.000
271	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(1), EPX(4), LPO(5), MPO(3), SHMT2(1), TPO(5)	12895954	20	20	20	4	9	3	2	3	3	0	0.142	0.987	1.000
272	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(6), G6PD(2), GCLC(2), GCLM(1), GGT1(3), GPX2(1), GPX4(1), GPX5(2), GSS(2), GSTA1(1), GSTA2(1), GSTA4(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(2), PGD(2)	19879962	32	30	31	5	7	6	6	9	4	0	0.0338	0.987	1.000
273	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(7), AGT(2), BDKRB2(1), KNG1(4), NOS3(3), REN(1)	10454834	18	18	18	5	2	4	6	3	3	0	0.414	0.987	1.000
274	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), IL10RA(2), IL10RB(4), IL1A(1), IL6(2), JAK1(4), STAT1(1), STAT3(3), STAT5A(4)	13440262	22	20	22	5	7	3	4	2	6	0	0.181	0.987	1.000
275	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	3766916	5	5	5	3	1	1	2	0	1	0	0.915	0.987	1.000
276	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), HADH(2), HADHB(2), HSD17B10(1), HSD17B4(6), PPT2(1)	9391173	14	13	14	4	0	5	6	2	1	0	0.563	0.987	1.000
277	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1)	15120364	13	13	13	2	3	5	5	0	0	0	0.155	0.988	1.000
278	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(4), ASNS(2), ASPA(2), CAD(10), CRAT(6), DARS(1), GAD1(2), GAD2(3), GPT(3), GPT2(2), NARS(1), PC(5)	28744332	52	47	52	7	7	15	18	6	6	0	0.00300	0.989	1.000
279	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	FUCA2(1), GLB1(2), HEXA(1), HEXB(3), LCT(11), MANBA(2), NEU2(1)	17013217	21	21	21	4	2	5	5	6	3	0	0.220	0.989	1.000
280	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(1), BIRC3(1), CASP8(10), JUN(3), MAP2K4(32), MAP3K7(1), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NR2C2(2), RALBP1(1), RIPK1(3), TNFAIP3(2), TNFRSF1A(1)	28347746	66	64	62	13	8	10	13	6	28	1	0.204	0.989	1.000
281	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), ADRB2(1), CFTR(9), GNAS(5), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(2)	13926292	27	26	27	6	4	2	6	6	9	0	0.507	0.990	1.000
282	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(2), ACP6(2), ACPP(5), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP3A4(3), CYP3A43(1), CYP3A7(4), DHRS2(4), DHRS7(1), PON1(1), PON2(1), PON3(1)	19702850	35	28	33	7	8	5	13	5	4	0	0.151	0.990	1.000
283	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB5(1), PSMB6(2), RPN1(2), UBE2A(1), UBE3A(2)	15146753	15	15	15	3	0	3	5	3	4	0	0.483	0.990	1.000
284	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), UGDH(1)	9285542	6	6	6	1	0	3	3	0	0	0	0.346	0.991	1.000
285	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(1), GBA3(2), GGT1(3), SHMT2(1)	6258949	7	7	6	3	1	4	1	1	0	0	0.648	0.991	1.000
286	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), JUN(3), MAPK14(2), THBS1(4)	8056805	10	9	10	7	1	1	1	3	4	0	0.992	0.991	1.000
287	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB5(1), PSMB6(2), PSMD1(5), PSMD11(2), PSMD12(1), PSMD2(2), PSMD6(2)	18410354	22	22	22	4	2	4	8	4	4	0	0.317	0.992	1.000
288	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), OXCT1(1)	3880956	3	3	3	2	0	1	1	1	0	0	0.904	0.993	1.000
289	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(4), BCAT2(3), COASY(5), DPYS(1), ENPP1(5), ENPP3(2), ILVBL(1), PANK1(1), PANK2(1), PANK4(3), UPB1(3), VNN1(3)	18922659	32	31	32	7	4	6	7	8	7	0	0.256	0.994	1.000
290	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(2), IFNG(2), IL2(1), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2), TOB1(3)	12166859	21	20	21	5	3	8	5	3	2	0	0.249	0.995	1.000
291	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1), TGM2(2)	5470914	4	4	4	3	1	0	1	0	2	0	0.929	0.995	1.000
292	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(1), GLB1(2), HEXA(1), HEXB(3), LCT(11), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(1)	17856135	30	30	30	7	5	7	6	8	4	0	0.225	0.995	1.000
293	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	22	ARSA(1), ARSB(4), ARSE(2), ASAH1(1), GAL3ST1(1), GBA(1), GLA(4), GLB1(2), LCT(11), NEU2(1), PPAP2A(1), PPAP2C(2), SMPD1(1), SPTLC1(2), SPTLC2(2)	25220776	36	32	36	5	8	5	10	9	4	0	0.0422	0.996	1.000
294	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(2), GFPT1(2), GNE(3), GNPDA2(1), HEXA(1), HEXB(3), HK1(1), HK2(2), HK3(2), PGM3(1), RENBP(1), UAP1(1)	19085118	22	22	22	4	3	5	5	6	3	0	0.179	0.997	1.000
295	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(2), GRB2(1), PTPRA(2)	10294125	11	11	11	3	3	1	5	1	1	0	0.516	0.997	1.000
296	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(2), ICAM1(1), ITGA4(2), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(4), SELE(1), SELL(5), SELP(8)	18469955	30	28	30	7	2	4	11	9	4	0	0.374	0.997	1.000
297	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	5008038	5	5	5	4	1	1	2	0	1	0	0.971	0.997	1.000
298	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(2), SULT1A2(1), SULT1E1(2), SUOX(3)	7012955	9	9	9	3	2	5	0	1	1	0	0.609	0.997	1.000
299	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), ADRB2(1), GNAS(5), PLCE1(12), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RAP2B(2)	15840474	30	30	30	8	6	3	7	6	8	0	0.508	0.998	1.000
300	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(6), NRG3(4), PSEN1(1)	10328413	11	11	11	3	1	4	4	1	1	0	0.515	0.998	1.000
301	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(6), CD2(3), CD33(1), CD5(2), IFNA1(1), IFNB1(1), IFNG(2), IL12A(1), IL12B(1), ITGAX(5), TLR2(1), TLR4(13), TLR7(8), TLR9(1)	20785093	46	42	45	10	9	9	9	10	9	0	0.0983	0.998	1.000
302	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(3), SNCAIP(3), UBE2F(1), UBE2L6(1)	7099745	10	10	10	4	1	2	5	2	0	0	0.809	0.998	1.000
303	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(1), JUN(3), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NFKB1(4), NFKBIA(1), PLCB1(4), RAF1(1), RELA(1)	16716966	19	18	19	4	5	6	2	1	5	0	0.145	0.998	1.000
304	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(4), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(4), ASNS(2), ASPA(2), ASS1(1), CAD(10), CRAT(6), DARS(1), DARS2(2), DLD(1), GAD1(2), GAD2(3), GPT(3), GPT2(2), NARS(1), NARS2(2), PC(5), PDHA1(2), PDHA2(2), PDHB(1)	41803868	67	60	67	9	12	18	23	8	6	0	0.00123	0.998	1.000
305	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLUD2(2)	5001258	4	4	4	2	2	0	0	1	1	0	0.791	0.998	1.000
306	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(7), C5(4), C6(5), C7(6), C9(1)	14680450	23	23	23	6	3	5	8	3	4	0	0.423	0.998	1.000
307	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(5), GNB1(1), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	10397489	14	14	14	5	1	2	3	3	5	0	0.842	0.998	1.000
308	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(4), CD38(3), ENPP1(5), ENPP3(2), NMNAT1(1), NMNAT2(1), NNT(4), NT5E(5), NT5M(1)	16477866	26	26	26	7	2	1	14	5	4	0	0.591	0.998	1.000
309	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(4), BCAT2(3), IARS(7), IARS2(2), ILVBL(1), LARS(2), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1)	18128619	26	24	26	5	5	7	6	5	3	0	0.135	0.999	1.000
310	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(5), ERBB3(11), NRG1(2)	11626119	21	21	21	6	3	2	10	5	1	0	0.617	0.999	1.000
311	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT2(2), GBGT1(1), GLA(4), HEXA(1), HEXB(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1)	10823740	17	17	16	6	3	4	3	2	5	0	0.480	0.999	1.000
312	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(7), EP300(7), LPL(1), NCOA1(2), NCOA2(3), PPARG(2), RXRA(1)	20754650	23	21	22	4	5	4	6	3	5	0	0.158	0.999	1.000
313	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS2(4), DHRS7(1), HEMK1(1), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), WBSCR22(2)	16248556	30	27	30	8	6	10	8	2	4	0	0.218	0.999	1.000
314	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), IMPDH1(2), POLB(1), POLD1(1), POLG(4), PRPS2(1), RRM1(2), SRM(1)	13694900	14	13	14	3	2	2	7	0	3	0	0.475	0.999	1.000
315	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT1(2), B4GALT3(1), B4GALT5(2), DPAGT1(2), DPM1(2), MAN1A1(1), MAN1B1(4), MGAT3(2), MGAT4A(1), MGAT4B(3), MGAT5(4), RPN1(2)	20779748	28	27	28	5	6	4	8	3	7	0	0.165	0.999	1.000
316	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(19), AP2A1(6), AP2M1(4), ARF1(1), BTK(4), EEA1(4), GRASP(1), GSK3A(3), LYN(4), PFKL(1), PFKM(4), PFKP(2), PLCG1(6), PRKCE(2), PRKCZ(1), RPS6KB1(2), VAV2(2)	27603180	66	64	49	15	9	26	10	9	12	0	0.0184	0.999	1.000
317	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(2), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CKMT2(3), CPS1(7), GAMT(1), GATM(4), OTC(1)	19236150	29	29	29	6	4	6	11	7	1	0	0.198	0.999	1.000
318	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(8), GABBR1(1), GPRC5A(1), GRM1(5), GRM2(3), GRM3(8), GRM4(1), GRM5(2), GRM7(3), GRM8(3)	21479340	35	32	35	7	9	7	11	3	5	0	0.0381	0.999	1.000
319	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(2), FUT2(2), GBGT1(1), GLA(4), HEXA(1), HEXB(3), ST3GAL1(2), ST3GAL2(1), ST8SIA1(1)	11488825	19	19	18	7	3	4	5	2	5	0	0.559	0.999	1.000
320	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(3), CMAS(2), CTBS(1), CYB5R1(2), GFPT1(2), GFPT2(3), GNE(3), GNPDA2(1), GNPNAT1(2), HEXA(1), HEXB(3), HK1(1), HK2(2), HK3(2), MTMR1(1), MTMR2(1), MTMR6(2), NAGK(1), NANS(1), PGM3(1), RENBP(1), UAP1(1)	32291826	38	37	38	5	5	10	9	9	5	0	0.0200	0.999	1.000
321	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(1), AOC3(3), CES1(2), ESD(1)	6413677	7	7	7	4	2	1	3	0	1	0	0.822	1.000	1.000
322	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3E(2), CD3G(2), CD4(4), ICAM1(1), ITGAL(1), ITGB2(4), PTPRC(3)	12582643	21	20	21	6	1	7	5	4	4	0	0.373	1.000	1.000
323	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(1)	6329092	7	7	7	3	4	0	0	2	1	0	0.684	1.000	1.000
324	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(1)	6329092	7	7	7	3	4	0	0	2	1	0	0.684	1.000	1.000
325	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(2), CA1(1), CA14(3), CA2(1), CA4(2), CA6(1), CA9(2), CPS1(7), CTH(3), GLS(2), GLUL(1), HAL(2)	21397292	29	29	29	6	2	4	9	7	7	0	0.205	1.000	1.000
326	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(2), ACO2(3), IDH1(2), MDH2(1), SDHB(1), SUCLA2(1)	10205370	10	10	10	4	2	1	3	4	0	0	0.717	1.000	1.000
327	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(6), G6PD(2), GCLC(2), GCLM(1), GGT1(3), GPX2(1), GPX4(1), GPX5(2), GPX7(1), GSS(2), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(2), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(2), TXNDC12(1)	22234778	34	32	33	7	7	7	8	8	4	0	0.0735	1.000	1.000
328	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(4), ALDOB(2), ALDOC(1), GPT(3), GPT2(2), MDH2(1), ME3(2), PGK1(3), PKLR(3), PKM2(1), TKT(2), TKTL1(2), TKTL2(1), TPI1(2)	22314990	29	29	29	6	8	8	7	5	1	0	0.0698	1.000	1.000
329	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(6), AP2A1(6), AP2M1(4), DNM1(6), EPN1(1), EPS15(4), PICALM(1), PPP3CA(4), PPP3CB(3), SYNJ1(2), SYNJ2(1)	25202726	38	35	38	7	5	4	15	6	8	0	0.176	1.000	1.000
330	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(2), GNAQ(1), JUN(3), MAPK14(2), MAPK8(2), PLCG1(6), PTK2B(3)	15262681	19	19	19	7	3	3	5	1	7	0	0.665	1.000	1.000
331	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(3), ASPH(4), CREB1(1), EDN1(2), EP300(7), HIF1A(1), JUN(3), NOS3(3), P4HB(1)	18745634	25	24	24	6	3	5	5	4	8	0	0.470	1.000	1.000
332	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(12), CARM1(2), CCND1(1), CREBBP(7), EP300(7), ERCC3(2), ESR1(3), GRIP1(3), GTF2A1(1), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(3), HDAC6(6), MEF2C(3), NCOR2(29), NRIP1(3), PELP1(2), POLR2A(5), SRA1(1), TBP(1)	51784914	101	92	78	18	9	16	21	8	47	0	0.203	1.000	1.000
333	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(2), FURIN(1), NOTCH1(5), PSEN1(1)	8242048	9	8	9	4	1	3	1	2	2	0	0.762	1.000	1.000
334	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(2), IL6R(1), JAK1(4), JAK2(5), JAK3(5), PTPRU(5), REG1A(1), STAT3(3)	16836850	27	26	27	8	4	5	5	4	9	0	0.546	1.000	1.000
335	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(6), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	11307734	9	9	9	3	1	5	2	1	0	0	0.544	1.000	1.000
336	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(4), CD38(3), ENPP1(5), ENPP3(2), NADK(1), NMNAT1(1), NMNAT2(1), NNT(4), NT5C1B(4), NT5C3(1), NT5E(5), NT5M(1), NUDT12(1)	23745898	33	33	33	8	4	1	16	7	5	0	0.410	1.000	1.000
337	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(2), IL12A(1), IL12B(1), IL15(2), IL18(1), IL1A(1), IL2(1), IL6(2), LTA(1)	10867765	14	13	14	5	3	2	2	4	3	0	0.654	1.000	1.000
338	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT3(1), B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1)	8553637	13	12	13	5	2	4	4	1	2	0	0.722	1.000	1.000
339	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(4), JAK2(5), JAK3(5), PIAS1(2), PTPRU(5), REG1A(1), SOAT1(1)	15345669	24	23	24	7	3	5	6	3	7	0	0.579	1.000	1.000
340	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(1), CRY1(1), CRY2(1), CSNK1E(2), PER1(3)	9212257	10	10	10	4	1	2	2	3	2	0	0.814	1.000	1.000
341	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), BDH1(1), HMGCS1(3), HMGCS2(1), OXCT1(1), OXCT2(1)	8248642	9	9	9	5	0	2	3	3	1	0	0.914	1.000	1.000
342	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(2), JUN(3), MAPK3(1), OPRK1(2), POLR2A(5), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	14254026	21	21	21	8	6	0	6	3	6	0	0.782	1.000	1.000
343	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(1), NDUFA1(1), SDHB(1), UQCRC1(3)	7422810	7	7	7	6	1	0	2	3	1	0	0.985	1.000	1.000
344	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(9), FASN(8), MCAT(1), OLAH(1), OXSM(1)	16625611	24	23	24	6	6	1	10	2	5	0	0.435	1.000	1.000
