Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.055 0.304 -9999.0 0.0 -0.833 109.0 109.0 IHH -0.013 0.078 -9999.0 0.0 -0.495 3.0 3.0 SHH Np/Cholesterol/GAS1 -0.03 0.118 -9999.0 0.0 -0.52 49.0 49.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.03 0.117 0.516 49.0 -9999.0 0.0 49.0 SMO/beta Arrestin2 -0.077 0.235 -9999.0 0.0 -0.86 68.0 68.0 SMO -0.054 0.262 -9999.0 0.0 -0.922 68.0 68.0 AKT1 -0.004 0.096 -9999.0 0.0 -0.307 66.0 66.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.061 0.217 -9999.0 0.0 -0.825 68.0 68.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.035 0.26 -9999.0 0.0 -0.895 68.0 68.0 STIL -0.04 0.215 -9999.0 0.0 -0.727 70.0 70.0 DHH N/PTCH2 -0.071 0.209 -9999.0 0.0 -0.667 97.0 97.0 DHH N/PTCH1 -0.091 0.248 -9999.0 0.0 -0.762 97.0 97.0 PIK3CA -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.024 0.137 -9999.0 0.0 -0.825 26.0 26.0 PTHLH -0.083 0.386 -9999.0 0.0 -1.083 109.0 109.0 determination of left/right symmetry -0.035 0.26 -9999.0 0.0 -0.895 68.0 68.0 PIK3R1 -0.001 0.027 -9999.0 0.0 -0.825 1.0 1.0 skeletal system development -0.08 0.376 -9999.0 0.0 -1.059 109.0 109.0 IHH N/Hhip -0.01 0.047 -9999.0 0.0 -0.684 1.0 1.0 DHH N/Hhip -0.021 0.11 -9999.0 0.0 -0.646 27.0 27.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.035 0.26 -9999.0 0.0 -0.895 68.0 68.0 pancreas development -0.004 0.039 -9999.0 0.0 -0.824 1.0 1.0 HHAT -0.001 0.027 -9999.0 0.0 -0.825 1.0 1.0 PI3K -0.001 0.022 -9999.0 0.0 -0.634 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.043 0.184 -9999.0 0.0 -0.825 48.0 48.0 somite specification -0.035 0.26 -9999.0 0.0 -0.895 68.0 68.0 SHH Np/Cholesterol/PTCH1 -0.072 0.211 -9999.0 0.0 -0.782 67.0 67.0 SHH Np/Cholesterol/PTCH2 -0.046 0.144 -9999.0 0.0 -0.515 78.0 78.0 SHH Np/Cholesterol/Megalin -0.139 0.224 -9999.0 0.0 -0.514 238.0 238.0 SHH 0.01 0.036 -9999.0 0.0 -0.643 1.0 1.0 catabolic process -0.048 0.263 -9999.0 0.0 -0.883 74.0 74.0 SMO/Vitamin D3 -0.075 0.229 -9999.0 0.0 -0.837 68.0 68.0 SHH Np/Cholesterol/Hhip -0.005 0.035 -9999.0 0.0 -0.518 2.0 2.0 LRP2 -0.221 0.36 -9999.0 0.0 -0.777 260.0 260.0 receptor-mediated endocytosis -0.152 0.26 -9999.0 0.0 -0.838 85.0 85.0 SHH Np/Cholesterol/BOC -0.041 0.137 -9999.0 0.0 -0.518 69.0 69.0 SHH Np/Cholesterol/CDO -0.01 0.063 -9999.0 0.0 -0.511 13.0 13.0 mesenchymal cell differentiation 0.005 0.035 0.514 2.0 -9999.0 0.0 2.0 mol:Vitamin D3 -0.031 0.226 -9999.0 0.0 -0.786 67.0 67.0 IHH N/PTCH2 -0.065 0.197 -9999.0 0.0 -0.705 77.0 77.0 CDON -0.011 0.094 -9999.0 0.0 -0.825 12.0 12.0 IHH N/PTCH1 -0.046 0.267 -9999.0 0.0 -0.891 74.0 74.0 Megalin/LRPAP1 -0.169 0.277 -9999.0 0.0 -0.634 237.0 237.0 PTCH2 -0.07 0.229 -9999.0 0.0 -0.825 77.0 77.0 SHH Np/Cholesterol -0.003 0.025 -9999.0 0.0 -0.522 1.0 1.0 PTCH1 -0.049 0.265 -9999.0 0.0 -0.889 74.0 74.0 HHIP -0.004 0.039 -9999.0 0.0 -0.825 1.0 1.0