Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.045 0.236 0.591 2.0 -0.557 73.0 75.0 IHH 0.021 0.075 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.068 0.148 -9999.0 0.0 -0.314 126.0 126.0 LRPAP1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.067 0.147 0.313 126.0 -9999.0 0.0 126.0 SMO/beta Arrestin2 -0.002 0.186 0.412 2.0 -0.487 28.0 30.0 SMO -0.016 0.185 0.444 2.0 -0.505 29.0 31.0 AKT1 -0.021 0.191 -9999.0 0.0 -0.601 36.0 36.0 ARRB2 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.091 0.238 -9999.0 0.0 -0.544 111.0 111.0 ADRBK1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.016 0.183 0.443 2.0 -0.497 29.0 31.0 STIL 0.042 0.15 0.34 32.0 -0.341 7.0 39.0 DHH N/PTCH2 0.049 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.006 0.162 0.379 2.0 -0.436 24.0 26.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.111 0.391 0.523 6.0 -0.899 94.0 100.0 determination of left/right symmetry -0.016 0.183 0.443 2.0 -0.497 29.0 31.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.544 47.0 47.0 skeletal system development -0.109 0.386 0.522 6.0 -0.887 94.0 100.0 IHH N/Hhip 0.038 0.053 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.05 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.016 0.183 0.443 2.0 -0.497 29.0 31.0 pancreas development 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.024 0.059 -9999.0 0.0 -0.544 5.0 5.0 PI3K 0.005 0.127 -9999.0 0.0 -0.368 51.0 51.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.144 0.266 -9999.0 0.0 -0.544 158.0 158.0 somite specification -0.016 0.183 0.443 2.0 -0.497 29.0 31.0 SHH Np/Cholesterol/PTCH1 -0.01 0.121 -9999.0 0.0 -0.368 9.0 9.0 SHH Np/Cholesterol/PTCH2 0.024 0.037 -9999.0 0.0 -0.312 5.0 5.0 SHH Np/Cholesterol/Megalin -0.056 0.145 -9999.0 0.0 -0.32 110.0 110.0 SHH 0.01 0.043 -9999.0 0.0 -0.4 5.0 5.0 catabolic process -0.009 0.175 0.466 2.0 -0.362 82.0 84.0 SMO/Vitamin D3 0.01 0.172 0.407 16.0 -0.463 12.0 28.0 SHH Np/Cholesterol/Hhip 0.024 0.038 -9999.0 0.0 -0.312 5.0 5.0 LRP2 -0.119 0.255 -9999.0 0.0 -0.544 136.0 136.0 receptor-mediated endocytosis -0.061 0.196 0.349 9.0 -0.514 37.0 46.0 SHH Np/Cholesterol/BOC -0.038 0.13 -9999.0 0.0 -0.313 86.0 86.0 SHH Np/Cholesterol/CDO 0.019 0.049 -9999.0 0.0 -0.352 7.0 7.0 mesenchymal cell differentiation -0.024 0.038 0.31 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 0.027 0.159 0.412 17.0 -0.369 9.0 26.0 IHH N/PTCH2 0.038 0.052 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.027 0.045 -9999.0 0.0 -0.544 3.0 3.0 IHH N/PTCH1 -0.001 0.18 0.468 2.0 -0.364 82.0 84.0 Megalin/LRPAP1 -0.071 0.198 -9999.0 0.0 -0.398 137.0 137.0 PTCH2 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.014 0.034 -9999.0 0.0 -0.31 5.0 5.0 PTCH1 -0.009 0.175 0.467 2.0 -0.363 82.0 84.0 HHIP 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0