345	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(3), CALR(1), CANX(2), CD4(4), CD8A(2), CIITA(1), CREB1(1), CTSB(1), CTSS(1), HLA-A(4), HLA-C(2), HLA-DMA(1), HLA-DMB(2), HLA-DRB1(8), HLA-E(1), HLA-F(4), HLA-G(2), HSP90AA1(2), HSP90AB1(3), IFI30(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), KIR2DL1(1), KIR2DL3(4), KIR2DL4(2), KIR2DS4(3), KIR3DL1(1), KIR3DL2(5), KIR3DL3(1), KLRC1(3), KLRC3(1), LTA(1), NFYB(1), NFYC(2), RFX5(1), RFXANK(2), TAP1(2)	45147255	90	84	87	18	8	21	28	10	22	1	0.0497	1.000	1.000
346	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(2), ACO2(3), CS(1), DLD(1), DLST(3), IDH1(2), IDH3A(1), IDH3B(2), IDH3G(1), MDH2(1), PC(5), PCK1(2), SDHB(1), SUCLA2(1)	23285861	26	24	26	5	4	6	9	6	1	0	0.128	1.000	1.000
347	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ICAM1(1), ITGA4(2), ITGAL(1), ITGB1(3), ITGB2(4), SELE(1), SELL(5)	13824709	19	19	19	6	0	1	8	7	3	0	0.742	1.000	1.000
348	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CAMKK1(3), CAMKK2(2), CREB1(1)	12835234	19	17	19	5	4	3	3	5	4	0	0.437	1.000	1.000
349	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(1), C1S(2), C2(1), C3(7), C5(4), C6(5), C7(6), C9(1)	19483461	28	27	28	7	4	7	9	3	5	0	0.268	1.000	1.000
350	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2)	14045927	16	15	16	9	3	1	3	3	6	0	0.944	1.000	1.000
351	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(5), ACTB(2), ACTG1(4), ARHGEF2(3), CD14(2), CDH1(56), CTNNB1(1), CTTN(1), EZR(3), HCLS1(1), ITGB1(3), KRT18(1), NCK1(1), NCK2(1), NCL(3), RHOA(2), ROCK1(4), ROCK2(4), TLR4(13), TLR5(2), TUBA1A(1), TUBA1B(2), TUBA1C(2), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), TUBB6(1), WAS(3), WASL(1), YWHAZ(1)	57229757	138	123	130	28	13	16	32	14	63	0	0.0887	1.000	1.000
352	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(5), ACTB(2), ACTG1(4), ARHGEF2(3), CD14(2), CDH1(56), CTNNB1(1), CTTN(1), EZR(3), HCLS1(1), ITGB1(3), KRT18(1), NCK1(1), NCK2(1), NCL(3), RHOA(2), ROCK1(4), ROCK2(4), TLR4(13), TLR5(2), TUBA1A(1), TUBA1B(2), TUBA1C(2), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), TUBB6(1), WAS(3), WASL(1), YWHAZ(1)	57229757	138	123	130	28	13	16	32	14	63	0	0.0887	1.000	1.000
353	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(1), JAK1(4), PTPRU(5), REG1A(1), STAT1(1), STAT2(2), TYK2(5)	13807981	20	20	20	6	5	4	3	3	5	0	0.545	1.000	1.000
354	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(2), ELOVL5(4), ELOVL6(3), FADS1(1), FADS2(4), FASN(8), SCD(1)	14880522	25	25	25	9	2	4	11	2	6	0	0.754	1.000	1.000
355	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(3), IGF1(1), IL11(1), IL1A(1), IL6(2), KITLG(3), TGFB1(2), TGFB3(1)	9518312	14	12	14	6	2	4	4	2	2	0	0.710	1.000	1.000
356	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), DARS(1), EPRS(4), FARS2(1), GARS(1), HARS(1), IARS(7), LARS(2), LARS2(2), MARS(2), NARS(1), QARS(3), RARS(3), SARS(3), TARS(5), WARS2(1)	36431020	41	40	41	6	7	10	11	9	4	0	0.0324	1.000	1.000
357	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(2), CA1(1), CA14(3), CA2(1), CA4(2), CA6(1), CA9(2), CPS1(7), CTH(3), GLS(2), GLUD2(2), GLUL(1), HAL(2)	23843910	31	31	31	7	3	4	9	8	7	0	0.231	1.000	1.000
358	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(4), ALDOB(2), ALDOC(1), GCK(2), GMDS(2), HK1(1), HK2(2), HK3(2), KHK(1), MPI(2), PFKFB1(1), PFKFB3(1), PFKM(4), PFKP(2), SORD(2), TPI1(2)	26903027	33	33	33	7	6	8	6	7	6	0	0.0600	1.000	1.000
359	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(2), ALOX15(2), ALOX15B(2), ALOX5(1), DPEP1(3), GGT1(3), PLA2G6(2), PTGIS(3), PTGS1(2), PTGS2(2), TBXAS1(1)	16474417	23	23	21	6	6	4	7	3	3	0	0.255	1.000	1.000
360	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(4), HMBS(1), PPOX(2)	8797329	7	7	7	3	2	2	3	0	0	0	0.816	1.000	1.000
361	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(3), BAX(2), BCL2L2(1), CASP1(1), CASP2(3), CASP4(1), CASP6(2), CASP7(1), CASP8(10), CASP9(1), CD40(1), CD40LG(1), DAXX(2), DFFB(2), FAS(1), FASLG(2), IKBKE(2), LTA(1), MCL1(1), NFKB1(4), NFKBIA(1), NGFR(1), NR3C1(2), NTRK1(4), PTPN13(5), RIPK1(3), SFRS2IP(4), TFG(1), TNFRSF1A(1), TRAF1(1), TRAF3(2), TRAF6(3)	48245924	70	64	69	10	9	21	15	9	15	1	0.00224	1.000	1.000
362	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	140	APC(5), AXIN1(1), AXIN2(1), BTRC(2), CAMK2A(2), CAMK2D(4), CAMK2G(1), CCND1(1), CCND3(2), CER1(1), CHD8(3), CREBBP(7), CSNK1A1(1), CSNK1A1L(3), CSNK1E(2), CSNK2A1(1), CSNK2A2(1), CTNNB1(1), CUL1(2), DAAM1(3), DAAM2(3), DKK2(1), DKK4(1), DVL1(2), DVL3(2), EP300(7), FZD1(1), FZD2(1), FZD3(3), FZD6(3), FZD7(1), FZD8(2), FZD9(3), JUN(3), LRP5(1), LRP6(3), MAP3K7(1), MAPK10(2), MAPK8(2), MYC(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NKD1(1), NKD2(1), NLK(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PORCN(1), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRICKLE1(2), PRICKLE2(3), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), PSEN1(1), RHOA(2), ROCK1(4), ROCK2(4), RUVBL1(1), SFRP1(2), SFRP4(2), SIAH1(3), SMAD2(4), SMAD3(3), SMAD4(3), TBL1X(4), TBL1XR1(9), TCF7(3), TCF7L1(2), TCF7L2(3), TP53(261), VANGL1(2), VANGL2(3), WIF1(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(2), WNT3A(2), WNT4(1), WNT5B(2), WNT7A(5), WNT8B(1), WNT9A(1)	172298951	488	363	369	73	82	65	96	105	138	2	4.80e-10	1.000	1.000
363	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), GNAQ(1), GNAS(5), GNB1(1), LIMK1(4), MAP2K1(1), MAPK1(1), MAPK3(1), NOX1(1), PIK3C2G(3), PLCB1(4), PPP1R12B(1), PTK2(5), RAF1(1), ROCK2(4)	28644181	35	33	35	6	4	9	8	8	6	0	0.165	1.000	1.000
364	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(2), FADS2(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2)	11650010	23	22	23	8	3	3	10	5	2	0	0.700	1.000	1.000
365	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(7), C5(4), C6(5), C7(6), ICAM1(1), IL1A(1), IL6(2), ITGA4(2), ITGAL(1), ITGB1(3), ITGB2(4), SELP(8), SELPLG(7), VCAM1(4)	27945041	55	52	52	14	7	9	15	12	12	0	0.322	1.000	1.000
366	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA2(1), GABRA3(3), GABRA4(1), GABRA5(2), GABRA6(3), PRKCE(2), SOD1(1)	8911312	14	14	14	9	2	2	5	4	1	0	0.931	1.000	1.000
367	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(3), BID(4), BIRC3(1), CASP6(2), CASP7(1), CASP8(10), CASP9(1), CHUK(1), DFFB(2), LMNA(1), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), SPTAN1(4), TNFRSF25(1)	36927372	40	39	40	6	8	12	6	5	9	0	0.0268	1.000	1.000
368	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(2), MMP9(1), RECK(1), TIMP3(1)	8432822	5	5	5	8	1	1	2	0	1	0	0.996	1.000	1.000
369	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(2), ADC(1), AGMAT(2), ALDH18A1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ARG2(1), ASL(4), ASS1(1), CPS1(7), GATM(4), MAOA(2), MAOB(1), OTC(1), SAT1(2), SAT2(1), SRM(1)	32554963	44	42	44	9	4	11	16	10	3	0	0.0826	1.000	1.000
370	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), EGR1(1), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1)	8682726	10	10	10	6	2	3	1	3	1	0	0.797	1.000	1.000
371	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(3), CBS(2), CTH(3), GGT1(3), MARS(2), MAT1A(1), MAT2B(1), PAPSS1(2), SEPHS1(1)	13522198	18	18	17	6	5	6	2	1	4	0	0.343	1.000	1.000
372	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AGPS(1), CHPT1(3), ENPP2(8), ENPP6(1), PAFAH1B1(3), PAFAH1B3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(5), PLD2(2), PPAP2A(1), PPAP2C(2)	26002660	49	46	49	10	7	8	16	12	6	0	0.0822	1.000	1.000
373	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	FUCA2(1), GLB1(2), HEXA(1), HEXB(3), LCT(11), MAN2B1(3), MAN2B2(2), MANBA(2), NEU2(1)	21041196	26	25	26	7	3	5	8	6	4	0	0.394	1.000	1.000
374	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(3), ALDH5A1(1), CAD(10), CPS1(7), EPRS(4), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(2), GLS(2), GLUL(1), GMPS(2), GPT(3), GPT2(2), GSS(2), PPAT(1), QARS(3)	37403080	51	48	51	9	7	9	18	13	4	0	0.0560	1.000	1.000
375	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(1), CHST11(2), PAPSS1(2), SULT1A2(1), SULT1E1(2), SUOX(3)	9737147	11	11	11	6	4	5	0	1	1	0	0.807	1.000	1.000
376	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), CPT1A(4), LEPR(4), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1)	16584567	18	18	18	8	6	1	5	1	5	0	0.915	1.000	1.000
377	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(1), PTK2B(3), SHC1(1), SOS1(4)	9652345	10	10	10	5	2	3	3	1	1	0	0.797	1.000	1.000
378	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), CHST1(1), CHST2(3), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1)	12315093	18	18	18	9	4	6	3	2	3	0	0.858	1.000	1.000
379	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), AMD1(1), BHMT(1), CBS(2), CTH(3), DNMT1(4), DNMT3A(4), DNMT3B(2), MARS(2), MAT1A(1), MAT2B(1), MTAP(1), MTR(5), SRM(1), TAT(2)	22905639	33	32	33	9	8	7	7	4	7	0	0.267	1.000	1.000
380	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(2), ARPC1A(1), ARPC1B(2), ARPC2(2), WASF1(5), WASL(1)	9313728	13	12	13	7	1	5	6	0	1	0	0.931	1.000	1.000
381	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(2), AKT1(19), AKT2(3), AKT3(4), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(9), PIK3CB(6), PITX2(3), PLD1(5), PLD2(2), PLD3(2)	49058113	98	87	81	20	11	34	23	16	13	1	0.00277	1.000	1.000
382	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(1), CALCRL(2), CD97(5), CRHR1(2), CRHR2(1), ELTD1(4), EMR1(2), EMR2(5), GHRHR(2), GIPR(1), GLP2R(2), GPR64(6), LPHN1(3), LPHN2(6), LPHN3(8), VIPR2(1)	31085123	52	50	52	12	6	5	23	7	10	1	0.164	1.000	1.000
383	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(1), CBS(2), CTH(3), DNMT1(4), DNMT3A(4), DNMT3B(2), MARS(2), MAT1A(1), MAT2B(1), MTR(5)	19283356	28	27	28	8	7	5	6	4	6	0	0.330	1.000	1.000
384	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(3), GRB2(1), IL3RA(2), JAK2(5), MAP2K1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5)	19554918	28	28	28	9	7	3	7	3	8	0	0.451	1.000	1.000
385	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), DRD2(2), GRM1(5), PLCB1(4), PPP2CA(2), PPP3CA(4), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	17668255	25	24	25	8	3	3	9	4	6	0	0.695	1.000	1.000
386	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(4), ALDOB(2), ALDOC(1), G6PD(2), GPI(2), H6PD(2), PFKM(4), PFKP(2), PGD(2), PGLS(2), PGM1(1), PGM3(1), PRPS2(1), TAL1(1), TKT(2)	21820367	29	29	29	8	7	5	4	7	6	0	0.259	1.000	1.000
387	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(4), EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), EIF5(2)	12921433	13	13	13	7	1	4	4	2	2	0	0.940	1.000	1.000
388	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(2), BRAF(3), CREB1(1), CREB3(1), CREB5(1), MAPK1(1), RAF1(1), SNX13(3), TERF2IP(3)	13170738	17	17	17	5	3	2	5	5	2	0	0.652	1.000	1.000
389	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), CS(1), OGDH(4), SUCLA2(1)	10873579	9	8	9	4	0	3	5	1	0	0	0.706	1.000	1.000
390	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(3), LDLR(1), MBTPS1(2), MBTPS2(3), SCAP(3), SREBF1(1), SREBF2(4)	12265663	17	17	17	7	0	5	8	2	2	0	0.696	1.000	1.000
391	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(1), POLQ(8)	18518416	23	22	23	6	2	4	8	4	5	0	0.504	1.000	1.000
392	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(2), ARPC1A(1), ARPC1B(2), ARPC2(2), NCK1(1), NCKAP1(6), NTRK1(4), PIR(2), PSMA7(1), WASF1(5), WASF3(1), WASL(1)	17398517	28	27	28	8	4	7	12	4	1	0	0.521	1.000	1.000
393	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDFT1(1), FDPS(1), HMGCR(1), HMGCS1(3), IDI1(2), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1)	14617273	12	12	12	9	2	1	5	1	3	0	0.988	1.000	1.000
394	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(3), HADH(2), HSD17B10(1), HSD17B4(6), NTAN1(1), SIRT1(2), SIRT2(1), SIRT7(3), VNN2(4)	13344017	23	23	23	8	1	7	10	4	1	0	0.708	1.000	1.000
395	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(6), ACO1(2), ACO2(3), IDH1(2), MDH2(1), SUCLA2(1)	15097889	15	14	15	5	3	2	5	4	1	0	0.518	1.000	1.000
396	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), CS(1), DLD(1), DLST(3), IDH3A(1), IDH3B(2), IDH3G(1), MDH2(1), OGDH(4), PC(5), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK2(2), PDK4(2), PDP2(1), SDHB(1), SUCLA2(1)	32078177	36	34	36	7	6	9	12	7	2	0	0.0960	1.000	1.000
397	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(2), BRAF(3), CHUK(1), CREB1(1), DAXX(2), ELK1(2), GRB2(1), IKBKB(4), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K4(32), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(69), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(7), MAP3K4(18), MAP3K5(2), MAP3K6(3), MAP3K7(1), MAP3K8(2), MAP3K9(4), MAP4K1(4), MAP4K3(2), MAP4K4(4), MAP4K5(1), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK4(6), MAPK6(3), MAPK8(2), MAPKAPK2(1), MAPKAPK3(1), MAX(3), MEF2A(14), MEF2B(1), MEF2C(3), MEF2D(2), MYC(1), NFKB1(4), NFKBIA(1), PAK1(2), PAK2(2), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA4(1), RPS6KA5(4), RPS6KB1(2), RPS6KB2(4), SHC1(1), SP1(3), STAT1(1), TGFB1(2), TGFB3(1), TGFBR1(2)	106611814	272	216	239	40	33	32	47	28	116	16	0.00401	1.000	1.000
398	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(4), ALDOB(2), ALDOC(1), DERA(1), G6PD(2), GPI(2), H6PD(2), PFKL(1), PFKM(4), PFKP(2), PGD(2), PGLS(2), PGM1(1), PGM3(1), PRPS2(1), TKT(2), TKTL1(2), TKTL2(1)	26336666	33	33	33	9	7	5	5	8	8	0	0.243	1.000	1.000
399	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(7), EP300(7), IKBKB(4), MAP2K3(2), MAP2K6(1), MAP3K7(1), MAPK14(2), NFKB1(4), NFKBIA(1), NR3C1(2), RELA(1), TGFBR1(2), TGFBR2(3), TLR2(1)	33002551	39	36	38	9	7	10	10	4	8	0	0.160	1.000	1.000
400	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGF(3), EGFR(5), HGS(4), TF(3), TFRC(1)	14360966	20	20	20	9	5	3	7	3	2	0	0.851	1.000	1.000
401	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(4), ACTG2(2), ADCY3(3), ADCY9(9), ARF1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(3), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ERO1L(3), GNAS(5), PDIA4(3), PLCG1(6), PLCG2(3), SEC61A1(2), TRIM23(4)	41585883	61	57	61	11	10	7	23	9	12	0	0.0578	1.000	1.000
