Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.011 0.059 -9999.0 0.0 -0.336 29.0 29.0 epithelial cell differentiation -0.014 0.081 -9999.0 0.0 -0.468 28.0 28.0 CYFIP2 -0.01 0.061 -9999.0 0.0 -0.316 29.0 29.0 ENAH 0.055 0.064 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.296 0.395 -9999.0 0.0 -0.817 331.0 331.0 EPHA2 -0.005 0.067 -9999.0 0.0 -0.825 6.0 6.0 MYO6 -0.014 0.078 -9999.0 0.0 -0.444 29.0 29.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.034 -9999.0 0.0 -0.548 2.0 2.0 AQP5 -0.25 0.305 -9999.0 0.0 -0.609 372.0 372.0 CTNND1 -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.075 -9999.0 0.0 -0.436 28.0 28.0 regulation of calcium-dependent cell-cell adhesion -0.036 0.122 -9999.0 0.0 -0.448 73.0 73.0 EGF -0.164 0.329 -9999.0 0.0 -0.819 183.0 183.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.041 0.148 -9999.0 0.0 -0.599 49.0 49.0 cortical microtubule organization -0.014 0.081 -9999.0 0.0 -0.468 28.0 28.0 GO:0000145 0.024 0.078 -9999.0 0.0 -0.416 28.0 28.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.015 0.082 -9999.0 0.0 -0.474 28.0 28.0 MLLT4 -0.005 0.061 -9999.0 0.0 -0.825 5.0 5.0 ARF6/GDP -0.014 0.069 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.004 0.041 -9999.0 0.0 -0.499 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.035 0.08 -9999.0 0.0 -0.407 28.0 28.0 PVRL2 -0.001 0.016 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.014 0.076 -9999.0 0.0 -0.444 28.0 28.0 ARF6/GTP -0.004 0.038 -9999.0 0.0 -0.458 6.0 6.0 CDH1 -0.025 0.142 -9999.0 0.0 -0.825 28.0 28.0 EGFR/EGFR/EGF/EGF -0.253 0.272 -9999.0 0.0 -0.493 467.0 467.0 RhoA/GDP -0.014 0.076 -9999.0 0.0 -0.438 28.0 28.0 actin cytoskeleton organization 0.03 0.081 -9999.0 0.0 -0.417 29.0 29.0 IGF-1R heterotetramer -0.022 0.124 -9999.0 0.0 -0.609 33.0 33.0 GIT1 -0.001 0.018 -9999.0 0.0 -0.279 4.0 4.0 IGF1R -0.022 0.125 -9999.0 0.0 -0.61 33.0 33.0 IGF1 -0.178 0.339 -9999.0 0.0 -0.825 197.0 197.0 DIAPH1 -0.001 0.033 -9999.0 0.0 -0.675 2.0 2.0 Wnt receptor signaling pathway 0.014 0.081 0.468 28.0 -9999.0 0.0 28.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.014 0.07 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.014 0.075 -9999.0 0.0 -0.428 29.0 29.0 EFNA1 -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.03 0.084 -9999.0 0.0 -0.417 31.0 31.0 Ephrin A1/EPHA2 -0.016 0.08 -9999.0 0.0 -0.425 34.0 34.0 SEC6/SEC8 -0.014 0.075 -9999.0 0.0 -0.789 1.0 1.0 MGAT3 -0.037 0.125 -9999.0 0.0 -0.456 73.0 73.0 HGF/MET -0.113 0.216 -9999.0 0.0 -0.483 213.0 213.0 HGF -0.051 0.2 -9999.0 0.0 -0.825 57.0 57.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.011 0.059 -9999.0 0.0 -0.339 29.0 29.0 actin cable formation 0.07 0.061 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.03 0.092 -9999.0 0.0 -0.46 28.0 28.0 KIFC3 -0.015 0.079 -9999.0 0.0 -0.444 30.0 30.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.014 0.078 -9999.0 0.0 -0.444 29.0 29.0 NCK1/GIT1 -0.001 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.014 0.081 -9999.0 0.0 -0.468 28.0 28.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.014 0.076 -9999.0 0.0 -0.444 28.0 28.0 PIP5K1C -0.014 0.076 -9999.0 0.0 -0.444 28.0 28.0 LIMA1 -0.001 0.027 -9999.0 0.0 -0.825 1.0 1.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.012 0.06 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.045 0.088 -9999.0 0.0 -0.659 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.116 0.205 -9999.0 0.0 -0.456 231.0 231.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.004 0.048 -9999.0 0.0 -0.634 5.0 5.0 MET -0.139 0.309 -9999.0 0.0 -0.822 155.0 155.0 PLEKHA7 -0.015 0.085 -9999.0 0.0 -0.476 28.0 28.0 mol:GTP -0.004 0.041 -9999.0 0.0 -0.495 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.013 0.071 -9999.0 0.0 -0.74 1.0 1.0 cortical actin cytoskeleton stabilization -0.011 0.059 -9999.0 0.0 -0.336 29.0 29.0 regulation of cell-cell adhesion 0.03 0.081 -9999.0 0.0 -0.417 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.011 0.059 -9999.0 0.0 -0.339 29.0 29.0