E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.038 0.15 -9999.0 0.0 -0.426 46.0 46.0 KLHL20 0.042 0.115 0.306 41.0 -0.259 14.0 55.0 CYFIP2 0.05 0.047 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.001 0.118 0.312 7.0 -0.302 25.0 32.0 ENAH -0.033 0.143 -9999.0 0.0 -0.413 43.0 43.0 AP1M1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.052 -9999.0 0.0 -0.544 4.0 4.0 CDC42/GTP 0.009 0.076 -9999.0 0.0 -0.291 2.0 2.0 ABI1/Sra1/Nap1 -0.016 0.04 -9999.0 0.0 -0.175 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.095 -9999.0 0.0 -0.311 26.0 26.0 RAPGEF1 -0.031 0.143 0.299 3.0 -0.398 40.0 43.0 CTNND1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.032 0.164 -9999.0 0.0 -0.439 51.0 51.0 CRK -0.028 0.145 0.309 2.0 -0.413 46.0 48.0 E-cadherin/gamma catenin/alpha catenin 0.037 0.089 -9999.0 0.0 -0.344 21.0 21.0 alphaE/beta7 Integrin 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.055 0.042 -9999.0 0.0 -0.31 3.0 3.0 DLG1 -0.042 0.16 -9999.0 0.0 -0.427 52.0 52.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.061 -9999.0 0.0 -0.199 14.0 14.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.543 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.058 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.022 0.081 -9999.0 0.0 -0.258 14.0 14.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.02 0.095 -9999.0 0.0 -0.317 33.0 33.0 TIAM1 0.035 0.012 0.179 3.0 -9999.0 0.0 3.0 E-cadherin(dimer)/Ca2+ 0.046 0.089 -9999.0 0.0 -0.293 26.0 26.0 AKT1 -0.007 0.057 -9999.0 0.0 -0.197 1.0 1.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.544 47.0 47.0 CDH1 0.006 0.118 -9999.0 0.0 -0.544 22.0 22.0 RhoA/GDP -0.0 0.117 0.305 7.0 -0.302 25.0 32.0 actin cytoskeleton organization 0.037 0.094 0.259 42.0 -0.188 13.0 55.0 CDC42/GDP -0.0 0.117 0.305 7.0 -0.302 25.0 32.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.004 0.067 -9999.0 0.0 -0.222 38.0 38.0 ITGB7 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.096 -9999.0 0.0 -0.312 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.082 -9999.0 0.0 -0.291 26.0 26.0 mol:GDP -0.019 0.124 0.309 7.0 -0.336 35.0 42.0 CDC42/GTP/IQGAP1 0.043 0.013 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.006 0.121 0.341 3.0 -0.31 24.0 27.0 RAC1/GTP/IQGAP1 0.044 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.068 0.211 23.0 -0.226 11.0 34.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.038 0.158 -9999.0 0.0 -0.435 49.0 49.0 regulation of cell-cell adhesion -0.001 0.061 -9999.0 0.0 -0.242 3.0 3.0 WASF2 0.02 0.044 0.119 32.0 -0.11 4.0 36.0 Rap1/GTP 0.012 0.087 0.281 1.0 -0.311 3.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.092 -9999.0 0.0 -0.3 21.0 21.0 CCND1 0.017 0.08 0.248 20.0 -0.284 11.0 31.0 VAV2 -0.02 0.193 0.389 3.0 -0.515 40.0 43.0 RAP1/GDP 0.009 0.1 0.311 3.0 -0.335 5.0 8.0 adherens junction assembly -0.035 0.155 -9999.0 0.0 -0.421 49.0 49.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.044 0.089 -9999.0 0.0 -0.289 24.0 24.0 E-cadherin/beta catenin -0.007 0.089 -9999.0 0.0 -0.336 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.039 0.157 -9999.0 0.0 -0.429 50.0 50.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.013 0.145 0.281 59.0 -0.409 19.0 78.0 E-cadherin/beta catenin/alpha catenin 0.036 0.096 -9999.0 0.0 -0.34 26.0 26.0 ITGAE 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.033 0.168 -9999.0 0.0 -0.448 51.0 51.0