402	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), DHRS2(4), DHRS7(1), ESCO1(3), MYST3(4), MYST4(8), PNPLA3(2), SH3GLB1(1)	28246967	33	32	33	9	6	7	8	9	2	1	0.393	1.000	1.000
403	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(5), EXT2(6), EXTL3(4), GLCE(4), HS2ST1(2), HS3ST2(3), HS3ST5(4), HS6ST1(5), HS6ST2(5), HS6ST3(1), NDST3(2)	22680958	41	39	38	10	5	5	13	11	7	0	0.338	1.000	1.000
404	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1)	17343659	16	16	16	7	3	1	7	1	4	0	0.879	1.000	1.000
405	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1)	17343659	16	16	16	7	3	1	7	1	4	0	0.879	1.000	1.000
406	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1)	17343659	16	16	16	7	3	1	7	1	4	0	0.879	1.000	1.000
407	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CD28(1), CD4(4), CXCR3(5), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL18R1(2), IL2(1), IL4R(4), TGFB1(2), TGFB3(1)	22974004	41	40	41	12	6	8	10	8	9	0	0.330	1.000	1.000
408	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(1), CRY1(1), CRY2(1), CSNK1E(2), NPAS2(2), NR1D1(2), PER1(3), PER2(3), PER3(3)	18523950	20	20	20	6	5	2	4	5	4	0	0.570	1.000	1.000
409	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), NQO1(1), NQO2(2), PMVK(1), SQLE(1), VKORC1(1)	12144925	11	11	11	8	3	2	5	0	1	0	0.973	1.000	1.000
410	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(3), PGAP1(5), PIGA(2), PIGB(1), PIGG(2), PIGM(1), PIGN(1), PIGO(1), PIGQ(3), PIGS(2), PIGT(1), PIGV(1), PIGW(3), PIGZ(2)	27747967	29	27	29	7	7	5	9	6	2	0	0.228	1.000	1.000
411	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA2(2), ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(2), SRD5A1(1)	25713190	30	29	30	9	5	9	11	4	1	0	0.401	1.000	1.000
412	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(4), DHRS7(1), ESCO1(3), MYST3(4), MYST4(8), PNPLA3(2), SH3GLB1(1)	18537327	23	22	23	8	3	4	5	8	2	1	0.694	1.000	1.000
413	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), FDXR(1)	18175410	17	17	17	7	3	1	8	1	4	0	0.852	1.000	1.000
414	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), HDAC5(3), MEF2A(14), MEF2B(1), MEF2C(3), MEF2D(2), PPARA(2), PPP3CA(4), PPP3CB(3), SLC2A4(1)	23236340	46	42	35	12	3	7	7	11	18	0	0.609	1.000	1.000
415	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(4), CARS2(2), DARS(1), DARS2(2), EARS2(3), EPRS(4), FARS2(1), FARSA(1), FARSB(3), GARS(1), HARS(1), IARS(7), IARS2(2), LARS(2), LARS2(2), MARS(2), NARS(1), NARS2(2), PARS2(1), QARS(3), RARS(3), RARS2(2), SARS(3), SARS2(2), TARS(5), TARS2(6), WARS2(1), YARS2(1)	58540245	72	67	72	10	16	16	22	12	6	0	0.00430	1.000	1.000
416	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(2), CAMK2D(4), CAMK2G(1), DAG1(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), NFAT5(6), PDE6A(1), PDE6B(2), PDE6C(6), SLC6A13(3), TF(3)	40189530	60	60	60	13	4	14	16	17	9	0	0.0836	1.000	1.000
417	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(4), DLG4(1), EPHB2(3), F2(4), F2RL2(1), JUN(3), MAP2K5(2), MAPK1(1), MAPK8(2), MYEF2(3), PLD1(5), PLD2(2), PLD3(2), PTK2(5), RAF1(1), RASAL1(2), TEC(2), VAV1(4)	30484081	47	42	47	10	8	9	15	6	9	0	0.123	1.000	1.000
418	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(2), ALOX15(2), ALOX5(1), CBR1(1), CYP4F2(2), EPX(4), GGT1(3), LPO(5), MPO(3), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PRDX1(1), PRDX5(1), PTGIS(3), PTGS1(2), PTGS2(2), TBXAS1(1), TPO(5)	30875978	51	49	50	11	15	5	16	7	8	0	0.0792	1.000	1.000
419	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(1), MRPS7(2), RPL10L(2), RPL13A(3), RPL14(1), RPL18(4), RPL18A(2), RPL19(1), RPL26(2), RPL29(1), RPL3(1), RPL35(2), RPL3L(1), RPL41(1), RPL7(1), RPL8(1), RPS10(1), RPS16(1), RPS2(1), RPS21(1), RPS27(1), RPS5(4), RPS6(2), RPSA(1)	25173384	38	36	37	9	5	5	14	7	7	0	0.537	1.000	1.000
420	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT2(1), B3GAT3(1), CHPF(1), CHST11(2), CHST3(1), CHSY1(1), DSE(8), UST(3), XYLT1(2), XYLT2(1)	13357388	22	22	22	8	9	5	4	3	1	0	0.508	1.000	1.000
421	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(7), GNAQ(1), GNB1(1), MYLK(8), PLCB1(4), PPP1R12B(1), ROCK1(4)	23463001	29	29	29	8	4	7	9	4	5	0	0.384	1.000	1.000
422	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BRAF(3), CREB1(1), CREB3(1), CREB5(1), DUSP4(1), DUSP6(1), DUSP9(1), EEF2K(4), GRB2(1), MAP2K1(1), MAP2K2(1), MAP3K8(2), MAPK1(1), MAPK3(1), MOS(3), NFKB1(4), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), SHC1(1), SOS1(4), SOS2(4), TRAF3(2)	33045893	50	46	50	11	14	8	12	8	7	1	0.0846	1.000	1.000
423	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADVL(3), ACSL1(1), ACSL3(1), ACSL4(2), CPT1A(4), CPT2(5), EHHADH(3), SLC25A20(1)	18856392	20	20	20	7	3	7	5	2	3	0	0.643	1.000	1.000
424	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG1(2), ARG2(1), ASL(4), ASS1(1), CKB(1), CKMT1B(1), CKMT2(3), CPS1(7), DAO(1), EPRS(4), GAMT(1), GATM(4), GLUD2(2), LAP3(1), NOS1(7), NOS3(3), OTC(1), P4HA1(1), P4HA2(1), P4HA3(2), PARS2(1), PRODH(1), PYCR2(1), RARS(3), RARS2(2)	39433355	56	55	56	11	11	10	23	8	4	0	0.0639	1.000	1.000
425	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(3), UCHL3(1), UGDH(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2)	19910024	21	21	21	9	2	4	4	8	3	0	0.782	1.000	1.000
426	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(1), ELK1(2), GRB2(1), IL6(2), IL6R(1), IL6ST(6), JAK1(4), JAK2(5), JAK3(5), JUN(3), MAP2K1(1), MAPK3(1), PTPN11(1), RAF1(1), SHC1(1), SOS1(4), SRF(1), STAT3(3)	26223925	43	40	43	10	6	7	12	7	11	0	0.272	1.000	1.000
427	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(4), F2R(3), GNAI1(1), GNB1(1), ITGA1(5), ITGB1(3), MAP2K1(1), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(4), PTGS1(2), PTK2(5), RAF1(1), SYK(2), TBXAS1(1)	27122565	42	37	42	11	5	7	21	6	3	0	0.444	1.000	1.000
428	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(3), CARM1(2), CBS(2), CTH(3), GGT1(3), HEMK1(1), LCMT1(1), LCMT2(5), MARS(2), MAT1A(1), MAT2B(1), METTL2B(2), PAPSS1(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), SEPHS1(1), SEPHS2(1), WBSCR22(2)	27059148	44	39	43	12	11	15	10	1	7	0	0.113	1.000	1.000
429	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(2), ATG7(3), GABARAP(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNG(2), PIK3C3(2), PIK3R4(4), PRKAA1(1), PRKAA2(3), ULK1(1), ULK2(4), ULK3(2)	23553425	40	39	40	10	3	11	16	6	4	0	0.389	1.000	1.000
430	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(3), ADC(1), ALDH5A1(1), CAD(10), CPS1(7), EARS2(3), EPRS(4), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(2), GFPT2(3), GLS(2), GLUD2(2), GLUL(1), GMPS(2), GNPNAT1(2), GPT(3), GPT2(2), GSS(2), NAGK(1), PPAT(1), QARS(3)	44573096	63	59	63	13	10	11	20	17	5	0	0.0667	1.000	1.000
431	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	35	ARSA(1), ARSE(2), ASAH1(1), B4GALT6(1), CERK(1), DEGS1(3), DEGS2(1), ENPP7(3), GAL3ST1(1), GBA(1), GLA(4), GLB1(2), LCT(11), NEU2(1), PPAP2A(1), PPAP2C(2), SGMS1(1), SGPP1(1), SGPP2(1), SMPD1(1), SMPD3(1), SMPD4(1), SPHK2(2), SPTLC1(2), SPTLC2(2), UGT8(2)	36669335	50	47	50	12	8	9	14	12	6	1	0.205	1.000	1.000
432	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), DDC(1), EPX(4), HPD(2), LPO(5), MAOA(2), MAOB(1), MPO(3), PRDX1(1), PRDX5(1), TAT(2), TPO(5)	23609061	36	34	36	10	11	5	8	4	8	0	0.271	1.000	1.000
433	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(6), ACO1(2), ACO2(3), CLYBL(3), CS(1), DLD(1), DLST(3), IDH1(2), IDH3A(1), IDH3B(2), IDH3G(1), MDH2(1), OGDH(4), OGDHL(4), PC(5), PCK1(2), PCK2(3), SDHB(1), SUCLA2(1)	33848098	46	42	46	10	7	9	18	10	2	0	0.0874	1.000	1.000
434	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(19), AKT2(3), AKT3(4), ASAH1(1), BRAF(3), DAG1(1), DRD2(2), EGFR(5), EPHB2(3), GRB2(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), KCNJ3(1), KCNJ5(1), MAPK1(1), PI3(1), PIK3CB(6), PITX2(3), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), RAF1(1), RGS20(2), SHC1(1), SOS1(4), SOS2(4), STAT3(3), TERF2IP(3)	65258020	120	111	103	27	16	40	25	23	16	0	0.00551	1.000	1.000
435	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(1), C1S(2), C2(1), C3(7), C5(4), C6(5), C7(6), C9(1), MASP1(3), MASP2(2), MBL2(1)	23892391	34	33	34	10	6	7	10	4	7	0	0.369	1.000	1.000
436	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(1), ATP6AP1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), CHUK(1), EGFR(5), F11R(2), GIT1(1), IGSF5(2), IKBKB(4), JAM3(1), JUN(3), LYN(4), MAP2K4(32), MAPK10(2), MAPK13(1), MAPK14(2), MAPK8(2), MET(7), NFKB1(4), NFKB2(3), NFKBIA(1), NOD1(3), PAK1(2), PLCG1(6), PLCG2(3), PTPN11(1), PTPRZ1(8), RELA(1), TCIRG1(1), TJP1(6)	79149830	130	118	126	25	17	21	37	13	41	1	0.0412	1.000	1.000
437	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), B4GALT1(2), G6PC(1), G6PC2(2), GAA(2), GALK2(1), GALT(1), GANC(2), GCK(2), GLA(4), GLB1(2), HK1(1), HK2(2), HK3(2), LCT(11), MGAM(12), PFKL(1), PFKM(4), PFKP(2), PGM1(1), PGM3(1), RDH11(2), RDH12(1), RDH14(2), UGP2(1)	42158438	64	62	64	16	11	12	11	20	10	0	0.0724	1.000	1.000
438	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN1(1), GRIN2A(12), GRIN2B(9), GRIN2C(4), GRIN2D(4), NOS1(7), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	28078190	52	48	52	15	10	4	23	7	8	0	0.344	1.000	1.000
439	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), MDH2(1), PC(5), PCK1(2), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PFKL(1), PFKM(4), PFKP(2), PGAM2(1), PGK1(3), PKLR(3), PKM2(1), TPI1(2)	46892082	55	53	55	11	9	17	12	10	7	0	0.0114	1.000	1.000
440	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(7), DLL1(2), DLL4(1), DTX1(4), DTX2(4), DTX3(1), DTX4(2), DVL1(2), DVL3(2), EP300(7), HDAC1(4), HDAC2(3), JAG1(3), MAML1(2), MAML2(4), MAML3(5), NCOR2(29), NCSTN(2), NOTCH1(5), NOTCH2(8), NOTCH3(3), NOTCH4(7), NUMB(2), NUMBL(5), PSEN1(1), PSEN2(3), PSENEN(1), PTCRA(1), RBPJL(5), RFNG(2), SNW1(2)	69265303	129	112	104	28	21	18	27	12	51	0	0.167	1.000	1.000
441	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA2(2), ACAD8(1), ACAD9(1), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(2), LIPA(1), RDH11(2), RDH12(1), RDH14(2), SLC27A5(3), SOAT1(1), SRD5A1(1)	35106899	40	40	40	10	7	12	11	7	3	0	0.171	1.000	1.000
442	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	47	ADORA3(2), ALG6(1), CCKBR(1), CCR2(5), CCR3(1), CCR5(2), CELSR1(6), CELSR2(10), CELSR3(7), CHRM2(4), CHRM3(1), CIDEB(2), CXCR3(5), EDNRA(1), EMR2(5), EMR3(3), F2R(3), FSHR(4), GHRHR(2), GPR116(3), GPR132(2), GPR133(2), GPR143(4), GPR17(2), GPR55(1), GPR56(1), GPR61(1), GPR77(1), GPR84(3), GRM1(5), GRPR(1), HRH4(1), LGR6(3), LPHN2(6), LPHN3(8), LTB4R2(1), P2RY11(1), P2RY13(3), PTGFR(1), SMO(2), SSTR2(1), TAAR5(3), TSHR(4)	67413213	125	108	126	28	24	25	27	26	23	0	0.00397	1.000	1.000
443	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	28	ARSB(4), FUCA2(1), GALNS(1), GBA(1), GLB1(2), GUSB(3), HEXA(1), HEXB(3), HGSNAT(4), HPSE(5), HPSE2(1), HYAL2(2), IDS(3), IDUA(1), LCT(11), MAN2B1(3), MAN2B2(2), MANBA(2), NAGLU(1), NEU2(1), SPAM1(2)	36479856	54	50	54	14	8	10	17	11	8	0	0.264	1.000	1.000
444	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(1), ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(2), PGK1(3), PGM1(1), PGM3(1), PKLR(3), PKM2(1), TPI1(2)	54042472	64	62	64	14	12	20	17	10	5	0	0.0192	1.000	1.000
445	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(1), ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(2), PGK1(3), PGM1(1), PGM3(1), PKLR(3), PKM2(1), TPI1(2)	54042472	64	62	64	14	12	20	17	10	5	0	0.0192	1.000	1.000
446	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), ALOX5(1), CYP1A2(3), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP3A4(3), CYP3A43(1), CYP3A7(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), RDH11(2), RDH12(1), RDH14(2)	26952869	43	41	42	12	7	7	14	7	8	0	0.293	1.000	1.000
447	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(3), CPEB1(4), EGFR(5), ERBB2(12), ERBB4(6), ETS1(3), ETS2(5), ETV6(2), ETV7(2), FMN2(12), GRB2(1), KRAS(6), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH1(5), NOTCH2(8), NOTCH3(3), NOTCH4(7), PIWIL1(8), PIWIL2(4), PIWIL3(5), PIWIL4(2), RAF1(1), SOS1(4), SOS2(4), SPIRE1(1), SPIRE2(1)	53869628	117	104	108	28	14	26	36	20	21	0	0.100	1.000	1.000
448	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), GRB2(1), IL2(1), IL2RB(1), IL2RG(1), JAK1(4), JAK3(5), JUN(3), LCK(1), MAP2K1(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5), SYK(2)	25808241	41	39	41	12	9	5	12	5	10	0	0.311	1.000	1.000
449	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), AGK(2), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(2), DAK(3), DGAT1(1), DGAT2(2), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKI(7), DGKQ(1), GK(1), GK2(3), GLA(4), GLB1(2), GPAM(1), LCT(11), LIPA(1), LIPC(1), LIPF(2), LIPG(1), LPL(1), MGLL(1), PNLIP(3), PNLIPRP1(3), PNPLA3(2), PPAP2A(1), PPAP2C(2)	65416087	99	91	97	24	22	20	24	17	15	1	0.0512	1.000	1.000
450	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(3), ANAPC10(1), ANAPC4(2), ANAPC5(5), ANAPC7(4), BTRC(2), CDC20(1), CDC23(1), CUL1(2), CUL3(2), FBXW7(6), ITCH(1), SKP2(1), SMURF1(2), SMURF2(1), TCEB1(1), UBA1(4), UBE2D2(3), UBE2D3(1), UBE2E1(1), UBE2E3(1), WWP1(2), WWP2(7)	43712872	54	50	54	11	10	18	9	9	7	1	0.0891	1.000	1.000
451	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(10), ASH2L(3), CARM1(2), CTCFL(3), DOT1L(5), EED(3), EHMT1(6), EZH1(1), EZH2(1), FBXO11(2), HCFC1(11), JMJD6(1), KDM6A(10), MEN1(4), MLL(10), MLL2(13), MLL3(58), MLL4(6), MLL5(7), NSD1(2), OGT(3), PAXIP1(5), PRDM2(3), PRDM6(2), PRDM7(2), PRDM9(2), PRMT1(1), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), RBBP5(2), SATB1(2), SETD1A(2), SETD1B(3), SETD2(11), SETD7(2), SETD8(1), SETDB1(9), SETDB2(1), SETMAR(1), SMYD3(3), SUV420H1(5), SUZ12(4), WHSC1(7), WHSC1L1(4)	136095532	242	200	238	33	29	36	59	34	81	3	0.000466	1.000	1.000
