Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.022 0.131 0.433 56.0 -0.228 11.0 67.0 KIRREL -0.015 0.151 -9999.0 0.0 -0.592 57.0 57.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.022 0.131 0.228 11.0 -0.434 56.0 67.0 PLCG1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.04 0.111 0.289 4.0 -0.333 54.0 58.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.012 0.082 0.24 1.0 -0.291 45.0 46.0 FYN 0.021 0.125 0.274 100.0 -0.318 53.0 153.0 mol:Ca2+ 0.037 0.107 0.28 4.0 -0.331 52.0 56.0 mol:DAG 0.038 0.109 0.284 4.0 -0.332 52.0 56.0 NPHS2 0.016 0.031 0.271 5.0 -9999.0 0.0 5.0 mol:IP3 0.038 0.109 0.284 4.0 -0.332 52.0 56.0 regulation of endocytosis 0.028 0.098 0.246 5.0 -0.301 53.0 58.0 Nephrin/NEPH1/podocin/Cholesterol 0.03 0.106 0.254 9.0 -0.331 54.0 63.0 establishment of cell polarity 0.022 0.131 0.228 11.0 -0.433 56.0 67.0 Nephrin/NEPH1/podocin/NCK1-2 0.05 0.106 0.325 1.0 -0.308 52.0 53.0 Nephrin/NEPH1/beta Arrestin2 0.032 0.1 0.254 5.0 -0.305 53.0 58.0 NPHS1 0.062 0.092 0.267 141.0 -9999.0 0.0 141.0 Nephrin/NEPH1/podocin 0.031 0.104 0.308 4.0 -0.32 53.0 57.0 TJP1 0.022 0.021 -9999.0 0.0 -0.59 1.0 1.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.039 0.11 0.289 4.0 -0.333 52.0 56.0 CD2AP 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.037 0.109 0.28 9.0 -0.333 51.0 60.0 GRB2 0.023 0.01 0.265 1.0 -9999.0 0.0 1.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.02 0.131 0.29 90.0 -0.318 59.0 149.0 cytoskeleton organization 0.009 0.101 0.27 15.0 -0.331 49.0 64.0 Nephrin/NEPH1 0.021 0.098 0.172 26.0 -0.308 56.0 82.0 Nephrin/NEPH1/ZO-1 0.031 0.114 0.232 1.0 -0.361 55.0 56.0