Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.01 0.046 -9999.0 0.0 -0.268 19.0 19.0 epithelial cell differentiation 0.034 0.058 -9999.0 0.0 -0.326 18.0 18.0 CYFIP2 0.03 0.046 0.265 26.0 -0.59 1.0 27.0 ENAH -0.005 0.059 0.274 8.0 -9999.0 0.0 8.0 EGFR -0.19 0.292 -9999.0 0.0 -0.59 312.0 312.0 EPHA2 0.019 0.046 -9999.0 0.0 -0.59 5.0 5.0 MYO6 -0.014 0.053 -9999.0 0.0 -0.316 19.0 19.0 CTNNB1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.032 -9999.0 0.0 -0.379 1.0 1.0 AQP5 -0.197 0.268 0.334 1.0 -0.512 366.0 367.0 CTNND1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.014 0.051 -9999.0 0.0 -0.311 18.0 18.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.078 -9999.0 0.0 -0.316 52.0 52.0 EGF -0.09 0.239 0.265 2.0 -0.59 167.0 169.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.019 0.121 0.292 1.0 -0.474 47.0 48.0 cortical microtubule organization 0.034 0.058 -9999.0 0.0 -0.326 18.0 18.0 GO:0000145 -0.014 0.049 -9999.0 0.0 -0.297 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.038 0.06 -9999.0 0.0 -0.329 18.0 18.0 MLLT4 0.02 0.036 -9999.0 0.0 -0.59 3.0 3.0 ARF6/GDP -0.022 0.043 -9999.0 0.0 -0.287 20.0 20.0 ARF6 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.044 0.04 -9999.0 0.0 -0.345 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.005 0.05 -9999.0 0.0 -0.297 18.0 18.0 PVRL2 0.024 0.009 0.265 1.0 -9999.0 0.0 1.0 ZYX -0.014 0.051 -9999.0 0.0 -0.315 18.0 18.0 ARF6/GTP 0.048 0.042 -9999.0 0.0 -0.324 5.0 5.0 CDH1 0.009 0.086 -9999.0 0.0 -0.59 18.0 18.0 EGFR/EGFR/EGF/EGF -0.149 0.203 -9999.0 0.0 -0.346 433.0 433.0 RhoA/GDP 0.035 0.056 -9999.0 0.0 -0.312 18.0 18.0 actin cytoskeleton organization -0.016 0.05 -9999.0 0.0 -0.307 19.0 19.0 IGF-1R heterotetramer 0.012 0.084 0.265 2.0 -0.589 17.0 19.0 GIT1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.085 0.265 2.0 -0.59 17.0 19.0 IGF1 -0.103 0.248 -9999.0 0.0 -0.59 185.0 185.0 DIAPH1 0.026 0.102 -9999.0 0.0 -0.557 10.0 10.0 Wnt receptor signaling pathway -0.034 0.058 0.326 18.0 -9999.0 0.0 18.0 RHOA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.022 0.044 -9999.0 0.0 -0.289 20.0 20.0 CTNNA1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.016 0.051 -9999.0 0.0 -0.314 19.0 19.0 EFNA1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.016 0.052 -9999.0 0.0 -0.304 20.0 20.0 Ephrin A1/EPHA2 0.023 0.058 -9999.0 0.0 -0.307 21.0 21.0 SEC6/SEC8 -0.023 0.046 -9999.0 0.0 -0.31 20.0 20.0 MGAT3 -0.026 0.079 -9999.0 0.0 -0.32 52.0 52.0 HGF/MET -0.042 0.16 -9999.0 0.0 -0.337 190.0 190.0 HGF -0.011 0.141 -9999.0 0.0 -0.59 50.0 50.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.01 0.047 -9999.0 0.0 -0.269 19.0 19.0 actin cable formation 0.039 0.094 0.305 29.0 -0.299 1.0 30.0 KIAA1543 -0.014 0.054 -9999.0 0.0 -0.332 18.0 18.0 KIFC3 -0.014 0.05 -9999.0 0.0 -0.316 18.0 18.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.014 0.052 -9999.0 0.0 -0.316 18.0 18.0 NCK1/GIT1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.034 0.058 -9999.0 0.0 -0.326 18.0 18.0 EXOC4 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.051 -9999.0 0.0 -0.316 18.0 18.0 PIP5K1C -0.014 0.052 -9999.0 0.0 -0.316 18.0 18.0 LIMA1 0.023 0.021 -9999.0 0.0 -0.59 1.0 1.0 ABI1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.014 0.088 0.296 20.0 -9999.0 0.0 20.0 adherens junction assembly -0.026 0.106 0.276 2.0 -0.642 14.0 16.0 IGF-1R heterotetramer/IGF1 -0.045 0.152 -9999.0 0.0 -0.321 196.0 196.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.031 0.031 -9999.0 0.0 -0.439 3.0 3.0 MET -0.076 0.226 -9999.0 0.0 -0.59 145.0 145.0 PLEKHA7 -0.014 0.057 -9999.0 0.0 -0.348 18.0 18.0 mol:GTP 0.042 0.04 -9999.0 0.0 -0.343 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.01 0.068 0.349 5.0 -0.539 1.0 6.0 cortical actin cytoskeleton stabilization 0.01 0.046 -9999.0 0.0 -0.268 19.0 19.0 regulation of cell-cell adhesion -0.016 0.05 -9999.0 0.0 -0.307 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.01 0.047 -9999.0 0.0 -0.269 19.0 19.0