452	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(4), ACAT1(2), ACYP1(1), ADH5(1), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLD(1), GRHPR(1), LDHC(2), MDH2(1), ME2(2), ME3(2), PC(5), PCK1(2), PDHA1(2), PDHA2(2), PDHB(1), PKLR(3), PKM2(1)	40700821	43	37	43	10	8	14	13	5	3	0	0.113	1.000	1.000
453	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), AMDHD1(3), AOC2(1), AOC3(3), ASPA(2), CARM1(2), CNDP1(3), DDC(1), FTCD(1), HAL(2), HARS(1), HEMK1(1), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), PRPS2(1), UROC1(2), WBSCR22(2)	42772465	55	48	55	14	9	15	20	3	8	0	0.125	1.000	1.000
454	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPOR(4), GRB2(1), JAK2(5), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(6), RAF1(1), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5)	24004079	41	39	41	12	9	6	10	4	12	0	0.334	1.000	1.000
455	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(2), AZIN1(1), CBX3(3), CLOCK(1), CRY1(1), CRY2(1), EIF4G2(2), ETV6(2), G0S2(1), GSTP1(1), HSPA8(4), IDI1(2), MYF6(3), NCKAP1(6), NR1D2(1), PER1(3), PER2(3), PPP1R3C(1), PPP2CB(3), TOB1(3), TUBB3(1), UCP3(2), UGP2(1), VAPA(1), ZFR(6)	40488934	55	51	55	13	4	12	19	9	11	0	0.350	1.000	1.000
456	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(5), COL4A5(6), COL4A6(7), F2(4), F2R(3), F5(14), F8(7), F9(1), FGA(5), FGB(1), FGG(4), KLKB1(1), PROC(1), PROS1(1), SERPINC1(4), SERPING1(2)	50584894	77	72	77	20	10	15	30	12	10	0	0.319	1.000	1.000
457	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(4), ACACB(9), ACAT1(2), ACYP1(1), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLD(1), GRHPR(1), LDHC(2), MDH2(1), ME2(2), ME3(2), PC(5), PCK1(2), PCK2(3), PDHA1(2), PDHA2(2), PDHB(1), PKLR(3), PKM2(1)	51688159	51	46	51	10	9	12	17	9	4	0	0.0538	1.000	1.000
458	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(2), ACPP(5), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(4), PON1(1)	32341955	56	47	53	16	11	8	21	9	7	0	0.323	1.000	1.000
459	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(2), ACTG1(4), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), AKT1(19), AKT2(3), AKT3(4), ARHGAP5(3), BCAR1(2), BIRC3(1), BRAF(3), CAPN2(3), CAV1(2), CCND1(1), CCND3(2), COL11A1(4), COL11A2(1), COL1A1(8), COL1A2(6), COL2A1(5), COL3A1(1), COL4A1(4), COL4A2(5), COL4A4(5), COL4A6(7), COL5A1(5), COL5A2(6), COL5A3(7), COL6A1(1), COL6A2(2), COL6A3(10), COL6A6(10), COMP(5), CRK(1), CRKL(1), CTNNB1(1), DIAPH1(4), EGF(3), EGFR(5), ELK1(2), ERBB2(12), FARP2(5), FIGF(2), FLNA(5), FLNB(13), FLNC(10), FLT1(2), FN1(5), GRB2(1), GRLF1(7), HGF(4), IBSP(2), IGF1(1), IGF1R(2), ILK(2), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAV(6), ITGB1(3), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), JUN(3), KDR(2), LAMA1(9), LAMA2(10), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(7), LAMB2(7), LAMB3(5), LAMB4(10), LAMC1(8), LAMC2(2), LAMC3(2), MAP2K1(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), MET(7), MYL5(1), MYLK(8), MYLK2(2), MYLPF(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PARVA(1), PDGFB(2), PDGFRA(3), PDGFRB(3), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PIP5K1C(4), PPP1R12A(3), PRKCG(2), PTEN(29), PTK2(5), RAF1(1), RAPGEF1(4), RELN(19), RHOA(2), ROCK1(4), ROCK2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(4), SPP1(2), THBS1(4), THBS2(1), THBS3(3), THBS4(2), TLN1(12), TLN2(5), TNC(6), TNN(6), TNR(6), TNXB(7), VAV1(4), VAV2(2), VAV3(4), VCL(4), VTN(1), VWF(10)	406748642	928	526	663	198	115	237	179	249	147	1	6.07e-09	1.000	1.000
460	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	ACVR1B(6), ACVR1C(2), AKT1(19), AKT2(3), AKT3(4), ARRB1(1), ARRB2(1), ATF2(2), ATF4(2), BDNF(1), BRAF(3), CACNA1A(13), CACNA1B(9), CACNA1C(10), CACNA1D(7), CACNA1E(17), CACNA1F(11), CACNA1G(6), CACNA1H(5), CACNA1I(2), CACNA1S(5), CACNA2D1(5), CACNA2D2(4), CACNA2D3(5), CACNA2D4(2), CACNB1(2), CACNB2(3), CACNB3(1), CACNG1(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(1), CACNG6(1), CACNG7(1), CD14(2), CDC25B(3), CHUK(1), CRK(1), CRKL(1), DAXX(2), DUSP10(2), DUSP16(5), DUSP4(1), DUSP6(1), DUSP7(1), DUSP9(1), EGF(3), EGFR(5), ELK1(2), FAS(1), FASLG(2), FGF10(1), FGF11(1), FGF13(3), FGF18(1), FGF23(2), FGF3(1), FGF6(1), FGF7(2), FGF9(1), FGFR2(7), FGFR3(2), FGFR4(4), FLNA(5), FLNB(13), FLNC(10), GRB2(1), IKBKB(4), IL1A(1), IL1R1(1), IL1R2(5), JUN(3), KRAS(6), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K4(32), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(69), MAP3K10(4), MAP3K12(2), MAP3K13(7), MAP3K4(18), MAP3K5(2), MAP3K6(3), MAP3K7(1), MAP3K8(2), MAP4K1(4), MAP4K3(2), MAP4K4(4), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MAPKAPK2(1), MAPKAPK3(1), MAPT(3), MAX(3), MEF2C(3), MOS(3), MYC(1), NF1(20), NFATC2(2), NFATC4(5), NFKB1(4), NFKB2(3), NLK(2), NR4A1(1), NRAS(1), NTRK1(4), NTRK2(6), PAK1(2), PAK2(2), PDGFB(2), PDGFRA(3), PDGFRB(3), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PPM1A(1), PPM1B(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), PPP5C(1), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), PTPN5(3), PTPN7(2), PTPRR(2), RAF1(1), RAPGEF2(3), RASA1(2), RASA2(2), RASGRF1(4), RASGRF2(2), RASGRP2(2), RASGRP3(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA4(1), RPS6KA5(4), RPS6KA6(3), SOS1(4), SOS2(4), SRF(1), STK3(1), STK4(3), TAOK1(5), TAOK2(1), TAOK3(4), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF1A(1), TP53(261), TRAF6(3), ZAK(2)	319554489	895	501	735	173	143	134	181	153	266	18	5.30e-09	1.000	1.000
461	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(1), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), APC(5), ARAF(4), ARHGEF1(7), ARHGEF12(2), ARHGEF4(4), ARHGEF6(4), ARHGEF7(2), ARPC1A(1), ARPC1B(2), ARPC2(2), BCAR1(2), BDKRB1(2), BDKRB2(1), BRAF(3), C3orf10(1), CD14(2), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CRK(1), CRKL(1), CYFIP1(2), CYFIP2(7), DIAPH1(4), DIAPH2(4), DIAPH3(3), EGF(3), EGFR(5), EZR(3), F2(4), F2R(3), FGD3(3), FGF10(1), FGF11(1), FGF13(3), FGF18(1), FGF23(2), FGF3(1), FGF6(1), FGF7(2), FGF9(1), FGFR2(7), FGFR3(2), FGFR4(4), FN1(5), GIT1(1), GRLF1(7), GSN(1), IQGAP1(2), IQGAP2(4), IQGAP3(6), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAD(3), ITGAE(1), ITGAL(1), ITGAM(3), ITGAV(6), ITGAX(5), ITGB1(3), ITGB2(4), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), KRAS(6), LIMK1(4), LIMK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MOS(3), MSN(2), MYH10(7), MYH14(11), MYH9(8), MYL5(1), MYLK(8), MYLK2(2), MYLPF(1), NCKAP1(6), NCKAP1L(5), NRAS(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PDGFB(2), PDGFRA(3), PDGFRB(3), PIK3CA(287), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R1(21), PIK3R3(2), PIP4K2A(1), PIP4K2C(6), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PPP1R12A(3), PPP1R12B(1), PTK2(5), RAF1(1), RDX(1), RHOA(2), ROCK1(4), ROCK2(4), SCIN(1), SLC9A1(1), SOS1(4), SOS2(4), SSH1(1), SSH2(1), SSH3(2), TIAM1(1), TIAM2(5), VAV1(4), VAV2(2), VAV3(4), VCL(4), WAS(3), WASF1(5), WASL(1)	309545313	730	470	484	159	85	180	131	236	98	0	4.01e-07	1.000	1.000
462	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(3), ADCY3(3), ADCY4(2), ADCY7(7), ADCY8(7), ADCY9(9), ADORA2A(2), ADRA1A(2), ADRA1B(1), ADRB2(1), ATP2A1(5), ATP2A2(1), ATP2A3(1), ATP2B1(5), ATP2B2(4), ATP2B3(10), ATP2B4(3), AVPR1B(2), BDKRB1(2), BDKRB2(1), CACNA1A(13), CACNA1B(9), CACNA1C(10), CACNA1D(7), CACNA1E(17), CACNA1F(11), CACNA1G(6), CACNA1H(5), CACNA1I(2), CACNA1S(5), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CCKAR(1), CCKBR(1), CD38(3), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CYSLTR1(2), CYSLTR2(2), EDNRA(1), EDNRB(2), EGFR(5), ERBB2(12), ERBB3(11), ERBB4(6), F2R(3), GNA14(1), GNAQ(1), GNAS(5), GRIN1(1), GRIN2A(12), GRIN2C(4), GRIN2D(4), GRM1(5), GRM5(2), GRPR(1), HRH1(2), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), LHCGR(5), LTB4R2(1), MYLK(8), MYLK2(2), NOS1(7), NOS3(3), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(2), PDE1A(2), PDE1B(2), PDE1C(2), PDGFRA(3), PDGFRB(3), PHKA1(4), PHKA2(9), PHKB(2), PHKG2(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCD3(3), PLCD4(1), PLCE1(12), PLCG1(6), PLCG2(3), PLCZ1(8), PLN(1), PPID(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), PTGER3(3), PTGFR(1), PTK2B(3), RYR1(16), RYR2(32), RYR3(24), SLC25A4(1), SLC25A5(3), SLC8A1(3), SLC8A3(1), SPHK2(2), TACR1(1), TACR2(2), TACR3(1), TNNC2(1), TRPC1(3), VDAC2(2)	303035240	536	340	527	189	131	73	166	110	55	1	0.388	1.000	1.000
463	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(2), ACTG1(4), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), AKT1(19), AKT2(3), AKT3(4), AMOTL1(4), ASH1L(10), CASK(6), CDK4(1), CGN(3), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(1), CLDN17(2), CLDN19(1), CLDN22(2), CLDN6(1), CRB3(1), CSNK2A1(1), CSNK2A2(1), CTNNA1(4), CTNNA2(8), CTNNA3(6), CTNNB1(1), CTTN(1), EPB41(3), EPB41L1(4), EPB41L2(2), EPB41L3(4), EXOC3(3), EXOC4(2), F11R(2), GNAI1(1), GNAI2(2), GNAI3(1), HCLS1(1), IGSF5(2), INADL(6), JAM3(1), KRAS(6), LLGL1(1), LLGL2(4), MAGI1(10), MAGI2(9), MAGI3(4), MLLT4(12), MPDZ(6), MPP5(2), MYH1(8), MYH10(7), MYH11(10), MYH13(7), MYH14(11), MYH15(6), MYH2(3), MYH3(2), MYH4(6), MYH6(12), MYH7(10), MYH7B(11), MYH8(13), MYH9(8), MYL5(1), MYLPF(1), NRAS(1), PARD3(4), PARD6B(2), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), PPP2R3A(3), PPP2R4(4), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(6), PRKCZ(1), PTEN(29), RAB13(1), RHOA(2), SPTAN1(4), SYMPK(5), TJP1(6), TJP2(1), TJP3(2), VAPA(1), YES1(2), ZAK(2)	217994388	401	301	372	115	73	69	113	58	86	2	0.218	1.000	1.000
464	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(2), ACTG1(4), COL11A1(4), COL11A2(1), COL17A1(5), COL1A1(8), COL1A2(6), COL2A1(5), COL3A1(1), COL4A1(4), COL4A2(5), COL4A4(5), COL4A6(7), COL5A1(5), COL5A2(6), COL5A3(7), COL6A1(1), COL6A2(2), COL6A3(10), COL6A6(10), COMP(5), DSC1(2), DSC2(5), DSC3(1), DSG1(3), DSG2(1), DSG3(5), DSG4(4), FN1(5), GJA1(2), GJA10(1), GJA4(1), GJA5(3), GJA8(1), GJA9(1), GJB2(1), GJB3(2), GJB4(1), GJB5(2), GJB6(1), GJC1(1), GJD4(1), IBSP(2), INA(1), ITGA6(4), ITGB4(4), KRT1(6), KRT14(2), KRT15(1), KRT17(4), KRT18(1), KRT19(3), KRT2(2), KRT20(1), KRT24(1), KRT25(1), KRT28(5), KRT3(1), KRT31(1), KRT32(1), KRT33A(1), KRT34(2), KRT35(1), KRT36(2), KRT38(4), KRT39(1), KRT4(2), KRT6A(1), KRT6B(1), KRT6C(1), KRT7(2), KRT71(1), KRT72(2), KRT73(2), KRT74(1), KRT76(2), KRT78(1), KRT79(2), KRT81(2), KRT82(2), KRT84(4), KRT85(1), KRT86(2), KRT9(3), LAMA1(9), LAMA2(10), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(7), LAMB2(7), LAMB3(5), LAMB4(10), LAMC1(8), LAMC2(2), LAMC3(2), LMNA(1), LMNB1(1), NES(4), RELN(19), SPP1(2), THBS1(4), THBS2(1), THBS3(3), THBS4(2), TNC(6), TNN(6), TNR(6), TNXB(7), VIM(1), VTN(1), VWF(10)	271695437	386	279	382	133	77	81	113	49	66	0	0.483	1.000	1.000
465	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	230	ADCYAP1R1(1), ADORA1(1), ADORA2A(2), ADORA3(2), ADRA1A(2), ADRA1B(1), ADRA2B(3), ADRB2(1), AVPR1B(2), AVPR2(3), BDKRB1(2), BDKRB2(1), BRS3(3), C3AR1(2), C5AR1(1), CALCR(1), CALCRL(2), CCKAR(1), CCKBR(1), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CNR1(2), CNR2(1), CRHR1(2), CRHR2(1), CTSG(1), CYSLTR1(2), CYSLTR2(2), DRD2(2), DRD3(1), DRD5(2), EDNRA(1), EDNRB(2), F2(4), F2R(3), F2RL2(1), FPR1(1), FSHR(4), GABBR1(1), GABBR2(2), GABRA1(1), GABRA2(1), GABRA3(3), GABRA4(1), GABRA5(2), GABRA6(3), GABRB1(1), GABRB2(2), GABRB3(1), GABRE(1), GABRG1(2), GABRG2(3), GABRG3(3), GABRP(1), GABRQ(3), GABRR1(1), GALR1(2), GALR2(2), GH1(1), GH2(4), GHR(2), GHRHR(2), GHSR(1), GIPR(1), GLP2R(2), GLRA2(1), GLRA3(3), GPR156(3), GPR35(1), GPR50(2), GPR63(1), GPR83(4), GRIA1(8), GRIA2(3), GRIA3(10), GRIA4(5), GRID1(8), GRID2(6), GRIK1(6), GRIK2(9), GRIK3(4), GRIK4(1), GRIK5(5), GRIN1(1), GRIN2A(12), GRIN2B(9), GRIN2C(4), GRIN2D(4), GRIN3A(4), GRM1(5), GRM2(3), GRM3(8), GRM4(1), GRM5(2), GRM6(3), GRM7(3), GRM8(3), GRPR(1), GZMA(2), HCRTR1(2), HCRTR2(3), HRH1(2), HRH2(2), HRH3(2), HRH4(1), HTR1A(4), HTR1B(1), HTR1E(3), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5), LEPR(4), LHCGR(5), LTB4R2(1), MAS1(2), MC2R(2), MC3R(2), MC4R(2), MCHR2(2), NMBR(2), NMUR1(1), NMUR2(2), NPBWR1(1), NPFFR2(4), NPY1R(4), NPY2R(1), NR3C1(2), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(5), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(2), P2RY1(3), P2RY10(2), P2RY11(1), P2RY13(3), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(2), PARD3(4), PPYR1(1), PRLR(1), PRSS3(1), PTGDR(1), PTGER3(3), PTGFR(1), PTH2R(2), RXFP1(3), RXFP2(1), SSTR2(1), SSTR3(2), SSTR5(1), TAAR1(1), TAAR2(1), TAAR5(3), TAAR6(2), TACR1(1), TACR2(2), TACR3(1), THRA(1), THRB(1), TSHR(4), VIPR2(1)	237322171	412	276	412	145	103	56	141	68	43	1	0.250	1.000	1.000
466	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ADRA1A(2), ADRA1B(1), ADRB2(1), ANXA6(4), ARRB1(1), ARRB2(1), ATP1A4(11), ATP1B1(2), ATP1B3(1), ATP2A2(1), ATP2A3(1), ATP2B1(5), ATP2B2(4), ATP2B3(10), CACNA1A(13), CACNA1B(9), CACNA1C(10), CACNA1D(7), CACNA1E(17), CACNA1S(5), CACNB1(2), CACNB3(1), CALR(1), CAMK1(2), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CASQ1(2), CASQ2(2), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), GJA1(2), GJA4(1), GJA5(3), GJB2(1), GJB3(2), GJB4(1), GJB5(2), GJB6(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNB1(1), GNB2(1), GNB3(3), GRK4(2), GRK6(1), ITPR1(10), ITPR2(7), ITPR3(6), KCNB1(4), KCNJ3(1), KCNJ5(1), MIB1(4), NME7(4), PKIG(1), PLCB3(3), PLN(1), PRKACA(2), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(6), PRKCZ(1), PRKD1(2), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(3), RGS17(2), RGS20(2), RGS3(7), RGS4(4), RGS5(1), RGS7(8), RGS9(4), RYR1(16), RYR2(32), RYR3(24), SLC8A1(3), SLC8A3(1), USP5(4), YWHAB(1)	214030558	382	273	382	142	100	53	110	75	43	1	0.503	1.000	1.000
