E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.022 0.116 -9999.0 0.0 -0.418 41.0 41.0 KLHL20 0.014 0.067 0.237 9.0 -0.225 12.0 21.0 CYFIP2 0.03 0.046 0.265 26.0 -0.59 1.0 27.0 Rac1/GDP -0.002 0.087 0.263 6.0 -0.318 18.0 24.0 ENAH -0.018 0.109 -9999.0 0.0 -0.432 31.0 31.0 AP1M1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.007 0.051 -9999.0 0.0 -0.419 1.0 1.0 ABI1/Sra1/Nap1 -0.013 0.033 -9999.0 0.0 -0.155 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.044 0.071 -9999.0 0.0 -0.349 20.0 20.0 RAPGEF1 -0.021 0.11 -9999.0 0.0 -0.41 28.0 28.0 CTNND1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.127 -9999.0 0.0 -0.421 48.0 48.0 CRK -0.018 0.106 -9999.0 0.0 -0.429 32.0 32.0 E-cadherin/gamma catenin/alpha catenin 0.03 0.065 -9999.0 0.0 -0.379 18.0 18.0 alphaE/beta7 Integrin 0.035 0.035 0.2 21.0 -0.439 2.0 23.0 IQGAP1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.039 0.028 -9999.0 0.0 -0.346 3.0 3.0 DLG1 -0.026 0.122 -9999.0 0.0 -0.418 44.0 44.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.031 -9999.0 0.0 -0.294 1.0 1.0 MLLT4 0.02 0.036 -9999.0 0.0 -0.59 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.043 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.003 0.045 -9999.0 0.0 -0.395 1.0 1.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.018 0.071 -9999.0 0.0 -0.439 18.0 18.0 TIAM1 0.025 0.016 0.265 4.0 -9999.0 0.0 4.0 E-cadherin(dimer)/Ca2+ 0.038 0.06 -9999.0 0.0 -0.329 18.0 18.0 AKT1 -0.007 0.034 -9999.0 0.0 -0.215 1.0 1.0 PIK3R1 0.022 0.021 -9999.0 0.0 -0.59 1.0 1.0 CDH1 0.009 0.086 -9999.0 0.0 -0.59 18.0 18.0 RhoA/GDP -0.001 0.088 0.258 9.0 -0.318 18.0 27.0 actin cytoskeleton organization 0.014 0.054 0.189 15.0 -0.166 10.0 25.0 CDC42/GDP -0.001 0.087 0.258 9.0 -0.318 18.0 27.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.006 0.046 -9999.0 0.0 -0.273 19.0 19.0 ITGB7 0.028 0.047 0.265 21.0 -0.59 2.0 23.0 RAC1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.042 0.064 -9999.0 0.0 -0.349 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.028 0.056 -9999.0 0.0 -0.326 18.0 18.0 mol:GDP -0.015 0.095 0.266 9.0 -0.366 19.0 28.0 CDC42/GTP/IQGAP1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.003 0.09 0.264 5.0 -0.326 18.0 23.0 RAC1/GTP/IQGAP1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.013 0.049 0.186 32.0 -0.249 3.0 35.0 NME1 0.025 0.029 0.265 12.0 -9999.0 0.0 12.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.024 0.12 -9999.0 0.0 -0.42 43.0 43.0 regulation of cell-cell adhesion 0.002 0.043 -9999.0 0.0 -0.293 2.0 2.0 WASF2 0.007 0.027 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.01 0.061 0.245 1.0 -0.383 2.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.071 -9999.0 0.0 -0.332 20.0 20.0 CCND1 0.015 0.057 0.215 30.0 -0.315 3.0 33.0 VAV2 -0.022 0.154 -9999.0 0.0 -0.544 37.0 37.0 RAP1/GDP 0.004 0.073 0.264 3.0 -0.362 3.0 6.0 adherens junction assembly -0.024 0.117 -9999.0 0.0 -0.407 43.0 43.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.038 0.067 -9999.0 0.0 -0.321 20.0 20.0 E-cadherin/beta catenin -0.001 0.064 -9999.0 0.0 -0.351 28.0 28.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.026 0.122 -9999.0 0.0 -0.418 45.0 45.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.006 0.093 0.271 28.0 -0.347 21.0 49.0 E-cadherin/beta catenin/alpha catenin 0.032 0.065 -9999.0 0.0 -0.379 18.0 18.0 ITGAE 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.025 0.129 -9999.0 0.0 -0.43 48.0 48.0