Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.011 0.091 -9999.0 0.0 -0.257 46.0 46.0 epithelial cell differentiation 0.04 0.086 -9999.0 0.0 -0.291 26.0 26.0 CYFIP2 0.05 0.047 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.008 0.071 0.282 5.0 -0.295 2.0 7.0 EGFR -0.27 0.288 -9999.0 0.0 -0.544 269.0 269.0 EPHA2 0.026 0.062 -9999.0 0.0 -0.544 6.0 6.0 MYO6 0.0 0.074 -9999.0 0.0 -0.285 25.0 25.0 CTNNB1 0.029 0.052 -9999.0 0.0 -0.544 4.0 4.0 ABI1/Sra1/Nap1 0.074 0.035 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.142 0.236 -9999.0 0.0 -0.489 151.0 151.0 CTNND1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.002 0.072 -9999.0 0.0 -0.281 25.0 25.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.105 -9999.0 0.0 -0.289 63.0 63.0 EGF -0.15 0.27 -9999.0 0.0 -0.544 164.0 164.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.053 0.181 -9999.0 0.0 -0.49 64.0 64.0 cortical microtubule organization 0.04 0.086 -9999.0 0.0 -0.291 26.0 26.0 GO:0000145 -0.022 0.064 -9999.0 0.0 -0.268 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.045 0.089 -9999.0 0.0 -0.294 26.0 26.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.544 3.0 3.0 ARF6/GDP -0.03 0.059 -9999.0 0.0 -0.272 25.0 25.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.059 -9999.0 0.0 -0.316 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.002 0.069 -9999.0 0.0 -0.264 23.0 23.0 PVRL2 0.039 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.003 0.073 -9999.0 0.0 -0.285 26.0 26.0 ARF6/GTP 0.062 0.061 -9999.0 0.0 -0.296 6.0 6.0 CDH1 0.006 0.118 -9999.0 0.0 -0.544 22.0 22.0 EGFR/EGFR/EGF/EGF -0.231 0.205 -9999.0 0.0 -0.348 357.0 357.0 RhoA/GDP 0.04 0.084 -9999.0 0.0 -0.282 25.0 25.0 actin cytoskeleton organization -0.022 0.067 -9999.0 0.0 -0.278 25.0 25.0 IGF-1R heterotetramer 0.011 0.116 -9999.0 0.0 -0.543 21.0 21.0 GIT1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.011 0.116 -9999.0 0.0 -0.544 21.0 21.0 IGF1 -0.25 0.289 -9999.0 0.0 -0.544 252.0 252.0 DIAPH1 0.057 0.125 -9999.0 0.0 -0.561 7.0 7.0 Wnt receptor signaling pathway -0.04 0.086 0.291 26.0 -9999.0 0.0 26.0 RHOA 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.03 0.059 -9999.0 0.0 -0.273 25.0 25.0 CTNNA1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.022 0.069 -9999.0 0.0 -0.284 25.0 25.0 EFNA1 0.028 0.016 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.024 0.066 -9999.0 0.0 -0.275 25.0 25.0 Ephrin A1/EPHA2 0.022 0.084 -9999.0 0.0 -0.29 26.0 26.0 SEC6/SEC8 -0.007 0.068 -9999.0 0.0 -0.272 26.0 26.0 MGAT3 -0.024 0.107 -9999.0 0.0 -0.293 63.0 63.0 HGF/MET 0.004 0.126 -9999.0 0.0 -0.29 73.0 73.0 HGF 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.011 0.092 -9999.0 0.0 -0.259 46.0 46.0 actin cable formation 0.054 0.108 0.344 17.0 -0.289 1.0 18.0 KIAA1543 -0.022 0.065 -9999.0 0.0 -0.272 25.0 25.0 KIFC3 0.0 0.07 -9999.0 0.0 -0.285 25.0 25.0 NCK1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.002 0.072 -9999.0 0.0 -0.285 25.0 25.0 NCK1/GIT1 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.04 0.086 -9999.0 0.0 -0.291 26.0 26.0 EXOC4 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.002 0.071 -9999.0 0.0 -0.285 25.0 25.0 PIP5K1C -0.002 0.072 -9999.0 0.0 -0.285 25.0 25.0 LIMA1 0.013 0.109 -9999.0 0.0 -0.544 19.0 19.0 ABI1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.014 0.104 0.304 13.0 -0.343 2.0 15.0 adherens junction assembly -0.032 0.131 0.297 1.0 -0.637 13.0 14.0 IGF-1R heterotetramer/IGF1 -0.132 0.184 -9999.0 0.0 -0.305 250.0 250.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.045 0.048 -9999.0 0.0 -0.249 9.0 9.0 MET -0.022 0.172 -9999.0 0.0 -0.544 50.0 50.0 PLEKHA7 -0.002 0.072 -9999.0 0.0 -0.285 25.0 25.0 mol:GTP 0.055 0.058 -9999.0 0.0 -0.314 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.013 0.087 0.362 5.0 -0.352 1.0 6.0 cortical actin cytoskeleton stabilization -0.011 0.091 -9999.0 0.0 -0.257 46.0 46.0 regulation of cell-cell adhesion -0.022 0.067 -9999.0 0.0 -0.278 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.011 0.092 -9999.0 0.0 -0.259 46.0 46.0