467	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ATF4(2), CACNA1C(10), CACNA1D(7), CACNA1F(11), CACNA1S(5), CAMK2A(2), CAMK2D(4), CAMK2G(1), EGFR(5), ELK1(2), GNAQ(1), GNAS(5), GNRH1(1), GNRH2(3), GRB2(1), ITPR1(10), ITPR2(7), ITPR3(6), JUN(3), KRAS(6), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAP3K1(69), MAP3K4(18), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MMP14(2), NRAS(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLD1(5), PLD2(2), PRKACA(2), PRKACG(1), PRKCD(2), PRKX(2), PTK2B(3), RAF1(1), SOS1(4), SOS2(4)	144185119	324	251	298	82	50	36	75	47	100	16	0.325	1.000	1.000
468	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(5), ABLIM1(4), ABLIM3(2), ARHGEF12(2), CDK5(1), DCC(10), DPYSL2(2), DPYSL5(2), EFNA3(1), EFNB1(1), EFNB2(2), EPHA1(3), EPHA2(3), EPHA3(4), EPHA4(2), EPHA5(7), EPHA6(3), EPHA7(3), EPHA8(1), EPHB1(5), EPHB2(3), EPHB3(3), EPHB4(2), EPHB6(3), FES(2), GNAI1(1), GNAI2(2), GNAI3(1), ITGB1(3), KRAS(6), L1CAM(4), LIMK1(4), LIMK2(2), LRRC4C(3), MAPK1(1), MAPK3(1), MET(7), NCK1(1), NCK2(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NGEF(2), NRAS(1), NRP1(6), NTNG1(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PLXNA1(7), PLXNA2(5), PLXNA3(6), PLXNB1(2), PLXNB2(3), PLXNB3(4), PLXNC1(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PTK2(5), RASA1(2), RGS3(7), RHOA(2), RND1(1), ROBO1(8), ROBO2(7), ROBO3(1), ROCK1(4), ROCK2(4), SEMA3A(5), SEMA3B(1), SEMA3C(3), SEMA3D(2), SEMA3E(1), SEMA3F(1), SEMA4A(4), SEMA4C(1), SEMA4D(3), SEMA4F(6), SEMA4G(3), SEMA5A(8), SEMA5B(6), SEMA6A(4), SEMA6C(1), SEMA6D(2), SEMA7A(2), SLIT1(1), SLIT2(6), SLIT3(3), SRGAP1(8), SRGAP2(5), SRGAP3(1), UNC5B(3), UNC5C(5), UNC5D(10)	211013463	324	246	321	91	62	64	104	42	52	0	0.0559	1.000	1.000
469	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD36(1), CD44(2), COL11A1(4), COL11A2(1), COL1A1(8), COL1A2(6), COL2A1(5), COL3A1(1), COL4A1(4), COL4A2(5), COL4A4(5), COL4A6(7), COL5A1(5), COL5A2(6), COL5A3(7), COL6A1(1), COL6A2(2), COL6A3(10), COL6A6(10), DAG1(1), FN1(5), FNDC1(9), FNDC3A(1), FNDC4(1), GP6(2), HMMR(1), HSPG2(8), IBSP(2), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAV(6), ITGB1(3), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), LAMA1(9), LAMA2(10), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(7), LAMB2(7), LAMB3(5), LAMB4(10), LAMC1(8), LAMC2(2), LAMC3(2), RELN(19), SDC2(2), SPP1(2), SV2A(3), SV2B(1), THBS1(4), THBS2(1), THBS3(3), THBS4(2), TNC(6), TNN(6), TNR(6), TNXB(7), VTN(1), VWF(10)	243632272	332	246	331	124	63	73	96	45	55	0	0.832	1.000	1.000
470	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(2), ACTA2(2), ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ARRB1(1), ARRB2(1), ATF1(2), ATF2(2), ATF3(1), ATF4(2), ATP2A2(1), ATP2A3(1), CACNB3(1), CALCA(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), CREB3(1), CRHR1(2), ETS2(5), GABPA(1), GJA1(2), GNAQ(1), GNB1(1), GNB2(1), GNB3(3), GRK4(2), GRK6(1), GUCY1A3(1), IGFBP2(1), IGFBP3(1), IGFBP4(1), IL6(2), ITPR1(10), ITPR2(7), ITPR3(6), JUN(3), MIB1(4), MYLK2(2), NFKB1(4), NOS1(7), NOS3(3), PDE4B(4), PDE4D(6), PKIG(1), PLCB3(3), PLCD1(1), PLCG1(6), PLCG2(3), PRKACA(2), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCH(1), PRKCQ(6), PRKCZ(1), PRKD1(2), RAMP3(1), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(3), RGS17(2), RGS20(2), RGS3(7), RGS4(4), RGS5(1), RGS7(8), RGS9(4), RLN1(1), RYR1(16), RYR2(32), RYR3(24), SLC8A1(3), SP1(3), TNXB(7), USP5(4), YWHAB(1)	191245200	311	242	311	112	75	40	93	60	43	0	0.534	1.000	1.000
471	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(1), ACVR1B(6), ACVR2A(4), ACVR2B(1), AMHR2(3), BMP2(3), BMPR1B(3), BMPR2(3), CCL11(1), CCL13(2), CCL14(1), CCL20(1), CCL21(1), CCL23(1), CCL28(1), CCL7(1), CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CD40(1), CD40LG(1), CLCF1(1), CNTFR(1), CSF1(3), CSF2RA(2), CSF2RB(3), CSF3R(3), CX3CL1(2), CX3CR1(3), CXCL6(1), CXCR3(5), EDA(2), EDA2R(1), EDAR(2), EGF(3), EGFR(5), EPOR(4), FAS(1), FASLG(2), FLT1(2), FLT3(3), FLT3LG(1), FLT4(1), GH1(1), GH2(4), GHR(2), HGF(4), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNK(1), IL10RA(2), IL10RB(4), IL11(1), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL13RA1(1), IL15(2), IL17B(2), IL17RA(2), IL17RB(2), IL18(1), IL18R1(2), IL18RAP(3), IL19(1), IL1A(1), IL1R1(1), IL1R2(5), IL1RAP(7), IL2(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA1(2), IL22RA2(1), IL23R(3), IL25(1), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(2), IL4R(4), IL5RA(2), IL6(2), IL6R(1), IL6ST(6), IL7R(4), IL9R(1), INHBA(3), INHBB(1), INHBC(1), INHBE(1), KDR(2), KIT(5), KITLG(3), LEPR(4), LIF(3), LIFR(7), LTA(1), MET(7), MPL(1), NGFR(1), OSMR(4), PDGFB(2), PDGFRA(3), PDGFRB(3), PF4(1), PLEKHO2(1), PRLR(1), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(4), TNFRSF19(2), TNFRSF1A(1), TNFRSF21(2), TNFRSF25(1), TNFRSF8(2), TNFRSF9(2), TNFSF13B(1), TNFSF14(1), TNFSF18(1), TNFSF4(3), TPO(5), TSLP(1), XCL1(2), XCR1(4)	197085524	317	241	314	86	59	62	90	48	58	0	0.0131	1.000	1.000
472	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	126	ALCAM(4), CADM1(3), CADM3(1), CD2(3), CD22(1), CD226(3), CD274(1), CD28(1), CD34(2), CD4(4), CD40(1), CD40LG(1), CD58(1), CD86(2), CD8A(2), CD99(2), CDH1(56), CDH15(3), CDH2(1), CDH3(1), CDH4(3), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(1), CLDN17(2), CLDN19(1), CLDN22(2), CLDN6(1), CNTN1(7), CNTN2(4), CNTNAP1(4), CNTNAP2(6), CTLA4(1), ESAM(2), F11R(2), GLG1(4), HLA-A(4), HLA-C(2), HLA-DMA(1), HLA-DMB(2), HLA-DRB1(8), HLA-E(1), HLA-F(4), HLA-G(2), ICAM1(1), ICAM3(2), ICOS(1), ICOSLG(2), ITGA4(2), ITGA6(4), ITGA8(3), ITGA9(2), ITGAL(1), ITGAM(3), ITGAV(6), ITGB1(3), ITGB2(4), ITGB8(2), JAM3(1), L1CAM(4), MAG(2), MPZL1(1), NCAM1(4), NCAM2(3), NEGR1(1), NEO1(5), NFASC(6), NLGN1(2), NLGN2(3), NLGN3(5), NRCAM(3), NRXN1(6), NRXN2(10), NRXN3(7), PDCD1(1), PTPRC(3), PTPRF(6), PTPRM(3), PVRL1(2), PVRL2(2), PVRL3(4), SDC2(2), SELE(1), SELL(5), SELP(8), SELPLG(7), SIGLEC1(2), SPN(2), VCAM1(4), VCAN(12)	157800810	323	240	305	76	48	54	70	43	107	1	0.0157	1.000	1.000
473	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(2), ACTA2(2), ACTN2(9), ACTN3(1), ACTN4(6), DMD(28), FAM48A(1), MYBPC1(3), MYBPC2(4), MYBPC3(2), MYH3(2), MYH6(12), MYH7(10), MYH8(13), MYL1(1), MYOM1(4), NEB(25), TMOD1(1), TNNC2(1), TNNI3(1), TNNT1(1), TNNT3(2), TPM1(3), TPM2(2), TPM3(3), TPM4(1), TTN(155), VIM(1)	162286787	296	220	294	55	47	41	101	67	39	1	0.000727	1.000	1.000
474	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(2), ACTG1(4), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), ACVR1B(6), ACVR1C(2), CDH1(56), CREBBP(7), CSNK2A1(1), CSNK2A2(1), CTNNA1(4), CTNNA2(8), CTNNA3(6), CTNNB1(1), CTNND1(1), EGFR(5), EP300(7), ERBB2(12), FARP2(5), FER(1), IGF1R(2), INSR(4), IQGAP1(2), LMO7(2), MAP3K7(1), MAPK1(1), MAPK3(1), MET(7), MLLT4(12), NLK(2), PARD3(4), PTPRB(10), PTPRF(6), PTPRJ(3), PTPRM(3), PVRL1(2), PVRL2(2), PVRL3(4), PVRL4(2), RHOA(2), SMAD2(4), SMAD3(3), SMAD4(3), SNAI1(2), SNAI2(1), SORBS1(5), SSX2IP(1), TCF7(3), TCF7L1(2), TCF7L2(3), TGFBR1(2), TGFBR2(3), TJP1(6), VCL(4), WAS(3), WASF1(5), WASF3(1), WASL(1), YES1(2)	135429038	272	217	259	64	41	40	67	29	95	0	0.109	1.000	1.000
475	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	ACTB(2), CABIN1(5), CAMK4(3), CD3E(2), CD3G(2), CD69(2), CNR1(2), CREBBP(7), CSNK2A1(1), CTLA4(1), EGR2(2), EGR3(2), EP300(7), FCER1A(4), FCGR3A(1), GATA3(84), GRLF1(7), GSK3A(3), ICOS(1), IFNA1(1), IFNB1(1), IFNG(2), IL2(1), IL6(2), ITK(4), KPNA5(2), MAP2K7(1), MAPK14(2), MAPK8(2), MEF2A(14), MEF2B(1), MEF2D(2), MYF5(1), NCK2(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NFKB2(3), NFKBIE(1), NUP214(5), OPRD1(2), PAK1(2), PPP3CB(3), PPP3R1(1), PTPRC(3), RELA(1), RPL13A(3), SP1(3), SP3(4), TGFB1(2), TRPV6(2), VAV1(4), VAV2(2), VAV3(4), XPO5(4)	99315608	241	202	195	46	17	32	41	25	124	2	0.424	1.000	1.000
476	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(2), ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ADK(1), ADSL(2), AK2(1), AK3L1(1), AK5(2), AK7(2), AMPD1(6), AMPD2(1), AMPD3(1), ATIC(3), CANT1(1), DGUOK(2), ENPP1(5), ENPP3(2), ENTPD1(2), ENTPD2(2), ENTPD4(3), ENTPD5(1), ENTPD6(2), FHIT(1), GART(1), GDA(1), GMPR2(1), GMPS(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), IMPDH1(2), IMPDH2(1), NME4(1), NME6(1), NME7(4), NPR1(3), NPR2(2), NT5C1B(4), NT5C3(1), NT5E(5), NT5M(1), NUDT2(1), NUDT5(1), NUDT9(1), PAICS(1), PAPSS1(2), PDE10A(6), PDE11A(4), PDE1A(2), PDE1C(2), PDE2A(4), PDE3B(2), PDE4A(1), PDE4B(4), PDE4C(5), PDE4D(6), PDE5A(1), PDE7B(1), PDE8A(1), PDE9A(5), PFAS(1), PKLR(3), PKM2(1), PNPT1(3), POLA1(5), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), POLE3(1), POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3A(2), POLR3B(2), POLR3GL(3), PPAT(1), PRPS2(1), PRUNE(4), RRM1(2), RRM2(1), XDH(4)	182345593	254	195	253	85	50	37	85	47	35	0	0.590	1.000	1.000
477	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(4), BRAF(3), C7orf16(2), CACNA1A(13), CRHR1(2), GNAI1(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(5), GRIA1(8), GRIA2(3), GRIA3(10), GRID2(6), GRM1(5), GRM5(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), IGF1(1), IGF1R(2), ITPR1(10), ITPR2(7), ITPR3(6), KRAS(6), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(7), NOS3(3), NPR1(3), NPR2(2), NRAS(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), PRKCG(2), PRKG1(3), PRKG2(6), RAF1(1), RYR1(16)	123398646	212	179	208	58	42	47	62	35	26	0	0.0212	1.000	1.000
478	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), DRD2(2), EGF(3), EGFR(5), GJA1(2), GNAI1(1), GNAI2(2), GNAI3(1), GNAQ(1), GNAS(5), GRB2(1), GRM1(5), GRM5(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), HTR2A(3), HTR2B(1), HTR2C(2), ITPR1(10), ITPR2(7), ITPR3(6), KRAS(6), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAPK1(1), MAPK3(1), NPR1(3), NPR2(2), NRAS(1), PDGFB(2), PDGFRA(3), PDGFRB(3), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PRKACA(2), PRKACG(1), PRKCG(2), PRKG1(3), PRKG2(6), PRKX(2), RAF1(1), SOS1(4), SOS2(4), TJP1(6), TUBA1A(1), TUBA1B(2), TUBA1C(2), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), TUBB6(1)	145778630	211	170	207	69	46	35	66	37	27	0	0.383	1.000	1.000
479	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(19), AKT3(4), BCAR1(2), CAPN1(4), CAPN10(1), CAPN11(1), CAPN2(3), CAPN3(2), CAPN6(2), CAPN7(1), CAV1(2), CRK(1), GRB2(1), ILK(2), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAD(3), ITGAE(1), ITGAL(1), ITGAM(3), ITGAV(6), ITGAX(5), ITGB1(3), ITGB2(4), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAPK10(2), MAPK4(6), MAPK6(3), MYLK2(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PTK2(5), RAPGEF1(4), RHO(4), ROCK1(4), ROCK2(4), SDCCAG8(6), SEPP1(2), SHC1(1), SHC3(1), SORBS1(5), SOS1(4), TLN1(12), TNS1(7), VAV2(2), VAV3(4), VCL(4)	150241323	209	169	190	72	35	56	45	39	34	0	0.526	1.000	1.000
480	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	147	ADORA1(1), ADORA2A(2), ADORA3(2), ADRA1A(2), ADRA1B(1), ADRB2(1), AVPR1B(2), AVPR2(3), BDKRB1(2), BDKRB2(1), BRS3(3), C3AR1(2), CCKAR(1), CCKBR(1), CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CCRL1(1), CCRL2(2), CHML(4), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CMKLR1(2), CNR1(2), CNR2(1), CX3CR1(3), CXCR3(5), DRD2(2), DRD3(1), DRD5(2), EDNRA(1), EDNRB(2), F2R(3), F2RL2(1), FPR1(1), FSHR(4), GALR1(2), GALR2(2), GALT(1), GHSR(1), GNB2L1(3), GPR17(2), GPR174(3), GPR3(2), GPR35(1), GPR37(2), GPR50(2), GPR6(2), GPR63(1), GPR77(1), GPR83(4), GPR85(1), GRPR(1), HCRTR1(2), HCRTR2(3), HRH1(2), HRH2(2), HRH3(2), HTR1A(4), HTR1B(1), HTR1E(3), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5), LHCGR(5), MAS1(2), MC3R(2), MC4R(2), NMBR(2), NMUR1(1), NMUR2(2), NPY1R(4), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(5), P2RY1(3), P2RY10(2), P2RY11(1), P2RY13(3), P2RY2(1), P2RY6(1), PPYR1(1), PTGDR(1), PTGFR(1), RHO(4), SSTR2(1), SSTR3(2)	120528259	199	163	200	75	52	25	52	45	25	0	0.471	1.000	1.000
481	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADK(1), ADSL(2), AK2(1), AK5(2), AMPD1(6), AMPD2(1), AMPD3(1), ATIC(3), ATP1B1(2), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), CANT1(1), DGUOK(2), ENPP1(5), ENPP3(2), ENTPD1(2), ENTPD2(2), FHIT(1), GART(1), GDA(1), GMPS(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), IMPDH1(2), IMPDH2(1), NPR1(3), NPR2(2), NT5E(5), NT5M(1), NUDT2(1), PAICS(1), PAPSS1(2), PDE1A(2), PDE4A(1), PDE4B(4), PDE4C(5), PDE4D(6), PDE5A(1), PDE6B(2), PDE6C(6), PDE7B(1), PDE8A(1), PDE9A(5), PFAS(1), PKLR(3), PKM2(1), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(1), POLQ(8), POLR1B(2), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), PPAT(1), PRPS2(1), PRUNE(4), RRM1(2), RRM2(1)	141799104	200	162	199	68	37	30	71	31	31	0	0.695	1.000	1.000
482	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), AKAP1(3), AKAP11(5), AKAP12(3), AKAP3(2), AKAP4(7), AKAP6(7), AKAP7(1), AKAP8(2), AKAP9(14), ARHGEF1(7), GNA14(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNB1(1), GNB2(1), GNB3(3), IL18BP(1), ITPR1(10), KCNJ3(1), KRAS(6), NRAS(1), PALM2(3), PDE1A(2), PDE1B(2), PDE1C(2), PDE4A(1), PDE4B(4), PDE4C(5), PDE4D(6), PDE7B(1), PDE8A(1), PLCB3(3), PPP3CA(4), PRKACA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(6), PRKCZ(1), PRKD1(2), PRKD3(3), RHOA(2), SLC9A1(1), USP5(4)	131014852	190	161	187	61	36	29	63	38	24	0	0.430	1.000	1.000
483	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(7), ABCA12(5), ABCA13(16), ABCA2(1), ABCA3(6), ABCA4(7), ABCA5(6), ABCA6(4), ABCA7(7), ABCA8(10), ABCA9(5), ABCB1(4), ABCB10(5), ABCB11(7), ABCB4(2), ABCB5(4), ABCB6(3), ABCB7(5), ABCB8(5), ABCB9(1), ABCC1(3), ABCC10(3), ABCC11(3), ABCC12(6), ABCC2(5), ABCC3(4), ABCC4(4), ABCC5(4), ABCC6(4), ABCC8(7), ABCC9(10), ABCD1(4), ABCD2(2), ABCD3(2), ABCD4(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG5(2), CFTR(9), TAP1(2)	131376662	195	160	195	55	35	30	71	33	26	0	0.0928	1.000	1.000
484	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), CAMK2A(2), CAMK2D(4), CAMK2G(1), CREB1(1), CREB3(1), CREB3L1(1), CREB3L2(2), CREB3L3(4), CREB3L4(2), CREBBP(7), CTNNB1(1), DCT(2), DVL1(2), DVL3(2), EDN1(2), EDNRB(2), EP300(7), FZD1(1), FZD2(1), FZD3(3), FZD6(3), FZD7(1), FZD8(2), FZD9(3), GNAI1(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(5), KIT(5), KITLG(3), KRAS(6), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), RAF1(1), TCF7(3), TCF7L1(2), TCF7L2(3), TYR(6), TYRP1(4), WNT10B(1), WNT11(2), WNT2(1), WNT2B(2), WNT3A(2), WNT4(1), WNT5B(2), WNT7A(5), WNT8B(1), WNT9A(1)	115299694	186	157	182	60	48	36	58	27	17	0	0.260	1.000	1.000
485	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(4), AMY2A(1), ASCC3(4), ATP13A2(1), DDX18(2), DDX23(1), DDX4(3), DDX41(3), DDX50(3), DDX51(1), DDX54(1), DDX55(4), DDX56(2), DHX58(2), ENPP1(5), ENPP3(2), ENTPD7(4), EP400(5), ERCC2(1), ERCC3(2), G6PC(1), G6PC2(2), GAA(2), GANC(2), GBA(1), GBA3(2), GBE1(3), GCK(2), GPI(2), GUSB(3), GYS1(5), GYS2(1), HK1(1), HK2(2), HK3(2), IFIH1(3), MGAM(12), MOV10L1(4), NUDT5(1), PGM1(1), PGM3(1), PYGB(3), PYGL(2), PYGM(5), RAD54B(6), RAD54L(2), SETX(11), SI(9), SKIV2L2(2), SMARCA2(5), SMARCA5(2), TREH(1), UGDH(1), UGP2(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1), UXS1(2)	139066234	179	155	179	46	27	33	48	46	25	0	0.121	1.000	1.000
486	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(3), ADCY8(7), ARAF(4), ATF4(2), BRAF(3), CACNA1C(10), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CREBBP(7), EP300(7), GNAQ(1), GRIA1(8), GRIA2(3), GRIN1(1), GRIN2A(12), GRIN2B(9), GRIN2C(4), GRIN2D(4), GRM1(5), GRM5(2), ITPR1(10), ITPR2(7), ITPR3(6), KRAS(6), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PPP1R12A(3), PPP1R1A(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), RAF1(1), RAPGEF3(2), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA6(3)	113472482	188	153	184	53	40	34	57	32	25	0	0.0752	1.000	1.000
487	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(5), BDKRB1(2), BDKRB2(1), C1QA(1), C1QB(1), C1QC(1), C1S(2), C2(1), C3(7), C3AR1(2), C4BPA(4), C4BPB(2), C5(4), C5AR1(1), C6(5), C7(6), C9(1), CD46(2), CD55(2), CFB(1), CFH(12), CPB2(1), CR1(10), CR2(4), F13A1(4), F13B(3), F2(4), F2R(3), F5(14), F7(1), F8(7), F9(1), FGA(5), FGB(1), FGG(4), KLKB1(1), KNG1(4), MASP1(3), MASP2(2), MBL2(1), PLAT(3), PLAU(2), PLAUR(1), PLG(4), PROC(1), PROS1(1), SERPINA1(5), SERPINA5(3), SERPINC1(4), SERPIND1(1), SERPINE1(3), SERPINF2(1), SERPING1(2), TFPI(2), VWF(10)	100804240	179	152	177	49	20	30	68	30	31	0	0.231	1.000	1.000
488	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	ALG1(1), ALG10(1), ALG10B(3), ALG11(1), ALG12(3), ALG13(6), ALG14(1), ALG2(2), ALG3(1), ALG6(1), ALG8(1), ALG9(2), B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), B4GALT5(2), C1GALT1(1), C1GALT1C1(1), CHPF(1), CHST1(1), CHST11(2), CHST2(3), CHST3(1), CHSY1(1), DPAGT1(2), EXT1(5), EXT2(6), EXTL3(4), FUT11(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT2(1), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(4), GALNT8(3), GALNT9(4), GALNTL1(1), GALNTL4(1), GALNTL5(4), GANAB(3), GCNT4(2), HS2ST1(2), HS3ST2(3), HS3ST5(4), HS6ST1(5), HS6ST2(5), HS6ST3(1), MAN1A1(1), MAN1A2(2), MAN1B1(4), MAN2A1(3), MGAT3(2), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), NDST3(2), OGT(3), RPN1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST6GALNAC1(3), STT3B(2), UST(3), WBSCR17(5), XYLT1(2), XYLT2(1)	118593122	174	142	171	64	31	31	43	35	34	0	0.759	1.000	1.000
489	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(1), ACVR1B(6), ACVR1C(2), ACVR2A(4), ACVR2B(1), ACVRL1(1), AMHR2(3), BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BMPR1B(3), BMPR2(3), CHRD(3), COMP(5), CREBBP(7), CUL1(2), E2F4(4), E2F5(1), EP300(7), FST(2), GDF6(2), ID2(1), IFNG(2), INHBA(3), INHBB(1), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(5), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), PITX2(3), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), RBL1(3), RBL2(1), RHOA(2), ROCK1(4), ROCK2(4), RPS6KB1(2), RPS6KB2(4), SMAD1(1), SMAD2(4), SMAD3(3), SMAD4(3), SMAD5(1), SMAD9(2), SMURF1(2), SMURF2(1), SP1(3), TFDP1(2), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), THBS1(4), THBS2(1), THBS3(3), THBS4(2), ZFYVE16(3), ZFYVE9(3)	108146897	161	139	156	40	29	25	38	31	38	0	0.134	1.000	1.000
490	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(6), CD14(2), CD19(3), CD1A(1), CD1B(4), CD1C(3), CD1D(3), CD1E(3), CD2(3), CD22(1), CD33(1), CD34(2), CD36(1), CD37(1), CD38(3), CD3E(2), CD3G(2), CD4(4), CD44(2), CD5(2), CD55(2), CD8A(2), CD9(2), CR1(10), CR2(4), CSF1(3), CSF2RA(2), CSF3R(3), DNTT(4), EPOR(4), FCGR1A(1), FLT3(3), FLT3LG(1), HLA-DRB1(8), IL11(1), IL11RA(4), IL1A(1), IL1R1(1), IL1R2(5), IL3RA(2), IL4R(4), IL5RA(2), IL6(2), IL6R(1), IL7R(4), IL9R(1), ITGA1(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGAM(3), ITGB3(3), KIT(5), KITLG(3), MS4A1(1), TFRC(1), TPO(5)	91882762	165	137	163	42	25	31	46	32	30	1	0.0684	1.000	1.000
491	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	90	CD2BP2(1), CDC40(2), CLK3(1), CLK4(1), COL2A1(5), CPSF1(4), CPSF3(3), CPSF4(3), CSTF2(1), CSTF2T(2), CSTF3(4), DDX20(2), DHX15(2), DHX16(1), DHX38(2), DHX8(2), DHX9(2), DICER1(5), FUS(2), GIPC1(1), METTL3(2), NCBP1(1), NONO(2), NUDT21(1), NXF1(3), PABPN1(1), PAPOLA(2), POLR2A(5), PRPF3(2), PRPF4(4), PRPF4B(6), PRPF8(7), PSKH1(2), PTBP1(3), RBM17(1), RBM5(3), RNGTT(1), SF3A1(1), SF3B1(14), SF3B2(3), SF3B4(2), SF4(6), SFRS12(1), SFRS14(2), SFRS16(4), SFRS2(1), SFRS4(2), SFRS5(1), SFRS7(1), SFRS8(1), SFRS9(1), SNRPB(1), SNRPN(2), SNURF(1), SPOP(1), SRPK1(2), SRRM1(3), SUPT5H(7), TXNL4A(1), U2AF1(1), U2AF2(1), XRN2(4)	117569592	156	136	149	27	23	35	43	35	19	1	0.00317	1.000	1.000
492	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	67	ACACB(9), ACSL1(1), ACSL3(1), ACSL4(2), ACSL5(2), ACSL6(2), AKT1(19), AKT2(3), AKT3(4), CAMKK1(3), CAMKK2(2), CD36(1), CHUK(1), CPT1A(4), CPT1B(2), CPT1C(3), CPT2(5), G6PC(1), G6PC2(2), IKBKB(4), IRS1(2), IRS4(6), JAK1(4), JAK2(5), JAK3(5), LEPR(4), MAPK10(2), MAPK8(2), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NPY(1), PCK1(2), PCK2(3), PPARA(2), PPARGC1A(5), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAG3(3), PRKCQ(6), PTPN11(1), RELA(1), RXRA(1), RXRG(1), SLC2A4(1), STAT3(3), STK11(2), TNFRSF1A(1), TYK2(5)	88270905	154	130	137	35	24	43	34	22	30	1	0.00822	1.000	1.000
493	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	84	CAD(10), CANT1(1), CTPS(1), CTPS2(3), DPYS(1), ENTPD1(2), ENTPD4(3), ENTPD5(1), ENTPD6(2), NME4(1), NME6(1), NME7(4), NT5C1B(4), NT5C3(1), NT5E(5), NT5M(1), NUDT2(1), PNPT1(3), POLA1(5), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), POLE3(1), POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3A(2), POLR3B(2), POLR3GL(3), RRM1(2), RRM2(1), TXNRD1(2), TXNRD2(1), TYMS(1), UCK1(1), UCK2(2), UMPS(3), UPB1(3), UPP1(3), UPRT(2)	90696126	118	106	118	41	20	20	35	21	22	0	0.658	1.000	1.000
494	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), CDS1(3), CDS2(2), CHAT(1), CHKB(2), CHPT1(3), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKI(7), DGKQ(1), ESCO1(3), ETNK1(3), ETNK2(1), GNPAT(3), GPAM(1), GPD1(2), GPD1L(1), GPD2(1), LCAT(1), MYST3(4), MYST4(8), PCYT1A(2), PCYT1B(3), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(5), PLD2(2), PNPLA3(2), PPAP2A(1), PPAP2C(2), PTDSS1(2), PTDSS2(2), SH3GLB1(1)	72332366	111	100	109	37	22	17	30	28	13	1	0.543	1.000	1.000
495	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACOX1(2), ACOX2(1), ACOX3(2), ACSL1(1), ACSL3(1), ACSL4(2), ACSL5(2), ACSL6(2), APOA5(1), AQP7(8), CD36(1), CPT1A(4), CPT1B(2), CPT1C(3), CPT2(5), CYP27A1(2), CYP4A11(1), CYP4A22(1), CYP7A1(1), CYP8B1(3), EHHADH(3), FABP1(1), FABP2(1), FABP4(1), FABP6(1), FADS2(4), GK(1), GK2(3), HMGCS2(1), ILK(2), LPL(1), PCK1(2), PCK2(3), PLTP(1), PPARA(2), PPARG(2), RXRA(1), RXRG(1), SCD(1), SLC27A1(1), SLC27A2(2), SLC27A4(5), SLC27A5(3), SORBS1(5), UBC(8), UCP1(1)	71651172	102	95	99	33	17	20	24	20	21	0	0.588	1.000	1.000
496	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(7), B3GALT4(2), CDR1(1), DGKI(7), IL6ST(6), RPL10(2), RPL13A(3), RPL14(1), RPL17(1), RPL18(4), RPL18A(2), RPL19(1), RPL26(2), RPL29(1), RPL3(1), RPL35(2), RPL36(1), RPL3L(1), RPL4(1), RPL41(1), RPL5(3), RPL7(1), RPL8(1), RPLP0(1), RPLP2(1), RPS10(1), RPS14(1), RPS16(1), RPS2(1), RPS21(1), RPS27(1), RPS4X(2), RPS5(4), RPS6(2), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA6(3), RPS6KB1(2), RPS6KB2(4), RPSA(1), SLC36A2(2), TBC1D10C(2), UBA52(1), UBC(8)	58849603	101	94	100	23	18	13	37	17	16	0	0.294	1.000	1.000
497	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(2), AKT1(19), BDKRB2(1), CAV1(2), CHRM1(2), CHRNA1(1), FLT1(2), FLT4(1), KDR(2), NOS3(3), PDE2A(4), PDE3A(8), PDE3B(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKG1(3), PRKG2(6), RYR2(32)	45739550	97	92	80	43	10	30	32	16	9	0	0.853	1.000	1.000
498	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	ATP8A1(2), AVPR1B(2), AVPR2(3), BDKRB1(2), BDKRB2(1), BRS3(3), C3AR1(2), CCKAR(1), CCKBR(1), CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CX3CR1(3), CXCR3(5), EDNRA(1), EDNRB(2), FPR1(1), FSHR(4), GALR1(2), GALR2(2), GALT(1), GHSR(1), GNB2L1(3), GPR77(1), GRPR(1), LHCGR(5), MC2R(2), MC3R(2), MC4R(2), NMBR(2), NPY1R(4), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(5), PPYR1(1), SSTR2(1), SSTR3(2), TACR1(1), TACR2(2), TACR3(1), TSHR(4)	56107893	98	89	98	33	22	15	27	23	11	0	0.253	1.000	1.000
499	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(1), ADCY4(2), ADCY6(1), ADCY8(7), CACNA1A(13), CACNA1B(9), GNAS(5), GNAT3(1), GNB1(1), GNB3(3), GRM4(1), ITPR3(6), KCNB1(4), PDE1A(2), PLCB2(2), PRKACA(2), PRKACG(1), PRKX(2), SCNN1B(2), SCNN1G(1), TAS1R1(1), TAS1R2(1), TAS1R3(1), TAS2R1(1), TAS2R10(3), TAS2R13(2), TAS2R14(2), TAS2R16(3), TAS2R3(1), TAS2R38(1), TAS2R40(1), TAS2R42(1), TAS2R43(2), TAS2R46(1), TAS2R5(1), TAS2R8(1), TAS2R9(2), TRPM5(4)	62556795	95	87	96	32	23	17	26	17	12	0	0.249	1.000	1.000
500	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(4), ACTG2(2), AKT1(19), ANGPTL2(1), FLNA(5), FLNC(10), FSCN3(1), GDI1(4), LIMK1(4), MYH2(3), MYLK(8), MYLK2(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), RHO(4), ROCK1(4), ROCK2(4), RPS4X(2), WASF1(5), WASL(1)	50782778	93	86	76	30	14	34	24	9	12	0	0.269	1.000	1.000
501	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(4), AMY2A(1), ENPP1(5), ENPP3(2), G6PC(1), GAA(2), GANAB(3), GBA3(2), GBE1(3), GCK(2), GPI(2), GUSB(3), GYS1(5), GYS2(1), HK1(1), HK2(2), HK3(2), MGAM(12), PGM1(1), PGM3(1), PYGB(3), PYGL(2), PYGM(5), RNPC3(1), SI(9), UCHL3(1), UGDH(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2), UXS1(2)	65078794	93	85	93	29	14	17	22	25	15	0	0.466	1.000	1.000
502	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), AOX1(4), CARM1(2), DBH(3), DCT(2), DDC(1), ESCO1(3), FAH(1), GSTZ1(1), HEMK1(1), HGD(1), HPD(2), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), MYST3(4), MYST4(8), PNPLA3(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), SH3GLB1(1), TAT(2), TH(1), TPO(5), TYR(6), TYRP1(4), WBSCR22(2)	64825432	96	84	96	27	18	23	29	11	14	1	0.231	1.000	1.000
503	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BTRC(2), CSNK1A1(1), CSNK1A1L(3), CSNK1E(2), CSNK1G3(2), DHH(1), GLI1(3), GLI2(5), GLI3(8), LRP2(24), PRKACA(2), PRKACG(1), PRKX(2), PTCH1(6), PTCH2(1), SMO(2), SUFU(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(2), WNT3A(2), WNT4(1), WNT5B(2), WNT7A(5), WNT8B(1), WNT9A(1), ZIC2(1)	62492805	95	84	95	26	32	9	22	20	12	0	0.182	1.000	1.000
504	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(3), AR(4), ESR1(3), ESR2(2), HNF4A(3), NR1D1(2), NR1D2(1), NR1H2(18), NR1I2(1), NR1I3(1), NR2C2(2), NR2E1(2), NR2F1(1), NR3C1(2), NR4A1(1), NR4A2(1), NR5A2(5), PGR(4), PPARA(2), PPARG(2), RARA(2), RARB(5), RARG(3), ROR1(8), RORA(1), RORC(3), RXRA(1), RXRG(1), THRA(1), THRB(1)	43985990	86	83	73	27	15	15	15	10	31	0	0.648	1.000	1.000
505	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(4), CD28(1), CTLA4(1), DAG1(1), EPHB2(3), FBXW7(6), GRAP2(1), GRB2(1), ITK(4), ITPKA(1), ITPKB(7), LAT(1), LCK(1), LCP2(1), MAPK1(1), NCK1(1), NFAT5(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PLCG1(6), PTPRC(3), RAF1(1), RASGRP2(2), RASGRP3(1), RASGRP4(1), SOS1(4), SOS2(4), VAV1(4), ZAP70(2)	61246445	88	80	88	29	17	20	21	17	12	1	0.531	1.000	1.000
506	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPS(1), CDS1(3), CDS2(2), CHAT(1), CHKB(2), CLC(1), CPT1B(2), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKQ(1), ETNK1(3), GNPAT(3), GPD1(2), GPD2(1), LCAT(1), LGALS13(2), PAFAH1B1(3), PCYT1A(2), PCYT1B(3), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB2(2), PLCG1(6), PLCG2(3), PPAP2A(1), PPAP2C(2)	54557613	84	78	82	28	15	12	23	21	13	0	0.540	1.000	1.000
507	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACAT1(2), AFMID(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), AOX1(4), ASMT(1), CARM1(2), CAT(1), CYP1A2(3), CYP1B1(1), DDC(1), EHHADH(3), GCDH(1), HAAO(1), HADH(2), HEMK1(1), HSD17B10(1), HSD17B4(6), INMT(3), KMO(1), KYNU(1), LCMT1(1), LCMT2(5), LNX1(4), MAOA(2), MAOB(1), METTL2B(2), NFX1(2), OGDH(4), OGDHL(4), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), TDO2(1), TPH2(2), WARS2(1), WBSCR22(2)	67826383	88	78	87	31	12	24	34	10	8	0	0.548	1.000	1.000
508	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	AKT1(19), APC(5), ASAH1(1), DAG1(1), DLG4(1), EPHB2(3), GNAI1(1), GNAQ(1), ITPR1(10), ITPR2(7), ITPR3(6), KCNJ3(1), KCNJ5(1), MAPK1(1), PITX2(3), PTX3(1), RHO(4), RYR1(16)	50974509	82	78	65	26	11	35	12	16	8	0	0.0966	1.000	1.000
509	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), AKR1C1(3), AKR1C2(4), AKR1C3(1), AKR1C4(2), ALDH1A3(3), ALDH3B2(2), CYP1A2(3), CYP1B1(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP2F1(1), CYP2S1(4), CYP3A4(3), CYP3A43(1), CYP3A7(4), EPHX1(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(2), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1)	63570817	87	77	86	29	14	19	31	13	10	0	0.489	1.000	1.000
510	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(5), ATP4B(4), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP6AP1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), COX10(3), COX15(1), COX4I2(2), COX5A(1), COX6C(1), COX7B2(1), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA2(1), NDUFA3(1), NDUFA4(1), NDUFA6(1), NDUFA9(2), NDUFB3(1), NDUFB4(1), NDUFB5(3), NDUFB9(2), NDUFS2(2), NDUFS3(1), NDUFS5(1), NDUFS7(1), NDUFS8(1), NDUFV1(3), NDUFV2(1), NDUFV3(1), PPA1(2), PPA2(1), SDHB(1), TCIRG1(1), UQCRC1(3), UQCRC2(1)	63095295	84	76	85	21	15	9	29	16	15	0	0.203	1.000	1.000
511	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3L1(1), CAD(10), CANT1(1), CTPS(1), CTPS2(3), DPYS(1), ENTPD1(2), NT5E(5), NT5M(1), NUDT2(1), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(1), POLQ(8), POLR1B(2), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), RRM1(2), RRM2(1), TXNRD1(2), TYMS(1), UCK1(1), UCK2(2), UMPS(3), UPB1(3), UPP1(3)	63346775	83	76	83	28	10	16	26	11	20	0	0.604	1.000	1.000
512	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(5), AXIN1(1), CCND1(1), CCND3(2), CSNK1E(2), CTNNB1(1), DVL1(2), DVL3(2), FBXW2(2), FZD1(1), FZD2(1), FZD3(3), FZD6(3), FZD7(1), FZD8(2), FZD9(3), JUN(3), LDLR(1), MAPK10(2), MYC(1), PAFAH1B1(3), PLAU(2), PPP2R5C(1), PPP2R5E(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(6), PRKCZ(1), PRKD1(2), RHOA(2), SFRP4(2), TCF7(3), WNT10B(1), WNT11(2), WNT2(1), WNT2B(2), WNT4(1), WNT5B(2), WNT7A(5)	61995744	84	76	84	29	22	14	20	19	9	0	0.373	1.000	1.000
513	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), ASCC3(4), ATP13A2(1), DDX18(2), DDX23(1), DDX4(3), DDX41(3), DDX50(3), DDX51(1), DDX54(1), DDX55(4), DDX56(2), DHX58(2), ENTPD7(4), EP400(5), ERCC2(1), ERCC3(2), FPGS(1), GCH1(1), IFIH1(3), MOV10L1(4), NUDT5(1), RAD54B(6), RAD54L(2), SETX(11), SKIV2L2(2), SMARCA2(5), SMARCA5(2)	69121848	85	74	84	18	15	15	27	18	10	0	0.0783	1.000	1.000
514	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(2), ACTN1(1), ACTN2(9), ACTN3(1), BCAR1(2), BCR(3), CAPN1(4), CAV1(2), CRKL(1), GRB2(1), ITGA1(5), ITGB1(3), JUN(3), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(1), PTK2(5), RAF1(1), ROCK1(4), SHC1(1), SOS1(4), TLN1(12), VCL(4)	51971535	75	72	75	26	14	15	19	13	14	0	0.654	1.000	1.000
515	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), AGPAT1(1), AGPAT3(2), AGPAT4(2), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(2), DGAT1(1), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKQ(1), GK(1), GLA(4), GLB1(2), LCT(11), LIPC(1), LIPF(2), LIPG(1), LPL(1), PNLIP(3), PNLIPRP1(3), PPAP2A(1), PPAP2C(2)	53452826	77	71	75	23	18	14	19	14	12	0	0.256	1.000	1.000
516	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(3), AASS(3), ACAT1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLST(3), DOT1L(5), EHHADH(3), EHMT1(6), GCDH(1), HADH(2), HSD17B10(1), HSD17B4(6), NSD1(2), OGDH(4), OGDHL(4), PIPOX(1), PLOD1(2), PLOD2(2), PLOD3(3), RDH11(2), RDH12(1), RDH14(2), SETD1A(2), SETD7(2), SETDB1(9), SHMT2(1)	61870776	77	71	76	25	11	20	28	10	8	0	0.394	1.000	1.000
517	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F13B(3), F2(4), F5(14), F7(1), F8(7), F9(1), FGA(5), FGB(1), FGG(4), LPA(11), PLAT(3), PLAU(2), PLG(4), SERPINE1(3), SERPINF2(1), VWF(10)	39139070	74	70	72	22	7	9	33	13	12	0	0.453	1.000	1.000
518	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(19), AKT2(3), AKT3(4), ANKRD6(4), APC(5), AXIN1(1), AXIN2(1), CER1(1), CSNK1A1(1), CTNNB1(1), DACT1(2), DKK2(1), DKK3(2), DKK4(1), DVL1(2), GSK3A(3), LRP1(11), MVP(1), NKD1(1), NKD2(1), PSEN1(1), PTPRA(2), SFRP1(2), WIF1(2)	44239265	72	68	55	21	11	32	13	8	8	0	0.0956	1.000	1.000
519	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACYP1(1), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), G6PC2(2), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), PDHA1(2), PDHA2(2), PDHB(1), PFKL(1), PFKM(4), PFKP(2), PGAM2(1), PGAM4(1), PGK1(3), PGM1(1), PGM3(1), PKLR(3), PKM2(1), TPI1(2)	64247562	67	64	67	15	12	20	17	12	6	0	0.0184	1.000	1.000
520	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(2), ACADSB(2), ACADVL(3), ACAT1(2), ACOX1(2), ACOX3(2), ACSL1(1), ACSL3(1), ACSL4(2), ACSL5(2), ACSL6(2), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CPT1A(4), CPT1B(2), CPT1C(3), CPT2(5), CYP4A11(1), CYP4A22(1), EHHADH(3), GCDH(1), HADH(2), HADHB(2), HSD17B10(1), HSD17B4(6), PECI(1)	55157495	66	63	66	18	10	18	21	11	6	0	0.211	1.000	1.000
521	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	52	AKR1C4(2), AKR1D1(1), ARSE(2), CARM1(2), CYP11B1(2), CYP11B2(5), HEMK1(1), HSD11B1(2), HSD17B2(1), HSD3B1(1), HSD3B2(3), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), SRD5A1(1), SULT1E1(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1), WBSCR22(2)	54068528	70	63	70	27	14	15	26	9	6	0	0.702	1.000	1.000
522	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(3), CDC7(1), CDK2(1), DIAPH2(4), MCM10(3), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), NACA(3), ORC1L(1), ORC2L(3), ORC3L(2), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), RFC1(4), RFC2(1), RFC4(3), RPA1(1), RPA2(1), RPA3(2), UBA52(1), UBC(8)	56595423	66	62	66	18	9	11	21	14	11	0	0.428	1.000	1.000
523	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), CAMK2A(2), CAMK2D(4), CAMK2G(1), CDK5(1), F2(4), GNAI1(1), GNB1(1), GRB2(1), JAK2(5), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPT(3), MYLK(8), PLCG1(6), PTK2B(3), RAF1(1), SHC1(1), SOS1(4), STAT1(1), STAT3(3), STAT5A(4)	46881867	64	61	64	23	10	12	18	11	13	0	0.644	1.000	1.000
524	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AGXT2(1), ALAS2(4), AMT(2), AOC2(1), AOC3(3), BHMT(1), CBS(2), CHKB(2), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(1), GARS(1), GATM(4), GCAT(2), GLDC(3), MAOA(2), MAOB(1), PIPOX(1), RDH11(2), RDH12(1), RDH14(2), SARDH(2), SARS(3), SARS2(2), SHMT2(1), TARS(5), TARS2(6)	47666235	67	61	67	20	7	15	16	16	13	0	0.332	1.000	1.000
525	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(2), CAPN1(4), CAPN2(3), CXCR3(5), EGF(3), EGFR(5), ITGA1(5), ITGB1(3), MAPK1(1), MAPK3(1), MYLK(8), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTK2(5), TLN1(12)	37365417	64	61	64	24	11	14	20	12	7	0	0.710	1.000	1.000
526	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AGXT2(1), ALAS2(4), AMT(2), AOC2(1), AOC3(3), BHMT(1), CBS(2), CHKB(2), CPT1B(2), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(1), GARS(1), GATM(4), GCAT(2), GLDC(3), MAOA(2), MAOB(1), PLCB2(2), PLCG1(6), PLCG2(3), SARDH(2), SARS(3), SHMT2(1), TARS(5)	46734941	66	60	66	22	8	12	16	16	14	0	0.559	1.000	1.000
527	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(1), ALG10B(3), ALG11(1), ALG12(3), ALG13(6), ALG14(1), ALG2(2), ALG3(1), ALG5(1), ALG6(1), ALG8(1), ALG9(2), B4GALT1(2), B4GALT3(1), DHDDS(1), DOLPP1(1), DPAGT1(2), DPM1(2), GANAB(3), MAN1A1(1), MAN1A2(2), MAN1B1(4), MAN2A1(3), MGAT3(2), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), RPN1(2), STT3B(2)	46412345	65	60	65	16	7	16	17	11	14	0	0.191	1.000	1.000
528	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(1), ARHGAP5(3), ARHGAP6(2), ARHGEF1(7), ARHGEF11(3), ARHGEF5(2), ARPC1A(1), ARPC1B(2), ARPC2(2), DIAPH1(4), GSN(1), LIMK1(4), MYLK(8), OPHN1(4), PIP5K1A(2), PIP5K1B(1), PPP1R12B(1), ROCK1(4), TLN1(12), VCL(4)	51386817	68	60	67	29	10	14	17	11	16	0	0.908	1.000	1.000
529	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), AOX1(4), ASMT(1), CAT(1), CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(4), DDC(1), EHHADH(3), GCDH(1), HAAO(1), KMO(1), KYNU(1), MAOA(2), MAOB(1), TDO2(1), WARS2(1)	62063169	71	60	70	33	7	15	26	14	9	0	0.941	1.000	1.000
530	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA2(2), ACAT1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(4), AUH(1), BCAT1(4), BCAT2(3), BCKDHA(1), DLD(1), EHHADH(3), HADH(2), HADHB(2), HIBADH(1), HIBCH(2), HMGCS1(3), HMGCS2(1), HSD17B10(1), HSD17B4(6), IVD(1), MCCC1(4), MUT(3), OXCT1(1), OXCT2(1), PCCA(1), PCCB(2)	48932258	60	57	60	16	5	17	17	14	7	0	0.294	1.000	1.000
531	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(1), ALOX12(2), ALOX12B(1), ALOX15(2), ALOX15B(2), ALOX5(1), CBR1(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP4A11(1), CYP4A22(1), CYP4F2(2), DHRS4(1), GGT1(3), GPX2(1), GPX4(1), GPX5(2), GPX7(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PTGIS(3), PTGS1(2), PTGS2(2), TBXAS1(1)	43269832	59	57	58	19	11	9	23	8	8	0	0.397	1.000	1.000
532	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CKMT2(3), CPS1(7), DAO(1), GAMT(1), GATM(4), MAOA(2), MAOB(1), NOS1(7), NOS3(3), OTC(1), P4HA1(1), P4HA2(1), P4HA3(2), P4HB(1), RARS(3)	48523766	62	55	62	19	10	14	26	8	4	0	0.313	1.000	1.000
533	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	A4GALT(1), B3GALNT1(1), B3GALT1(1), B3GALT2(1), B3GALT4(2), B3GALT5(2), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALNT1(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), B4GALT6(1), FUT2(2), FUT3(3), FUT5(2), FUT6(2), GBGT1(1), GCNT2(1), PIGA(2), PIGB(1), PIGG(2), PIGM(1), PIGN(1), PIGO(1), PIGQ(3), PIGS(2), PIGT(1), PIGV(1), PIGZ(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(1)	52110992	60	55	59	23	12	14	17	6	11	0	0.621	1.000	1.000
534	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1B2(1), EEF1D(1), EEF2(4), EEF2K(4), EIF1AX(2), EIF2AK1(1), EIF2AK3(1), EIF2B1(2), EIF2B2(2), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), EIF4A2(6), EIF4G1(2), EIF4G3(4), EIF5(2), EIF5B(3), ETF1(2), GSPT2(2), KIAA0664(2), PABPC1(3), PABPC3(8), SLC35A4(1)	49226752	60	54	56	18	10	12	16	6	16	0	0.595	1.000	1.000
535	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), G6PC(1), GAA(2), GALK2(1), GALT(1), GANAB(3), GCK(2), GLA(4), GLB1(2), HK1(1), HK2(2), HK3(2), LCT(11), MGAM(12), PFKM(4), PFKP(2), PGM1(1), PGM3(1)	35865078	56	53	56	17	11	10	11	16	8	0	0.269	1.000	1.000
536	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), CREB1(1), ELK1(2), GNAI1(1), GNAQ(1), GNAS(5), GNB1(1), JUN(3), MAP2K1(1), MAPK3(1), NFATC2(2), NFATC3(4), NFATC4(5), PLCG1(6), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RAF1(1), RPS6KA3(4)	36969691	55	53	55	20	9	10	14	10	12	0	0.716	1.000	1.000
537	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(3), ABAT(3), ACAT1(2), ACSM1(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), BDH1(1), EHHADH(3), GAD1(2), GAD2(3), HADH(2), HMGCS1(3), HMGCS2(1), HSD17B10(1), HSD17B4(6), ILVBL(1), OXCT1(1), OXCT2(1), PDHA1(2), PDHA2(2), PDHB(1), PLA1A(2), PPME1(1), RDH11(2), RDH12(1), RDH14(2)	45639536	55	53	55	19	2	17	17	14	5	0	0.587	1.000	1.000
538	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP4B(4), ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ATP7A(7), ATP7B(2), COX10(3), COX5A(1), COX6C(1), NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB4(1), NDUFB5(3), NDUFS2(2), NDUFV1(3), NDUFV2(1), PPA2(1), SDHB(1), UQCRC1(3)	43706867	55	50	55	19	13	6	16	10	10	0	0.684	1.000	1.000
539	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(2), ACTN1(1), ACTN2(9), ACTN3(1), CAPN1(4), ITGA1(5), ITGB1(3), ITGB3(3), PTK2(5), SPTAN1(4), TLN1(12)	32339637	49	49	49	15	11	9	13	11	5	0	0.507	1.000	1.000
540	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(5), ELK1(2), GNAS(5), GNB1(1), GRB2(1), IGF1R(2), ITGB1(3), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MYC(1), NGFR(1), PDGFRA(3), PPP2CA(2), PTPRR(2), RAF1(1), RPS6KA1(2), RPS6KA5(4), SHC1(1), SOS1(4), STAT3(3)	36412137	49	48	49	17	11	14	10	9	5	0	0.504	1.000	1.000
541	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(4), BLVRB(1), COX10(3), COX15(1), CP(3), EARS2(3), EPRS(4), GUSB(3), HMBS(1), HMOX2(1), PPOX(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1)	46673959	49	47	49	24	7	10	16	10	6	0	0.967	1.000	1.000
542	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	25	ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), DDC(1), EPX(4), ESCO1(3), HPD(2), LPO(5), MAOA(2), MAOB(1), MPO(3), MYST3(4), MYST4(8), PNPLA3(2), SH3GLB1(1), TAT(2), TPO(5)	37191744	52	46	52	16	13	7	13	10	8	1	0.411	1.000	1.000
543	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(2), C1GALT1(1), C1GALT1C1(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT2(1), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(4), GALNT8(3), GALNT9(4), GALNTL1(1), GALNTL4(1), GALNTL5(4), GCNT4(2), OGT(3), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(3), WBSCR17(5)	36533178	53	46	53	25	9	7	14	11	12	0	0.946	1.000	1.000
544	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(2), CD3G(2), CD4(4), CREBBP(7), GNAS(5), GNB1(1), HLA-DRB1(8), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTPRC(3), ZAP70(2)	24354810	45	45	43	16	6	8	10	7	13	1	0.785	1.000	1.000
545	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(2), CD3G(2), CD4(4), CREBBP(7), GNAS(5), GNB1(1), HLA-DRB1(8), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTPRC(3), ZAP70(2)	24354810	45	45	43	16	6	8	10	7	13	1	0.785	1.000	1.000
546	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(1), ARRB2(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CLCA1(2), CLCA2(1), CLCA4(2), CNGA3(5), CNGA4(2), CNGB1(2), GUCA1A(2), GUCA1C(1), PDC(1), PDE1C(2), PRKACA(2), PRKACG(1), PRKG1(3), PRKG2(6), PRKX(2)	34582616	46	45	46	22	6	9	13	14	4	0	0.930	1.000	1.000
547	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), AOX1(4), DBH(3), DCT(2), DDC(1), FAH(1), GSTZ1(1), HGD(1), HPD(2), MAOA(2), MAOB(1), TAT(2), TH(1), TPO(5), TYR(6)	34172816	48	45	48	15	11	9	15	5	8	0	0.463	1.000	1.000
548	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(5), POLB(1), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), POLE3(1), POLG(4), POLH(2), POLI(3), POLL(1), POLM(1), POLQ(8), REV1(2), REV3L(8)	45787032	47	44	47	12	3	9	15	9	11	0	0.458	1.000	1.000
549	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(5), ATF2(2), AXIN1(1), BMP10(1), BMP2(3), BMP4(2), BMP5(1), BMPR2(3), CHRD(3), CTNNB1(1), DVL1(2), FZD1(1), MAP3K7(1), MEF2C(3), NPPA(1), RFC1(4), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2)	39579606	45	43	44	21	7	10	10	12	6	0	0.894	1.000	1.000
550	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), ALDOA(4), ALDOB(2), ALDOC(1), FUK(2), GMDS(2), HK1(1), HK2(2), HK3(2), KHK(1), MPI(2), MTMR1(1), MTMR2(1), MTMR6(2), PFKFB1(1), PFKFB3(1), PFKL(1), PFKM(4), PFKP(2), PGM2(1), RDH11(2), RDH12(1), RDH14(2), SORD(2), TPI1(2), TSTA3(1)	41210738	45	43	45	13	8	11	9	9	8	0	0.143	1.000	1.000
551	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), CDK7(2), ERCC3(2), GTF2E2(1), GTF2H1(1), ILK(2), MNAT1(2), POLR1A(6), POLR1B(2), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3B(2), POLR3D(1), POLR3E(2), TAF13(1), TAF5(1), TAF6(1), TAF7(1), TAF9(1), TBP(1)	38821072	45	43	45	22	7	8	13	6	11	0	0.932	1.000	1.000
552	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	30	ADRA1A(2), ADRA1B(1), ADRB2(1), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), DRD2(2), DRD3(1), DRD5(2), HRH1(2), HRH2(2), HTR1A(4), HTR1B(1), HTR1E(3), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5)	27141231	43	41	43	19	16	3	11	6	7	0	0.766	1.000	1.000
553	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(1), AASDHPPT(3), AASS(3), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLST(3), DOT1L(5), EHHADH(3), EHMT1(6), GCDH(1), PLOD1(2), PLOD2(2), PLOD3(3), SHMT2(1)	38376925	43	40	43	18	7	11	16	5	4	0	0.753	1.000	1.000
554	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(5), AXIN1(1), CREBBP(7), CTNNB1(1), DVL1(2), EP300(7), FZD1(1), HDAC1(4), LDB1(1), PITX2(3), TRRAP(9)	36445341	41	40	40	13	7	6	7	11	10	0	0.550	1.000	1.000
555	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(2), ACADSB(2), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(4), BCAT1(4), BCKDHA(1), EHHADH(3), HADHB(2), HIBADH(1), IVD(1), MCCC1(4), MUT(3), OXCT1(1), PCCA(1), PCCB(2)	40777570	41	39	41	14	3	11	13	10	4	0	0.649	1.000	1.000
556	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2E2(1), GTF2H1(1), GTF2H3(1), GTF2I(1), TAF1(10), TAF13(1), TAF1L(9), TAF4(2), TAF4B(2), TAF5(1), TAF5L(2), TAF6(1), TAF7(1), TAF7L(2), TAF9(1)	40044984	37	37	37	12	6	9	10	7	5	0	0.611	1.000	1.000
557	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(4), EGF(3), EGFR(5), GRB2(1), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(10), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SPRY1(1), SPRY2(1), SPRY3(3)	28381502	39	37	39	21	8	7	10	8	6	0	0.986	1.000	1.000
558	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	28	AKR1C4(2), AKR1D1(1), ARSB(4), ARSE(2), CYP11B1(2), CYP11B2(5), HSD11B1(2), HSD17B2(1), HSD3B1(1), HSD3B2(3), SRD5A1(1), SULT1E1(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2)	29995524	40	36	40	15	9	6	15	8	2	0	0.612	1.000	1.000
559	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(4), ACACB(9), ACAT1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), EHHADH(3), HIBCH(2), LDHC(2), MLYCD(2), MUT(3), PCCA(1), PCCB(2), SUCLA2(1)	44929187	39	36	39	15	2	10	14	10	3	0	0.748	1.000	1.000
560	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(5), AXIN1(1), BTRC(2), CCND1(1), CREBBP(7), CSNK1A1(1), CSNK2A1(1), CTNNB1(1), DVL1(2), FZD1(1), HDAC1(4), MAP3K7(1), MYC(1), NLK(2), PPP2CA(2), TLE1(2), WIF1(2)	32297770	36	35	36	16	4	9	9	7	7	0	0.913	1.000	1.000
561	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(4), AGT(2), EDN1(2), EDNRA(1), EDNRB(2), EGF(3), EGFR(5), JUN(3), MYC(1), NFKB1(4), PLCG1(6), RELA(1)	22935997	34	34	34	14	6	8	7	8	5	0	0.728	1.000	1.000
562	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CYP2C19(1), CYP2C9(2), DHRS2(4), DHRS7(1), EHHADH(3), ESCO1(3), MYST3(4), MYST4(8), PNPLA3(2), SH3GLB1(1)	34582262	36	34	36	15	3	8	12	10	2	1	0.830	1.000	1.000
563	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(2), ADCY1(3), CAP1(2), CCNB1(2), CDC25C(2), GNAI1(1), GNAS(5), GNB1(1), MAPK1(1), MAPK3(1), MYT1(5), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RPS6KA1(2)	22005132	34	34	34	11	6	6	10	5	7	0	0.598	1.000	1.000
564	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(2), EPHA4(2), EPHB1(5), ITGA1(5), ITGB1(3), L1CAM(4), LYN(4), SELP(8)	17950964	33	33	33	14	10	8	10	5	0	0	0.750	1.000	1.000
565	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3A(2), POLR3B(2), POLR3GL(3)	26200314	35	33	35	17	6	4	9	7	9	0	0.943	1.000	1.000
566	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(5), COL4A5(6), COL4A6(7), P4HB(1), SLC23A1(2), SLC2A3(3)	29109121	35	33	35	14	7	7	11	6	4	0	0.700	1.000	1.000
567	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(2), COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(5), COL4A5(6), COL4A6(7), REN(1)	29250009	33	32	33	14	7	6	10	5	5	0	0.801	1.000	1.000
568	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ACADSB(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), CNDP1(3), DPYS(1), EHHADH(3), GAD1(2), GAD2(3), MLYCD(2), UPB1(3)	32216855	34	32	34	18	4	10	10	6	4	0	0.914	1.000	1.000
569	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(1), ACTN2(9), ACTN3(1), BCAR1(2), CTNNA1(4), CTNNA2(8), CTNNB1(1), PTK2(5), VCL(4)	21003993	35	32	35	14	8	6	9	5	7	0	0.750	1.000	1.000
570	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), AOC2(1), AOC3(3), CES1(2), CES7(2), ESCO1(3), LIPA(1), MYST3(4), MYST4(8), PLA1A(2), PNPLA3(2), PPME1(1), SH3GLB1(1)	28264013	33	32	33	14	4	9	8	7	4	1	0.827	1.000	1.000
571	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(14), MAP2(10), PPP2CA(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCE(2)	20565300	31	31	31	11	2	5	12	6	6	0	0.902	1.000	1.000
572	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(10), CR2(4), HLA-DRB1(8), ICAM1(1), ITGAL(1), ITGB2(4), PTPRC(3)	16683181	31	31	29	13	0	7	10	5	8	1	0.910	1.000	1.000
573	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACOT11(2), ACYP1(1), DHRS2(4), DHRS7(1), EHHADH(3), ESCO1(3), FN3K(1), GCDH(1), ITGB1BP3(1), MYST3(4), MYST4(8), PNPLA3(2), SH3GLB1(1)	28973800	34	31	34	15	6	6	8	11	2	1	0.849	1.000	1.000
574	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1L(1), GOSR1(1), SNAP23(2), SNAP25(2), STX10(1), STX11(1), STX12(1), STX16(1), STX17(1), STX19(2), STX2(1), STX3(2), STX4(1), STX6(2), STX7(1), STX8(1), TSNARE1(4), USE1(2), VAMP1(1), VAMP3(1), VAMP7(1), VTI1B(1)	18337277	31	31	31	11	7	4	10	2	8	0	0.651	1.000	1.000
575	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(4), ACADSB(2), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), EHHADH(3), LDHC(2), MLYCD(2), MUT(3), PCCA(1), PCCB(2), SUCLA2(1)	37548898	33	31	33	17	1	12	10	8	2	0	0.934	1.000	1.000
576	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA3(1), ANXA4(1), ANXA6(4), CYP11A1(1), EDN1(2), EDNRA(1), EDNRB(2), HSD11B1(2), PLA2G4A(7), PTGDR(1), PTGFR(1), PTGIS(3), PTGS1(2), PTGS2(2), S100A6(1), TBXAS1(1)	22803981	33	31	33	13	6	5	12	8	2	0	0.790	1.000	1.000
577	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(3), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), EHHADH(3), GAD1(2), GAD2(3), OXCT1(1), PDHA1(2), PDHA2(2), PDHB(1), SDHB(1)	28804758	31	30	31	15	2	10	11	8	0	0	0.860	1.000	1.000
578	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(1), C1S(2), C2(1), C3(7), C5(4), C6(5), C7(6), C9(1), MASP1(3)	23274390	31	30	31	10	5	7	10	3	6	0	0.450	1.000	1.000
579	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), CNDP1(3), DPYS(1), EHHADH(3), GAD1(2), GAD2(3), HIBCH(2), MLYCD(2), SRM(1), UPB1(3)	29707214	32	30	32	14	4	8	10	6	4	0	0.774	1.000	1.000
580	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CAPN2(3), EP300(7), HDAC1(4), HDAC2(3), MEF2D(2), NFATC2(2), PPP3CA(4), PPP3CB(3)	26213419	33	30	32	14	2	9	6	6	10	0	0.813	1.000	1.000
581	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	GNAQ(1), NFATC2(2), NFATC3(4), NFATC4(5), PLCG1(6), PPP3CA(4), PPP3CB(3), SP1(3), SP3(4)	21968397	32	29	32	11	1	6	10	9	6	0	0.743	1.000	1.000
582	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(3), UGDH(1), UGP2(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1)	29774155	30	29	30	14	4	5	9	8	4	0	0.911	1.000	1.000
583	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(7), ACE2(1), AGT(2), ANPEP(6), CTSA(4), CTSG(1), ENPEP(3), MAS1(2), NLN(1), REN(1), THOP1(1)	23547354	29	29	27	13	5	5	7	4	8	0	0.916	1.000	1.000
584	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(7), DYRK1B(1), GLI2(5), GLI3(8), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), SMO(2), SUFU(2)	16926113	32	29	32	12	6	4	11	4	7	0	0.723	1.000	1.000
585	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRB(1), CP(3), EPRS(4), GUSB(3), HMBS(1), HMOX2(1), PPOX(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2)	31009951	29	28	29	15	3	7	8	8	3	0	0.928	1.000	1.000
586	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), CETP(1), CYP7A1(1), DGAT1(1), HMGCR(1), LCAT(1), LDLR(1), LIPC(1), LPL(1), LRP1(11), SCARB1(2), SOAT1(1)	29769822	28	28	28	14	5	8	9	2	4	0	0.870	1.000	1.000
587	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(2), ATIC(3), FTCD(1), GART(1), MTHFD1(5), MTHFD1L(4), MTHFS(2), MTR(5), SHMT2(1), TYMS(1)	21416257	28	27	28	11	1	7	11	4	5	0	0.802	1.000	1.000
588	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(5), ABCG2(1), BCHE(3), CES1(2), CES2(1), CYP3A4(3), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1)	26198984	27	27	27	13	6	3	7	8	3	0	0.900	1.000	1.000
589	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(2), ATIC(3), GART(1), MTHFD1(5), MTHFD1L(4), MTHFS(2), MTR(5), SHMT2(1), TYMS(1)	20408586	27	26	27	11	1	7	11	3	5	0	0.821	1.000	1.000
590	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), AOC2(1), AOC3(3), ASPA(2), CNDP1(3), DDC(1), HAL(2), HARS(1), MAOA(2), MAOB(1), PRPS2(1)	26568635	27	24	27	11	4	6	11	2	4	0	0.690	1.000	1.000
591	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(2), GALNT2(1), GALNT3(2), GALNT4(1), GALNT7(4), GALNT8(3), GALNT9(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(5)	16610733	26	24	26	15	3	4	4	8	7	0	0.965	1.000	1.000
592	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), EGF(3), EGFR(5), GRB2(1), MET(7), PDGFRA(3), SH3GLB1(1), SH3KBP1(3)	22173244	27	23	27	14	6	5	6	7	3	0	0.950	1.000	1.000
593	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNAS(5), GNB1(1), PPP2CA(2), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACG(1), PRKAG2(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	16560908	24	23	24	11	5	3	4	5	7	0	0.958	1.000	1.000
594	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(2), CD4(4), HLA-DRB1(8), LCK(1), PTPRC(3), ZAP70(2)	9615290	22	22	20	11	2	6	4	2	7	1	0.928	1.000	1.000
595	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(6), GABARAP(1), GABRA1(1), GABRA2(1), GABRA3(3), GABRA4(1), GABRA5(2), GABRA6(3), GPHN(2), NSF(1), UBQLN1(1)	13596683	22	21	22	11	3	3	9	6	1	0	0.902	1.000	1.000
596	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(7), ABCB4(2), ABCC1(3), ABCC3(4), GSTP1(1)	16816867	21	21	21	15	2	4	9	3	3	0	0.981	1.000	1.000
597	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), FUT2(2), FUT3(3), FUT5(2), FUT6(2), GCNT2(1), ST8SIA1(1)	15615127	19	19	18	10	3	3	5	3	5	0	0.874	1.000	1.000
598	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(5), AXIN1(1), BTRC(2), CTNNB1(1), DLL1(2), DVL1(2), FZD1(1), NOTCH1(5), PSEN1(1)	21202287	20	19	20	10	2	7	2	6	3	0	0.902	1.000	1.000
599	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR24(3), EBP(1), FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), NQO1(1), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1), VKORC1(1)	21414468	16	16	16	13	5	2	6	1	2	0	0.996	1.000	1.000
600	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), XDH(4)	9184339	13	13	12	6	4	2	4	3	0	0	0.672	1.000	1.000
601	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(2), GPR109B(2), GPR161(2), GPR34(1), GPR45(1), GPR75(2)	11219658	12	12	12	10	2	1	3	5	1	0	0.981	1.000	1.000
602	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(1), ATF3(1), CYR61(1), IFNG(2), IFRD1(1), IL18(1), IL1A(1), IL1R1(1), NR4A3(2), WDR1(1)	12077855	12	12	12	5	3	1	5	3	0	0	0.749	1.000	1.000
603	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), EHHADH(3)	13556469	11	11	11	9	0	4	6	1	0	0	0.975	1.000	1.000
604	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(2), ACAT1(2), EHHADH(3), HADHB(2)	9550156	9	9	9	6	0	3	3	3	0	0	0.929	1.000	1.000
605	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	CNR1(2), CNR2(1), DNMT1(4), PTGDR(1), PTGFR(1)	11136424	9	9	9	11	3	0	2	3	1	0	0.999	1.000	1.000
606	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1)	8825917	8	8	8	5	0	3	5	0	0	0	0.889	1.000	1.000
607	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1)	8825917	8	8	8	5	0	3	5	0	0	0	0.889	1.000	1.000
608	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACYP1(1), EHHADH(3), GCDH(1), SDHB(1)	8825949	8	8	8	6	1	2	2	3	0	0	0.941	1.000	1.000
609	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(4), GATA1(1), HBB(1), HMBS(1)	9293125	7	7	7	4	3	1	3	0	0	0	0.906	1.000	1.000
610	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(1), NR0B2(2), NR1H4(1), RXRA(1)	5641024	6	6	6	4	2	0	3	1	0	0	0.893	1.000	1.000
611	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(1), SNAP25(2)	3602521	5	5	5	4	1	0	4	0	0	0	0.931	1.000	1.000
612	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), KERA(1), LUM(2)	4134244	4	4	4	3	2	0	1	1	0	0	0.863	1.000	1.000
613	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(3)	5507205	3	3	3	4	0	1	1	1	0	0	0.978	1.000	1.000
614	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(2)	2325939	3	3	3	2	0	1	2	0	0	0	0.927	1.000	1.000
615	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACAT1(2)	5960466	2	2	2	3	0	1	0	1	0	0	0.976	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		584187	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000